LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
AAA domain (Cdc48 subfamily)/AAA domain (dynein-related subfamily) - putative
Species:
Leishmania infantum
UniProt:
A4I5J7_LEIIN
TriTrypDb:
LINF_300021900
Length:
860

Annotations

LeishMANIAdb annotations

These proteins are apparently divergent members of the greater ClpB family found in both Eukaryota and Prokaryota. The TM segments are unusual additions.. Anchored into the membrane using the very last 3 helical segment (similar to tail-anchored proteins)

Annotations by Jardim et al.

Plasma membrane, AAA ATPase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9

Expansion

Sequence features

A4I5J7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5J7

Function

Biological processes
Term Name Level Count
GO:0006950 response to stress 2 1
GO:0009266 response to temperature stimulus 3 1
GO:0009408 response to heat 3 1
GO:0009628 response to abiotic stimulus 2 1
GO:0009987 cellular process 1 1
GO:0033554 cellular response to stress 3 1
GO:0034605 cellular response to heat 4 1
GO:0050896 response to stimulus 1 1
GO:0051716 cellular response to stimulus 2 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 11
GO:0003824 catalytic activity 1 11
GO:0005488 binding 1 11
GO:0005524 ATP binding 5 11
GO:0016462 pyrophosphatase activity 5 11
GO:0016787 hydrolase activity 2 11
GO:0016817 hydrolase activity, acting on acid anhydrides 3 11
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 11
GO:0016887 ATP hydrolysis activity 7 11
GO:0017076 purine nucleotide binding 4 11
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 11
GO:0030554 adenyl nucleotide binding 5 11
GO:0032553 ribonucleotide binding 3 11
GO:0032555 purine ribonucleotide binding 4 11
GO:0032559 adenyl ribonucleotide binding 5 11
GO:0035639 purine ribonucleoside triphosphate binding 4 11
GO:0036094 small molecule binding 2 11
GO:0043167 ion binding 2 11
GO:0043168 anion binding 3 11
GO:0097159 organic cyclic compound binding 2 11
GO:0097367 carbohydrate derivative binding 2 11
GO:1901265 nucleoside phosphate binding 3 11
GO:1901363 heterocyclic compound binding 2 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 517 519 PF00675 0.355
CLV_NRD_NRD_1 586 588 PF00675 0.398
CLV_NRD_NRD_1 694 696 PF00675 0.617
CLV_NRD_NRD_1 71 73 PF00675 0.723
CLV_PCSK_FUR_1 86 90 PF00082 0.770
CLV_PCSK_KEX2_1 274 276 PF00082 0.432
CLV_PCSK_KEX2_1 344 346 PF00082 0.296
CLV_PCSK_KEX2_1 517 519 PF00082 0.346
CLV_PCSK_KEX2_1 586 588 PF00082 0.398
CLV_PCSK_KEX2_1 694 696 PF00082 0.620
CLV_PCSK_KEX2_1 71 73 PF00082 0.725
CLV_PCSK_KEX2_1 88 90 PF00082 0.773
CLV_PCSK_PC1ET2_1 274 276 PF00082 0.457
CLV_PCSK_PC1ET2_1 344 346 PF00082 0.362
CLV_PCSK_PC1ET2_1 88 90 PF00082 0.762
CLV_PCSK_SKI1_1 163 167 PF00082 0.496
CLV_PCSK_SKI1_1 286 290 PF00082 0.481
CLV_PCSK_SKI1_1 434 438 PF00082 0.282
CLV_PCSK_SKI1_1 480 484 PF00082 0.353
CLV_PCSK_SKI1_1 527 531 PF00082 0.361
CLV_PCSK_SKI1_1 641 645 PF00082 0.468
CLV_PCSK_SKI1_1 753 757 PF00082 0.413
CLV_PCSK_SKI1_1 769 773 PF00082 0.297
CLV_PCSK_SKI1_1 77 81 PF00082 0.747
CLV_PCSK_SKI1_1 827 831 PF00082 0.386
DEG_APCC_DBOX_1 162 170 PF00400 0.362
DEG_APCC_DBOX_1 264 272 PF00400 0.677
DEG_SCF_FBW7_1 708 715 PF00400 0.670
DEG_SPOP_SBC_1 222 226 PF00917 0.784
DEG_SPOP_SBC_1 615 619 PF00917 0.725
DEG_SPOP_SBC_1 703 707 PF00917 0.741
DOC_CKS1_1 540 545 PF01111 0.532
DOC_CKS1_1 709 714 PF01111 0.742
DOC_CYCLIN_RxL_1 738 748 PF00134 0.600
DOC_CYCLIN_RxL_1 750 760 PF00134 0.565
DOC_CYCLIN_RxL_1 769 783 PF00134 0.477
DOC_CYCLIN_yCln2_LP_2 815 821 PF00134 0.447
DOC_CYCLIN_yCln2_LP_2 832 838 PF00134 0.447
DOC_MAPK_gen_1 161 168 PF00069 0.315
DOC_MAPK_gen_1 514 523 PF00069 0.542
DOC_MAPK_HePTP_8 772 784 PF00069 0.562
DOC_MAPK_JIP1_4 325 331 PF00069 0.562
DOC_MAPK_MEF2A_6 161 170 PF00069 0.335
DOC_MAPK_MEF2A_6 325 332 PF00069 0.482
DOC_MAPK_MEF2A_6 517 525 PF00069 0.528
DOC_MAPK_MEF2A_6 775 784 PF00069 0.493
DOC_MAPK_MEF2A_6 837 845 PF00069 0.447
DOC_PP2B_LxvP_1 681 684 PF13499 0.751
DOC_PP2B_LxvP_1 815 818 PF13499 0.447
DOC_PP4_FxxP_1 331 334 PF00568 0.534
DOC_USP7_MATH_1 188 192 PF00917 0.608
DOC_USP7_MATH_1 222 226 PF00917 0.796
DOC_USP7_MATH_1 254 258 PF00917 0.690
DOC_USP7_MATH_1 288 292 PF00917 0.637
DOC_USP7_MATH_1 296 300 PF00917 0.581
DOC_USP7_MATH_1 310 314 PF00917 0.585
DOC_USP7_MATH_1 439 443 PF00917 0.482
DOC_USP7_MATH_1 48 52 PF00917 0.449
DOC_USP7_MATH_1 599 603 PF00917 0.678
DOC_USP7_MATH_1 610 614 PF00917 0.746
DOC_USP7_MATH_1 647 651 PF00917 0.591
DOC_USP7_MATH_1 702 706 PF00917 0.778
DOC_USP7_MATH_1 712 716 PF00917 0.691
DOC_USP7_MATH_1 720 724 PF00917 0.722
DOC_USP7_MATH_1 850 854 PF00917 0.460
DOC_WW_Pin1_4 223 228 PF00397 0.705
DOC_WW_Pin1_4 286 291 PF00397 0.680
DOC_WW_Pin1_4 469 474 PF00397 0.586
DOC_WW_Pin1_4 539 544 PF00397 0.534
DOC_WW_Pin1_4 606 611 PF00397 0.762
DOC_WW_Pin1_4 64 69 PF00397 0.583
DOC_WW_Pin1_4 679 684 PF00397 0.777
DOC_WW_Pin1_4 708 713 PF00397 0.737
DOC_WW_Pin1_4 89 94 PF00397 0.566
LIG_14-3-3_CanoR_1 221 227 PF00244 0.707
LIG_14-3-3_CanoR_1 265 269 PF00244 0.652
LIG_14-3-3_CanoR_1 275 279 PF00244 0.695
LIG_14-3-3_CanoR_1 345 350 PF00244 0.562
LIG_14-3-3_CanoR_1 441 447 PF00244 0.482
LIG_14-3-3_CanoR_1 552 557 PF00244 0.607
LIG_14-3-3_CanoR_1 9 17 PF00244 0.459
LIG_Actin_WH2_2 784 800 PF00022 0.447
LIG_AP2alpha_2 497 499 PF02296 0.465
LIG_APCC_ABBA_1 147 152 PF00400 0.492
LIG_BIR_III_2 287 291 PF00653 0.551
LIG_EH1_1 788 796 PF00400 0.402
LIG_eIF4E_1 836 842 PF01652 0.480
LIG_FHA_1 116 122 PF00498 0.418
LIG_FHA_1 144 150 PF00498 0.453
LIG_FHA_1 214 220 PF00498 0.803
LIG_FHA_1 235 241 PF00498 0.620
LIG_FHA_1 325 331 PF00498 0.505
LIG_FHA_1 447 453 PF00498 0.490
LIG_FHA_1 558 564 PF00498 0.661
LIG_FHA_1 565 571 PF00498 0.614
LIG_FHA_1 576 582 PF00498 0.507
LIG_FHA_1 590 596 PF00498 0.616
LIG_FHA_1 704 710 PF00498 0.763
LIG_FHA_1 735 741 PF00498 0.634
LIG_FHA_2 108 114 PF00498 0.463
LIG_FHA_2 287 293 PF00498 0.648
LIG_FHA_2 492 498 PF00498 0.495
LIG_FHA_2 511 517 PF00498 0.440
LIG_FHA_2 598 604 PF00498 0.681
LIG_FHA_2 672 678 PF00498 0.793
LIG_FHA_2 749 755 PF00498 0.634
LIG_FHA_2 763 769 PF00498 0.537
LIG_FHA_2 97 103 PF00498 0.602
LIG_GBD_Chelix_1 777 785 PF00786 0.338
LIG_GBD_Chelix_1 807 815 PF00786 0.393
LIG_LIR_Apic_2 538 543 PF02991 0.600
LIG_LIR_Gen_1 109 117 PF02991 0.484
LIG_LIR_Gen_1 376 387 PF02991 0.482
LIG_LIR_Gen_1 542 553 PF02991 0.569
LIG_LIR_Gen_1 646 655 PF02991 0.578
LIG_LIR_Gen_1 730 740 PF02991 0.677
LIG_LIR_Nem_3 146 150 PF02991 0.471
LIG_LIR_Nem_3 376 382 PF02991 0.482
LIG_LIR_Nem_3 504 509 PF02991 0.518
LIG_LIR_Nem_3 542 548 PF02991 0.564
LIG_LIR_Nem_3 646 651 PF02991 0.589
LIG_LIR_Nem_3 730 736 PF02991 0.684
LIG_MYND_3 355 359 PF01753 0.546
LIG_NRBOX 524 530 PF00104 0.597
LIG_NRBOX 780 786 PF00104 0.408
LIG_NRBOX 828 834 PF00104 0.402
LIG_NRBOX 840 846 PF00104 0.250
LIG_PAM2_1 225 237 PF00658 0.579
LIG_PCNA_PIPBox_1 476 485 PF02747 0.562
LIG_PCNA_yPIPBox_3 161 169 PF02747 0.369
LIG_PCNA_yPIPBox_3 476 488 PF02747 0.574
LIG_Pex14_1 423 427 PF04695 0.482
LIG_SH2_CRK 540 544 PF00017 0.624
LIG_SH2_GRB2like 468 471 PF00017 0.516
LIG_SH2_NCK_1 379 383 PF00017 0.482
LIG_SH2_NCK_1 512 516 PF00017 0.583
LIG_SH2_NCK_1 540 544 PF00017 0.624
LIG_SH2_SRC 468 471 PF00017 0.516
LIG_SH2_STAP1 150 154 PF00017 0.463
LIG_SH2_STAP1 177 181 PF00017 0.515
LIG_SH2_STAT3 301 304 PF00017 0.517
LIG_SH2_STAT5 301 304 PF00017 0.517
LIG_SH2_STAT5 366 369 PF00017 0.513
LIG_SH2_STAT5 468 471 PF00017 0.482
LIG_SH2_STAT5 512 515 PF00017 0.556
LIG_SH3_3 179 185 PF00018 0.623
LIG_SH3_3 214 220 PF00018 0.813
LIG_SH3_3 379 385 PF00018 0.482
LIG_SH3_3 505 511 PF00018 0.508
LIG_SH3_3 592 598 PF00018 0.555
LIG_SH3_3 649 655 PF00018 0.670
LIG_SH3_3 719 725 PF00018 0.744
LIG_SUMO_SIM_anti_2 241 246 PF11976 0.620
LIG_SUMO_SIM_anti_2 403 410 PF11976 0.484
LIG_SUMO_SIM_anti_2 592 597 PF11976 0.604
LIG_SUMO_SIM_anti_2 768 774 PF11976 0.615
LIG_SUMO_SIM_par_1 403 410 PF11976 0.484
LIG_SUMO_SIM_par_1 578 585 PF11976 0.542
LIG_SUMO_SIM_par_1 778 783 PF11976 0.398
LIG_SUMO_SIM_par_1 840 846 PF11976 0.393
LIG_TRAF2_1 474 477 PF00917 0.528
LIG_TRFH_1 507 511 PF08558 0.457
LIG_UBA3_1 394 400 PF00899 0.480
LIG_UBA3_1 482 488 PF00899 0.460
LIG_UBA3_1 742 747 PF00899 0.636
LIG_UBA3_1 790 798 PF00899 0.283
LIG_UBA3_1 829 837 PF00899 0.424
LIG_WRC_WIRS_1 108 113 PF05994 0.503
LIG_WRC_WIRS_1 144 149 PF05994 0.448
LIG_WRC_WIRS_1 369 374 PF05994 0.482
LIG_WRC_WIRS_1 553 558 PF05994 0.556
MOD_CDC14_SPxK_1 682 685 PF00782 0.728
MOD_CDK_SPxK_1 679 685 PF00069 0.726
MOD_CDK_SPxxK_3 286 293 PF00069 0.673
MOD_CDK_SPxxK_3 64 71 PF00069 0.574
MOD_CK1_1 107 113 PF00069 0.372
MOD_CK1_1 225 231 PF00069 0.735
MOD_CK1_1 282 288 PF00069 0.607
MOD_CK1_1 371 377 PF00069 0.482
MOD_CK1_1 442 448 PF00069 0.482
MOD_CK1_1 64 70 PF00069 0.447
MOD_CK1_1 698 704 PF00069 0.738
MOD_CK1_1 91 97 PF00069 0.560
MOD_CK2_1 254 260 PF00069 0.649
MOD_CK2_1 286 292 PF00069 0.608
MOD_CK2_1 411 417 PF00069 0.562
MOD_CK2_1 432 438 PF00069 0.513
MOD_CK2_1 510 516 PF00069 0.509
MOD_CK2_1 528 534 PF00069 0.531
MOD_CK2_1 597 603 PF00069 0.664
MOD_CK2_1 671 677 PF00069 0.787
MOD_CK2_1 748 754 PF00069 0.606
MOD_GlcNHglycan 12 15 PF01048 0.645
MOD_GlcNHglycan 139 142 PF01048 0.732
MOD_GlcNHglycan 211 214 PF01048 0.546
MOD_GlcNHglycan 281 285 PF01048 0.503
MOD_GlcNHglycan 316 319 PF01048 0.436
MOD_GlcNHglycan 334 337 PF01048 0.225
MOD_GlcNHglycan 359 363 PF01048 0.296
MOD_GlcNHglycan 390 393 PF01048 0.308
MOD_GlcNHglycan 395 398 PF01048 0.282
MOD_GlcNHglycan 424 427 PF01048 0.289
MOD_GlcNHglycan 45 48 PF01048 0.812
MOD_GlcNHglycan 50 53 PF01048 0.809
MOD_GlcNHglycan 578 581 PF01048 0.383
MOD_GlcNHglycan 700 703 PF01048 0.595
MOD_GlcNHglycan 722 725 PF01048 0.498
MOD_GlcNHglycan 845 848 PF01048 0.407
MOD_GlcNHglycan 854 857 PF01048 0.703
MOD_GlcNHglycan 93 96 PF01048 0.811
MOD_GSK3_1 126 133 PF00069 0.527
MOD_GSK3_1 209 216 PF00069 0.778
MOD_GSK3_1 221 228 PF00069 0.767
MOD_GSK3_1 282 289 PF00069 0.597
MOD_GSK3_1 310 317 PF00069 0.550
MOD_GSK3_1 38 45 PF00069 0.564
MOD_GSK3_1 437 444 PF00069 0.482
MOD_GSK3_1 446 453 PF00069 0.483
MOD_GSK3_1 535 542 PF00069 0.626
MOD_GSK3_1 576 583 PF00069 0.618
MOD_GSK3_1 605 612 PF00069 0.767
MOD_GSK3_1 616 623 PF00069 0.779
MOD_GSK3_1 625 632 PF00069 0.614
MOD_GSK3_1 684 691 PF00069 0.745
MOD_GSK3_1 694 701 PF00069 0.747
MOD_GSK3_1 704 711 PF00069 0.727
MOD_GSK3_1 84 91 PF00069 0.564
MOD_LATS_1 272 278 PF00433 0.541
MOD_N-GLC_1 209 214 PF02516 0.545
MOD_N-GLC_1 469 474 PF02516 0.385
MOD_N-GLC_2 489 491 PF02516 0.302
MOD_NEK2_1 264 269 PF00069 0.632
MOD_NEK2_1 358 363 PF00069 0.534
MOD_NEK2_1 411 416 PF00069 0.517
MOD_NEK2_1 422 427 PF00069 0.441
MOD_NEK2_1 450 455 PF00069 0.482
MOD_NEK2_1 528 533 PF00069 0.582
MOD_NEK2_1 605 610 PF00069 0.643
MOD_NEK2_1 789 794 PF00069 0.360
MOD_NEK2_1 797 802 PF00069 0.337
MOD_NEK2_1 843 848 PF00069 0.320
MOD_PIKK_1 115 121 PF00454 0.483
MOD_PIKK_1 296 302 PF00454 0.606
MOD_PIKK_1 528 534 PF00454 0.611
MOD_PIKK_1 564 570 PF00454 0.627
MOD_PK_1 345 351 PF00069 0.562
MOD_PKA_1 274 280 PF00069 0.581
MOD_PKA_1 694 700 PF00069 0.795
MOD_PKA_1 88 94 PF00069 0.590
MOD_PKA_2 220 226 PF00069 0.736
MOD_PKA_2 254 260 PF00069 0.674
MOD_PKA_2 264 270 PF00069 0.649
MOD_PKA_2 274 280 PF00069 0.616
MOD_PKA_2 446 452 PF00069 0.531
MOD_PKA_2 48 54 PF00069 0.545
MOD_PKA_2 625 631 PF00069 0.772
MOD_PKA_2 669 675 PF00069 0.704
MOD_PKA_2 694 700 PF00069 0.750
MOD_PKA_2 850 856 PF00069 0.478
MOD_PKA_2 88 94 PF00069 0.590
MOD_Plk_1 104 110 PF00069 0.544
MOD_Plk_1 677 683 PF00069 0.771
MOD_Plk_1 695 701 PF00069 0.750
MOD_Plk_2-3 104 110 PF00069 0.544
MOD_Plk_2-3 748 754 PF00069 0.554
MOD_Plk_2-3 762 768 PF00069 0.575
MOD_Plk_4 324 330 PF00069 0.526
MOD_Plk_4 345 351 PF00069 0.562
MOD_Plk_4 374 380 PF00069 0.482
MOD_Plk_4 446 452 PF00069 0.490
MOD_Plk_4 704 710 PF00069 0.795
MOD_Plk_4 780 786 PF00069 0.372
MOD_Plk_4 789 795 PF00069 0.295
MOD_Plk_4 797 803 PF00069 0.198
MOD_Plk_4 817 823 PF00069 0.150
MOD_ProDKin_1 223 229 PF00069 0.703
MOD_ProDKin_1 286 292 PF00069 0.678
MOD_ProDKin_1 469 475 PF00069 0.586
MOD_ProDKin_1 539 545 PF00069 0.532
MOD_ProDKin_1 606 612 PF00069 0.762
MOD_ProDKin_1 64 70 PF00069 0.575
MOD_ProDKin_1 679 685 PF00069 0.780
MOD_ProDKin_1 708 714 PF00069 0.737
MOD_ProDKin_1 89 95 PF00069 0.569
MOD_SUMO_rev_2 148 154 PF00179 0.475
TRG_DiLeu_BaEn_2 515 521 PF01217 0.574
TRG_DiLeu_BaEn_4 103 109 PF01217 0.555
TRG_DiLeu_BaLyEn_6 524 529 PF01217 0.598
TRG_ENDOCYTIC_2 366 369 PF00928 0.501
TRG_ENDOCYTIC_2 379 382 PF00928 0.448
TRG_ENDOCYTIC_2 733 736 PF00928 0.674
TRG_ER_diArg_1 586 588 PF00400 0.598
TRG_ER_diArg_1 71 74 PF00400 0.528
TRG_Pf-PMV_PEXEL_1 434 438 PF00026 0.282
TRG_Pf-PMV_PEXEL_1 480 484 PF00026 0.386
TRG_Pf-PMV_PEXEL_1 527 532 PF00026 0.325
TRG_Pf-PMV_PEXEL_1 641 646 PF00026 0.492
TRG_Pf-PMV_PEXEL_1 741 746 PF00026 0.433
TRG_Pf-PMV_PEXEL_1 753 758 PF00026 0.390
TRG_Pf-PMV_PEXEL_1 759 764 PF00026 0.327

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IHZ4 Leptomonas seymouri 56% 87%
A0A1X0P2X6 Trypanosomatidae 38% 98%
A0A3Q8IEX3 Leishmania donovani 99% 100%
A0A422P3I3 Trypanosoma rangeli 39% 100%
A4HIB3 Leishmania braziliensis 81% 100%
C9ZQX4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 39% 100%
E9B0U2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
Q4Q7C4 Leishmania major 92% 100%
V5BPI4 Trypanosoma cruzi 42% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS