LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
CRAL/TRIO - N-terminal domain/CRAL/TRIO domain containing protein - putative
Species:
Leishmania infantum
UniProt:
A4I5J5_LEIIN
TriTrypDb:
LINF_300021700
Length:
296

Annotations

Annotations by Jardim et al.

Intracellular protein trafficking, SEC14 proteins putative

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 2
Forrest at al. (procyclic) yes yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I5J5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5J5

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 1
GO:0005319 lipid transporter activity 2 1
GO:0005548 phospholipid transporter activity 3 1
GO:0008526 phosphatidylinositol transfer activity 5 1
GO:0120013 lipid transfer activity 3 1
GO:0120014 phospholipid transfer activity 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 260 264 PF00656 0.527
CLV_NRD_NRD_1 126 128 PF00675 0.318
CLV_NRD_NRD_1 153 155 PF00675 0.301
CLV_PCSK_KEX2_1 285 287 PF00082 0.709
CLV_PCSK_PC1ET2_1 285 287 PF00082 0.583
CLV_PCSK_SKI1_1 171 175 PF00082 0.485
CLV_PCSK_SKI1_1 182 186 PF00082 0.380
DOC_CDC14_PxL_1 235 243 PF14671 0.559
DOC_CKS1_1 175 180 PF01111 0.336
DOC_CYCLIN_RxL_1 168 177 PF00134 0.350
DOC_MAPK_gen_1 114 121 PF00069 0.315
DOC_MAPK_gen_1 151 160 PF00069 0.301
DOC_PP1_RVXF_1 130 136 PF00149 0.350
DOC_USP7_UBL2_3 151 155 PF12436 0.334
DOC_USP7_UBL2_3 5 9 PF12436 0.419
DOC_USP7_UBL2_3 78 82 PF12436 0.292
DOC_WW_Pin1_4 174 179 PF00397 0.301
LIG_14-3-3_CanoR_1 132 136 PF00244 0.357
LIG_BIR_II_1 1 5 PF00653 0.580
LIG_BIR_III_3 1 5 PF00653 0.481
LIG_FHA_1 1 7 PF00498 0.528
LIG_FHA_1 113 119 PF00498 0.423
LIG_FHA_1 132 138 PF00498 0.191
LIG_FHA_1 155 161 PF00498 0.315
LIG_FHA_2 108 114 PF00498 0.409
LIG_FHA_2 204 210 PF00498 0.368
LIG_FHA_2 270 276 PF00498 0.588
LIG_FHA_2 5 11 PF00498 0.398
LIG_FHA_2 71 77 PF00498 0.542
LIG_LIR_Gen_1 177 188 PF02991 0.350
LIG_LIR_Gen_1 36 45 PF02991 0.361
LIG_LIR_Nem_3 36 42 PF02991 0.361
LIG_PCNA_PIPBox_1 158 167 PF02747 0.292
LIG_PDZ_Class_3 291 296 PF00595 0.569
LIG_Pex14_1 135 139 PF04695 0.292
LIG_SH2_NCK_1 130 134 PF00017 0.350
LIG_SH2_STAP1 70 74 PF00017 0.512
LIG_SH2_STAT5 120 123 PF00017 0.331
LIG_SH2_STAT5 180 183 PF00017 0.343
LIG_SH2_STAT5 39 42 PF00017 0.338
LIG_SH2_STAT5 87 90 PF00017 0.476
LIG_TRAF2_1 110 113 PF00917 0.409
LIG_TRAF2_1 206 209 PF00917 0.368
LIG_TRAF2_1 273 276 PF00917 0.593
LIG_TRAF2_1 73 76 PF00917 0.553
MOD_CK1_1 230 236 PF00069 0.534
MOD_CK1_1 240 246 PF00069 0.644
MOD_CK1_1 269 275 PF00069 0.637
MOD_CK1_1 35 41 PF00069 0.433
MOD_CK2_1 107 113 PF00069 0.409
MOD_CK2_1 203 209 PF00069 0.373
MOD_CK2_1 230 236 PF00069 0.460
MOD_CK2_1 269 275 PF00069 0.585
MOD_CK2_1 4 10 PF00069 0.408
MOD_CK2_1 70 76 PF00069 0.607
MOD_GlcNHglycan 229 232 PF01048 0.580
MOD_GlcNHglycan 259 262 PF01048 0.644
MOD_GSK3_1 223 230 PF00069 0.477
MOD_GSK3_1 265 272 PF00069 0.574
MOD_N-GLC_1 269 274 PF02516 0.592
MOD_N-GLC_2 107 109 PF02516 0.350
MOD_NEK2_1 122 127 PF00069 0.350
MOD_NEK2_1 227 232 PF00069 0.473
MOD_NEK2_1 266 271 PF00069 0.573
MOD_NEK2_1 34 39 PF00069 0.559
MOD_NEK2_1 57 62 PF00069 0.511
MOD_NEK2_1 81 86 PF00069 0.499
MOD_NEK2_2 223 228 PF00069 0.465
MOD_PIKK_1 122 128 PF00454 0.417
MOD_PKA_1 154 160 PF00069 0.318
MOD_PKA_2 131 137 PF00069 0.401
MOD_PKA_2 51 57 PF00069 0.437
MOD_Plk_1 107 113 PF00069 0.391
MOD_Plk_1 35 41 PF00069 0.419
MOD_Plk_4 35 41 PF00069 0.462
MOD_Plk_4 82 88 PF00069 0.473
MOD_ProDKin_1 174 180 PF00069 0.301
MOD_SUMO_for_1 17 20 PF00179 0.490
MOD_SUMO_rev_2 75 80 PF00179 0.380
TRG_DiLeu_BaEn_3 208 214 PF01217 0.368
TRG_DiLeu_BaEn_4 236 242 PF01217 0.508
TRG_ENDOCYTIC_2 130 133 PF00928 0.350
TRG_ENDOCYTIC_2 180 183 PF00928 0.398
TRG_ENDOCYTIC_2 39 42 PF00928 0.338
TRG_Pf-PMV_PEXEL_1 205 209 PF00026 0.283

