WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain - G-beta repeat - putative

Species:

Leishmania infantum

UniProt:

A4I5P4_LEIIN

TriTrypDb:

LINF_300026900

Length:

851

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I5P4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5P4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	514	518	PF00656	0.400
CLV_C14_Caspase3-7	557	561	PF00656	0.440
CLV_NRD_NRD_1	254	256	PF00675	0.692
CLV_NRD_NRD_1	266	268	PF00675	0.739
CLV_NRD_NRD_1	421	423	PF00675	0.687
CLV_NRD_NRD_1	440	442	PF00675	0.582
CLV_NRD_NRD_1	452	454	PF00675	0.500
CLV_NRD_NRD_1	56	58	PF00675	0.405
CLV_NRD_NRD_1	635	637	PF00675	0.543
CLV_PCSK_FUR_1	264	268	PF00082	0.470
CLV_PCSK_KEX2_1	253	255	PF00082	0.668
CLV_PCSK_KEX2_1	266	268	PF00082	0.720
CLV_PCSK_KEX2_1	420	422	PF00082	0.648
CLV_PCSK_KEX2_1	442	444	PF00082	0.587
CLV_PCSK_KEX2_1	55	57	PF00082	0.416
CLV_PCSK_KEX2_1	635	637	PF00082	0.406
CLV_PCSK_PC1ET2_1	442	444	PF00082	0.568
CLV_PCSK_SKI1_1	131	135	PF00082	0.395
CLV_PCSK_SKI1_1	412	416	PF00082	0.769
CLV_PCSK_SKI1_1	622	626	PF00082	0.338
CLV_PCSK_SKI1_1	66	70	PF00082	0.293
CLV_PCSK_SKI1_1	723	727	PF00082	0.445
CLV_PCSK_SKI1_1	760	764	PF00082	0.442
CLV_PCSK_SKI1_1	832	836	PF00082	0.388
DEG_APCC_DBOX_1	254	262	PF00400	0.510
DEG_APCC_DBOX_1	485	493	PF00400	0.455
DEG_COP1_1	769	779	PF00400	0.375
DEG_SPOP_SBC_1	12	16	PF00917	0.411
DEG_SPOP_SBC_1	649	653	PF00917	0.695
DOC_CKS1_1	320	325	PF01111	0.438
DOC_PP1_RVXF_1	527	534	PF00149	0.380
DOC_PP1_RVXF_1	64	71	PF00149	0.362
DOC_PP2B_PxIxI_1	784	790	PF00149	0.402
DOC_SPAK_OSR1_1	667	671	PF12202	0.418
DOC_USP7_MATH_1	11	15	PF00917	0.396
DOC_USP7_MATH_1	248	252	PF00917	0.634
DOC_USP7_MATH_1	272	276	PF00917	0.724
DOC_USP7_MATH_1	334	338	PF00917	0.631
DOC_USP7_MATH_1	425	429	PF00917	0.549
DOC_USP7_MATH_1	465	469	PF00917	0.614
DOC_USP7_MATH_1	494	498	PF00917	0.506
DOC_USP7_MATH_1	648	652	PF00917	0.697
DOC_USP7_MATH_1	791	795	PF00917	0.316
DOC_WW_Pin1_4	167	172	PF00397	0.586
DOC_WW_Pin1_4	25	30	PF00397	0.633
DOC_WW_Pin1_4	319	324	PF00397	0.523
DOC_WW_Pin1_4	580	585	PF00397	0.433
DOC_WW_Pin1_4	586	591	PF00397	0.426
LIG_14-3-3_CanoR_1	190	195	PF00244	0.416
LIG_14-3-3_CanoR_1	307	311	PF00244	0.493
LIG_14-3-3_CanoR_1	486	490	PF00244	0.554
LIG_14-3-3_CanoR_1	658	666	PF00244	0.551
LIG_14-3-3_CanoR_1	667	671	PF00244	0.473
LIG_BIR_III_4	38	42	PF00653	0.581
LIG_BRCT_BRCA1_1	13	17	PF00533	0.412
LIG_BRCT_BRCA1_1	27	31	PF00533	0.549
LIG_BRCT_BRCA1_1	613	617	PF00533	0.368
LIG_BRCT_BRCA1_1	88	92	PF00533	0.454
LIG_Clathr_ClatBox_1	133	137	PF01394	0.426
LIG_Clathr_ClatBox_1	20	24	PF01394	0.373
LIG_CSL_BTD_1	581	584	PF09270	0.412
LIG_CSL_BTD_1	827	830	PF09270	0.443
LIG_EH1_1	683	691	PF00400	0.292
LIG_eIF4E_1	619	625	PF01652	0.333
LIG_FHA_1	186	192	PF00498	0.446
LIG_FHA_1	213	219	PF00498	0.330
LIG_FHA_1	227	233	PF00498	0.323
LIG_FHA_1	307	313	PF00498	0.399
LIG_FHA_1	315	321	PF00498	0.387
LIG_FHA_1	334	340	PF00498	0.578
LIG_FHA_1	404	410	PF00498	0.572
LIG_FHA_1	467	473	PF00498	0.492
LIG_FHA_1	502	508	PF00498	0.423
LIG_FHA_1	716	722	PF00498	0.407
LIG_FHA_1	751	757	PF00498	0.331
LIG_FHA_2	281	287	PF00498	0.397
LIG_FHA_2	488	494	PF00498	0.454
LIG_FHA_2	49	55	PF00498	0.549
LIG_FHA_2	512	518	PF00498	0.391
LIG_FHA_2	555	561	PF00498	0.422
LIG_FHA_2	59	65	PF00498	0.493
LIG_Integrin_isoDGR_2	220	222	PF01839	0.337
LIG_Integrin_isoDGR_2	349	351	PF01839	0.428
LIG_LIR_Gen_1	14	23	PF02991	0.474
LIG_LIR_Gen_1	28	39	PF02991	0.696
LIG_LIR_Gen_1	313	324	PF02991	0.507
LIG_LIR_Gen_1	477	484	PF02991	0.526
LIG_LIR_LC3C_4	204	208	PF02991	0.352
LIG_LIR_Nem_3	14	20	PF02991	0.471
LIG_LIR_Nem_3	313	319	PF02991	0.563
LIG_LIR_Nem_3	355	361	PF02991	0.404
LIG_LIR_Nem_3	365	369	PF02991	0.366
LIG_LIR_Nem_3	477	481	PF02991	0.571
LIG_LIR_Nem_3	614	620	PF02991	0.293
LIG_LIR_Nem_3	825	831	PF02991	0.357
LIG_NRBOX	619	625	PF00104	0.333
LIG_Pex14_1	88	92	PF04695	0.333
LIG_Pex14_2	474	478	PF04695	0.472
LIG_PTB_Apo_2	685	692	PF02174	0.286
LIG_SH2_CRK	316	320	PF00017	0.420
LIG_SH2_CRK	354	358	PF00017	0.462
LIG_SH2_GRB2like	354	357	PF00017	0.389
LIG_SH2_NCK_1	271	275	PF00017	0.601
LIG_SH2_NCK_1	354	358	PF00017	0.508
LIG_SH2_NCK_1	430	434	PF00017	0.592
LIG_SH2_NCK_1	732	736	PF00017	0.460
LIG_SH2_STAP1	316	320	PF00017	0.488
LIG_SH2_STAP1	354	358	PF00017	0.453
LIG_SH2_STAT5	316	319	PF00017	0.418
LIG_SH2_STAT5	354	357	PF00017	0.475
LIG_SH2_STAT5	363	366	PF00017	0.388
LIG_SH2_STAT5	430	433	PF00017	0.665
LIG_SH2_STAT5	619	622	PF00017	0.331
LIG_SH2_STAT5	822	825	PF00017	0.413
LIG_SH3_3	600	606	PF00018	0.525
LIG_SH3_3	827	833	PF00018	0.460
LIG_SUMO_SIM_anti_2	204	210	PF11976	0.458
LIG_SUMO_SIM_anti_2	8	16	PF11976	0.333
LIG_SUMO_SIM_par_1	132	138	PF11976	0.372
LIG_SUMO_SIM_par_1	19	24	PF11976	0.346
LIG_SUMO_SIM_par_1	292	299	PF11976	0.452
LIG_SUMO_SIM_par_1	567	572	PF11976	0.414
LIG_SUMO_SIM_par_1	788	794	PF11976	0.305
LIG_SUMO_SIM_par_1	8	16	PF11976	0.345
LIG_TRAF2_1	278	281	PF00917	0.365
LIG_TRAF2_1	51	54	PF00917	0.439
LIG_UBA3_1	689	697	PF00899	0.313
LIG_WRC_WIRS_1	107	112	PF05994	0.398
MOD_CDK_SPxxK_3	580	587	PF00069	0.445
MOD_CK1_1	153	159	PF00069	0.532
MOD_CK1_1	212	218	PF00069	0.356
MOD_CK1_1	256	262	PF00069	0.678
MOD_CK1_1	27	33	PF00069	0.524
MOD_CK1_1	306	312	PF00069	0.457
MOD_CK1_1	314	320	PF00069	0.458
MOD_CK1_1	428	434	PF00069	0.690
MOD_CK1_1	5	11	PF00069	0.505
MOD_CK1_1	644	650	PF00069	0.710
MOD_CK1_1	651	657	PF00069	0.657
MOD_CK1_1	669	675	PF00069	0.293
MOD_CK1_1	72	78	PF00069	0.400
MOD_CK1_1	749	755	PF00069	0.463
MOD_CK1_1	821	827	PF00069	0.364
MOD_CK2_1	240	246	PF00069	0.469
MOD_CK2_1	41	47	PF00069	0.522
MOD_CK2_1	465	471	PF00069	0.513
MOD_CK2_1	48	54	PF00069	0.579
MOD_CK2_1	487	493	PF00069	0.454
MOD_CK2_1	649	655	PF00069	0.604
MOD_CK2_1	692	698	PF00069	0.476
MOD_GlcNHglycan	198	201	PF01048	0.569
MOD_GlcNHglycan	255	258	PF01048	0.756
MOD_GlcNHglycan	313	316	PF01048	0.532
MOD_GlcNHglycan	378	381	PF01048	0.672
MOD_GlcNHglycan	42	46	PF01048	0.531
MOD_GlcNHglycan	427	430	PF01048	0.580
MOD_GlcNHglycan	461	464	PF01048	0.620
MOD_GlcNHglycan	496	499	PF01048	0.462
MOD_GlcNHglycan	571	574	PF01048	0.414
MOD_GlcNHglycan	598	601	PF01048	0.674
MOD_GlcNHglycan	613	616	PF01048	0.476
MOD_GlcNHglycan	671	674	PF01048	0.392
MOD_GlcNHglycan	677	680	PF01048	0.354
MOD_GlcNHglycan	738	741	PF01048	0.547
MOD_GlcNHglycan	746	749	PF01048	0.392
MOD_GlcNHglycan	82	85	PF01048	0.531
MOD_GlcNHglycan	840	843	PF01048	0.379
MOD_GSK3_1	1	8	PF00069	0.536
MOD_GSK3_1	102	109	PF00069	0.624
MOD_GSK3_1	116	123	PF00069	0.376
MOD_GSK3_1	146	153	PF00069	0.406
MOD_GSK3_1	185	192	PF00069	0.504
MOD_GSK3_1	23	30	PF00069	0.536
MOD_GSK3_1	249	256	PF00069	0.654
MOD_GSK3_1	292	299	PF00069	0.416
MOD_GSK3_1	314	321	PF00069	0.425
MOD_GSK3_1	461	468	PF00069	0.698
MOD_GSK3_1	507	514	PF00069	0.336
MOD_GSK3_1	592	599	PF00069	0.513
MOD_GSK3_1	640	647	PF00069	0.628
MOD_GSK3_1	649	656	PF00069	0.590
MOD_GSK3_1	723	730	PF00069	0.466
MOD_GSK3_1	746	753	PF00069	0.519
MOD_GSK3_1	771	778	PF00069	0.497
MOD_GSK3_1	818	825	PF00069	0.405
MOD_N-GLC_1	167	172	PF02516	0.651
MOD_N-GLC_1	212	217	PF02516	0.546
MOD_N-GLC_1	561	566	PF02516	0.414
MOD_NEK2_1	110	115	PF00069	0.475
MOD_NEK2_1	209	214	PF00069	0.407
MOD_NEK2_1	362	367	PF00069	0.450
MOD_NEK2_1	492	497	PF00069	0.486
MOD_NEK2_1	569	574	PF00069	0.350
MOD_NEK2_1	623	628	PF00069	0.421
MOD_NEK2_1	744	749	PF00069	0.409
MOD_NEK2_1	750	755	PF00069	0.310
MOD_NEK2_1	86	91	PF00069	0.544
MOD_PIKK_1	116	122	PF00454	0.548
MOD_PIKK_1	256	262	PF00454	0.587
MOD_PIKK_1	314	320	PF00454	0.572
MOD_PIKK_1	766	772	PF00454	0.493
MOD_PIKK_1	791	797	PF00454	0.397
MOD_PK_1	190	196	PF00069	0.283
MOD_PKA_1	253	259	PF00069	0.560
MOD_PKA_2	189	195	PF00069	0.428
MOD_PKA_2	253	259	PF00069	0.691
MOD_PKA_2	306	312	PF00069	0.474
MOD_PKA_2	485	491	PF00069	0.462
MOD_PKA_2	644	650	PF00069	0.706
MOD_PKA_2	666	672	PF00069	0.524
MOD_PKA_2	727	733	PF00069	0.556
MOD_Plk_1	110	116	PF00069	0.427
MOD_Plk_1	280	286	PF00069	0.473
MOD_Plk_1	5	11	PF00069	0.414
MOD_Plk_1	592	598	PF00069	0.457
MOD_Plk_1	72	78	PF00069	0.539
MOD_Plk_4	120	126	PF00069	0.534
MOD_Plk_4	13	19	PF00069	0.449
MOD_Plk_4	202	208	PF00069	0.532
MOD_Plk_4	27	33	PF00069	0.557
MOD_Plk_4	280	286	PF00069	0.511
MOD_Plk_4	334	340	PF00069	0.635
MOD_Plk_4	477	483	PF00069	0.551
MOD_Plk_4	5	11	PF00069	0.444
MOD_Plk_4	608	614	PF00069	0.310
MOD_Plk_4	705	711	PF00069	0.507
MOD_Plk_4	818	824	PF00069	0.410
MOD_ProDKin_1	167	173	PF00069	0.575
MOD_ProDKin_1	25	31	PF00069	0.639
MOD_ProDKin_1	319	325	PF00069	0.522
MOD_ProDKin_1	580	586	PF00069	0.445
TRG_DiLeu_BaLyEn_6	565	570	PF01217	0.395
TRG_ENDOCYTIC_2	305	308	PF00928	0.522
TRG_ENDOCYTIC_2	316	319	PF00928	0.316
TRG_ENDOCYTIC_2	354	357	PF00928	0.501
TRG_ER_diArg_1	253	255	PF00400	0.666
TRG_ER_diArg_1	420	422	PF00400	0.583
TRG_ER_diArg_1	55	57	PF00400	0.532
TRG_ER_diArg_1	634	636	PF00400	0.394
TRG_NLS_MonoExtC_3	441	446	PF00514	0.458
TRG_NLS_MonoExtN_4	441	447	PF00514	0.572
TRG_Pf-PMV_PEXEL_1	658	662	PF00026	0.369

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P916	Leptomonas seymouri	45%	91%
A0A1X0P1Y6	Trypanosomatidae	26%	100%
A0A3S5IQN0	Trypanosoma rangeli	26%	100%
A0A3S7X3K9	Leishmania donovani	100%	100%
A4HIE7	Leishmania braziliensis	74%	100%
C9ZR12	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9B0Y8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q778	Leishmania major	91%	100%
V5BC72	Trypanosoma cruzi	25%	96%