PNPLA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF3336)/Patatin-like phospholipase - putative

Species:

Leishmania infantum

UniProt:

A4I5P3_LEIIN

TriTrypDb:

LINF_300026800

Length:

890

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4I5P3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5P3

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	7
GO:0008152	metabolic process	1	7
GO:0009056	catabolic process	2	7
GO:0016042	lipid catabolic process	4	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:1901575	organic substance catabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004806	triglyceride lipase activity	5	5
GO:0016298	lipase activity	4	5
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	5
GO:0052689	carboxylic ester hydrolase activity	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	222	226	PF00656	0.619
CLV_MEL_PAP_1	796	802	PF00089	0.523
CLV_NRD_NRD_1	120	122	PF00675	0.320
CLV_NRD_NRD_1	14	16	PF00675	0.488
CLV_NRD_NRD_1	31	33	PF00675	0.424
CLV_NRD_NRD_1	325	327	PF00675	0.573
CLV_NRD_NRD_1	36	38	PF00675	0.466
CLV_NRD_NRD_1	50	52	PF00675	0.375
CLV_NRD_NRD_1	522	524	PF00675	0.415
CLV_NRD_NRD_1	732	734	PF00675	0.314
CLV_PCSK_KEX2_1	120	122	PF00082	0.320
CLV_PCSK_KEX2_1	13	15	PF00082	0.487
CLV_PCSK_KEX2_1	198	200	PF00082	0.346
CLV_PCSK_KEX2_1	30	32	PF00082	0.428
CLV_PCSK_KEX2_1	50	52	PF00082	0.371
CLV_PCSK_KEX2_1	614	616	PF00082	0.526
CLV_PCSK_KEX2_1	732	734	PF00082	0.346
CLV_PCSK_PC1ET2_1	198	200	PF00082	0.346
CLV_PCSK_PC1ET2_1	614	616	PF00082	0.563
CLV_PCSK_PC7_1	116	122	PF00082	0.320
CLV_PCSK_PC7_1	26	32	PF00082	0.508
CLV_PCSK_SKI1_1	15	19	PF00082	0.474
CLV_PCSK_SKI1_1	37	41	PF00082	0.479
CLV_PCSK_SKI1_1	386	390	PF00082	0.568
CLV_PCSK_SKI1_1	52	56	PF00082	0.380
CLV_PCSK_SKI1_1	523	527	PF00082	0.388
CLV_PCSK_SKI1_1	531	535	PF00082	0.287
CLV_PCSK_SKI1_1	614	618	PF00082	0.526
CLV_PCSK_SKI1_1	668	672	PF00082	0.546
CLV_PCSK_SKI1_1	732	736	PF00082	0.386
CLV_PCSK_SKI1_1	84	88	PF00082	0.406
CLV_PCSK_SKI1_1	864	868	PF00082	0.398
DEG_APCC_DBOX_1	731	739	PF00400	0.584
DOC_CDC14_PxL_1	448	456	PF14671	0.663
DOC_CYCLIN_yCln2_LP_2	54	57	PF00134	0.649
DOC_MAPK_gen_1	267	276	PF00069	0.739
DOC_MAPK_gen_1	614	625	PF00069	0.346
DOC_MAPK_gen_1	732	738	PF00069	0.663
DOC_MAPK_gen_1	799	807	PF00069	0.643
DOC_MAPK_gen_1	875	885	PF00069	0.617
DOC_MAPK_MEF2A_6	164	172	PF00069	0.530
DOC_MAPK_MEF2A_6	84	93	PF00069	0.605
DOC_MAPK_NFAT4_5	84	92	PF00069	0.605
DOC_MAPK_RevD_3	105	121	PF00069	0.595
DOC_PP1_RVXF_1	114	120	PF00149	0.596
DOC_PP1_RVXF_1	773	779	PF00149	0.644
DOC_PP2B_LxvP_1	54	57	PF13499	0.649
DOC_PP2B_LxvP_1	757	760	PF13499	0.643
DOC_PP4_FxxP_1	402	405	PF00568	0.766
DOC_PP4_FxxP_1	756	759	PF00568	0.605
DOC_USP7_MATH_1	142	146	PF00917	0.546
DOC_USP7_MATH_1	299	303	PF00917	0.762
DOC_USP7_MATH_1	341	345	PF00917	0.730
DOC_USP7_MATH_1	405	409	PF00917	0.709
DOC_USP7_MATH_1	446	450	PF00917	0.752
DOC_USP7_MATH_1	489	493	PF00917	0.712
DOC_USP7_MATH_1	57	61	PF00917	0.634
DOC_USP7_MATH_1	6	10	PF00917	0.690
DOC_USP7_MATH_1	822	826	PF00917	0.631
DOC_USP7_UBL2_3	520	524	PF12436	0.619
DOC_USP7_UBL2_3	614	618	PF12436	0.363
DOC_WW_Pin1_4	289	294	PF00397	0.769
DOC_WW_Pin1_4	418	423	PF00397	0.749
DOC_WW_Pin1_4	462	467	PF00397	0.718
DOC_WW_Pin1_4	577	582	PF00397	0.419
DOC_WW_Pin1_4	598	603	PF00397	0.346
LIG_14-3-3_CanoR_1	120	129	PF00244	0.520
LIG_14-3-3_CanoR_1	13	21	PF00244	0.690
LIG_14-3-3_CanoR_1	211	217	PF00244	0.619
LIG_14-3-3_CanoR_1	326	336	PF00244	0.688
LIG_14-3-3_CanoR_1	345	353	PF00244	0.787
LIG_14-3-3_CanoR_1	472	481	PF00244	0.713
LIG_14-3-3_CanoR_1	504	508	PF00244	0.801
LIG_14-3-3_CanoR_1	758	766	PF00244	0.624
LIG_14-3-3_CanoR_1	84	90	PF00244	0.604
LIG_Actin_WH2_2	508	525	PF00022	0.577
LIG_ActinCP_TwfCPI_2	402	412	PF01115	0.684
LIG_APCC_ABBA_1	600	605	PF00400	0.346
LIG_BIR_III_2	158	162	PF00653	0.619
LIG_BIR_III_2	394	398	PF00653	0.665
LIG_BIR_III_2	410	414	PF00653	0.678
LIG_BRCT_BRCA1_1	398	402	PF00533	0.696
LIG_BRCT_BRCA1_2	398	404	PF00533	0.687
LIG_eIF4E_1	529	535	PF01652	0.620
LIG_FHA_1	135	141	PF00498	0.494
LIG_FHA_1	16	22	PF00498	0.678
LIG_FHA_1	181	187	PF00498	0.565
LIG_FHA_1	222	228	PF00498	0.546
LIG_FHA_1	312	318	PF00498	0.691
LIG_FHA_1	370	376	PF00498	0.692
LIG_FHA_1	437	443	PF00498	0.759
LIG_FHA_1	530	536	PF00498	0.541
LIG_FHA_1	617	623	PF00498	0.343
LIG_FHA_1	854	860	PF00498	0.578
LIG_FHA_2	136	142	PF00498	0.546
LIG_FHA_2	389	395	PF00498	0.667
LIG_FHA_2	405	411	PF00498	0.692
LIG_FHA_2	638	644	PF00498	0.398
LIG_FHA_2	674	680	PF00498	0.379
LIG_FHA_2	865	871	PF00498	0.570
LIG_GBD_Chelix_1	865	873	PF00786	0.440
LIG_IBAR_NPY_1	750	752	PF08397	0.597
LIG_LIR_Apic_2	399	405	PF02991	0.759
LIG_LIR_Gen_1	123	130	PF02991	0.530
LIG_LIR_Gen_1	133	144	PF02991	0.552
LIG_LIR_Gen_1	416	424	PF02991	0.776
LIG_LIR_Gen_1	63	73	PF02991	0.594
LIG_LIR_Gen_1	804	814	PF02991	0.617
