LeishMANIAdb
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ER membrane protein complex subunit 4

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
ER membrane protein complex subunit 4
Gene product:
Protein of unknown function (DUF1077) - putative
Species:
Leishmania infantum
UniProt:
A4I5J3_LEIIN
TriTrypDb:
LINF_300021500
Length:
150

Annotations

Annotations by Jardim et al.

ER/Golgi Proteins, ER Membrane complex EC 4Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005789 endoplasmic reticulum membrane 4 10
GO:0016020 membrane 2 10
GO:0031090 organelle membrane 3 10
GO:0110165 cellular anatomical entity 1 10
GO:0032991 protein-containing complex 1 1
GO:0072546 EMC complex 3 1
GO:0098796 membrane protein complex 2 1
GO:0140534 endoplasmic reticulum protein-containing complex 2 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I5J3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5J3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 131 135 PF00656 0.200
CLV_PCSK_SKI1_1 13 17 PF00082 0.589
CLV_PCSK_SKI1_1 18 22 PF00082 0.449
DOC_MAPK_MEF2A_6 38 46 PF00069 0.217
DOC_PP1_RVXF_1 116 122 PF00149 0.204
DOC_USP7_MATH_1 126 130 PF00917 0.216
DOC_USP7_MATH_1 69 73 PF00917 0.385
DOC_WW_Pin1_4 133 138 PF00397 0.182
LIG_14-3-3_CanoR_1 28 36 PF00244 0.209
LIG_BIR_II_1 1 5 PF00653 0.337
LIG_BIR_III_3 1 5 PF00653 0.379
LIG_BRCT_BRCA1_1 144 148 PF00533 0.323
LIG_BRCT_BRCA1_1 57 61 PF00533 0.222
LIG_eIF4E_1 104 110 PF01652 0.235
LIG_FHA_1 32 38 PF00498 0.290
LIG_FHA_2 137 143 PF00498 0.351
LIG_FHA_2 14 20 PF00498 0.366
LIG_FHA_2 85 91 PF00498 0.320
LIG_LIR_Gen_1 139 148 PF02991 0.379
LIG_LIR_Gen_1 55 65 PF02991 0.222
LIG_LIR_Nem_3 139 143 PF02991 0.387
LIG_Pex14_2 57 61 PF04695 0.204
LIG_SH2_STAT5 104 107 PF00017 0.211
LIG_SH3_3 63 69 PF00018 0.213
LIG_TRAF2_1 139 142 PF00917 0.338
LIG_UBA3_1 109 118 PF00899 0.223
LIG_WW_1 137 140 PF00397 0.302
MOD_CK1_1 55 61 PF00069 0.222
MOD_CK1_1 72 78 PF00069 0.441
MOD_CK2_1 13 19 PF00069 0.331
MOD_CK2_1 136 142 PF00069 0.344
MOD_GlcNHglycan 10 13 PF01048 0.478
MOD_GlcNHglycan 144 147 PF01048 0.625
MOD_GlcNHglycan 2 5 PF01048 0.523
MOD_GlcNHglycan 74 77 PF01048 0.205
MOD_GlcNHglycan 94 97 PF01048 0.112
MOD_GSK3_1 27 34 PF00069 0.233
MOD_N-GLC_1 8 13 PF02516 0.525
MOD_PIKK_1 31 37 PF00454 0.216
MOD_PKA_2 27 33 PF00069 0.264
MOD_Plk_1 52 58 PF00069 0.227
MOD_Plk_4 40 46 PF00069 0.181
MOD_Plk_4 52 58 PF00069 0.224
MOD_Plk_4 69 75 PF00069 0.381
MOD_ProDKin_1 133 139 PF00069 0.182
MOD_SUMO_rev_2 82 89 PF00179 0.469
TRG_ENDOCYTIC_2 140 143 PF00928 0.388
TRG_ER_diArg_1 22 25 PF00400 0.189
TRG_NES_CRM1_1 39 53 PF08389 0.313

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HZL3 Leptomonas seymouri 80% 100%
A0A0S4J2Y6 Bodo saltans 51% 100%
A0A1X0P234 Trypanosomatidae 66% 100%
A0A3Q8IJD4 Leishmania donovani 99% 100%
A0A3R7RTR5 Trypanosoma rangeli 56% 100%
A4HIA9 Leishmania braziliensis 89% 100%
B5XB24 Salmo salar 32% 80%
C9ZQS8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 57% 100%
E9B0T8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
O94520 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 32% 78%
P53073 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 30% 79%
Q3T0K8 Bos taurus 32% 82%
Q4Q7D8 Leishmania major 96% 100%
Q5J8M3 Homo sapiens 32% 82%
Q5RC35 Pongo abelii 32% 82%
Q6GR43 Xenopus laevis 32% 83%
Q6P011 Danio rerio 32% 79%
Q6PBF7 Xenopus tropicalis 32% 83%
Q9CZX9 Mus musculus 32% 82%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS