Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Uncharacterised ACR - YagE family COG1723 - putative

Species:

Leishmania infantum

UniProt:

A4I5Q0_LEIIN

TriTrypDb:

LINF_300027600

Length:

538

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:0016020	membrane	2	10

Expansion

Sequence features

A4I5Q0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5Q0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	208	212	PF00656	0.619
CLV_NRD_NRD_1	174	176	PF00675	0.358
CLV_NRD_NRD_1	189	191	PF00675	0.395
CLV_NRD_NRD_1	206	208	PF00675	0.394
CLV_NRD_NRD_1	222	224	PF00675	0.418
CLV_NRD_NRD_1	262	264	PF00675	0.334
CLV_NRD_NRD_1	298	300	PF00675	0.245
CLV_NRD_NRD_1	30	32	PF00675	0.519
CLV_NRD_NRD_1	435	437	PF00675	0.298
CLV_NRD_NRD_1	504	506	PF00675	0.308
CLV_PCSK_FUR_1	172	176	PF00082	0.432
CLV_PCSK_KEX2_1	174	176	PF00082	0.371
CLV_PCSK_KEX2_1	189	191	PF00082	0.397
CLV_PCSK_KEX2_1	206	208	PF00082	0.394
CLV_PCSK_KEX2_1	222	224	PF00082	0.421
CLV_PCSK_KEX2_1	262	264	PF00082	0.341
CLV_PCSK_KEX2_1	30	32	PF00082	0.519
CLV_PCSK_KEX2_1	434	436	PF00082	0.295
CLV_PCSK_KEX2_1	504	506	PF00082	0.308
CLV_PCSK_PC1ET2_1	434	436	PF00082	0.270
CLV_PCSK_PC7_1	170	176	PF00082	0.337
CLV_PCSK_SKI1_1	174	178	PF00082	0.389
CLV_PCSK_SKI1_1	30	34	PF00082	0.401
CLV_PCSK_SKI1_1	367	371	PF00082	0.288
CLV_PCSK_SKI1_1	415	419	PF00082	0.236
CLV_PCSK_SKI1_1	90	94	PF00082	0.515
DEG_APCC_DBOX_1	113	121	PF00400	0.615
DEG_APCC_DBOX_1	169	177	PF00400	0.621
DEG_APCC_DBOX_1	249	257	PF00400	0.518
DEG_APCC_DBOX_1	504	512	PF00400	0.428
DEG_Nend_UBRbox_2	1	3	PF02207	0.635
DEG_ODPH_VHL_1	87	100	PF01847	0.635
DEG_SCF_FBW7_1	63	70	PF00400	0.805
DEG_SPOP_SBC_1	193	197	PF00917	0.600
DOC_CDC14_PxL_1	461	469	PF14671	0.515
DOC_CKS1_1	348	353	PF01111	0.434
DOC_CKS1_1	418	423	PF01111	0.470
DOC_CYCLIN_RxL_1	113	123	PF00134	0.628
DOC_CYCLIN_RxL_1	170	181	PF00134	0.633
DOC_CYCLIN_RxL_1	367	375	PF00134	0.525
DOC_CYCLIN_yCln2_LP_2	418	424	PF00134	0.532
DOC_MAPK_gen_1	114	122	PF00069	0.628
DOC_MAPK_gen_1	434	446	PF00069	0.535
DOC_MAPK_MEF2A_6	114	122	PF00069	0.547
DOC_MAPK_MEF2A_6	386	393	PF00069	0.428
DOC_MAPK_RevD_3	161	175	PF00069	0.516
DOC_PP1_RVXF_1	368	375	PF00149	0.487
DOC_PP1_RVXF_1	481	487	PF00149	0.532
DOC_USP7_MATH_1	193	197	PF00917	0.600
DOC_USP7_MATH_1	213	217	PF00917	0.664
DOC_USP7_MATH_1	384	388	PF00917	0.470
DOC_USP7_MATH_1	450	454	PF00917	0.499
DOC_USP7_MATH_1	67	71	PF00917	0.715
DOC_WW_Pin1_4	162	167	PF00397	0.506
DOC_WW_Pin1_4	189	194	PF00397	0.591
DOC_WW_Pin1_4	347	352	PF00397	0.472
DOC_WW_Pin1_4	417	422	PF00397	0.470
DOC_WW_Pin1_4	63	68	PF00397	0.732
DOC_WW_Pin1_4	70	75	PF00397	0.681
DOC_WW_Pin1_4	93	98	PF00397	0.728
LIG_14-3-3_CanoR_1	189	193	PF00244	0.688
LIG_14-3-3_CanoR_1	263	273	PF00244	0.560
LIG_14-3-3_CanoR_1	415	421	PF00244	0.532
LIG_14-3-3_CanoR_1	483	487	PF00244	0.477
LIG_14-3-3_CanoR_1	90	99	PF00244	0.728
LIG_BRCT_BRCA1_1	28	32	PF00533	0.619
LIG_BRCT_BRCA1_1	512	516	PF00533	0.268
LIG_Clathr_ClatBox_1	520	524	PF01394	0.355
LIG_deltaCOP1_diTrp_1	459	466	PF00928	0.438
LIG_EH1_1	515	523	PF00400	0.262
LIG_FHA_1	113	119	PF00498	0.653
LIG_FHA_1	124	130	PF00498	0.552
LIG_FHA_1	179	185	PF00498	0.597
LIG_FHA_1	423	429	PF00498	0.545
LIG_FHA_1	527	533	PF00498	0.437
LIG_FHA_1	7	13	PF00498	0.673
LIG_FHA_1	93	99	PF00498	0.642
LIG_FHA_2	128	134	PF00498	0.572
LIG_FHA_2	206	212	PF00498	0.657
LIG_FHA_2	418	424	PF00498	0.587
LIG_FHA_2	491	497	PF00498	0.572
LIG_LIR_Apic_2	375	380	PF02991	0.428
LIG_LIR_Apic_2	459	465	PF02991	0.431
LIG_LIR_Gen_1	157	166	PF02991	0.564
LIG_LIR_Gen_1	241	251	PF02991	0.474
LIG_LIR_Gen_1	279	287	PF02991	0.511
LIG_LIR_Gen_1	513	523	PF02991	0.276
LIG_LIR_Nem_3	147	151	PF02991	0.562
LIG_LIR_Nem_3	157	161	PF02991	0.552
LIG_LIR_Nem_3	241	247	PF02991	0.469
LIG_LIR_Nem_3	279	285	PF02991	0.548
LIG_LIR_Nem_3	353	359	PF02991	0.581
LIG_LIR_Nem_3	404	409	PF02991	0.495
LIG_LIR_Nem_3	423	427	PF02991	0.379
LIG_LIR_Nem_3	513	519	PF02991	0.276
LIG_MYND_1	85	89	PF01753	0.663
LIG_NRBOX	516	522	PF00104	0.295
LIG_PCNA_PIPBox_1	326	335	PF02747	0.428
LIG_PCNA_yPIPBox_3	314	323	PF02747	0.449
LIG_Pex14_1	140	144	PF04695	0.509
LIG_Pex14_1	466	470	PF04695	0.430
LIG_SH2_CRK	148	152	PF00017	0.513
LIG_SH2_CRK	158	162	PF00017	0.485
LIG_SH2_CRK	244	248	PF00017	0.472
LIG_SH2_NCK_1	244	248	PF00017	0.551
LIG_SH2_NCK_1	471	475	PF00017	0.532
LIG_SH2_STAP1	144	148	PF00017	0.613
LIG_SH2_STAP1	244	248	PF00017	0.486
LIG_SH2_STAT5	154	157	PF00017	0.481
LIG_SH2_STAT5	377	380	PF00017	0.428
LIG_SH2_STAT5	405	408	PF00017	0.495
LIG_SH3_3	107	113	PF00018	0.595
LIG_SH3_3	160	166	PF00018	0.572
LIG_SH3_3	224	230	PF00018	0.713
LIG_SH3_3	345	351	PF00018	0.468
LIG_SH3_3	83	89	PF00018	0.740
LIG_SH3_CIN85_PxpxPR_1	72	77	PF14604	0.623
LIG_SUMO_SIM_par_1	357	362	PF11976	0.470
LIG_SUMO_SIM_par_1	387	392	PF11976	0.443
LIG_SUMO_SIM_par_1	518	524	PF11976	0.276
LIG_TYR_ITIM	242	247	PF00017	0.466
LIG_UBA3_1	494	502	PF00899	0.507
LIG_WRC_WIRS_1	390	395	PF05994	0.532
MOD_CDK_SPxxK_3	70	77	PF00069	0.623
MOD_CK1_1	157	163	PF00069	0.610
MOD_CK1_1	178	184	PF00069	0.625
MOD_CK1_1	196	202	PF00069	0.738
MOD_CK1_1	228	234	PF00069	0.685
MOD_CK1_1	482	488	PF00069	0.525
MOD_CK1_1	70	76	PF00069	0.692
MOD_CK2_1	127	133	PF00069	0.540
MOD_CK2_1	417	423	PF00069	0.587
MOD_CK2_1	490	496	PF00069	0.569
MOD_Cter_Amidation	204	207	PF01082	0.435
MOD_Cter_Amidation	502	505	PF01082	0.404
MOD_GlcNHglycan	217	220	PF01048	0.519
MOD_GlcNHglycan	230	233	PF01048	0.425
