RNA pseudouridylate synthase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA pseudouridylate synthase-like protein

Species:

Leishmania infantum

UniProt:

A4I5M1_LEIIN

TriTrypDb:

LINF_300024300

Length:

533

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I5M1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5M1

Function

Biological processes
Term	Name	Level	Count
GO:0001522	pseudouridine synthesis	6	9
GO:0006139	nucleobase-containing compound metabolic process	3	9
GO:0006364	rRNA processing	8	7
GO:0006396	RNA processing	6	7
GO:0006725	cellular aromatic compound metabolic process	3	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0009451	RNA modification	5	9
GO:0009987	cellular process	1	9
GO:0016070	RNA metabolic process	5	9
GO:0016072	rRNA metabolic process	7	7
GO:0034470	ncRNA processing	7	7
GO:0034641	cellular nitrogen compound metabolic process	3	9
GO:0034660	ncRNA metabolic process	6	7
GO:0043170	macromolecule metabolic process	3	9
GO:0043412	macromolecule modification	4	9
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0046483	heterocycle metabolic process	3	9
GO:0071704	organic substance metabolic process	2	9
GO:0090304	nucleic acid metabolic process	4	9
GO:1901360	organic cyclic compound metabolic process	3	9
GO:0000154	rRNA modification	6	1
GO:0000455	enzyme-directed rRNA pseudouridine synthesis	8	1
GO:0031118	rRNA pseudouridine synthesis	7	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0003723	RNA binding	4	9
GO:0003824	catalytic activity	1	9
GO:0005488	binding	1	9
GO:0009982	pseudouridine synthase activity	4	9
GO:0016853	isomerase activity	2	9
GO:0016866	intramolecular transferase activity	3	9
GO:0097159	organic cyclic compound binding	2	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	163	167	PF00656	0.659
CLV_C14_Caspase3-7	49	53	PF00656	0.567
CLV_NRD_NRD_1	11	13	PF00675	0.557
CLV_NRD_NRD_1	117	119	PF00675	0.511
CLV_NRD_NRD_1	182	184	PF00675	0.704
CLV_NRD_NRD_1	377	379	PF00675	0.230
CLV_NRD_NRD_1	438	440	PF00675	0.584
CLV_NRD_NRD_1	466	468	PF00675	0.492
CLV_PCSK_FUR_1	436	440	PF00082	0.575
CLV_PCSK_FUR_1	9	13	PF00082	0.551
CLV_PCSK_KEX2_1	11	13	PF00082	0.557
CLV_PCSK_KEX2_1	116	118	PF00082	0.456
CLV_PCSK_KEX2_1	181	183	PF00082	0.649
CLV_PCSK_KEX2_1	438	440	PF00082	0.584
CLV_PCSK_KEX2_1	466	468	PF00082	0.379
CLV_PCSK_SKI1_1	331	335	PF00082	0.269
CLV_PCSK_SKI1_1	341	345	PF00082	0.282
CLV_PCSK_SKI1_1	467	471	PF00082	0.346
CLV_PCSK_SKI1_1	486	490	PF00082	0.486
CLV_Separin_Metazoa	113	117	PF03568	0.444
CLV_Separin_Metazoa	279	283	PF03568	0.510
DOC_CYCLIN_RxL_1	462	473	PF00134	0.461
DOC_MAPK_gen_1	223	233	PF00069	0.384
DOC_MAPK_gen_1	264	272	PF00069	0.666
DOC_MAPK_MEF2A_6	438	447	PF00069	0.573
DOC_PP1_RVXF_1	472	478	PF00149	0.470
DOC_PP4_FxxP_1	477	480	PF00568	0.407
DOC_PP4_FxxP_1	65	68	PF00568	0.422
DOC_PP4_FxxP_1	71	74	PF00568	0.426
DOC_USP7_MATH_1	14	18	PF00917	0.544
DOC_USP7_MATH_1	153	157	PF00917	0.642
DOC_USP7_MATH_1	159	163	PF00917	0.622
