LeishMANIAdb
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Putative splicing factor 3a

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative splicing factor 3a
Gene product:
splicing factor 3a - putative
Species:
Leishmania infantum
UniProt:
A4I5K9_LEIIN
TriTrypDb:
LINF_300023100
Length:
621

Annotations

Annotations by Jardim et al.

RNA Processing, splicing factor 3a

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005681 spliceosomal complex 3 11
GO:0032991 protein-containing complex 1 11
GO:0140513 nuclear protein-containing complex 2 11
GO:1990904 ribonucleoprotein complex 2 11

Expansion

Sequence features

A4I5K9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5K9

Function

Biological processes
Term Name Level Count
GO:0000375 RNA splicing, via transesterification reactions 8 11
GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 9 11
GO:0000398 mRNA splicing, via spliceosome 8 11
GO:0006139 nucleobase-containing compound metabolic process 3 11
GO:0006396 RNA processing 6 11
GO:0006397 mRNA processing 7 11
GO:0006725 cellular aromatic compound metabolic process 3 11
GO:0006807 nitrogen compound metabolic process 2 11
GO:0008152 metabolic process 1 11
GO:0008380 RNA splicing 7 11
GO:0009987 cellular process 1 11
GO:0016070 RNA metabolic process 5 11
GO:0016071 mRNA metabolic process 6 11
GO:0034641 cellular nitrogen compound metabolic process 3 11
GO:0043170 macromolecule metabolic process 3 11
GO:0044237 cellular metabolic process 2 11
GO:0044238 primary metabolic process 2 11
GO:0046483 heterocycle metabolic process 3 11
GO:0071704 organic substance metabolic process 2 11
GO:0090304 nucleic acid metabolic process 4 11
GO:1901360 organic cyclic compound metabolic process 3 11
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 11
GO:0003723 RNA binding 4 11
GO:0005488 binding 1 11
GO:0008270 zinc ion binding 6 10
GO:0043167 ion binding 2 11
GO:0043169 cation binding 3 11
GO:0046872 metal ion binding 4 11
GO:0046914 transition metal ion binding 5 10
GO:0097159 organic cyclic compound binding 2 11
GO:1901363 heterocyclic compound binding 2 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 431 435 PF00656 0.519
CLV_C14_Caspase3-7 593 597 PF00656 0.366
CLV_C14_Caspase3-7 599 603 PF00656 0.304
CLV_NRD_NRD_1 210 212 PF00675 0.367
CLV_NRD_NRD_1 235 237 PF00675 0.551
CLV_NRD_NRD_1 439 441 PF00675 0.531
