Oligomerization domain containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Oligomerisation domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4I5P1_LEIIN

TriTrypDb:

LINF_300026600

Length:

479

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4I5P1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5P1

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	5
GO:0006396	RNA processing	6	5
GO:0006725	cellular aromatic compound metabolic process	3	5
GO:0006807	nitrogen compound metabolic process	2	5
GO:0008152	metabolic process	1	5
GO:0009987	cellular process	1	5
GO:0016070	RNA metabolic process	5	5
GO:0031123	RNA 3'-end processing	7	5
GO:0034641	cellular nitrogen compound metabolic process	3	5
GO:0043170	macromolecule metabolic process	3	5
GO:0044237	cellular metabolic process	2	5
GO:0044238	primary metabolic process	2	5
GO:0046483	heterocycle metabolic process	3	5
GO:0071076	RNA 3' uridylation	8	5
GO:0071704	organic substance metabolic process	2	5
GO:0090304	nucleic acid metabolic process	4	5
GO:1901360	organic cyclic compound metabolic process	3	5

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0016740	transferase activity	2	5
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	5
GO:0016779	nucleotidyltransferase activity	4	5
GO:0050265	RNA uridylyltransferase activity	4	5
GO:0070569	uridylyltransferase activity	5	5
GO:0140098	catalytic activity, acting on RNA	3	5
GO:0140640	catalytic activity, acting on a nucleic acid	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	391	393	PF00675	0.211
CLV_NRD_NRD_1	423	425	PF00675	0.211
CLV_NRD_NRD_1	88	90	PF00675	0.422
CLV_PCSK_FUR_1	86	90	PF00082	0.400
CLV_PCSK_KEX2_1	391	393	PF00082	0.220
CLV_PCSK_KEX2_1	86	88	PF00082	0.425
CLV_PCSK_PC1ET2_1	391	393	PF00082	0.220
CLV_PCSK_SKI1_1	446	450	PF00082	0.367
CLV_PCSK_SKI1_1	472	476	PF00082	0.280
DEG_Nend_Nbox_1	1	3	PF02207	0.419
DOC_CKS1_1	130	135	PF01111	0.411
DOC_CYCLIN_yCln2_LP_2	219	225	PF00134	0.502
DOC_MAPK_DCC_7	63	73	PF00069	0.389
DOC_MAPK_gen_1	215	223	PF00069	0.389
DOC_MAPK_gen_1	341	350	PF00069	0.211
DOC_MAPK_MEF2A_6	129	137	PF00069	0.417
DOC_MAPK_MEF2A_6	215	223	PF00069	0.389
DOC_MAPK_MEF2A_6	301	309	PF00069	0.310
DOC_MAPK_MEF2A_6	406	413	PF00069	0.255
DOC_PP1_RVXF_1	115	122	PF00149	0.543
DOC_PP2B_LxvP_1	135	138	PF13499	0.433
DOC_PP2B_LxvP_1	219	222	PF13499	0.354
DOC_PP2B_LxvP_1	54	57	PF13499	0.387
DOC_PP2B_LxvP_1	66	69	PF13499	0.371
DOC_USP7_MATH_1	187	191	PF00917	0.468
DOC_USP7_MATH_1	196	200	PF00917	0.410
DOC_USP7_MATH_1	254	258	PF00917	0.648
DOC_USP7_MATH_1	290	294	PF00917	0.452
DOC_USP7_UBL2_3	389	393	PF12436	0.217
DOC_WW_Pin1_4	109	114	PF00397	0.555
DOC_WW_Pin1_4	129	134	PF00397	0.594
DOC_WW_Pin1_4	185	190	PF00397	0.693
DOC_WW_Pin1_4	288	293	PF00397	0.423
DOC_WW_Pin1_4	30	35	PF00397	0.406
DOC_WW_Pin1_4	61	66	PF00397	0.456
LIG_14-3-3_CanoR_1	141	146	PF00244	0.625
LIG_14-3-3_CanoR_1	238	242	PF00244	0.457
LIG_14-3-3_CanoR_1	392	401	PF00244	0.255
LIG_14-3-3_CanoR_1	86	92	PF00244	0.424
LIG_APCC_ABBA_1	100	105	PF00400	0.456
LIG_CaM_IQ_9	375	391	PF13499	0.224
LIG_Clathr_ClatBox_1	306	310	PF01394	0.294
LIG_DLG_GKlike_1	87	95	PF00625	0.402
LIG_eIF4E_1	11	17	PF01652	0.296
LIG_eIF4E_1	470	476	PF01652	0.282
LIG_EVH1_1	68	72	PF00568	0.379
LIG_FHA_1	130	136	PF00498	0.443
LIG_FHA_1	393	399	PF00498	0.215
LIG_FHA_1	453	459	PF00498	0.296
LIG_FHA_1	94	100	PF00498	0.462
