Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I5N5_LEIIN

TriTrypDb:

LINF_300025800

Length:

313

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I5N5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5N5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	12	14	PF00675	0.518
CLV_NRD_NRD_1	125	127	PF00675	0.720
CLV_NRD_NRD_1	154	156	PF00675	0.733
CLV_NRD_NRD_1	207	209	PF00675	0.614
CLV_NRD_NRD_1	226	228	PF00675	0.663
CLV_NRD_NRD_1	255	257	PF00675	0.673
CLV_NRD_NRD_1	292	294	PF00675	0.610
CLV_NRD_NRD_1	300	302	PF00675	0.515
CLV_NRD_NRD_1	70	72	PF00675	0.604
CLV_NRD_NRD_1	95	97	PF00675	0.615
CLV_PCSK_FUR_1	123	127	PF00082	0.719
CLV_PCSK_FUR_1	152	156	PF00082	0.641
CLV_PCSK_FUR_1	68	72	PF00082	0.703
CLV_PCSK_KEX2_1	12	14	PF00082	0.518
CLV_PCSK_KEX2_1	125	127	PF00082	0.670
CLV_PCSK_KEX2_1	154	156	PF00082	0.733
CLV_PCSK_KEX2_1	207	209	PF00082	0.590
CLV_PCSK_KEX2_1	226	228	PF00082	0.666
CLV_PCSK_KEX2_1	255	257	PF00082	0.673
CLV_PCSK_KEX2_1	292	294	PF00082	0.609
CLV_PCSK_KEX2_1	300	302	PF00082	0.513
CLV_PCSK_KEX2_1	70	72	PF00082	0.604
CLV_PCSK_KEX2_1	95	97	PF00082	0.614
CLV_PCSK_SKI1_1	96	100	PF00082	0.627
DEG_Nend_UBRbox_1	1	4	PF02207	0.613
DEG_SCF_FBW7_1	111	116	PF00400	0.711
DEG_SPOP_SBC_1	132	136	PF00917	0.555
DOC_CKS1_1	281	286	PF01111	0.755
DOC_MAPK_DCC_7	196	204	PF00069	0.628
DOC_MAPK_MEF2A_6	196	204	PF00069	0.628
DOC_MAPK_MEF2A_6	244	253	PF00069	0.632
DOC_USP7_MATH_1	100	104	PF00917	0.750
DOC_USP7_MATH_1	113	117	PF00917	0.649
DOC_USP7_MATH_1	131	135	PF00917	0.544
DOC_USP7_MATH_1	15	19	PF00917	0.542
DOC_USP7_MATH_1	160	164	PF00917	0.620
DOC_USP7_MATH_1	30	34	PF00917	0.698
DOC_USP7_UBL2_3	192	196	PF12436	0.630
DOC_USP7_UBL2_3	205	209	PF12436	0.471
DOC_WW_Pin1_4	109	114	PF00397	0.674
DOC_WW_Pin1_4	255	260	PF00397	0.633
DOC_WW_Pin1_4	280	285	PF00397	0.715
DOC_WW_Pin1_4	294	299	PF00397	0.583
DOC_WW_Pin1_4	62	67	PF00397	0.708
LIG_14-3-3_CanoR_1	114	122	PF00244	0.682
LIG_14-3-3_CanoR_1	133	142	PF00244	0.657
LIG_14-3-3_CanoR_1	162	167	PF00244	0.662
LIG_14-3-3_CanoR_1	173	183	PF00244	0.547
LIG_14-3-3_CanoR_1	300	304	PF00244	0.578
LIG_14-3-3_CanoR_1	95	104	PF00244	0.540
LIG_BRCT_BRCA1_1	167	171	PF00533	0.620
LIG_deltaCOP1_diTrp_1	243	248	PF00928	0.618
LIG_FHA_1	300	306	PF00498	0.543
LIG_FHA_1	42	48	PF00498	0.483
LIG_FHA_2	2	8	PF00498	0.642
LIG_LIR_Gen_1	18	24	PF02991	0.584
LIG_LIR_Gen_1	243	253	PF02991	0.629
LIG_LIR_Gen_1	302	311	PF02991	0.473
LIG_LIR_Nem_3	18	23	PF02991	0.580
LIG_LIR_Nem_3	243	249	PF02991	0.621
LIG_LIR_Nem_3	302	306	PF02991	0.485
LIG_SH2_PTP2	127	130	PF00017	0.660
LIG_SH2_SRC	127	130	PF00017	0.663
LIG_SH2_STAP1	55	59	PF00017	0.643
LIG_SH2_STAT5	127	130	PF00017	0.685
LIG_SH3_1	278	284	PF00018	0.608