MOD_GlcNHglycan	310	313	PF01048	0.272
MOD_GlcNHglycan	399	402	PF01048	0.332
MOD_GlcNHglycan	4	7	PF01048	0.581
MOD_GlcNHglycan	452	455	PF01048	0.282
MOD_GlcNHglycan	49	52	PF01048	0.547
MOD_GlcNHglycan	69	72	PF01048	0.505
MOD_GlcNHglycan	77	80	PF01048	0.514
MOD_GSK3_1	123	130	PF00069	0.544
MOD_GSK3_1	188	195	PF00069	0.749
MOD_GSK3_1	2	9	PF00069	0.630
MOD_GSK3_1	22	29	PF00069	0.679
MOD_GSK3_1	221	228	PF00069	0.668
MOD_GSK3_1	238	245	PF00069	0.417
MOD_GSK3_1	389	396	PF00069	0.452
MOD_GSK3_1	482	489	PF00069	0.526
MOD_GSK3_1	59	66	PF00069	0.737
MOD_GSK3_1	75	82	PF00069	0.673
MOD_N-GLC_1	123	128	PF02516	0.443
MOD_N-GLC_1	477	482	PF02516	0.270
MOD_NEK2_1	120	125	PF00069	0.630
MOD_NEK2_1	21	26	PF00069	0.630
MOD_NEK2_1	285	290	PF00069	0.472
MOD_NEK2_1	310	315	PF00069	0.435
MOD_NEK2_1	32	37	PF00069	0.729
MOD_NEK2_1	391	396	PF00069	0.428
MOD_NEK2_1	397	402	PF00069	0.428
MOD_NEK2_1	527	532	PF00069	0.405
MOD_NEK2_1	92	97	PF00069	0.714
MOD_NEK2_2	255	260	PF00069	0.577
MOD_PIKK_1	213	219	PF00454	0.671
MOD_PIKK_1	52	58	PF00454	0.757
MOD_PK_1	175	181	PF00069	0.637
MOD_PKA_2	188	194	PF00069	0.684
MOD_PKA_2	205	211	PF00069	0.633
MOD_PKA_2	221	227	PF00069	0.697
MOD_PKA_2	482	488	PF00069	0.525
MOD_Plk_1	59	65	PF00069	0.758
MOD_Plk_4	157	163	PF00069	0.552
MOD_Plk_4	255	261	PF00069	0.520
MOD_Plk_4	482	488	PF00069	0.491
MOD_Plk_4	490	496	PF00069	0.554
MOD_ProDKin_1	162	168	PF00069	0.505
MOD_ProDKin_1	189	195	PF00069	0.595
MOD_ProDKin_1	347	353	PF00069	0.472
MOD_ProDKin_1	417	423	PF00069	0.470
MOD_ProDKin_1	63	69	PF00069	0.731
MOD_ProDKin_1	70	76	PF00069	0.680
MOD_ProDKin_1	93	99	PF00069	0.729
TRG_DiLeu_BaEn_1	423	428	PF01217	0.528
TRG_DiLeu_BaLyEn_6	113	118	PF01217	0.628
TRG_DiLeu_BaLyEn_6	94	99	PF01217	0.672
TRG_ENDOCYTIC_2	148	151	PF00928	0.517
TRG_ENDOCYTIC_2	158	161	PF00928	0.497
TRG_ENDOCYTIC_2	244	247	PF00928	0.468
TRG_ENDOCYTIC_2	470	473	PF00928	0.420
TRG_ENDOCYTIC_2	506	509	PF00928	0.532
TRG_ER_diArg_1	100	103	PF00400	0.801
TRG_ER_diArg_1	113	116	PF00400	0.595
TRG_ER_diArg_1	170	173	PF00400	0.519
TRG_ER_diArg_1	174	176	PF00400	0.563
TRG_ER_diArg_1	188	190	PF00400	0.565
TRG_ER_diArg_1	30	32	PF00400	0.718
TRG_ER_diArg_1	435	437	PF00400	0.537
TRG_ER_diArg_1	504	506	PF00400	0.509
TRG_Pf-PMV_PEXEL_1	90	94	PF00026	0.416

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8P4	Leptomonas seymouri	65%	79%
A0A0S4IQM3	Bodo saltans	42%	100%
A0A1X0P1X6	Trypanosomatidae	47%	82%
A0A3Q8IS20	Leishmania donovani	100%	100%
A0A422NW98	Trypanosoma rangeli	43%	87%
A4HIF4	Leishmania braziliensis	81%	100%
C9ZR20	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	83%
E9B0Z5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q771	Leishmania major	94%	100%
V5BGV1	Trypanosoma cruzi	42%	86%