Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I5N9_LEIIN

TriTrypDb:

LINF_300026400

Length:

636

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I5N9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5N9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	172	178	PF00089	0.435
CLV_NRD_NRD_1	126	128	PF00675	0.511
CLV_NRD_NRD_1	208	210	PF00675	0.425
CLV_NRD_NRD_1	343	345	PF00675	0.669
CLV_NRD_NRD_1	382	384	PF00675	0.618
CLV_NRD_NRD_1	75	77	PF00675	0.757
CLV_PCSK_KEX2_1	126	128	PF00082	0.531
CLV_PCSK_KEX2_1	343	345	PF00082	0.669
CLV_PCSK_KEX2_1	382	384	PF00082	0.618
CLV_PCSK_KEX2_1	423	425	PF00082	0.392
CLV_PCSK_KEX2_1	75	77	PF00082	0.766
CLV_PCSK_PC1ET2_1	423	425	PF00082	0.392
CLV_PCSK_SKI1_1	242	246	PF00082	0.497
CLV_PCSK_SKI1_1	275	279	PF00082	0.523
CLV_PCSK_SKI1_1	423	427	PF00082	0.366
CLV_PCSK_SKI1_1	470	474	PF00082	0.461
DEG_APCC_DBOX_1	501	509	PF00400	0.412
DEG_MDM2_SWIB_1	258	265	PF02201	0.448
DEG_SPOP_SBC_1	560	564	PF00917	0.356
DOC_CYCLIN_RxL_1	420	428	PF00134	0.476
DOC_CYCLIN_yCln2_LP_2	202	208	PF00134	0.447
DOC_MAPK_RevD_3	329	344	PF00069	0.522
DOC_MIT_MIM_1	498	508	PF04212	0.494
DOC_PP1_RVXF_1	326	333	PF00149	0.403
DOC_PP1_RVXF_1	411	418	PF00149	0.407
DOC_PP2B_LxvP_1	247	250	PF13499	0.417
DOC_PP4_FxxP_1	122	125	PF00568	0.587
DOC_PP4_FxxP_1	309	312	PF00568	0.504
DOC_PP4_FxxP_1	417	420	PF00568	0.367
DOC_SPAK_OSR1_1	328	332	PF12202	0.340
DOC_USP7_MATH_1	108	112	PF00917	0.678
DOC_USP7_MATH_1	214	218	PF00917	0.520
DOC_USP7_MATH_1	368	372	PF00917	0.720
DOC_USP7_MATH_1	395	399	PF00917	0.607
DOC_USP7_MATH_1	408	412	PF00917	0.611
DOC_USP7_MATH_1	560	564	PF00917	0.471
DOC_USP7_MATH_1	608	612	PF00917	0.511
DOC_USP7_MATH_1	87	91	PF00917	0.763
DOC_WW_Pin1_4	104	109	PF00397	0.659
DOC_WW_Pin1_4	125	130	PF00397	0.596
DOC_WW_Pin1_4	162	167	PF00397	0.478
DOC_WW_Pin1_4	201	206	PF00397	0.349
DOC_WW_Pin1_4	364	369	PF00397	0.765
DOC_WW_Pin1_4	38	43	PF00397	0.442
DOC_WW_Pin1_4	416	421	PF00397	0.420
DOC_WW_Pin1_4	58	63	PF00397	0.407
DOC_WW_Pin1_4	83	88	PF00397	0.753
LIG_14-3-3_CanoR_1	291	295	PF00244	0.519
LIG_14-3-3_CanoR_1	424	433	PF00244	0.387
LIG_14-3-3_CanoR_1	533	539	PF00244	0.487
LIG_14-3-3_CanoR_1	54	62	PF00244	0.577
LIG_14-3-3_CanoR_1	82	87	PF00244	0.757
LIG_14-3-3_CanoR_1	95	99	PF00244	0.584
LIG_BIR_II_1	1	5	PF00653	0.374
LIG_BIR_III_4	547	551	PF00653	0.391
LIG_CaM_NSCaTE_8	52	59	PF13499	0.459
LIG_Clathr_ClatBox_1	264	268	PF01394	0.318
LIG_CSL_BTD_1	417	420	PF09270	0.401
LIG_deltaCOP1_diTrp_1	260	267	PF00928	0.407
LIG_deltaCOP1_diTrp_1	456	465	PF00928	0.402
LIG_eIF4E_1	17	23	PF01652	0.415