LIG_SH3_2	200	205	PF14604	0.647
LIG_SH3_3	116	122	PF00018	0.715
LIG_SH3_3	125	131	PF00018	0.711
LIG_SH3_3	184	190	PF00018	0.577
LIG_SH3_3	191	197	PF00018	0.544
LIG_SH3_3	200	206	PF00018	0.516
LIG_SH3_3	268	274	PF00018	0.698
LIG_SH3_3	278	284	PF00018	0.669
LIG_SH3_4	192	199	PF00018	0.658
LIG_SH3_4	205	212	PF00018	0.676
LIG_SUMO_SIM_par_1	273	279	PF11976	0.673
LIG_WW_2	200	203	PF00397	0.494
MOD_CDK_SPK_2	109	114	PF00069	0.678
MOD_CDK_SPxK_1	294	300	PF00069	0.552
MOD_CDK_SPxK_1	62	68	PF00069	0.730
MOD_CDK_SPxxK_3	280	287	PF00069	0.609
MOD_CDK_SPxxK_3	294	301	PF00069	0.514
MOD_CK1_1	165	171	PF00069	0.690
MOD_CK1_1	172	178	PF00069	0.615
MOD_CK1_1	28	34	PF00069	0.731
MOD_CK2_1	1	7	PF00069	0.652
MOD_Cter_Amidation	253	256	PF01082	0.512
MOD_Cter_Amidation	290	293	PF01082	0.669
MOD_Cter_Amidation	68	71	PF01082	0.624
MOD_GlcNHglycan	149	152	PF01048	0.730
MOD_GlcNHglycan	158	161	PF01048	0.665
MOD_GlcNHglycan	220	223	PF01048	0.589
MOD_GlcNHglycan	239	242	PF01048	0.392
MOD_GSK3_1	109	116	PF00069	0.608
MOD_GSK3_1	156	163	PF00069	0.708
MOD_GSK3_1	165	172	PF00069	0.662
MOD_GSK3_1	43	50	PF00069	0.547
MOD_GSK3_1	96	103	PF00069	0.624
MOD_N-GLC_1	100	105	PF02516	0.713
MOD_N-GLC_1	173	178	PF02516	0.636
MOD_N-GLC_1	264	269	PF02516	0.557
MOD_NEK2_1	1	6	PF00069	0.610
MOD_NEK2_2	15	20	PF00069	0.499
MOD_PIKK_1	165	171	PF00454	0.650
MOD_PK_1	162	168	PF00069	0.735
MOD_PKA_2	113	119	PF00069	0.614
MOD_PKA_2	132	138	PF00069	0.593
MOD_PKA_2	172	178	PF00069	0.642
MOD_PKA_2	25	31	PF00069	0.552
MOD_PKA_2	299	305	PF00069	0.545
MOD_PKA_2	88	94	PF00069	0.752
MOD_Plk_1	117	123	PF00069	0.754
MOD_Plk_1	264	270	PF00069	0.620
MOD_Plk_1	50	56	PF00069	0.655
MOD_Plk_4	15	21	PF00069	0.486
MOD_Plk_4	182	188	PF00069	0.674
MOD_Plk_4	50	56	PF00069	0.668
MOD_ProDKin_1	109	115	PF00069	0.673
MOD_ProDKin_1	255	261	PF00069	0.636
MOD_ProDKin_1	280	286	PF00069	0.717
MOD_ProDKin_1	294	300	PF00069	0.578
MOD_ProDKin_1	62	68	PF00069	0.714
TRG_ER_diArg_1	122	125	PF00400	0.721
TRG_ER_diArg_1	152	155	PF00400	0.677
TRG_ER_diArg_1	206	208	PF00400	0.646
TRG_ER_diArg_1	217	220	PF00400	0.441
TRG_ER_diArg_1	292	294	PF00400	0.615
TRG_ER_diArg_1	299	301	PF00400	0.540
TRG_ER_diArg_1	67	70	PF00400	0.707
TRG_ER_diArg_1	94	96	PF00400	0.656
TRG_Pf-PMV_PEXEL_1	6	10	PF00026	0.607

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P913	Leptomonas seymouri	62%	100%
A0A1X0P1U3	Trypanosomatidae	31%	100%
A0A3Q8IFW1	Leishmania donovani	100%	100%
A0A422P3E4	Trypanosoma rangeli	34%	100%
A4HID8	Leishmania braziliensis	77%	100%
C9ZR04	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9B0X9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q787	Leishmania major	93%	100%
V5BYT6	Trypanosoma cruzi	32%	99%