Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I5M5_LEIIN

TriTrypDb:

LINF_300024700

Length:

327

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I5M5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5M5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	224	228	PF00656	0.777
CLV_C14_Caspase3-7	278	282	PF00656	0.692
CLV_C14_Caspase3-7	75	79	PF00656	0.652
CLV_NRD_NRD_1	15	17	PF00675	0.732
CLV_NRD_NRD_1	18	20	PF00675	0.685
CLV_PCSK_FUR_1	16	20	PF00082	0.731
CLV_PCSK_KEX2_1	15	17	PF00082	0.732
CLV_PCSK_KEX2_1	18	20	PF00082	0.685
CLV_PCSK_SKI1_1	18	22	PF00082	0.640
CLV_PCSK_SKI1_1	192	196	PF00082	0.681
DEG_Nend_UBRbox_3	1	3	PF02207	0.701
DEG_SPOP_SBC_1	286	290	PF00917	0.696
DOC_MAPK_gen_1	3	13	PF00069	0.713
DOC_MAPK_MEF2A_6	192	200	PF00069	0.687
DOC_PP1_RVXF_1	63	69	PF00149	0.649
DOC_PP2B_PxIxI_1	195	201	PF00149	0.553
DOC_PP4_FxxP_1	108	111	PF00568	0.629
DOC_PP4_FxxP_1	283	286	PF00568	0.657
DOC_USP7_MATH_1	138	142	PF00917	0.669
DOC_USP7_MATH_1	218	222	PF00917	0.779
DOC_USP7_MATH_1	275	279	PF00917	0.668
DOC_USP7_MATH_1	310	314	PF00917	0.724
DOC_WW_Pin1_4	192	197	PF00397	0.579
DOC_WW_Pin1_4	78	83	PF00397	0.636
LIG_14-3-3_CanoR_1	146	151	PF00244	0.725
LIG_14-3-3_CanoR_1	235	242	PF00244	0.645
LIG_14-3-3_CanoR_1	298	302	PF00244	0.652
LIG_14-3-3_CanoR_1	6	13	PF00244	0.669
LIG_Actin_WH2_2	179	194	PF00022	0.484
LIG_BRCT_BRCA1_1	289	293	PF00533	0.596
LIG_CSL_BTD_1	283	286	PF09270	0.519
LIG_deltaCOP1_diTrp_1	281	287	PF00928	0.668
LIG_deltaCOP1_diTrp_1	315	319	PF00928	0.604
LIG_FHA_1	167	173	PF00498	0.643
LIG_FHA_1	193	199	PF00498	0.583
LIG_FHA_1	318	324	PF00498	0.667
LIG_FHA_1	6	12	PF00498	0.730
LIG_FHA_2	210	216	PF00498	0.805
LIG_FHA_2	82	88	PF00498	0.835
LIG_Integrin_RGD_1	225	227	PF01839	0.777
LIG_LIR_Apic_2	281	286	PF02991	0.663
LIG_LIR_Gen_1	128	139	PF02991	0.543
LIG_LIR_Gen_1	262	271	PF02991	0.572
LIG_LIR_Nem_3	128	134	PF02991	0.528
LIG_LIR_Nem_3	262	268	PF02991	0.561
LIG_LIR_Nem_3	281	287	PF02991	0.496
LIG_NRBOX	129	135	PF00104	0.481
LIG_Pex14_2	283	287	PF04695	0.666
LIG_PTB_Apo_2	118	125	PF02174	0.586
LIG_SH2_NCK_1	279	283	PF00017	0.682
LIG_SH2_SRC	241	244	PF00017	0.669
LIG_SH2_STAT3	171	174	PF00017	0.530
LIG_SH2_STAT5	171	174	PF00017	0.627
LIG_SH2_STAT5	241	244	PF00017	0.639
LIG_SH2_STAT5	324	327	PF00017	0.648
LIG_SH3_3	108	114	PF00018	0.591
LIG_SH3_3	92	98	PF00018	0.776
LIG_SH3_3	99	105	PF00018	0.789
MOD_CDK_SPxxK_3	78	85	PF00069	0.642
MOD_CK1_1	148	154	PF00069	0.711
MOD_CK1_1	160	166	PF00069	0.785
MOD_CK1_1	270	276	PF00069	0.520
MOD_CK1_1	36	42	PF00069	0.675
MOD_CK1_1	58	64	PF00069	0.746
MOD_CK1_1	81	87	PF00069	0.659
MOD_CK2_1	146	152	PF00069	0.793
MOD_CK2_1	218	224	PF00069	0.792
MOD_CK2_1	69	75	PF00069	0.673
MOD_CK2_1	81	87	PF00069	0.714
MOD_DYRK1A_RPxSP_1	192	196	PF00069	0.646
MOD_GSK3_1	182	189	PF00069	0.570
MOD_GSK3_1	204	211	PF00069	0.690
MOD_GSK3_1	266	273	PF00069	0.526
MOD_GSK3_1	285	292	PF00069	0.653
MOD_GSK3_1	297	304	PF00069	0.552
MOD_N-GLC_1	120	125	PF02516	0.673
MOD_N-GLC_1	61	66	PF02516	0.570
MOD_NEK2_1	11	16	PF00069	0.739
MOD_NEK2_1	120	125	PF00069	0.597
MOD_NEK2_1	177	182	PF00069	0.591
MOD_NEK2_1	287	292	PF00069	0.675
MOD_NEK2_1	43	48	PF00069	0.614
MOD_PKA_2	145	151	PF00069	0.676
MOD_PKA_2	297	303	PF00069	0.615
MOD_PKA_2	317	323	PF00069	0.666
MOD_PKA_2	5	11	PF00069	0.766
MOD_Plk_1	120	126	PF00069	0.598
MOD_Plk_1	166	172	PF00069	0.618
MOD_Plk_1	186	192	PF00069	0.335
MOD_Plk_1	218	224	PF00069	0.764
MOD_Plk_1	266	272	PF00069	0.639
MOD_Plk_1	36	42	PF00069	0.660
MOD_Plk_4	114	120	PF00069	0.699
MOD_Plk_4	186	192	PF00069	0.503
MOD_Plk_4	38	44	PF00069	0.742
MOD_ProDKin_1	192	198	PF00069	0.573
MOD_ProDKin_1	78	84	PF00069	0.638
TRG_DiLeu_BaEn_1	26	31	PF01217	0.568
TRG_DiLeu_BaEn_2	126	132	PF01217	0.638
TRG_ER_diArg_1	15	18	PF00400	0.737

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P910	Leptomonas seymouri	35%	94%
A0A3S7X3F3	Leishmania donovani	99%	100%
E9B0X0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q796	Leishmania major	87%	100%