LIG_FHA_1	154	160	PF00498	0.555
LIG_FHA_1	340	346	PF00498	0.681
LIG_FHA_1	533	539	PF00498	0.436
LIG_FHA_1	7	13	PF00498	0.389
LIG_FHA_2	16	22	PF00498	0.414
LIG_FHA_2	276	282	PF00498	0.562
LIG_FHA_2	446	452	PF00498	0.365
LIG_Integrin_isoDGR_2	354	356	PF01839	0.680
LIG_LIR_Apic_2	119	125	PF02991	0.615
LIG_LIR_Apic_2	307	312	PF02991	0.499
LIG_LIR_Apic_2	414	420	PF02991	0.380
LIG_LIR_Gen_1	2	12	PF02991	0.466
LIG_LIR_Gen_1	27	37	PF02991	0.416
LIG_LIR_Gen_1	303	312	PF02991	0.416
LIG_LIR_Gen_1	471	479	PF02991	0.433
LIG_LIR_Gen_1	497	505	PF02991	0.504
LIG_LIR_Gen_1	585	593	PF02991	0.507
LIG_LIR_Nem_3	167	172	PF02991	0.504
LIG_LIR_Nem_3	2	8	PF02991	0.371
LIG_LIR_Nem_3	260	265	PF02991	0.415
LIG_LIR_Nem_3	27	33	PF02991	0.383
LIG_LIR_Nem_3	303	309	PF02991	0.415
LIG_LIR_Nem_3	471	476	PF02991	0.457
LIG_LIR_Nem_3	497	501	PF02991	0.441
LIG_LIR_Nem_3	585	590	PF02991	0.452
LIG_NBox_RRM_1	267	277	PF00076	0.468
LIG_Pex14_2	258	262	PF04695	0.483
LIG_SH2_SRC	587	590	PF00017	0.515
LIG_SH2_STAP1	240	244	PF00017	0.324
LIG_SH2_STAT5	138	141	PF00017	0.496
LIG_SH2_STAT5	17	20	PF00017	0.447
LIG_SH2_STAT5	24	27	PF00017	0.439
LIG_SH2_STAT5	629	632	PF00017	0.408
LIG_SH3_3	358	364	PF00018	0.738
LIG_SH3_3	616	622	PF00018	0.454
LIG_SUMO_SIM_anti_2	26	35	PF11976	0.449
LIG_SUMO_SIM_anti_2	561	571	PF11976	0.417
LIG_SUMO_SIM_par_1	156	163	PF11976	0.488
LIG_SUMO_SIM_par_1	337	342	PF11976	0.601
LIG_SUMO_SIM_par_1	580	585	PF11976	0.508
LIG_TRAF2_1	250	253	PF00917	0.510
LIG_TRAF2_1	278	281	PF00917	0.602
LIG_TRAF2_1	448	451	PF00917	0.513
LIG_TRAF2_1	601	604	PF00917	0.509
LIG_WW_3	123	127	PF00397	0.557
MOD_CDC14_SPxK_1	128	131	PF00782	0.578
MOD_CDK_SPxK_1	125	131	PF00069	0.586
MOD_CDK_SPxxK_3	416	423	PF00069	0.423
MOD_CK1_1	111	117	PF00069	0.676
MOD_CK1_1	15	21	PF00069	0.554
MOD_CK1_1	204	210	PF00069	0.411
MOD_CK1_1	26	32	PF00069	0.350
MOD_CK1_1	396	402	PF00069	0.622
MOD_CK1_1	411	417	PF00069	0.468
MOD_CK1_1	532	538	PF00069	0.462
MOD_CK1_1	611	617	PF00069	0.504
MOD_CK2_1	144	150	PF00069	0.485
MOD_CK2_1	151	157	PF00069	0.443
MOD_CK2_1	275	281	PF00069	0.547
MOD_CK2_1	331	337	PF00069	0.484
MOD_CK2_1	416	422	PF00069	0.400
MOD_CK2_1	445	451	PF00069	0.372
MOD_CK2_1	582	588	PF00069	0.484
MOD_GlcNHglycan	1	4	PF01048	0.450
MOD_GlcNHglycan	14	17	PF01048	0.366
MOD_GlcNHglycan	146	149	PF01048	0.502
MOD_GlcNHglycan	186	189	PF01048	0.659
MOD_GlcNHglycan	216	219	PF01048	0.558
MOD_GlcNHglycan	234	237	PF01048	0.290
MOD_GlcNHglycan	370	373	PF01048	0.760
MOD_GlcNHglycan	56	59	PF01048	0.516
MOD_GlcNHglycan	570	573	PF01048	0.506
MOD_GlcNHglycan	584	587	PF01048	0.486
MOD_GlcNHglycan	594	598	PF01048	0.494
MOD_GlcNHglycan	66	69	PF01048	0.756
MOD_GlcNHglycan	90	93	PF01048	0.758
MOD_GSK3_1	104	111	PF00069	0.612
MOD_GSK3_1	180	187	PF00069	0.598
MOD_GSK3_1	364	371	PF00069	0.635
MOD_GSK3_1	395	402	PF00069	0.637
MOD_GSK3_1	54	61	PF00069	0.671
MOD_GSK3_1	62	69	PF00069	0.692
MOD_GSK3_1	77	84	PF00069	0.653
MOD_GSK3_1	94	101	PF00069	0.558
MOD_N-GLC_1	108	113	PF02516	0.656
MOD_NEK2_1	12	17	PF00069	0.439
MOD_NEK2_1	221	226	PF00069	0.514
MOD_NEK2_1	232	237	PF00069	0.386
MOD_NEK2_1	345	350	PF00069	0.554
MOD_NEK2_1	425	430	PF00069	0.391
MOD_NEK2_1	527	532	PF00069	0.405
MOD_NEK2_1	568	573	PF00069	0.378
MOD_PIKK_1	434	440	PF00454	0.519
MOD_PIKK_1	463	469	PF00454	0.589
MOD_PIKK_1	481	487	PF00454	0.336
MOD_PKA_2	174	180	PF00069	0.491
MOD_PKA_2	184	190	PF00069	0.534
MOD_PKA_2	290	296	PF00069	0.525
MOD_PKA_2	355	361	PF00069	0.676
MOD_PKA_2	381	387	PF00069	0.643
MOD_PKA_2	396	402	PF00069	0.445
MOD_PKA_2	532	538	PF00069	0.424
MOD_PKA_2	6	12	PF00069	0.394
MOD_PKA_2	81	87	PF00069	0.644
MOD_PKA_2	94	100	PF00069	0.538
MOD_Plk_1	108	114	PF00069	0.788
MOD_Plk_1	118	124	PF00069	0.635
MOD_Plk_1	242	248	PF00069	0.474
MOD_Plk_1	26	32	PF00069	0.490
MOD_Plk_1	78	84	PF00069	0.615
MOD_Plk_2-3	468	474	PF00069	0.471
MOD_Plk_4	118	124	PF00069	0.662
MOD_Plk_4	26	32	PF00069	0.490
MOD_Plk_4	468	474	PF00069	0.456
MOD_ProDKin_1	104	110	PF00069	0.660
MOD_ProDKin_1	125	131	PF00069	0.594
MOD_ProDKin_1	162	168	PF00069	0.471
MOD_ProDKin_1	201	207	PF00069	0.346
MOD_ProDKin_1	364	370	PF00069	0.760
MOD_ProDKin_1	38	44	PF00069	0.438
MOD_ProDKin_1	416	422	PF00069	0.423
MOD_ProDKin_1	58	64	PF00069	0.410
MOD_ProDKin_1	83	89	PF00069	0.748
MOD_SUMO_for_1	132	135	PF00179	0.505
MOD_SUMO_rev_2	466	472	PF00179	0.454
TRG_DiLeu_BaEn_1	135	140	PF01217	0.478
TRG_DiLeu_BaEn_1	260	265	PF01217	0.415
TRG_DiLeu_BaEn_4	280	286	PF01217	0.480
TRG_DiLeu_BaEn_4	450	456	PF01217	0.506
TRG_DiLeu_BaLyEn_6	168	173	PF01217	0.468
TRG_DiLeu_BaLyEn_6	421	426	PF01217	0.485
TRG_ENDOCYTIC_2	587	590	PF00928	0.422
TRG_ER_diArg_1	125	127	PF00400	0.536
TRG_ER_diArg_1	343	345	PF00400	0.669
TRG_ER_diArg_1	501	504	PF00400	0.512
TRG_NES_CRM1_1	284	296	PF08389	0.451
TRG_Pf-PMV_PEXEL_1	343	347	PF00026	0.665

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IBM3	Leptomonas seymouri	63%	96%
A0A1X0P209	Trypanosomatidae	33%	100%
A0A3S5H7N2	Leishmania donovani	100%	100%
A4HIE2	Leishmania braziliensis	85%	100%
E9B0Y3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q783	Leishmania major	95%	100%
V5BL95	Trypanosoma cruzi	35%	100%