Tubulin-tyrosine ligase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tubulin-tyrosine ligase-like protein

Species:

Leishmania infantum

UniProt:

A4I5Q6_LEIIN

TriTrypDb:

LINF_300028200

Length:

704

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

A4I5Q6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5Q6

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	18
GO:0008152	metabolic process	1	18
GO:0019538	protein metabolic process	3	18
GO:0036211	protein modification process	4	18
GO:0043170	macromolecule metabolic process	3	18
GO:0043412	macromolecule modification	4	18
GO:0044238	primary metabolic process	2	18
GO:0071704	organic substance metabolic process	2	18
GO:1901564	organonitrogen compound metabolic process	3	18
GO:0000226	microtubule cytoskeleton organization	3	2
GO:0006996	organelle organization	4	2
GO:0007010	cytoskeleton organization	5	2
GO:0007017	microtubule-based process	2	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0018095	protein polyglutamylation	7	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018200	peptidyl-glutamic acid modification	6	2
GO:0071840	cellular component organization or biogenesis	2	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	17
GO:0005488	binding	1	8
GO:0005524	ATP binding	5	7
GO:0016874	ligase activity	2	17
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7
GO:0005515	protein binding	2	2
GO:0008092	cytoskeletal protein binding	3	2
GO:0015631	tubulin binding	4	2
GO:0016879	ligase activity, forming carbon-nitrogen bonds	3	4
GO:0016881	acid-amino acid ligase activity	4	4
GO:0070739	protein-glutamic acid ligase activity	3	2
GO:0070740	tubulin-glutamic acid ligase activity	4	2
GO:0140096	catalytic activity, acting on a protein	2	4
GO:0004835	tubulin-tyrosine ligase activity	3	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	348	352	PF00656	0.514
CLV_C14_Caspase3-7	356	360	PF00656	0.518
CLV_C14_Caspase3-7	453	457	PF00656	0.398
CLV_NRD_NRD_1	109	111	PF00675	0.423
CLV_NRD_NRD_1	190	192	PF00675	0.309
CLV_NRD_NRD_1	205	207	PF00675	0.314
CLV_NRD_NRD_1	285	287	PF00675	0.257
CLV_NRD_NRD_1	305	307	PF00675	0.242
CLV_NRD_NRD_1	413	415	PF00675	0.466
CLV_NRD_NRD_1	473	475	PF00675	0.470
CLV_NRD_NRD_1	503	505	PF00675	0.229
CLV_NRD_NRD_1	55	57	PF00675	0.392
CLV_PCSK_KEX2_1	109	111	PF00082	0.364
CLV_PCSK_KEX2_1	182	184	PF00082	0.279
CLV_PCSK_KEX2_1	190	192	PF00082	0.301
CLV_PCSK_KEX2_1	285	287	PF00082	0.313
CLV_PCSK_KEX2_1	413	415	PF00082	0.486
CLV_PCSK_KEX2_1	473	475	PF00082	0.459
CLV_PCSK_KEX2_1	503	505	PF00082	0.316
CLV_PCSK_PC1ET2_1	182	184	PF00082	0.257
CLV_PCSK_SKI1_1	190	194	PF00082	0.249
CLV_PCSK_SKI1_1	253	257	PF00082	0.266
CLV_PCSK_SKI1_1	285	289	PF00082	0.309
CLV_PCSK_SKI1_1	404	408	PF00082	0.396
CLV_PCSK_SKI1_1	423	427	PF00082	0.528
CLV_Separin_Metazoa	132	136	PF03568	0.605
DEG_Nend_Nbox_1	1	3	PF02207	0.572
DEG_SPOP_SBC_1	345	349	PF00917	0.537
DOC_ANK_TNKS_1	566	573	PF00023	0.395
DOC_CKS1_1	138	143	PF01111	0.497
DOC_CYCLIN_yCln2_LP_2	585	591	PF00134	0.472
DOC_CYCLIN_yCln2_LP_2	668	674	PF00134	0.303
DOC_MAPK_FxFP_2	60	63	PF00069	0.392
DOC_MAPK_gen_1	182	189	PF00069	0.541
DOC_MAPK_gen_1	306	314	PF00069	0.452
DOC_MAPK_MEF2A_6	182	189	PF00069	0.518
DOC_MAPK_MEF2A_6	306	314	PF00069	0.443
DOC_MAPK_MEF2A_6	617	624	PF00069	0.366
DOC_MAPK_NFAT4_5	307	315	PF00069	0.452
DOC_PP2B_LxvP_1	662	665	PF13499	0.501
DOC_PP2B_LxvP_1	99	102	PF13499	0.300
DOC_PP4_FxxP_1	60	63	PF00568	0.382
DOC_USP7_MATH_1	147	151	PF00917	0.550
DOC_USP7_MATH_1	20	24	PF00917	0.440
DOC_USP7_MATH_1	208	212	PF00917	0.490
DOC_USP7_MATH_1	235	239	PF00917	0.499
DOC_USP7_MATH_1	315	319	PF00917	0.421
DOC_USP7_MATH_1	345	349	PF00917	0.732
DOC_USP7_MATH_1	37	41	PF00917	0.612
DOC_USP7_MATH_1	676	680	PF00917	0.514
DOC_USP7_MATH_1	687	691	PF00917	0.494
DOC_USP7_MATH_2	223	229	PF00917	0.429
DOC_USP7_UBL2_3	278	282	PF12436	0.401
DOC_WW_Pin1_4	137	142	PF00397	0.518
DOC_WW_Pin1_4	199	204	PF00397	0.418
DOC_WW_Pin1_4	39	44	PF00397	0.618
DOC_WW_Pin1_4	50	55	PF00397	0.489
LIG_14-3-3_CanoR_1	161	169	PF00244	0.433
LIG_14-3-3_CanoR_1	199	203	PF00244	0.523
LIG_14-3-3_CanoR_1	212	216	PF00244	0.476
LIG_14-3-3_CanoR_1	285	293	PF00244	0.483
LIG_14-3-3_CanoR_1	423	429	PF00244	0.603
LIG_14-3-3_CanoR_1	56	61	PF00244	0.348
LIG_Actin_WH2_2	34	51	PF00022	0.553
LIG_BIR_III_4	456	460	PF00653	0.381
LIG_BRCT_BRCA1_1	126	130	PF00533	0.518
LIG_BRCT_BRCA1_1	540	544	PF00533	0.516
LIG_BRCT_BRCA1_1	58	62	PF00533	0.331
LIG_BRCT_BRCA1_1	655	659	PF00533	0.686
LIG_EH_1	525	529	PF12763	0.429
LIG_eIF4E_1	296	302	PF01652	0.411
LIG_eIF4E_1	688	694	PF01652	0.350
LIG_FHA_1	138	144	PF00498	0.616
LIG_FHA_1	282	288	PF00498	0.524
LIG_FHA_1	430	436	PF00498	0.705
LIG_FHA_1	460	466	PF00498	0.440
LIG_FHA_1	486	492	PF00498	0.513
LIG_FHA_1	548	554	PF00498	0.455
LIG_FHA_1	600	606	PF00498	0.544
LIG_FHA_1	697	703	PF00498	0.318
LIG_FHA_2	200	206	PF00498	0.502
LIG_FHA_2	369	375	PF00498	0.506
LIG_FXI_DFP_1	142	146	PF00024	0.469
LIG_GBD_Chelix_1	483	491	PF00786	0.221
LIG_GBD_Chelix_1	553	561	PF00786	0.260
LIG_Integrin_isoDGR_2	421	423	PF01839	0.465
LIG_Integrin_RGD_1	381	383	PF01839	0.548
LIG_LIR_Apic_2	219	223	PF02991	0.461
LIG_LIR_Apic_2	59	63	PF02991	0.401
LIG_LIR_Gen_1	127	134	PF02991	0.429
LIG_LIR_Gen_1	211	221	PF02991	0.453
LIG_LIR_Gen_1	267	275	PF02991	0.516
LIG_LIR_Nem_3	267	271	PF02991	0.441
LIG_LIR_Nem_3	317	322	PF02991	0.459
LIG_LIR_Nem_3	401	406	PF02991	0.454
LIG_LIR_Nem_3	510	515	PF02991	0.477
LIG_LIR_Nem_3	656	662	PF02991	0.665
LIG_LIR_Nem_3	93	99	PF02991	0.390
LIG_MLH1_MIPbox_1	58	62	PF16413	0.446
LIG_MYND_3	535	539	PF01753	0.477
LIG_Pex14_2	634	638	PF04695	0.297
LIG_SH2_CRK	319	323	PF00017	0.463
LIG_SH2_NCK_1	339	343	PF00017	0.450
LIG_SH2_PTP2	313	316	PF00017	0.414
LIG_SH2_SRC	454	457	PF00017	0.472
LIG_SH2_STAP1	97	101	PF00017	0.353
LIG_SH2_STAT3	291	294	PF00017	0.442
LIG_SH2_STAT3	688	691	PF00017	0.346
LIG_SH2_STAT3	73	76	PF00017	0.482
LIG_SH2_STAT5	291	294	PF00017	0.442
LIG_SH2_STAT5	296	299	PF00017	0.442
LIG_SH2_STAT5	313	316	PF00017	0.442
LIG_SH2_STAT5	415	418	PF00017	0.551
LIG_SH2_STAT5	454	457	PF00017	0.512
LIG_SH2_STAT5	47	50	PF00017	0.409
LIG_SH2_STAT5	511	514	PF00017	0.496
LIG_SH2_STAT5	61	64	PF00017	0.403
LIG_SH2_STAT5	681	684	PF00017	0.317
LIG_SH3_3	502	508	PF00018	0.488
LIG_SUMO_SIM_anti_2	604	609	PF11976	0.488
LIG_SUMO_SIM_par_1	298	304	PF11976	0.439
LIG_SUMO_SIM_par_1	461	467	PF11976	0.450
LIG_SUMO_SIM_par_1	528	534	PF11976	0.455
LIG_UBA3_1	271	278	PF00899	0.503
LIG_WW_1	70	73	PF00397	0.406
MOD_CDC14_SPxK_1	53	56	PF00782	0.507
MOD_CDK_SPxK_1	50	56	PF00069	0.495
MOD_CDK_SPxxK_3	199	206	PF00069	0.418
MOD_CDK_SPxxK_3	50	57	PF00069	0.488
MOD_CK1_1	211	217	PF00069	0.481
MOD_CK1_1	228	234	PF00069	0.499
MOD_CK1_1	23	29	PF00069	0.649
MOD_CK1_1	247	253	PF00069	0.494
MOD_CK1_1	281	287	PF00069	0.536
MOD_CK1_1	340	346	PF00069	0.550
MOD_CK1_1	372	378	PF00069	0.800
MOD_CK1_1	424	430	PF00069	0.668
MOD_CK1_1	461	467	PF00069	0.683
MOD_CK1_1	537	543	PF00069	0.431
MOD_CK1_1	644	650	PF00069	0.597
MOD_CK1_1	655	661	PF00069	0.608
MOD_CK1_1	79	85	PF00069	0.472
MOD_CK1_1	88	94	PF00069	0.490
MOD_CK2_1	199	205	PF00069	0.503
MOD_CK2_1	368	374	PF00069	0.500
MOD_CK2_1	507	513	PF00069	0.477
MOD_CK2_1	89	95	PF00069	0.406
MOD_Cter_Amidation	304	307	PF01082	0.272
MOD_Cter_Amidation	411	414	PF01082	0.436
MOD_DYRK1A_RPxSP_1	199	203	PF00069	0.368
MOD_GlcNHglycan	22	25	PF01048	0.699
MOD_GlcNHglycan	343	346	PF01048	0.489
MOD_GlcNHglycan	374	377	PF01048	0.788
MOD_GlcNHglycan	385	388	PF01048	0.712
MOD_GlcNHglycan	643	646	PF01048	0.621
MOD_GlcNHglycan	654	658	PF01048	0.530
MOD_GlcNHglycan	659	662	PF01048	0.420
MOD_GSK3_1	22	29	PF00069	0.622
MOD_GSK3_1	255	262	PF00069	0.555
MOD_GSK3_1	337	344	PF00069	0.549
MOD_GSK3_1	365	372	PF00069	0.682
MOD_GSK3_1	385	392	PF00069	0.786
MOD_GSK3_1	534	541	PF00069	0.467
MOD_GSK3_1	571	578	PF00069	0.563
MOD_GSK3_1	639	646	PF00069	0.455
MOD_GSK3_1	653	660	PF00069	0.584
MOD_GSK3_1	692	699	PF00069	0.433
MOD_GSK3_1	75	82	PF00069	0.550
MOD_GSK3_1	85	92	PF00069	0.426
MOD_N-GLC_1	407	412	PF02516	0.467
MOD_N-GLC_1	576	581	PF02516	0.561
MOD_NEK2_1	162	167	PF00069	0.478
MOD_NEK2_1	287	292	PF00069	0.483
MOD_NEK2_1	444	449	PF00069	0.356
MOD_NEK2_1	521	526	PF00069	0.475
MOD_NEK2_1	538	543	PF00069	0.433
MOD_NEK2_1	575	580	PF00069	0.519
MOD_NEK2_1	643	648	PF00069	0.611
MOD_NEK2_1	653	658	PF00069	0.651
MOD_NEK2_1	677	682	PF00069	0.483
MOD_NEK2_1	87	92	PF00069	0.405
MOD_NEK2_2	124	129	PF00069	0.341
MOD_PIKK_1	255	261	PF00454	0.431
MOD_PIKK_1	576	582	PF00454	0.416
MOD_PIKK_1	645	651	PF00454	0.625
MOD_PIKK_1	687	693	PF00454	0.315
MOD_PKA_1	473	479	PF00069	0.329
MOD_PKA_1	56	62	PF00069	0.348
MOD_PKA_2	198	204	PF00069	0.396
MOD_PKA_2	211	217	PF00069	0.506
MOD_PKA_2	225	231	PF00069	0.519
MOD_PKA_2	247	253	PF00069	0.434
MOD_PKA_2	372	378	PF00069	0.524
MOD_PKA_2	473	479	PF00069	0.337
MOD_PKB_1	402	410	PF00069	0.574
MOD_Plk_1	407	413	PF00069	0.474
MOD_Plk_1	521	527	PF00069	0.508
MOD_Plk_1	576	582	PF00069	0.534
MOD_Plk_1	696	702	PF00069	0.317
MOD_Plk_4	211	217	PF00069	0.480
MOD_Plk_4	225	231	PF00069	0.471
MOD_Plk_4	287	293	PF00069	0.520
MOD_Plk_4	30	36	PF00069	0.500
MOD_Plk_4	320	326	PF00069	0.411
MOD_Plk_4	507	513	PF00069	0.464
MOD_Plk_4	56	62	PF00069	0.309
MOD_Plk_4	571	577	PF00069	0.591
MOD_Plk_4	677	683	PF00069	0.552
MOD_ProDKin_1	137	143	PF00069	0.515
MOD_ProDKin_1	199	205	PF00069	0.418
MOD_ProDKin_1	39	45	PF00069	0.609
MOD_ProDKin_1	50	56	PF00069	0.487
MOD_SUMO_for_1	651	654	PF00179	0.511
MOD_SUMO_rev_2	273	280	PF00179	0.483
TRG_DiLeu_BaEn_1	225	230	PF01217	0.452
TRG_DiLeu_BaEn_1	298	303	PF01217	0.434
TRG_DiLeu_BaEn_1	482	487	PF01217	0.518
TRG_DiLeu_BaEn_1	689	694	PF01217	0.327
TRG_DiLeu_BaLyEn_6	138	143	PF01217	0.542
TRG_DiLeu_BaLyEn_6	297	302	PF01217	0.411
TRG_DiLeu_BaLyEn_6	99	104	PF01217	0.298
TRG_ENDOCYTIC_2	169	172	PF00928	0.477
TRG_ENDOCYTIC_2	213	216	PF00928	0.434
TRG_ENDOCYTIC_2	313	316	PF00928	0.414
TRG_ENDOCYTIC_2	319	322	PF00928	0.463
TRG_ENDOCYTIC_2	511	514	PF00928	0.476
TRG_ENDOCYTIC_2	96	99	PF00928	0.339
TRG_ER_diArg_1	108	110	PF00400	0.413
TRG_ER_diArg_1	189	191	PF00400	0.556
TRG_ER_diArg_1	285	287	PF00400	0.513
TRG_ER_diArg_1	413	415	PF00400	0.542
TRG_ER_diArg_1	502	504	PF00400	0.429
TRG_ER_diArg_1	622	625	PF00400	0.449
TRG_ER_diArg_1	63	66	PF00400	0.434

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1Q6	Leptomonas seymouri	56%	98%
A0A0S4ISF0	Bodo saltans	37%	100%
A0A1X0P1M0	Trypanosomatidae	40%	100%
A0A3Q8IDL7	Leishmania donovani	25%	97%
A0A3Q8IEC1	Leishmania donovani	100%	100%
A0A3R7LAU2	Trypanosoma rangeli	25%	75%
A0A3S5IS28	Trypanosoma rangeli	41%	100%
A4HIG0	Leishmania braziliensis	76%	100%
A4HYN9	Leishmania infantum	25%	100%
A4Q9F0	Mus musculus	25%	77%
A8X9V4	Caenorhabditis briggsae	24%	100%
C9ZR25	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AID0	Leishmania braziliensis	27%	94%
E9AUL7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9B101	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q765	Leishmania major	93%	100%
Q4QCW7	Leishmania major	26%	100%
Q8NHH1	Homo sapiens	24%	88%
V5BLC0	Trypanosoma cruzi	42%	100%