RNA binding protein

Quick info Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

RNA binding protein

Gene product:

RNA recognition motif. (a.k.a. RRM - RBD - or RNP domain)/RNA recognition motif (a.k.a. RRM - RBD - or RNP domain) - putative

Species:

Leishmania infantum

UniProt:

A4I5P7_LEIIN

TriTrypDb:

LINF_300027200

Length:

503

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Phosphorylation

Amastigote: 205

Expansion

Sequence features

A4I5P7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5P7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0003723	RNA binding	4	6
GO:0005488	binding	1	6
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	186	188	PF00675	0.591
CLV_NRD_NRD_1	405	407	PF00675	0.651
CLV_PCSK_FUR_1	181	185	PF00082	0.578
CLV_PCSK_KEX2_1	150	152	PF00082	0.301
CLV_PCSK_KEX2_1	180	182	PF00082	0.565
CLV_PCSK_KEX2_1	183	185	PF00082	0.552
CLV_PCSK_KEX2_1	186	188	PF00082	0.535
CLV_PCSK_KEX2_1	405	407	PF00082	0.651
CLV_PCSK_PC1ET2_1	150	152	PF00082	0.301
CLV_PCSK_PC1ET2_1	180	182	PF00082	0.565
CLV_PCSK_PC7_1	181	187	PF00082	0.583
CLV_PCSK_SKI1_1	14	18	PF00082	0.332
CLV_PCSK_SKI1_1	150	154	PF00082	0.395
CLV_PCSK_SKI1_1	34	38	PF00082	0.199
DEG_SCF_FBW7_1	354	361	PF00400	0.688
DEG_SCF_FBW7_1	423	429	PF00400	0.672
DEG_SCF_FBW7_1	436	442	PF00400	0.539
DEG_SIAH_1	419	427	PF03145	0.652
DEG_SPOP_SBC_1	426	430	PF00917	0.677
DOC_CKS1_1	363	368	PF01111	0.700
DOC_CKS1_1	400	405	PF01111	0.680
DOC_CKS1_1	423	428	PF01111	0.670
DOC_CKS1_1	436	441	PF01111	0.539
DOC_CYCLIN_yCln2_LP_2	492	498	PF00134	0.625
DOC_MAPK_gen_1	150	156	PF00069	0.501
DOC_MAPK_gen_1	43	52	PF00069	0.532
DOC_MAPK_gen_1	64	72	PF00069	0.532
DOC_PP2B_LxvP_1	225	228	PF13499	0.629
DOC_PP2B_LxvP_1	267	270	PF13499	0.631
DOC_PP2B_LxvP_1	469	472	PF13499	0.542
DOC_PP2B_LxvP_1	492	495	PF13499	0.652
DOC_PP2B_PxIxI_1	473	479	PF00149	0.613
DOC_PP4_FxxP_1	203	206	PF00568	0.612
DOC_USP7_MATH_1	152	156	PF00917	0.517
DOC_USP7_MATH_1	209	213	PF00917	0.624
DOC_USP7_MATH_1	240	244	PF00917	0.643
DOC_USP7_MATH_1	300	304	PF00917	0.634
DOC_USP7_MATH_1	324	328	PF00917	0.574
DOC_USP7_MATH_1	358	362	PF00917	0.688
DOC_USP7_MATH_1	426	430	PF00917	0.693
DOC_USP7_MATH_1	439	443	PF00917	0.566
DOC_USP7_UBL2_3	85	89	PF12436	0.588
DOC_WW_Pin1_4	202	207	PF00397	0.607
DOC_WW_Pin1_4	236	241	PF00397	0.615
DOC_WW_Pin1_4	320	325	PF00397	0.674
DOC_WW_Pin1_4	354	359	PF00397	0.686
DOC_WW_Pin1_4	362	367	PF00397	0.622
DOC_WW_Pin1_4	399	404	PF00397	0.674
DOC_WW_Pin1_4	422	427	PF00397	0.634
DOC_WW_Pin1_4	435	440	PF00397	0.541
DOC_WW_Pin1_4	462	467	PF00397	0.660
LIG_14-3-3_CanoR_1	14	21	PF00244	0.532
LIG_14-3-3_CanoR_1	151	157	PF00244	0.491
LIG_14-3-3_CanoR_1	244	250	PF00244	0.591
LIG_BIR_III_4	394	398	PF00653	0.560
LIG_BRCT_BRCA1_1	275	279	PF00533	0.671
LIG_BRCT_BRCA1_1	327	331	PF00533	0.687
LIG_BRCT_BRCA1_1	43	47	PF00533	0.532
LIG_eIF4E_1	446	452	PF01652	0.580
LIG_EVH1_1	225	229	PF00568	0.595
LIG_FHA_1	205	211	PF00498	0.630
LIG_FHA_1	311	317	PF00498	0.763
LIG_FHA_1	436	442	PF00498	0.638
LIG_FHA_1	446	452	PF00498	0.564
LIG_FHA_2	15	21	PF00498	0.532
LIG_FHA_2	177	183	PF00498	0.520
LIG_FHA_2	58	64	PF00498	0.523
LIG_IBAR_NPY_1	419	421	PF08397	0.626
LIG_LIR_Gen_1	123	132	PF02991	0.532
LIG_LIR_Gen_1	142	149	PF02991	0.406
LIG_LIR_Gen_1	271	280	PF02991	0.680
LIG_LIR_Gen_1	328	338	PF02991	0.807
LIG_LIR_Gen_1	60	70	PF02991	0.532
LIG_LIR_Nem_3	135	140	PF02991	0.532
LIG_LIR_Nem_3	142	146	PF02991	0.486
LIG_LIR_Nem_3	22	28	PF02991	0.493
LIG_LIR_Nem_3	271	275	PF02991	0.680
LIG_LIR_Nem_3	328	334	PF02991	0.692
LIG_LIR_Nem_3	347	351	PF02991	0.504
LIG_LIR_Nem_3	44	50	PF02991	0.532
LIG_LIR_Nem_3	60	65	PF02991	0.426
LIG_PCNA_PIPBox_1	1	10	PF02747	0.463
LIG_PCNA_PIPBox_1	109	118	PF02747	0.532
LIG_PCNA_yPIPBox_3	106	116	PF02747	0.532
LIG_Pex14_2	115	119	PF04695	0.532
LIG_Pex14_2	344	348	PF04695	0.676
LIG_PROFILIN_1	226	232	PF00235	0.582
LIG_PTAP_UEV_1	446	451	PF05743	0.634
LIG_PTB_Apo_2	330	337	PF02174	0.679
LIG_PTB_Apo_2	450	457	PF02174	0.588
LIG_PTB_Apo_2	477	484	PF02174	0.659
LIG_SH2_CRK	421	425	PF00017	0.655
LIG_SH2_GRB2like	162	165	PF00017	0.532
LIG_SH2_NCK_1	421	425	PF00017	0.655
LIG_SH2_SRC	173	176	PF00017	0.629
LIG_SH2_SRC	421	424	PF00017	0.653
LIG_SH2_STAT5	124	127	PF00017	0.568
LIG_SH2_STAT5	162	165	PF00017	0.634
LIG_SH2_STAT5	491	494	PF00017	0.650
LIG_SH2_STAT5	99	102	PF00017	0.573
LIG_SH3_1	360	366	PF00018	0.694
LIG_SH3_1	417	423	PF00018	0.640
LIG_SH3_2	232	237	PF14604	0.615
LIG_SH3_2	400	405	PF14604	0.636
LIG_SH3_3	221	227	PF00018	0.646
LIG_SH3_3	229	235	PF00018	0.572
LIG_SH3_3	293	299	PF00018	0.648
LIG_SH3_3	360	366	PF00018	0.694
LIG_SH3_3	397	403	PF00018	0.630
LIG_SH3_3	417	423	PF00018	0.498
LIG_SH3_3	433	439	PF00018	0.514
LIG_SH3_3	444	450	PF00018	0.537
LIG_SH3_3	468	474	PF00018	0.635
LIG_SUMO_SIM_anti_2	165	171	PF11976	0.473
LIG_TRAF2_1	91	94	PF00917	0.539
LIG_WW_2	232	235	PF00397	0.530
MOD_CDK_SPxK_1	354	360	PF00069	0.688
MOD_CDK_SPxK_1	399	405	PF00069	0.634
MOD_CDK_SPxxK_3	399	406	PF00069	0.680
MOD_CK1_1	145	151	PF00069	0.528
MOD_CK1_1	176	182	PF00069	0.558
MOD_CK1_1	327	333	PF00069	0.615
MOD_CK1_1	359	365	PF00069	0.649
MOD_CK1_1	408	414	PF00069	0.679
MOD_CK2_1	105	111	PF00069	0.587
MOD_CK2_1	176	182	PF00069	0.512
MOD_CK2_1	57	63	PF00069	0.523
MOD_GlcNHglycan	147	150	PF01048	0.332
MOD_GlcNHglycan	253	256	PF01048	0.560
MOD_GlcNHglycan	263	266	PF01048	0.534
MOD_GlcNHglycan	31	34	PF01048	0.285
MOD_GlcNHglycan	316	319	PF01048	0.683
MOD_GlcNHglycan	327	330	PF01048	0.619
MOD_GlcNHglycan	339	342	PF01048	0.541
MOD_GlcNHglycan	376	380	PF01048	0.786
MOD_GlcNHglycan	394	398	PF01048	0.562
MOD_GlcNHglycan	412	415	PF01048	0.511
MOD_GSK3_1	158	165	PF00069	0.501
MOD_GSK3_1	236	243	PF00069	0.669
MOD_GSK3_1	245	252	PF00069	0.624
MOD_GSK3_1	306	313	PF00069	0.709
MOD_GSK3_1	320	327	PF00069	0.578
MOD_GSK3_1	332	339	PF00069	0.545
MOD_GSK3_1	354	361	PF00069	0.688
MOD_GSK3_1	37	44	PF00069	0.532
MOD_GSK3_1	404	411	PF00069	0.796
MOD_GSK3_1	422	429	PF00069	0.502
MOD_GSK3_1	430	437	PF00069	0.596
MOD_LATS_1	242	248	PF00433	0.589
MOD_N-GLC_1	14	19	PF02516	0.332
MOD_N-GLC_1	158	163	PF02516	0.403
MOD_N-GLC_1	332	337	PF02516	0.687
MOD_N-GLC_1	367	372	PF02516	0.696
MOD_N-GLC_1	408	413	PF02516	0.685
MOD_N-GLC_1	431	436	PF02516	0.628
MOD_N-GLC_1	65	70	PF02516	0.332
MOD_N-GLC_2	78	80	PF02516	0.405
MOD_NEK2_1	105	110	PF00069	0.517
MOD_NEK2_1	132	137	PF00069	0.516
MOD_NEK2_1	163	168	PF00069	0.610
MOD_NEK2_1	249	254	PF00069	0.788
MOD_NEK2_1	260	265	PF00069	0.614
MOD_NEK2_1	332	337	PF00069	0.723
MOD_NEK2_1	344	349	PF00069	0.618
MOD_NEK2_1	367	372	PF00069	0.739
MOD_NEK2_1	37	42	PF00069	0.532
MOD_NEK2_1	375	380	PF00069	0.705
MOD_NEK2_1	393	398	PF00069	0.567
MOD_NEK2_1	410	415	PF00069	0.597
MOD_NEK2_1	440	445	PF00069	0.656
MOD_NEK2_1	456	461	PF00069	0.504
MOD_NEK2_1	65	70	PF00069	0.532
MOD_NEK2_1	92	97	PF00069	0.462
MOD_NEK2_2	152	157	PF00069	0.517
MOD_PIKK_1	105	111	PF00454	0.532
MOD_PIKK_1	310	316	PF00454	0.653
MOD_PKA_1	405	411	PF00069	0.645
MOD_PKA_2	404	410	PF00069	0.689
MOD_Plk_1	158	164	PF00069	0.603
MOD_Plk_1	332	338	PF00069	0.614
MOD_Plk_1	367	373	PF00069	0.693
MOD_Plk_1	65	71	PF00069	0.547
MOD_Plk_2-3	142	148	PF00069	0.532
MOD_Plk_4	132	138	PF00069	0.539
MOD_Plk_4	300	306	PF00069	0.653
MOD_Plk_4	327	333	PF00069	0.728
MOD_ProDKin_1	202	208	PF00069	0.608
MOD_ProDKin_1	236	242	PF00069	0.616
MOD_ProDKin_1	320	326	PF00069	0.675
MOD_ProDKin_1	354	360	PF00069	0.688
MOD_ProDKin_1	362	368	PF00069	0.623
MOD_ProDKin_1	399	405	PF00069	0.677
MOD_ProDKin_1	422	428	PF00069	0.635
MOD_ProDKin_1	435	441	PF00069	0.539
MOD_ProDKin_1	462	468	PF00069	0.661
MOD_SUMO_rev_2	84	91	PF00179	0.541
TRG_DiLeu_BaEn_2	110	116	PF01217	0.532
TRG_DiLeu_BaEn_4	93	99	PF01217	0.471
TRG_ENDOCYTIC_2	124	127	PF00928	0.552
TRG_ENDOCYTIC_2	140	143	PF00928	0.528
TRG_ENDOCYTIC_2	351	354	PF00928	0.685
TRG_ENDOCYTIC_2	421	424	PF00928	0.653
TRG_ENDOCYTIC_2	62	65	PF00928	0.532
TRG_ER_diArg_1	183	186	PF00400	0.583
TRG_ER_diArg_1	404	406	PF00400	0.653
TRG_Pf-PMV_PEXEL_1	14	18	PF00026	0.332

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X3L2	Leishmania donovani	100%	100%
A4HIF0	Leishmania braziliensis	72%	98%
E9B0Z1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q775	Leishmania major	93%	100%