CLV_NRD_NRD_1 470 472 PF00675 0.658
CLV_NRD_NRD_1 553 555 PF00675 0.335
CLV_NRD_NRD_1 587 589 PF00675 0.329
CLV_PCSK_KEX2_1 235 237 PF00082 0.502
CLV_PCSK_KEX2_1 470 472 PF00082 0.658
CLV_PCSK_KEX2_1 553 555 PF00082 0.335
CLV_PCSK_KEX2_1 589 591 PF00082 0.331
CLV_PCSK_KEX2_1 619 621 PF00082 0.585
CLV_PCSK_PC1ET2_1 589 591 PF00082 0.335
CLV_PCSK_PC7_1 615 621 PF00082 0.449
CLV_PCSK_SKI1_1 39 43 PF00082 0.467
CLV_PCSK_SKI1_1 408 412 PF00082 0.429
CLV_PCSK_SKI1_1 460 464 PF00082 0.628
DEG_COP1_1 113 120 PF00400 0.514
DEG_Nend_UBRbox_3 1 3 PF02207 0.674
DEG_SPOP_SBC_1 305 309 PF00917 0.796
DEG_SPOP_SBC_1 368 372 PF00917 0.674
DOC_CYCLIN_RxL_1 36 46 PF00134 0.486
DOC_CYCLIN_RxL_1 405 415 PF00134 0.435
DOC_CYCLIN_yClb1_LxF_4 187 192 PF00134 0.530
DOC_CYCLIN_yCln2_LP_2 218 224 PF00134 0.440
DOC_MAPK_DCC_7 340 349 PF00069 0.514
DOC_MAPK_MEF2A_6 197 204 PF00069 0.490
DOC_PP1_RVXF_1 187 193 PF00149 0.526
DOC_PP1_RVXF_1 210 217 PF00149 0.484
DOC_PP2B_LxvP_1 115 118 PF13499 0.538
DOC_PP2B_LxvP_1 329 332 PF13499 0.431
DOC_USP7_MATH_1 161 165 PF00917 0.583
DOC_USP7_MATH_1 277 281 PF00917 0.640
DOC_USP7_MATH_1 304 308 PF00917 0.792
DOC_USP7_MATH_1 367 371 PF00917 0.745
DOC_WW_Pin1_4 116 121 PF00397 0.538
DOC_WW_Pin1_4 172 177 PF00397 0.574
DOC_WW_Pin1_4 481 486 PF00397 0.765
DOC_WW_Pin1_4 77 82 PF00397 0.673
LIG_14-3-3_CanoR_1 145 151 PF00244 0.498
LIG_14-3-3_CanoR_1 440 447 PF00244 0.519
LIG_14-3-3_CanoR_1 54 61 PF00244 0.555
LIG_14-3-3_CanoR_1 560 565 PF00244 0.309
LIG_Actin_WH2_2 444 462 PF00022 0.630
LIG_APCC_ABBA_1 61 66 PF00400 0.450
LIG_BIR_III_4 602 606 PF00653 0.355
LIG_CtBP_PxDLS_1 332 336 PF00389 0.506
LIG_FHA_1 1 7 PF00498 0.623
LIG_FHA_1 151 157 PF00498 0.535
LIG_FHA_1 194 200 PF00498 0.454
LIG_FHA_1 381 387 PF00498 0.500
LIG_FHA_2 126 132 PF00498 0.445
LIG_FHA_2 153 159 PF00498 0.532
LIG_FHA_2 279 285 PF00498 0.670
LIG_FHA_2 399 405 PF00498 0.453
LIG_FHA_2 415 421 PF00498 0.395
LIG_FHA_2 579 585 PF00498 0.447
LIG_FHA_2 593 599 PF00498 0.232
LIG_FHA_2 607 613 PF00498 0.249
LIG_KLC1_Yacidic_2 62 66 PF13176 0.458
LIG_LIR_Apic_2 343 348 PF02991 0.529
LIG_LIR_Apic_2 531 536 PF02991 0.312
LIG_LIR_Gen_1 100 109 PF02991 0.532
LIG_LIR_Gen_1 257 268 PF02991 0.414
LIG_LIR_Gen_1 397 404 PF02991 0.418
LIG_LIR_Nem_3 100 104 PF02991 0.586
LIG_LIR_Nem_3 140 146 PF02991 0.385
LIG_LIR_Nem_3 191 195 PF02991 0.392
LIG_LIR_Nem_3 231 237 PF02991 0.502
LIG_LIR_Nem_3 257 263 PF02991 0.403
LIG_LIR_Nem_3 397 403 PF02991 0.417
LIG_LIR_Nem_3 563 567 PF02991 0.341
LIG_LIR_Nem_3 612 616 PF02991 0.480
LIG_NRBOX 394 400 PF00104 0.377
LIG_NRP_CendR_1 619 621 PF00754 0.663
LIG_Pex14_2 539 543 PF04695 0.335
LIG_RPA_C_Fungi 206 218 PF08784 0.485
LIG_SH2_CRK 234 238 PF00017 0.404
LIG_SH2_CRK 533 537 PF00017 0.447
LIG_SH2_SRC 229 232 PF00017 0.462
LIG_SH2_STAP1 146 150 PF00017 0.375
LIG_SH2_STAP1 414 418 PF00017 0.510
LIG_SH2_STAT5 229 232 PF00017 0.363
LIG_SH2_STAT5 400 403 PF00017 0.564
LIG_SH2_STAT5 613 616 PF00017 0.480
LIG_SH2_STAT5 64 67 PF00017 0.449
LIG_SH3_1 236 242 PF00018 0.549
LIG_SH3_3 114 120 PF00018 0.564
LIG_SH3_3 170 176 PF00018 0.600
LIG_SH3_3 236 242 PF00018 0.518
LIG_SH3_3 479 485 PF00018 0.768
LIG_SH3_3 487 493 PF00018 0.783
LIG_TRAF2_1 417 420 PF00917 0.515
LIG_TRAF2_1 428 431 PF00917 0.475
LIG_TRAF2_1 435 438 PF00917 0.453
LIG_TRAF2_1 462 465 PF00917 0.454
LIG_TRAF2_1 493 496 PF00917 0.707
LIG_TRFH_1 342 346 PF08558 0.377
LIG_TYR_ITIM 398 403 PF00017 0.461
LIG_WRC_WIRS_1 192 197 PF05994 0.460
LIG_WRPW_2 219 222 PF00400 0.438
MOD_CDK_SPK_2 116 121 PF00069 0.501
MOD_CK1_1 175 181 PF00069 0.536
MOD_CK1_1 361 367 PF00069 0.733
MOD_CK1_1 443 449 PF00069 0.532
MOD_CK1_1 466 472 PF00069 0.678
MOD_CK2_1 125 131 PF00069 0.407
MOD_CK2_1 152 158 PF00069 0.522
MOD_CK2_1 251 257 PF00069 0.447
MOD_CK2_1 259 265 PF00069 0.467
MOD_CK2_1 278 284 PF00069 0.401
MOD_CK2_1 398 404 PF00069 0.452
MOD_CK2_1 414 420 PF00069 0.405
MOD_CK2_1 432 438 PF00069 0.454
MOD_CK2_1 52 58 PF00069 0.481
MOD_CK2_1 578 584 PF00069 0.493
MOD_CK2_1 592 598 PF00069 0.289
MOD_CK2_1 606 612 PF00069 0.447
MOD_GlcNHglycan 146 149 PF01048 0.456
MOD_GlcNHglycan 163 166 PF01048 0.538
MOD_GlcNHglycan 360 363 PF01048 0.661
MOD_GlcNHglycan 442 445 PF01048 0.510
MOD_GlcNHglycan 477 480 PF01048 0.764
MOD_GlcNHglycan 584 587 PF01048 0.403
MOD_GSK3_1 306 313 PF00069 0.727
MOD_GSK3_1 369 376 PF00069 0.683
MOD_GSK3_1 394 401 PF00069 0.478
MOD_GSK3_1 402 409 PF00069 0.428
MOD_GSK3_1 443 450 PF00069 0.486
MOD_GSK3_1 578 585 PF00069 0.384
MOD_N-GLC_1 406 411 PF02516 0.578
MOD_NEK2_1 150 155 PF00069 0.422
MOD_NEK2_1 180 185 PF00069 0.569
MOD_NEK2_1 193 198 PF00069 0.426
MOD_NEK2_1 394 399 PF00069 0.401
MOD_NEK2_1 403 408 PF00069 0.417
MOD_NEK2_1 447 452 PF00069 0.598
MOD_NEK2_1 463 468 PF00069 0.620
MOD_NEK2_2 528 533 PF00069 0.312
MOD_NEK2_2 566 571 PF00069 0.335
