Helicase ATP-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I5K1_LEIIN

TriTrypDb:

LINF_300022300

Length:

313

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I5K1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5K1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	217	221	PF00656	0.424
CLV_NRD_NRD_1	120	122	PF00675	0.527
CLV_NRD_NRD_1	17	19	PF00675	0.662
CLV_NRD_NRD_1	9	11	PF00675	0.713
CLV_PCSK_KEX2_1	120	122	PF00082	0.596
CLV_PCSK_KEX2_1	16	18	PF00082	0.702
CLV_PCSK_KEX2_1	264	266	PF00082	0.441
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.612
CLV_PCSK_PC1ET2_1	264	266	PF00082	0.404
CLV_PCSK_SKI1_1	264	268	PF00082	0.419
CLV_PCSK_SKI1_1	5	9	PF00082	0.558
CLV_PCSK_SKI1_1	79	83	PF00082	0.471
DEG_Nend_UBRbox_3	1	3	PF02207	0.549
DOC_CKS1_1	111	116	PF01111	0.620
DOC_MAPK_gen_1	33	42	PF00069	0.535
DOC_MAPK_MEF2A_6	203	210	PF00069	0.317
DOC_MAPK_MEF2A_6	36	44	PF00069	0.528
DOC_USP7_MATH_1	9	13	PF00917	0.723
DOC_USP7_UBL2_3	29	33	PF12436	0.647
DOC_WW_Pin1_4	110	115	PF00397	0.627
DOC_WW_Pin1_4	184	189	PF00397	0.506
DOC_WW_Pin1_4	5	10	PF00397	0.654
LIG_14-3-3_CanoR_1	10	14	PF00244	0.631
LIG_14-3-3_CanoR_1	121	127	PF00244	0.432
LIG_14-3-3_CanoR_1	265	270	PF00244	0.434
LIG_AP2alpha_2	59	61	PF02296	0.439
LIG_APCC_ABBA_1	178	183	PF00400	0.418
LIG_BRCT_BRCA1_1	229	233	PF00533	0.446
LIG_BRCT_BRCA1_1	96	100	PF00533	0.550
LIG_FHA_1	22	28	PF00498	0.662
LIG_FHA_1	245	251	PF00498	0.555
LIG_FHA_1	291	297	PF00498	0.308
LIG_FHA_1	35	41	PF00498	0.515
LIG_FHA_1	46	52	PF00498	0.538
LIG_FHA_2	101	107	PF00498	0.531
LIG_FHA_2	215	221	PF00498	0.377
LIG_FHA_2	256	262	PF00498	0.515
LIG_FHA_2	283	289	PF00498	0.392
LIG_FHA_2	72	78	PF00498	0.446
LIG_LIR_Gen_1	209	219	PF02991	0.364
LIG_LIR_Gen_1	275	284	PF02991	0.372
LIG_LIR_Gen_1	297	306	PF02991	0.398
LIG_LIR_Nem_3	148	153	PF02991	0.386
LIG_LIR_Nem_3	209	214	PF02991	0.347
LIG_LIR_Nem_3	220	225	PF02991	0.370
LIG_LIR_Nem_3	275	281	PF02991	0.384
LIG_LIR_Nem_3	297	302	PF02991	0.396
LIG_LIR_Nem_3	304	309	PF02991	0.463
LIG_LIR_Nem_3	62	67	PF02991	0.536
LIG_PCNA_TLS_4	216	223	PF02747	0.410
LIG_Pex14_2	277	281	PF04695	0.360
LIG_PTB_Apo_2	300	307	PF02174	0.387
LIG_PTB_Phospho_1	300	306	PF10480	0.383
LIG_SH2_PTP2	222	225	PF00017	0.357
LIG_SH2_STAP1	67	71	PF00017	0.442
LIG_SH2_STAT5	179	182	PF00017	0.403
LIG_SH2_STAT5	222	225	PF00017	0.357
LIG_SH2_STAT5	278	281	PF00017	0.353
LIG_SH2_STAT5	298	301	PF00017	0.219
LIG_SH2_STAT5	309	312	PF00017	0.397
LIG_SH3_2	151	156	PF14604	0.431
LIG_SH3_3	148	154	PF00018	0.421
LIG_SH3_3	182	188	PF00018	0.504
LIG_SH3_3	48	54	PF00018	0.623
LIG_SUMO_SIM_par_1	226	232	PF11976	0.355
LIG_TRAF2_1	258	261	PF00917	0.455
LIG_TRAF2_1	284	287	PF00917	0.390
LIG_TRFH_1	233	237	PF08558	0.458
LIG_TYR_ITIM	296	301	PF00017	0.329
LIG_WRC_WIRS_1	278	283	PF05994	0.346
MOD_CDK_SPK_2	5	10	PF00069	0.621
MOD_CDK_SPxK_1	5	11	PF00069	0.632
MOD_CK1_1	112	118	PF00069	0.585
MOD_CK1_1	12	18	PF00069	0.678
MOD_CK1_1	125	131	PF00069	0.420
MOD_CK1_1	84	90	PF00069	0.505
MOD_CK2_1	255	261	PF00069	0.482
MOD_CK2_1	269	275	PF00069	0.315
MOD_CK2_1	71	77	PF00069	0.461
MOD_GlcNHglycan	271	274	PF01048	0.436
MOD_GSK3_1	112	119	PF00069	0.608
MOD_GSK3_1	122	129	PF00069	0.502
MOD_GSK3_1	145	152	PF00069	0.411
MOD_GSK3_1	223	230	PF00069	0.374
MOD_GSK3_1	246	253	PF00069	0.455
MOD_GSK3_1	255	262	PF00069	0.530
MOD_GSK3_1	265	272	PF00069	0.276
MOD_GSK3_1	45	52	PF00069	0.605
MOD_GSK3_1	5	12	PF00069	0.743
MOD_N-GLC_1	116	121	PF02516	0.535
MOD_N-GLC_1	122	127	PF02516	0.394
MOD_N-GLC_1	244	249	PF02516	0.426
MOD_N-GLC_2	303	305	PF02516	0.325
MOD_NEK2_1	122	127	PF00069	0.561
MOD_NEK2_1	190	195	PF00069	0.448
MOD_NEK2_1	227	232	PF00069	0.369
MOD_NEK2_1	244	249	PF00069	0.521
MOD_NEK2_1	269	274	PF00069	0.424
MOD_NEK2_1	277	282	PF00069	0.328
MOD_NEK2_1	301	306	PF00069	0.384
MOD_NEK2_1	40	45	PF00069	0.605
MOD_NEK2_1	81	86	PF00069	0.598
MOD_PIKK_1	282	288	PF00454	0.392
MOD_PIKK_1	45	51	PF00454	0.590
MOD_PKA_2	9	15	PF00069	0.648
MOD_Plk_1	122	128	PF00069	0.412
MOD_Plk_1	204	210	PF00069	0.363
MOD_Plk_1	214	220	PF00069	0.426
MOD_Plk_1	45	51	PF00069	0.590
MOD_Plk_4	122	128	PF00069	0.536
MOD_Plk_4	145	151	PF00069	0.398
MOD_Plk_4	206	212	PF00069	0.418
MOD_Plk_4	223	229	PF00069	0.362
MOD_Plk_4	277	283	PF00069	0.352
MOD_Plk_4	89	95	PF00069	0.376
MOD_ProDKin_1	110	116	PF00069	0.623
MOD_ProDKin_1	184	190	PF00069	0.498
MOD_ProDKin_1	5	11	PF00069	0.656
MOD_SUMO_rev_2	106	112	PF00179	0.632
TRG_DiLeu_BaLyEn_6	185	190	PF01217	0.528
TRG_DiLeu_BaLyEn_6	193	198	PF01217	0.412
TRG_ENDOCYTIC_2	222	225	PF00928	0.357
TRG_ENDOCYTIC_2	278	281	PF00928	0.353
TRG_ENDOCYTIC_2	298	301	PF00928	0.262
TRG_ENDOCYTIC_2	67	70	PF00928	0.397
TRG_ER_diArg_1	120	122	PF00400	0.686
TRG_ER_diArg_1	36	39	PF00400	0.534

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HT80	Leptomonas seymouri	58%	100%
A0A3Q8IFU1	Leishmania donovani	99%	100%
A4HIB7	Leishmania braziliensis	67%	100%
E9B0U6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q7C0	Leishmania major	88%	100%