LIG_LIR_Gen_1	832	840	PF02991	0.621
LIG_LIR_Nem_3	123	129	PF02991	0.530
LIG_LIR_Nem_3	133	139	PF02991	0.556
LIG_LIR_Nem_3	147	152	PF02991	0.559
LIG_LIR_Nem_3	208	213	PF02991	0.546
LIG_LIR_Nem_3	416	420	PF02991	0.779
LIG_LIR_Nem_3	63	68	PF02991	0.608
LIG_LIR_Nem_3	711	715	PF02991	0.546
LIG_LIR_Nem_3	804	810	PF02991	0.632
LIG_LIR_Nem_3	832	836	PF02991	0.624
LIG_LIR_Nem_3	841	847	PF02991	0.618
LIG_LIR_Nem_3	854	860	PF02991	0.578
LIG_MYND_1	422	426	PF01753	0.678
LIG_MYND_1	53	57	PF01753	0.649
LIG_MYND_1	755	759	PF01753	0.632
LIG_NRBOX	102	108	PF00104	0.501
LIG_NRBOX	192	198	PF00104	0.546
LIG_NRBOX	88	94	PF00104	0.603
LIG_PCNA_PIPBox_1	97	106	PF02747	0.606
LIG_PCNA_yPIPBox_3	97	108	PF02747	0.606
LIG_Pex14_1	109	113	PF04695	0.608
LIG_Pex14_1	321	325	PF04695	0.611
LIG_Pex14_2	617	621	PF04695	0.346
LIG_Pex14_2	803	807	PF04695	0.628
LIG_REV1ctd_RIR_1	614	622	PF16727	0.346
LIG_SH2_CRK	149	153	PF00017	0.530
LIG_SH2_CRK	833	837	PF00017	0.549
LIG_SH2_GRB2like	212	215	PF00017	0.563
LIG_SH2_GRB2like	833	836	PF00017	0.629
LIG_SH2_NCK_1	213	217	PF00017	0.563
LIG_SH2_PTP2	752	755	PF00017	0.602
LIG_SH2_SRC	715	718	PF00017	0.546
LIG_SH2_SRC	743	746	PF00017	0.585
LIG_SH2_SRC	752	755	PF00017	0.566
LIG_SH2_STAP1	136	140	PF00017	0.514
LIG_SH2_STAP1	223	227	PF00017	0.546
LIG_SH2_STAT5	136	139	PF00017	0.572
LIG_SH2_STAT5	149	152	PF00017	0.531
LIG_SH2_STAT5	223	226	PF00017	0.562
LIG_SH2_STAT5	674	677	PF00017	0.304
LIG_SH2_STAT5	715	718	PF00017	0.546
LIG_SH2_STAT5	743	746	PF00017	0.523
LIG_SH2_STAT5	752	755	PF00017	0.545
LIG_SH2_STAT5	81	84	PF00017	0.553
LIG_SH2_STAT5	844	847	PF00017	0.630
LIG_SH3_1	50	56	PF00018	0.657
LIG_SH3_3	281	287	PF00018	0.751
LIG_SH3_3	417	423	PF00018	0.743
LIG_SH3_3	447	453	PF00018	0.754
LIG_SH3_3	460	466	PF00018	0.626
LIG_SH3_3	50	56	PF00018	0.657
LIG_SH3_3	504	510	PF00018	0.790
LIG_SH3_3	672	678	PF00018	0.330
LIG_SH3_3	711	717	PF00018	0.589
LIG_SH3_3	834	840	PF00018	0.625
LIG_SH3_5	840	844	PF00018	0.691
LIG_TRAF2_1	659	662	PF00917	0.346
LIG_TYR_ITIM	741	746	PF00017	0.434
LIG_UBA3_1	571	579	PF00899	0.411
LIG_WRC_WIRS_1	136	141	PF05994	0.402
LIG_WRC_WIRS_1	189	194	PF05994	0.513
LIG_WRC_WIRS_1	441	446	PF05994	0.576
MOD_CDK_SPxxK_3	422	429	PF00069	0.797
MOD_CK1_1	135	141	PF00069	0.411
MOD_CK1_1	243	249	PF00069	0.703
MOD_CK1_1	302	308	PF00069	0.696
MOD_CK1_1	359	365	PF00069	0.739
MOD_CK1_1	371	377	PF00069	0.793
MOD_CK1_1	477	483	PF00069	0.548
MOD_CK1_1	537	543	PF00069	0.411
MOD_CK1_1	567	573	PF00069	0.411
MOD_CK1_1	60	66	PF00069	0.515
MOD_CK1_1	684	690	PF00069	0.411
MOD_CK2_1	135	141	PF00069	0.513
MOD_CK2_1	577	583	PF00069	0.411
MOD_CK2_1	637	643	PF00069	0.470
MOD_CK2_1	656	662	PF00069	0.411
MOD_CK2_1	864	870	PF00069	0.446
MOD_CMANNOS	777	780	PF00535	0.620
MOD_GlcNHglycan	18	21	PF01048	0.568
MOD_GlcNHglycan	214	217	PF01048	0.436
MOD_GlcNHglycan	242	245	PF01048	0.705
MOD_GlcNHglycan	247	251	PF01048	0.729
MOD_GlcNHglycan	260	263	PF01048	0.451
MOD_GlcNHglycan	277	281	PF01048	0.580
MOD_GlcNHglycan	297	300	PF01048	0.773
MOD_GlcNHglycan	301	304	PF01048	0.724
MOD_GlcNHglycan	329	332	PF01048	0.567
MOD_GlcNHglycan	349	352	PF01048	0.706
MOD_GlcNHglycan	358	361	PF01048	0.625
MOD_GlcNHglycan	434	437	PF01048	0.634
MOD_GlcNHglycan	454	457	PF01048	0.753
MOD_GlcNHglycan	491	494	PF01048	0.688
MOD_GlcNHglycan	536	539	PF01048	0.411
MOD_GlcNHglycan	566	569	PF01048	0.411
MOD_GlcNHglycan	647	650	PF01048	0.411
MOD_GlcNHglycan	683	686	PF01048	0.384
MOD_GlcNHglycan	768	771	PF01048	0.674
MOD_GlcNHglycan	814	817	PF01048	0.589
MOD_GlcNHglycan	840	843	PF01048	0.518
MOD_GlcNHglycan	9	12	PF01048	0.606
MOD_GSK3_1	125	132	PF00069	0.386
MOD_GSK3_1	188	195	PF00069	0.513
MOD_GSK3_1	295	302	PF00069	0.752
MOD_GSK3_1	337	344	PF00069	0.698
MOD_GSK3_1	345	352	PF00069	0.708
MOD_GSK3_1	355	362	PF00069	0.664
MOD_GSK3_1	365	372	PF00069	0.515
MOD_GSK3_1	374	381	PF00069	0.611
MOD_GSK3_1	384	391	PF00069	0.662
MOD_GSK3_1	418	425	PF00069	0.700
MOD_GSK3_1	427	434	PF00069	0.726
MOD_GSK3_1	436	443	PF00069	0.732
MOD_GSK3_1	473	480	PF00069	0.607
MOD_GSK3_1	525	532	PF00069	0.459
MOD_GSK3_1	534	541	PF00069	0.353
MOD_GSK3_1	563	570	PF00069	0.411
MOD_GSK3_1	587	594	PF00069	0.400
MOD_GSK3_1	652	659	PF00069	0.411
MOD_GSK3_1	786	793	PF00069	0.521
MOD_GSK3_1	812	819	PF00069	0.588
MOD_GSK3_1	843	850	PF00069	0.499
MOD_N-GLC_1	130	135	PF02516	0.411
MOD_N-GLC_1	436	441	PF02516	0.716
MOD_N-GLC_1	652	657	PF02516	0.411
MOD_NEK2_1	119	124	PF00069	0.375
MOD_NEK2_1	180	185	PF00069	0.472
MOD_NEK2_1	192	197	PF00069	0.333
MOD_NEK2_1	205	210	PF00069	0.411
MOD_NEK2_1	276	281	PF00069	0.624
MOD_NEK2_1	325	330	PF00069	0.727
MOD_NEK2_1	356	361	PF00069	0.710
MOD_NEK2_1	367	372	PF00069	0.569
MOD_NEK2_1	474	479	PF00069	0.535
MOD_NEK2_1	534	539	PF00069	0.472
MOD_NEK2_1	563	568	PF00069	0.411
MOD_NEK2_1	575	580	PF00069	0.411
MOD_NEK2_1	587	592	PF00069	0.485
MOD_NEK2_1	616	621	PF00069	0.411
MOD_NEK2_1	652	657	PF00069	0.411
MOD_NEK2_1	744	749	PF00069	0.428
MOD_NEK2_2	57	62	PF00069	0.535
MOD_PIKK_1	120	126	PF00454	0.375
MOD_PIKK_1	24	30	PF00454	0.634
MOD_PIKK_1	656	662	PF00454	0.411
MOD_PIKK_1	744	750	PF00454	0.504
MOD_PK_1	125	131	PF00069	0.375
MOD_PKA_1	120	126	PF00069	0.375
MOD_PKA_1	13	19	PF00069	0.609
MOD_PKA_1	30	36	PF00069	0.512
MOD_PKA_2	119	125	PF00069	0.375
MOD_PKA_2	13	19	PF00069	0.609
MOD_PKA_2	30	36	PF00069	0.512
MOD_PKA_2	325	331	PF00069	0.646
MOD_PKA_2	474	480	PF00069	0.651
MOD_PKA_2	503	509	PF00069	0.782
MOD_PKB_1	13	21	PF00069	0.593
MOD_PKB_1	862	870	PF00069	0.447
MOD_Plk_1	205	211	PF00069	0.513
MOD_Plk_1	384	390	PF00069	0.748
MOD_Plk_1	436	442	PF00069	0.657
MOD_Plk_1	637	643	PF00069	0.411
MOD_Plk_1	652	658	PF00069	0.411
MOD_Plk_1	816	822	PF00069	0.464
MOD_Plk_4	125	131	PF00069	0.396
MOD_Plk_4	135	141	PF00069	0.434
MOD_Plk_4	188	194	PF00069	0.429
MOD_Plk_4	205	211	PF00069	0.339
MOD_Plk_4	384	390	PF00069	0.752
MOD_Plk_4	503	509	PF00069	0.569
MOD_Plk_4	567	573	PF00069	0.397
MOD_Plk_4	637	643	PF00069	0.378
MOD_Plk_4	768	774	PF00069	0.489
MOD_Plk_4	786	792	PF00069	0.519
MOD_Plk_4	822	828	PF00069	0.646
MOD_ProDKin_1	289	295	PF00069	0.723
MOD_ProDKin_1	418	424	PF00069	0.698
MOD_ProDKin_1	462	468	PF00069	0.648
MOD_ProDKin_1	577	583	PF00069	0.513
MOD_ProDKin_1	598	604	PF00069	0.411
MOD_SUMO_rev_2	408	414	PF00179	0.634
TRG_DiLeu_BaEn_1	385	390	PF01217	0.587
TRG_DiLeu_BaEn_2	582	588	PF01217	0.393
TRG_DiLeu_BaLyEn_6	284	289	PF01217	0.797
TRG_DiLeu_BaLyEn_6	423	428	PF01217	0.739
TRG_DiLeu_BaLyEn_6	50	55	PF01217	0.572
TRG_DiLeu_BaLyEn_6	730	735	PF01217	0.411
TRG_ENDOCYTIC_2	136	139	PF00928	0.405
TRG_ENDOCYTIC_2	149	152	PF00928	0.427
TRG_ENDOCYTIC_2	743	746	PF00928	0.424
TRG_ENDOCYTIC_2	833	836	PF00928	0.527
TRG_ER_diArg_1	119	121	PF00400	0.375
TRG_ER_diArg_1	12	15	PF00400	0.611
TRG_ER_diArg_1	30	32	PF00400	0.520
TRG_ER_diArg_1	731	733	PF00400	0.411
TRG_ER_diArg_1	862	865	PF00400	0.457
TRG_NES_CRM1_1	876	887	PF08389	0.423
TRG_Pf-PMV_PEXEL_1	108	112	PF00026	0.497
TRG_Pf-PMV_PEXEL_1	551	555	PF00026	0.411
TRG_Pf-PMV_PEXEL_1	732	737	PF00026	0.473
TRG_Pf-PMV_PEXEL_1	871	876	PF00026	0.452

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8P1	Leptomonas seymouri	55%	100%
A0A3S7X3I0	Leishmania donovani	99%	70%
A4HIE6	Leishmania braziliensis	78%	100%
E9B0Y7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q779	Leishmania major	92%	100%