MOD_PKA_1 340 346 PF00069 0.433
MOD_PKA_1 440 446 PF00069 0.546
MOD_PKA_2 144 150 PF00069 0.404
MOD_PKA_2 298 304 PF00069 0.789
MOD_PKA_2 53 59 PF00069 0.551
MOD_PKA_2 578 584 PF00069 0.344
MOD_PKB_1 590 598 PF00069 0.482
MOD_Plk_1 268 274 PF00069 0.574
MOD_Plk_1 406 412 PF00069 0.544
MOD_Plk_2-3 125 131 PF00069 0.524
MOD_Plk_2-3 251 257 PF00069 0.487
MOD_Plk_4 175 181 PF00069 0.562
MOD_Plk_4 19 25 PF00069 0.466
MOD_Plk_4 259 265 PF00069 0.542
MOD_Plk_4 394 400 PF00069 0.418
MOD_Plk_4 406 412 PF00069 0.416
MOD_Plk_4 528 534 PF00069 0.312
MOD_ProDKin_1 116 122 PF00069 0.535
MOD_ProDKin_1 172 178 PF00069 0.571
MOD_ProDKin_1 481 487 PF00069 0.764
MOD_ProDKin_1 77 83 PF00069 0.668
MOD_SUMO_for_1 111 114 PF00179 0.568
MOD_SUMO_for_1 167 170 PF00179 0.588
MOD_SUMO_rev_2 262 268 PF00179 0.472
MOD_SUMO_rev_2 377 384 PF00179 0.446
MOD_SUMO_rev_2 464 469 PF00179 0.583
MOD_SUMO_rev_2 90 96 PF00179 0.544
TRG_DiLeu_BaEn_1 497 502 PF01217 0.697
TRG_DiLeu_BaLyEn_6 118 123 PF01217 0.560
TRG_DiLeu_BaLyEn_6 345 350 PF01217 0.539
TRG_ENDOCYTIC_2 101 104 PF00928 0.516
TRG_ENDOCYTIC_2 105 108 PF00928 0.590
TRG_ENDOCYTIC_2 146 149 PF00928 0.377
TRG_ENDOCYTIC_2 219 222 PF00928 0.384
TRG_ENDOCYTIC_2 234 237 PF00928 0.381
TRG_ENDOCYTIC_2 400 403 PF00928 0.564
TRG_ENDOCYTIC_2 564 567 PF00928 0.335
TRG_ENDOCYTIC_2 613 616 PF00928 0.355
TRG_ER_diArg_1 234 236 PF00400 0.532
TRG_ER_diArg_1 37 40 PF00400 0.492
TRG_ER_diArg_1 470 473 PF00400 0.668
TRG_ER_diArg_1 552 554 PF00400 0.335
TRG_ER_diArg_1 587 590 PF00400 0.335
TRG_ER_diArg_1 619 621 PF00400 0.660
TRG_NES_CRM1_1 565 578 PF08389 0.417
TRG_NLS_MonoExtC_3 587 592 PF00514 0.355
TRG_Pf-PMV_PEXEL_1 10 15 PF00026 0.532
TRG_Pf-PMV_PEXEL_1 121 125 PF00026 0.546
TRG_Pf-PMV_PEXEL_1 154 158 PF00026 0.584
TRG_Pf-PMV_PEXEL_1 39 43 PF00026 0.476
TRG_Pf-PMV_PEXEL_1 416 420 PF00026 0.593
TRG_Pf-PMV_PEXEL_1 511 515 PF00026 0.408
TRG_PTS2 1 45 PF00400 0.439

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5M4 Leptomonas seymouri 62% 97%
A0A1X0P1R3 Trypanosomatidae 42% 100%
A0A3S7X3F0 Leishmania donovani 100% 100%
A0A422P3I2 Trypanosoma rangeli 44% 100%
A4H930 Leishmania braziliensis 84% 100%
C9ZQY7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 100%
E9B0V4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
Q4Q7B2 Leishmania major 95% 100%
V5DQL3 Trypanosoma cruzi 43% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS