Succinyl-CoA:3-ketoacid-coenzyme A transferase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

succinyl-coa:3-ketoacid-coenzyme a transferase- like protein

Species:

Leishmania infantum

UniProt:

A4I5L9_LEIIN

TriTrypDb:

LINF_300024100

Length:

499

Annotations

Annotations by Jardim et al.

Tricarboxylic acid cycle, Succinyl-CoA:3-ketoacid-coenzyme A transferase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 35

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 24

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	13
GO:0043226	organelle	2	13
GO:0043227	membrane-bounded organelle	3	13
GO:0043229	intracellular organelle	3	13
GO:0043231	intracellular membrane-bounded organelle	4	13
GO:0110165	cellular anatomical entity	1	13

Expansion

Sequence features

A4I5L9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5L9

Function

Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	13
GO:0006629	lipid metabolic process	3	13
GO:0008152	metabolic process	1	13
GO:0009056	catabolic process	2	13
GO:0009987	cellular process	1	13
GO:0016042	lipid catabolic process	4	13
GO:0044237	cellular metabolic process	2	13
GO:0044238	primary metabolic process	2	13
GO:0044248	cellular catabolic process	3	13
GO:0044281	small molecule metabolic process	2	13
GO:0044282	small molecule catabolic process	3	13
GO:0046950	cellular ketone body metabolic process	3	13
GO:0046952	ketone body catabolic process	4	13
GO:0071704	organic substance metabolic process	2	13
GO:1901568	fatty acid derivative metabolic process	4	13
GO:1901569	fatty acid derivative catabolic process	5	13
GO:1901575	organic substance catabolic process	3	13
GO:1902224	ketone body metabolic process	4	13

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0008260	succinyl-CoA:3-oxo-acid CoA-transferase activity	5	13
GO:0008410	CoA-transferase activity	4	13
GO:0016740	transferase activity	2	13
GO:0016782	transferase activity, transferring sulphur-containing groups	3	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	283	287	PF00656	0.495
CLV_NRD_NRD_1	248	250	PF00675	0.554
CLV_NRD_NRD_1	256	258	PF00675	0.516
CLV_NRD_NRD_1	278	280	PF00675	0.284
CLV_NRD_NRD_1	3	5	PF00675	0.561
CLV_NRD_NRD_1	6	8	PF00675	0.559
CLV_PCSK_FUR_1	4	8	PF00082	0.431
CLV_PCSK_KEX2_1	189	191	PF00082	0.370
CLV_PCSK_KEX2_1	248	250	PF00082	0.506
CLV_PCSK_KEX2_1	278	280	PF00082	0.301
CLV_PCSK_KEX2_1	3	5	PF00082	0.561
CLV_PCSK_KEX2_1	6	8	PF00082	0.559
CLV_PCSK_PC1ET2_1	189	191	PF00082	0.306
CLV_PCSK_SKI1_1	208	212	PF00082	0.382
CLV_PCSK_SKI1_1	279	283	PF00082	0.299
CLV_PCSK_SKI1_1	390	394	PF00082	0.299
CLV_PCSK_SKI1_1	6	10	PF00082	0.579
CLV_PCSK_SKI1_1	80	84	PF00082	0.295
CLV_PCSK_SKI1_1	94	98	PF00082	0.262
DEG_APCC_DBOX_1	433	441	PF00400	0.430
DEG_APCC_DBOX_1	5	13	PF00400	0.476
DEG_MDM2_SWIB_1	164	171	PF02201	0.593
DEG_Nend_Nbox_1	1	3	PF02207	0.623
DOC_CKS1_1	125	130	PF01111	0.593
DOC_CYCLIN_RxL_1	91	100	PF00134	0.408
DOC_MAPK_DCC_7	229	238	PF00069	0.593
DOC_MAPK_gen_1	186	195	PF00069	0.503
DOC_MAPK_gen_1	278	284	PF00069	0.492
DOC_MAPK_HePTP_8	282	294	PF00069	0.593
DOC_MAPK_MEF2A_6	229	238	PF00069	0.593
DOC_MAPK_MEF2A_6	285	294	PF00069	0.593
DOC_MAPK_MEF2A_6	362	370	PF00069	0.502
DOC_MAPK_NFAT4_5	285	293	PF00069	0.593
DOC_PP4_FxxP_1	125	128	PF00568	0.593
DOC_USP7_MATH_1	16	20	PF00917	0.474
DOC_USP7_MATH_1	494	498	PF00917	0.504
DOC_WW_Pin1_4	124	129	PF00397	0.593
LIG_14-3-3_CanoR_1	167	172	PF00244	0.516
LIG_14-3-3_CanoR_1	196	204	PF00244	0.593
LIG_AP_GAE_1	66	72	PF02883	0.452
LIG_Clathr_ClatBox_1	459	463	PF01394	0.408
LIG_CSL_BTD_1	385	388	PF09270	0.593
LIG_FHA_1	228	234	PF00498	0.608
LIG_FHA_1	287	293	PF00498	0.590
LIG_FHA_1	377	383	PF00498	0.573
LIG_FHA_1	406	412	PF00498	0.540
LIG_FHA_1	487	493	PF00498	0.420
LIG_FHA_1	81	87	PF00498	0.494
LIG_FHA_1	91	97	PF00498	0.479
LIG_FHA_2	108	114	PF00498	0.527
LIG_FHA_2	413	419	PF00498	0.559
LIG_FHA_2	430	436	PF00498	0.559
LIG_FHA_2	467	473	PF00498	0.510
LIG_Integrin_isoDGR_2	165	167	PF01839	0.359
LIG_LIR_Apic_2	154	158	PF02991	0.563
LIG_LIR_Apic_2	302	306	PF02991	0.561
LIG_LIR_Apic_2	384	388	PF02991	0.593
LIG_LIR_Gen_1	178	187	PF02991	0.495
LIG_LIR_Gen_1	356	366	PF02991	0.503
LIG_LIR_Gen_1	42	52	PF02991	0.520
LIG_LIR_LC3C_4	400	403	PF02991	0.474
LIG_LIR_Nem_3	178	182	PF02991	0.508
LIG_LIR_Nem_3	356	361	PF02991	0.503
LIG_LIR_Nem_3	42	47	PF02991	0.520
LIG_LIR_Nem_3	66	72	PF02991	0.452
LIG_MAD2	422	430	PF02301	0.499
LIG_Pex14_2	164	168	PF04695	0.561
LIG_Pex14_2	181	185	PF04695	0.561
LIG_Pex14_2	97	101	PF04695	0.571
LIG_PTB_Apo_2	86	93	PF02174	0.482
LIG_SH2_CRK	155	159	PF00017	0.549
LIG_SH2_PTP2	303	306	PF00017	0.527
LIG_SH2_SRC	303	306	PF00017	0.559
LIG_SH2_STAT5	126	129	PF00017	0.484
LIG_SH2_STAT5	237	240	PF00017	0.484
LIG_SH2_STAT5	303	306	PF00017	0.529
LIG_SH2_STAT5	85	88	PF00017	0.502
LIG_SH3_1	488	494	PF00018	0.388
LIG_SH3_3	228	234	PF00018	0.504
LIG_SH3_3	239	245	PF00018	0.455
LIG_SH3_3	488	494	PF00018	0.369
LIG_SUMO_SIM_anti_2	408	413	PF11976	0.495
LIG_SUMO_SIM_anti_2	458	463	PF11976	0.408
LIG_SUMO_SIM_anti_2	53	59	PF11976	0.471
LIG_SUMO_SIM_par_1	407	413	PF11976	0.518
LIG_TRAF2_1	469	472	PF00917	0.524
MOD_CK1_1	262	268	PF00069	0.675
MOD_CK1_1	347	353	PF00069	0.514
MOD_CK1_1	354	360	PF00069	0.463
MOD_CK2_1	12	18	PF00069	0.440
MOD_CK2_1	412	418	PF00069	0.582
MOD_CK2_1	429	435	PF00069	0.398
MOD_CK2_1	466	472	PF00069	0.490
MOD_GlcNHglycan	14	17	PF01048	0.299
MOD_GlcNHglycan	205	208	PF01048	0.343
MOD_GlcNHglycan	346	349	PF01048	0.325
MOD_GlcNHglycan	353	356	PF01048	0.276
MOD_GlcNHglycan	375	379	PF01048	0.355
MOD_GlcNHglycan	66	69	PF01048	0.365
MOD_GSK3_1	12	19	PF00069	0.317
MOD_GSK3_1	126	133	PF00069	0.498
MOD_GSK3_1	338	345	PF00069	0.566
MOD_GSK3_1	347	354	PF00069	0.554
MOD_N-GLC_1	47	52	PF02516	0.257
MOD_N-GLC_1	53	58	PF02516	0.260
MOD_NEK2_1	12	17	PF00069	0.368
MOD_NEK2_1	195	200	PF00069	0.484
MOD_NEK2_1	2	7	PF00069	0.574
MOD_NEK2_1	299	304	PF00069	0.582
MOD_NEK2_1	344	349	PF00069	0.534
MOD_NEK2_1	366	371	PF00069	0.529
MOD_NEK2_1	374	379	PF00069	0.502
MOD_PIKK_1	153	159	PF00454	0.549
MOD_PIKK_1	196	202	PF00454	0.593
MOD_PKA_2	158	164	PF00069	0.561
MOD_PKA_2	195	201	PF00069	0.502
MOD_PKA_2	2	8	PF00069	0.558
MOD_Plk_1	366	372	PF00069	0.502
MOD_Plk_1	53	59	PF00069	0.430
MOD_Plk_2-3	466	472	PF00069	0.481
MOD_Plk_4	107	113	PF00069	0.599
MOD_Plk_4	299	305	PF00069	0.568
MOD_Plk_4	347	353	PF00069	0.577
MOD_Plk_4	366	372	PF00069	0.365
MOD_Plk_4	381	387	PF00069	0.527
MOD_Plk_4	405	411	PF00069	0.452
MOD_Plk_4	53	59	PF00069	0.484
MOD_Plk_4	81	87	PF00069	0.502
MOD_ProDKin_1	124	130	PF00069	0.593
MOD_SUMO_for_1	475	478	PF00179	0.462
MOD_SUMO_rev_2	222	231	PF00179	0.593
MOD_SUMO_rev_2	252	259	PF00179	0.593
MOD_SUMO_rev_2	413	421	PF00179	0.582
MOD_SUMO_rev_2	466	475	PF00179	0.484
TRG_ER_diArg_1	2	4	PF00400	0.575
TRG_ER_diArg_1	247	249	PF00400	0.509
TRG_NES_CRM1_1	435	450	PF08389	0.503

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P584	Leptomonas seymouri	52%	100%
A0A0N1I0F3	Leptomonas seymouri	47%	100%
A0A0S4JH09	Bodo saltans	53%	100%
A0A1X0NIU4	Trypanosomatidae	48%	100%
A0A1X0P425	Trypanosomatidae	50%	100%
A0A3Q8IC07	Leishmania donovani	83%	100%
A0A3Q8IMK1	Leishmania donovani	46%	100%
A0A3R7LBN6	Trypanosoma rangeli	50%	100%
A0A3S7X3G0	Leishmania donovani	100%	100%
A4HLU7	Leishmania braziliensis	45%	98%
A4I5L8	Leishmania infantum	83%	100%
B2GV06	Rattus norvegicus	48%	96%
D0A680	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9AHQ2	Leishmania infantum	46%	100%
E9B0W3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
E9B0W4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
E9B473	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	98%
F1CYZ5	Acetobacterium woodii	26%	95%
P37766	Escherichia coli (strain K12)	26%	94%
P55809	Homo sapiens	49%	96%
Q09450	Caenorhabditis elegans	47%	96%
Q29551	Sus scrofa	48%	96%
Q4Q3V3	Leishmania major	46%	98%
Q4Q7A2	Leishmania major	95%	100%
Q4Q7A3	Leishmania major	81%	100%
Q54JD9	Dictyostelium discoideum	49%	98%
Q5XIJ9	Rattus norvegicus	47%	96%
Q8X5X6	Escherichia coli O157:H7	26%	94%
Q9BYC2	Homo sapiens	48%	97%
Q9D0K2	Mus musculus	48%	96%
Q9ESL0	Mus musculus	47%	96%
Q9JJN4	Mus musculus	47%	96%
Q9W058	Drosophila melanogaster	46%	97%
V5DQB8	Trypanosoma cruzi	49%	100%