LIG_FHA_2	277	283	PF00498	0.491
LIG_GBD_Chelix_1	91	99	PF00786	0.407
LIG_LIR_Apic_2	64	70	PF02991	0.601
LIG_LIR_Gen_1	161	171	PF02991	0.496
LIG_LIR_Gen_1	214	223	PF02991	0.308
LIG_LIR_Gen_1	299	309	PF02991	0.313
LIG_LIR_Gen_1	354	362	PF02991	0.211
LIG_LIR_Gen_1	396	407	PF02991	0.211
LIG_LIR_Nem_3	161	167	PF02991	0.496
LIG_LIR_Nem_3	214	219	PF02991	0.301
LIG_LIR_Nem_3	358	362	PF02991	0.211
LIG_LIR_Nem_3	396	402	PF02991	0.286
LIG_SH2_CRK	216	220	PF00017	0.385
LIG_SH2_SRC	107	110	PF00017	0.455
LIG_SH2_SRC	67	70	PF00017	0.384
LIG_SH2_STAT3	19	22	PF00017	0.355
LIG_SH2_STAT5	107	110	PF00017	0.405
LIG_SH2_STAT5	11	14	PF00017	0.338
LIG_SH2_STAT5	470	473	PF00017	0.292
LIG_SH2_STAT5	67	70	PF00017	0.384
LIG_SH3_3	127	133	PF00018	0.544
LIG_SH3_3	33	39	PF00018	0.393
LIG_SH3_3	54	60	PF00018	0.380
LIG_SH3_3	66	72	PF00018	0.369
LIG_TRAF2_1	209	212	PF00917	0.557
LIG_TRAF2_1	243	246	PF00917	0.516
LIG_TRAF2_1	283	286	PF00917	0.490
LIG_UBA3_1	336	341	PF00899	0.215
LIG_WRC_WIRS_1	413	418	PF05994	0.255
LIG_WW_2	69	72	PF00397	0.376
MOD_CDC14_SPxK_1	291	294	PF00782	0.397
MOD_CDK_SPxK_1	288	294	PF00069	0.414
MOD_CDK_SPxxK_3	129	136	PF00069	0.444
MOD_CDK_SPxxK_3	185	192	PF00069	0.417
MOD_CK1_1	112	118	PF00069	0.531
MOD_CK1_1	188	194	PF00069	0.577
MOD_CK1_1	351	357	PF00069	0.219
MOD_CK1_1	90	96	PF00069	0.496
MOD_CK2_1	276	282	PF00069	0.494
MOD_CK2_1	412	418	PF00069	0.211
MOD_Cter_Amidation	84	87	PF01082	0.396
MOD_DYRK1A_RPxSP_1	129	133	PF00069	0.406
MOD_GlcNHglycan	255	259	PF01048	0.556
MOD_GlcNHglycan	80	83	PF01048	0.415
MOD_GlcNHglycan	92	95	PF01048	0.440
MOD_GSK3_1	141	148	PF00069	0.550
MOD_GSK3_1	263	270	PF00069	0.532
MOD_GSK3_1	3	10	PF00069	0.627
MOD_GSK3_1	348	355	PF00069	0.280
MOD_GSK3_1	39	46	PF00069	0.376
MOD_GSK3_1	55	62	PF00069	0.403
MOD_LATS_1	139	145	PF00433	0.480
MOD_N-GLC_2	3	5	PF02516	0.452
MOD_NEK2_1	145	150	PF00069	0.522
MOD_NEK2_1	412	417	PF00069	0.299
MOD_NEK2_1	44	49	PF00069	0.359
MOD_NEK2_1	78	83	PF00069	0.565
MOD_NEK2_2	39	44	PF00069	0.361
MOD_OFUCOSY	38	43	PF10250	0.358
MOD_PIKK_1	174	180	PF00454	0.621
MOD_PKA_1	392	398	PF00069	0.255
MOD_PKA_1	87	93	PF00069	0.400
MOD_PKA_2	128	134	PF00069	0.444
MOD_PKA_2	214	220	PF00069	0.388
MOD_PKA_2	237	243	PF00069	0.456
MOD_PKA_2	385	391	PF00069	0.255
MOD_PKA_2	87	93	PF00069	0.420
MOD_PKB_1	232	240	PF00069	0.402
MOD_Plk_1	262	268	PF00069	0.551
MOD_Plk_1	418	424	PF00069	0.211
MOD_Plk_2-3	418	424	PF00069	0.211
MOD_Plk_4	237	243	PF00069	0.409
MOD_Plk_4	7	13	PF00069	0.327
MOD_ProDKin_1	109	115	PF00069	0.556
MOD_ProDKin_1	129	135	PF00069	0.598
MOD_ProDKin_1	185	191	PF00069	0.692
MOD_ProDKin_1	288	294	PF00069	0.414
MOD_ProDKin_1	30	36	PF00069	0.406
MOD_ProDKin_1	61	67	PF00069	0.456
MOD_SUMO_rev_2	316	325	PF00179	0.365
MOD_SUMO_rev_2	328	333	PF00179	0.286
MOD_SUMO_rev_2	418	427	PF00179	0.211
TRG_ENDOCYTIC_2	111	114	PF00928	0.533
TRG_ENDOCYTIC_2	216	219	PF00928	0.375
TRG_ENDOCYTIC_2	359	362	PF00928	0.211
TRG_ER_diArg_1	218	221	PF00400	0.361
TRG_ER_diArg_1	86	89	PF00400	0.425
TRG_NES_CRM1_1	332	344	PF08389	0.211
TRG_NLS_MonoExtC_3	322	328	PF00514	0.345
TRG_NLS_MonoExtC_3	390	396	PF00514	0.255
TRG_NLS_MonoExtN_4	389	395	PF00514	0.255

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I395	Leptomonas seymouri	66%	100%
C9ZR09	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9B0Y5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%