Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I5Q1_LEIIN

TriTrypDb:

LINF_300027700

Length:

251

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I5Q1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5Q1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	3	5	PF00675	0.456
CLV_NRD_NRD_1	44	46	PF00675	0.518
CLV_PCSK_KEX2_1	155	157	PF00082	0.472
CLV_PCSK_KEX2_1	2	4	PF00082	0.494
CLV_PCSK_KEX2_1	44	46	PF00082	0.518
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.472
CLV_PCSK_SKI1_1	184	188	PF00082	0.372
CLV_PCSK_SKI1_1	4	8	PF00082	0.507
DEG_Nend_UBRbox_1	1	4	PF02207	0.508
DOC_CYCLIN_RxL_1	1	10	PF00134	0.528
DOC_MAPK_gen_1	2	8	PF00069	0.499
DOC_PP1_RVXF_1	42	49	PF00149	0.423
DOC_PP2B_LxvP_1	232	235	PF13499	0.431
DOC_USP7_MATH_1	105	109	PF00917	0.632
DOC_USP7_MATH_1	160	164	PF00917	0.684
DOC_USP7_MATH_1	31	35	PF00917	0.314
DOC_USP7_UBL2_3	28	32	PF12436	0.354
DOC_WW_Pin1_4	109	114	PF00397	0.675
DOC_WW_Pin1_4	125	130	PF00397	0.457
LIG_14-3-3_CanoR_1	12	19	PF00244	0.478
LIG_14-3-3_CanoR_1	141	146	PF00244	0.560
LIG_Actin_WH2_2	227	245	PF00022	0.371
LIG_AP_GAE_1	118	124	PF02883	0.447
LIG_APCC_ABBA_1	36	41	PF00400	0.378
LIG_BRCT_BRCA1_1	163	167	PF00533	0.531
LIG_BRCT_BRCA1_1	70	74	PF00533	0.416
LIG_eIF4E_1	30	36	PF01652	0.454
LIG_FHA_2	90	96	PF00498	0.652
LIG_LIR_Apic_2	170	174	PF02991	0.366
LIG_LIR_Gen_1	118	129	PF02991	0.558
LIG_LIR_Gen_1	14	24	PF02991	0.365
LIG_LIR_Gen_1	140	151	PF02991	0.420
LIG_LIR_Gen_1	200	209	PF02991	0.506
LIG_LIR_Nem_3	118	124	PF02991	0.571
LIG_LIR_Nem_3	140	145	PF02991	0.434
LIG_LIR_Nem_3	200	204	PF02991	0.476
LIG_LIR_Nem_3	60	66	PF02991	0.518
LIG_LYPXL_L_2	225	234	PF13949	0.375
LIG_MLH1_MIPbox_1	164	168	PF16413	0.504
LIG_PDZ_Class_2	246	251	PF00595	0.376
LIG_Pex14_2	167	171	PF04695	0.422
LIG_SH2_NCK_1	127	131	PF00017	0.401
LIG_SH2_STAT3	67	70	PF00017	0.334
LIG_SH2_STAT5	64	67	PF00017	0.333
LIG_SH3_3	107	113	PF00018	0.662
LIG_WRC_WIRS_1	142	147	PF05994	0.428
LIG_WRC_WIRS_1	198	203	PF05994	0.473
LIG_WRC_WIRS_1	246	251	PF05994	0.559
LIG_WRC_WIRS_1	66	71	PF05994	0.341
MOD_CDC14_SPxK_1	112	115	PF00782	0.577
MOD_CDK_SPxK_1	109	115	PF00069	0.580
MOD_CDK_SPxxK_3	109	116	PF00069	0.660
MOD_CK1_1	109	115	PF00069	0.574
MOD_CK1_1	128	134	PF00069	0.501
MOD_CK1_1	200	206	PF00069	0.459
MOD_CK1_1	34	40	PF00069	0.434
MOD_GlcNHglycan	102	106	PF01048	0.521
MOD_GlcNHglycan	121	124	PF01048	0.397
MOD_GlcNHglycan	158	161	PF01048	0.604
MOD_GlcNHglycan	84	87	PF01048	0.798
MOD_GSK3_1	105	112	PF00069	0.625
MOD_GSK3_1	156	163	PF00069	0.556
MOD_GSK3_1	65	72	PF00069	0.457
MOD_GSK3_1	7	14	PF00069	0.443
MOD_GSK3_1	97	104	PF00069	0.611
MOD_N-GLC_1	160	165	PF02516	0.572
MOD_NEK2_1	101	106	PF00069	0.518
MOD_NEK2_1	242	247	PF00069	0.445
MOD_NEK2_1	65	70	PF00069	0.334
MOD_NEK2_1	7	12	PF00069	0.475
MOD_PKA_2	11	17	PF00069	0.462
MOD_PKA_2	242	248	PF00069	0.385
MOD_PKB_1	139	147	PF00069	0.437
MOD_Plk_4	184	190	PF00069	0.480
MOD_Plk_4	200	206	PF00069	0.307
MOD_Plk_4	31	37	PF00069	0.375
MOD_ProDKin_1	109	115	PF00069	0.676
MOD_ProDKin_1	125	131	PF00069	0.445
MOD_SUMO_for_1	114	117	PF00179	0.651
TRG_ENDOCYTIC_2	63	66	PF00928	0.338
TRG_ER_diArg_1	1	4	PF00400	0.508
TRG_ER_diArg_1	44	47	PF00400	0.478
TRG_Pf-PMV_PEXEL_1	4	9	PF00026	0.498

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P919	Leptomonas seymouri	54%	100%
A0A0N1I9X1	Leptomonas seymouri	47%	100%
A0A3S7X3I9	Leishmania donovani	99%	100%
A4HIF5	Leishmania braziliensis	76%	100%
E9B0Z6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q770	Leishmania major	92%	100%