GPI mannosyltransferase 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mannosyltransferase - putative

Species:

Leishmania infantum

UniProt:

A4I5N0_LEIIN

TriTrypDb:

LINF_300025400

Length:

432

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005635	nuclear envelope	4	1
GO:0005737	cytoplasm	2	1
GO:0005789	endoplasmic reticulum membrane	4	12
GO:0016020	membrane	2	12
GO:0031090	organelle membrane	3	12
GO:0031501	mannosyltransferase complex	3	1
GO:0031967	organelle envelope	3	1
GO:0031975	envelope	2	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	12

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Expansion

Sequence features

A4I5N0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5N0

Function

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Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	12
GO:0006505	GPI anchor metabolic process	6	12
GO:0006506	GPI anchor biosynthetic process	6	12
GO:0006629	lipid metabolic process	3	12
GO:0006643	membrane lipid metabolic process	4	12
GO:0006644	phospholipid metabolic process	4	12
GO:0006650	glycerophospholipid metabolic process	5	12
GO:0006661	phosphatidylinositol biosynthetic process	6	12
GO:0006664	glycolipid metabolic process	5	12
GO:0006793	phosphorus metabolic process	3	12

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Molecular functions
Term	Name	Level	Count
GO:0000030	mannosyltransferase activity	5	12
GO:0003824	catalytic activity	1	12
GO:0004376	glycolipid mannosyltransferase activity	6	12
GO:0016740	transferase activity	2	12
GO:0016757	glycosyltransferase activity	3	12
GO:0016758	hexosyltransferase activity	4	12
GO:0051751	alpha-1,4-mannosyltransferase activity	6	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	265	267	PF00675	0.430
CLV_NRD_NRD_1	295	297	PF00675	0.217
CLV_PCSK_KEX2_1	265	267	PF00082	0.430
CLV_PCSK_KEX2_1	340	342	PF00082	0.180
CLV_PCSK_KEX2_1	430	432	PF00082	0.438
CLV_PCSK_PC1ET2_1	340	342	PF00082	0.180
CLV_PCSK_PC1ET2_1	430	432	PF00082	0.438
CLV_PCSK_PC7_1	426	432	PF00082	0.464
CLV_PCSK_SKI1_1	115	119	PF00082	0.260
CLV_PCSK_SKI1_1	13	17	PF00082	0.208

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I387	Leptomonas seymouri	79%	100%
A0A0S4JVL8	Bodo saltans	54%	98%
A0A1X0P1P7	Trypanosomatidae	60%	95%
A0A3Q8IS10	Leishmania donovani	100%	100%
A0A422P3K4	Trypanosoma rangeli	59%	100%
A4HID4	Leishmania braziliensis	88%	100%
C9ZR01	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	100%
E9B0X5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
P47088	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	100%
Q2TXB8	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	32%	100%

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