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HSE8 Leptomonas seymouri 60% 100%
A0A0S4IM09 Bodo saltans 28% 100%
A0A0S4INM2 Bodo saltans 24% 73%
A0A0S4IP40 Bodo saltans 25% 100%
A0A0S4J1X8 Bodo saltans 25% 82%
A0A0S4JUF9 Bodo saltans 39% 100%
A0A1X0P8J0 Trypanosomatidae 22% 75%
A0A3R7MB63 Trypanosoma rangeli 51% 100%
A0A3S7X3C3 Leishmania donovani 99% 100%
A6JUQ6 Rattus norvegicus 26% 91%
E1C1U1 Gallus gallus 26% 94%
E9B0U0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
F4JYJ3 Arabidopsis thaliana 27% 79%
O76054 Homo sapiens 26% 73%
P12271 Homo sapiens 27% 93%
P24280 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 29% 97%
P24859 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 28% 98%
P33324 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 26% 95%
P46250 Candida albicans (strain SC5314 / ATCC MYA-2876) 28% 98%
P53844 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 28% 85%
P53860 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 24% 84%
P53989 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 29% 98%
P58875 Bos taurus 25% 73%
Q06705 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 27% 73%
Q10137 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 26% 100%
Q4Q7C6 Leishmania major 94% 100%
Q55CU8 Dictyostelium discoideum 26% 81%
Q5SYC1 Homo sapiens 26% 91%
Q757H2 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 25% 68%
Q75DK1 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 28% 96%
Q8BG92 Mus musculus 27% 91%
Q8R0F9 Mus musculus 25% 73%
Q95KF7 Macaca fascicularis 26% 91%
Q99J08 Mus musculus 26% 73%
Q99MS0 Rattus norvegicus 27% 73%
Q9SCU1 Arabidopsis thaliana 24% 72%
Q9UDX3 Homo sapiens 26% 73%
V5BZX6 Trypanosoma cruzi 23% 75%
V5DQM7 Trypanosoma cruzi 50% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS