Ferric reductase transmembrane protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ferric reductase transmembrane protein-like protein

Species:

Leishmania infantum

UniProt:

A4I5N2_LEIIN

TriTrypDb:

LINF_300025600

Length:

220

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4I5N2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5N2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016491	oxidoreductase activity	2	11
GO:0140575	transmembrane monodehydroascorbate reductase activity	3	11
GO:0005488	binding	1	1
GO:0020037	heme binding	4	1
GO:0046906	tetrapyrrole binding	3	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	22	24	PF00675	0.252
CLV_NRD_NRD_1	38	40	PF00675	0.410
CLV_NRD_NRD_1	78	80	PF00675	0.339
CLV_PCSK_FUR_1	20	24	PF00082	0.245
CLV_PCSK_KEX2_1	160	162	PF00082	0.346
CLV_PCSK_KEX2_1	22	24	PF00082	0.251
CLV_PCSK_KEX2_1	78	80	PF00082	0.356
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.346
CLV_PCSK_PC7_1	74	80	PF00082	0.251
CLV_PCSK_SKI1_1	151	155	PF00082	0.382
DEG_Nend_UBRbox_1	1	4	PF02207	0.556
DEG_SPOP_SBC_1	7	11	PF00917	0.553
DOC_ANK_TNKS_1	22	29	PF00023	0.433
DOC_CYCLIN_yCln2_LP_2	153	159	PF00134	0.387
DOC_MAPK_gen_1	20	29	PF00069	0.528
DOC_MAPK_MEF2A_6	22	31	PF00069	0.515
DOC_PP1_SILK_1	147	152	PF00149	0.292
DOC_PP2B_LxvP_1	153	156	PF13499	0.387
DOC_PP4_MxPP_1	196	199	PF00568	0.250
DOC_WW_Pin1_4	77	82	PF00397	0.470
DOC_WW_Pin1_4	8	13	PF00397	0.705
LIG_14-3-3_CanoR_1	2	6	PF00244	0.609
LIG_Actin_WH2_2	60	76	PF00022	0.344
LIG_EH1_1	50	58	PF00400	0.279
LIG_FHA_1	172	178	PF00498	0.374
LIG_FHA_1	202	208	PF00498	0.455
LIG_LIR_Gen_1	114	123	PF02991	0.270
LIG_LIR_Nem_3	114	118	PF02991	0.324
LIG_LIR_Nem_3	134	138	PF02991	0.371
LIG_LIR_Nem_3	4	8	PF02991	0.551
LIG_LIR_Nem_3	41	47	PF02991	0.322
LIG_LIR_Nem_3	49	53	PF02991	0.232
LIG_LYPXL_yS_3	122	125	PF13949	0.251
LIG_LYPXL_yS_3	5	8	PF13949	0.549
LIG_MYND_2	198	202	PF01753	0.205
LIG_NRBOX	149	155	PF00104	0.283
LIG_SH2_CRK	115	119	PF00017	0.372
LIG_SH2_CRK	44	48	PF00017	0.314
LIG_SH2_CRK	50	54	PF00017	0.239
LIG_SH2_STAP1	192	196	PF00017	0.380
LIG_SH2_STAT5	115	118	PF00017	0.288
LIG_SH2_STAT5	152	155	PF00017	0.546
LIG_SH2_STAT5	44	47	PF00017	0.435
LIG_SH3_2	156	161	PF14604	0.488
LIG_SH3_3	153	159	PF00018	0.473
LIG_SH3_3	28	34	PF00018	0.408
LIG_SUMO_SIM_par_1	172	178	PF11976	0.295
LIG_TRFH_1	152	156	PF08558	0.533
LIG_TYR_ITIM	113	118	PF00017	0.288
LIG_WRC_WIRS_1	132	137	PF05994	0.201
LIG_WRC_WIRS_1	97	102	PF05994	0.344
LIG_WW_3	11	15	PF00397	0.528
LIG_WW_3	85	89	PF00397	0.387
MOD_CDC14_SPxK_1	11	14	PF00782	0.560
MOD_CDK_SPxK_1	8	14	PF00069	0.579
MOD_CK1_1	127	133	PF00069	0.187
MOD_CK2_1	77	83	PF00069	0.519
MOD_GlcNHglycan	171	174	PF01048	0.282
MOD_GlcNHglycan	40	43	PF01048	0.562
MOD_GSK3_1	127	134	PF00069	0.324
MOD_GSK3_1	171	178	PF00069	0.310
MOD_GSK3_1	197	204	PF00069	0.288
MOD_GSK3_1	38	45	PF00069	0.473
MOD_NEK2_1	1	6	PF00069	0.557
MOD_NEK2_1	201	206	PF00069	0.371
MOD_NEK2_1	38	43	PF00069	0.470
MOD_PKA_2	1	7	PF00069	0.646
MOD_PKA_2	38	44	PF00069	0.484
MOD_PKA_2	67	73	PF00069	0.204
MOD_Plk_4	127	133	PF00069	0.187
MOD_Plk_4	136	142	PF00069	0.325
MOD_Plk_4	145	151	PF00069	0.259
MOD_Plk_4	197	203	PF00069	0.296
MOD_Plk_4	96	102	PF00069	0.528
MOD_ProDKin_1	77	83	PF00069	0.470
MOD_ProDKin_1	8	14	PF00069	0.703
MOD_SUMO_rev_2	65	73	PF00179	0.292
TRG_ENDOCYTIC_2	115	118	PF00928	0.379
TRG_ENDOCYTIC_2	122	125	PF00928	0.288
TRG_ENDOCYTIC_2	44	47	PF00928	0.339
TRG_ENDOCYTIC_2	5	8	PF00928	0.549
TRG_ENDOCYTIC_2	50	53	PF00928	0.237
TRG_ER_diArg_1	20	23	PF00400	0.509

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JNM4	Bodo saltans	25%	92%
A0A1X0P2F3	Trypanosomatidae	25%	89%
A0A3Q8IC17	Leishmania donovani	99%	100%
A0A3R7RSY6	Trypanosoma rangeli	30%	91%
A4HID6	Leishmania braziliensis	66%	100%
C9ZR03	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	21%	92%
E9B0X7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q789	Leishmania major	84%	100%
V5BPF8	Trypanosoma cruzi	26%	92%