DOC_USP7_MATH_1	193	197	PF00917	0.739
DOC_USP7_MATH_1	198	202	PF00917	0.694
DOC_USP7_MATH_1	235	239	PF00917	0.521
DOC_USP7_MATH_1	258	262	PF00917	0.528
DOC_USP7_MATH_1	271	275	PF00917	0.555
DOC_USP7_MATH_1	319	323	PF00917	0.585
DOC_USP7_MATH_1	348	352	PF00917	0.533
DOC_USP7_MATH_1	528	532	PF00917	0.692
DOC_USP7_MATH_1	74	78	PF00917	0.519
DOC_WW_Pin1_4	175	180	PF00397	0.728
DOC_WW_Pin1_4	204	209	PF00397	0.794
DOC_WW_Pin1_4	211	216	PF00397	0.615
DOC_WW_Pin1_4	415	420	PF00397	0.478
DOC_WW_Pin1_4	480	485	PF00397	0.610
DOC_WW_Pin1_4	490	495	PF00397	0.477
LIG_14-3-3_CanoR_1	129	133	PF00244	0.615
LIG_14-3-3_CanoR_1	474	478	PF00244	0.333
LIG_14-3-3_CanoR_1	486	491	PF00244	0.505
LIG_AP2alpha_2	442	444	PF02296	0.474
LIG_BIR_III_4	166	170	PF00653	0.666
LIG_BRCT_BRCA1_1	22	26	PF00533	0.490
LIG_BRCT_BRCA1_1	273	277	PF00533	0.555
LIG_BRCT_BRCA1_1	509	513	PF00533	0.468
LIG_eIF4E_1	106	112	PF01652	0.421
LIG_eIF4E_1	84	90	PF01652	0.497
LIG_EVH1_1	352	356	PF00568	0.453
LIG_EVH1_2	67	71	PF00568	0.397
LIG_FHA_1	137	143	PF00498	0.695
LIG_FHA_1	205	211	PF00498	0.595
LIG_FHA_1	226	232	PF00498	0.372
LIG_FHA_1	254	260	PF00498	0.489
LIG_FHA_1	291	297	PF00498	0.536
LIG_FHA_1	303	309	PF00498	0.536
LIG_FHA_1	497	503	PF00498	0.401
LIG_FHA_1	516	522	PF00498	0.482
LIG_FHA_1	86	92	PF00498	0.561
LIG_FHA_2	108	114	PF00498	0.443
LIG_FHA_2	133	139	PF00498	0.691
LIG_FHA_2	161	167	PF00498	0.659
LIG_FHA_2	274	280	PF00498	0.485
LIG_FHA_2	47	53	PF00498	0.483
LIG_KLC1_Yacidic_2	430	435	PF13176	0.542
LIG_LIR_Apic_2	4	10	PF02991	0.448
LIG_LIR_Apic_2	476	480	PF02991	0.349
LIG_LIR_Apic_2	70	74	PF02991	0.617
LIG_LIR_Gen_1	23	30	PF02991	0.444
LIG_LIR_Gen_1	274	285	PF02991	0.485
LIG_LIR_Gen_1	291	300	PF02991	0.529
LIG_LIR_Gen_1	303	312	PF02991	0.531
LIG_LIR_Nem_3	23	29	PF02991	0.453
LIG_LIR_Nem_3	274	280	PF02991	0.499
LIG_LIR_Nem_3	291	295	PF02991	0.478
LIG_LIR_Nem_3	303	309	PF02991	0.531
LIG_LIR_Nem_3	441	447	PF02991	0.540
LIG_LYPXL_yS_3	406	409	PF13949	0.378
LIG_SH2_CRK	292	296	PF00017	0.496
LIG_SH2_CRK	7	11	PF00017	0.445
LIG_SH2_SRC	84	87	PF00017	0.435
LIG_SH2_STAP1	292	296	PF00017	0.536
LIG_SH2_STAT5	106	109	PF00017	0.492
LIG_SH2_STAT5	124	127	PF00017	0.527
LIG_SH2_STAT5	21	24	PF00017	0.370
LIG_SH2_STAT5	28	31	PF00017	0.435
LIG_SH2_STAT5	292	295	PF00017	0.496
LIG_SH2_STAT5	414	417	PF00017	0.422
LIG_SH2_STAT5	433	436	PF00017	0.395
LIG_SH2_STAT5	55	58	PF00017	0.447
LIG_SH2_STAT5	7	10	PF00017	0.483
LIG_SH3_3	350	356	PF00018	0.601
LIG_SH3_3	401	407	PF00018	0.532
LIG_SH3_3	440	446	PF00018	0.573
LIG_SH3_3	518	524	PF00018	0.523
LIG_SUMO_SIM_anti_2	110	116	PF11976	0.429
LIG_SUMO_SIM_anti_2	227	235	PF11976	0.366
LIG_SUMO_SIM_anti_2	85	93	PF11976	0.458
LIG_SUMO_SIM_par_1	214	220	PF11976	0.418
LIG_SUMO_SIM_par_1	85	93	PF11976	0.430
LIG_TYR_ITIM	404	409	PF00017	0.378
LIG_UBA3_1	18	25	PF00899	0.479
LIG_WRC_WIRS_1	487	492	PF05994	0.446
LIG_WW_3	66	70	PF00397	0.491
MOD_CDC14_SPxK_1	178	181	PF00782	0.620
MOD_CDC14_SPxK_1	483	486	PF00782	0.515
MOD_CDK_SPxK_1	175	181	PF00069	0.619
MOD_CDK_SPxK_1	415	421	PF00069	0.587
MOD_CDK_SPxK_1	480	486	PF00069	0.493
MOD_CDK_SPxxK_3	175	182	PF00069	0.687
MOD_CK1_1	127	133	PF00069	0.576
MOD_CK1_1	177	183	PF00069	0.659
MOD_CK1_1	240	246	PF00069	0.457
MOD_CK1_1	273	279	PF00069	0.339
MOD_CK1_1	511	517	PF00069	0.396
MOD_CK2_1	107	113	PF00069	0.440
MOD_CK2_1	243	249	PF00069	0.503
MOD_CK2_1	273	279	PF00069	0.257
MOD_GlcNHglycan	191	194	PF01048	0.737
MOD_GlcNHglycan	195	198	PF01048	0.752
MOD_GlcNHglycan	204	207	PF01048	0.598
MOD_GlcNHglycan	227	231	PF01048	0.418
MOD_GlcNHglycan	239	242	PF01048	0.461
MOD_GlcNHglycan	448	454	PF01048	0.606
MOD_GSK3_1	124	131	PF00069	0.546
MOD_GSK3_1	132	139	PF00069	0.705
MOD_GSK3_1	140	147	PF00069	0.624
MOD_GSK3_1	173	180	PF00069	0.733
MOD_GSK3_1	189	196	PF00069	0.768
MOD_GSK3_1	198	205	PF00069	0.703
MOD_GSK3_1	20	27	PF00069	0.503
MOD_GSK3_1	249	256	PF00069	0.424
MOD_GSK3_1	284	291	PF00069	0.403
MOD_GSK3_1	486	493	PF00069	0.578
MOD_GSK3_1	507	514	PF00069	0.522
MOD_GSK3_1	515	522	PF00069	0.503
MOD_NEK2_1	188	193	PF00069	0.692
MOD_NEK2_1	29	34	PF00069	0.491
MOD_NEK2_1	343	348	PF00069	0.462
MOD_NEK2_1	366	371	PF00069	0.448
MOD_NEK2_1	380	385	PF00069	0.331
MOD_NEK2_1	413	418	PF00069	0.443
MOD_NEK2_1	470	475	PF00069	0.461
MOD_NEK2_1	90	95	PF00069	0.465
MOD_NEK2_2	153	158	PF00069	0.556
MOD_PIKK_1	29	35	PF00454	0.373
MOD_PIKK_1	325	331	PF00454	0.431
MOD_PIKK_1	511	517	PF00454	0.374
MOD_PK_1	284	290	PF00069	0.369
MOD_PKA_2	128	134	PF00069	0.521
MOD_PKA_2	473	479	PF00069	0.336
MOD_Plk_1	107	113	PF00069	0.430
MOD_Plk_1	14	20	PF00069	0.577
MOD_Plk_1	153	159	PF00069	0.715
MOD_Plk_1	302	308	PF00069	0.375
MOD_Plk_1	41	47	PF00069	0.427
MOD_Plk_1	507	513	PF00069	0.486
MOD_Plk_1	84	90	PF00069	0.484
MOD_Plk_4	107	113	PF00069	0.421
MOD_Plk_4	14	20	PF00069	0.493
MOD_Plk_4	302	308	PF00069	0.397
MOD_Plk_4	486	492	PF00069	0.458
MOD_Plk_4	508	514	PF00069	0.424
MOD_Plk_4	51	57	PF00069	0.566
MOD_Plk_4	85	91	PF00069	0.450
MOD_ProDKin_1	175	181	PF00069	0.730
MOD_ProDKin_1	204	210	PF00069	0.793
MOD_ProDKin_1	211	217	PF00069	0.603
MOD_ProDKin_1	415	421	PF00069	0.484
MOD_ProDKin_1	480	486	PF00069	0.608
MOD_ProDKin_1	490	496	PF00069	0.480
MOD_SUMO_rev_2	70	80	PF00179	0.411
TRG_DiLeu_BaEn_1	85	90	PF01217	0.499
TRG_DiLeu_BaEn_2	301	307	PF01217	0.406
TRG_DiLeu_BaEn_2	439	445	PF01217	0.496
TRG_ENDOCYTIC_2	292	295	PF00928	0.314
TRG_ENDOCYTIC_2	406	409	PF00928	0.378
TRG_ER_diArg_1	115	118	PF00400	0.457
TRG_ER_diArg_1	181	183	PF00400	0.720
TRG_ER_diArg_1	370	373	PF00400	0.350
TRG_ER_diArg_1	436	439	PF00400	0.547
TRG_ER_diArg_1	9	12	PF00400	0.546
TRG_Pf-PMV_PEXEL_1	182	186	PF00026	0.707

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IME7	Leptomonas seymouri	48%	100%
A0A0S4JCR9	Bodo saltans	29%	89%
A0A3Q8IFN9	Leishmania donovani	99%	100%
A4HIC8	Leishmania braziliensis	74%	100%
E9B0W6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q7A0	Leishmania major	90%	100%
V5DQK8	Trypanosoma cruzi	37%	100%