Putative ferric reductase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ferric reductase transmembrane protein - putative

Species:

Leishmania infantum

UniProt:

A4I5J0_LEIIN

TriTrypDb:

LINF_300021200

Length:

984

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

A4I5J0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5J0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0016491	oxidoreductase activity	2	8
GO:0000293	ferric-chelate reductase activity	4	2
GO:0016722	oxidoreductase activity, acting on metal ions	3	2
GO:0016723	oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor	4	2
GO:0140618	ferric-chelate reductase (NADH) activity	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	211	215	PF00656	0.356
CLV_C14_Caspase3-7	754	758	PF00656	0.642
CLV_C14_Caspase3-7	905	909	PF00656	0.497
CLV_NRD_NRD_1	183	185	PF00675	0.608
CLV_NRD_NRD_1	202	204	PF00675	0.612
CLV_NRD_NRD_1	265	267	PF00675	0.320
CLV_NRD_NRD_1	435	437	PF00675	0.263
CLV_NRD_NRD_1	511	513	PF00675	0.471
CLV_NRD_NRD_1	745	747	PF00675	0.391
CLV_NRD_NRD_1	772	774	PF00675	0.447
CLV_NRD_NRD_1	866	868	PF00675	0.503
CLV_PCSK_FUR_1	200	204	PF00082	0.617
CLV_PCSK_KEX2_1	183	185	PF00082	0.608
CLV_PCSK_KEX2_1	202	204	PF00082	0.612
CLV_PCSK_KEX2_1	265	267	PF00082	0.322
CLV_PCSK_KEX2_1	434	436	PF00082	0.263
CLV_PCSK_KEX2_1	511	513	PF00082	0.471
CLV_PCSK_SKI1_1	654	658	PF00082	0.292
CLV_PCSK_SKI1_1	679	683	PF00082	0.550
CLV_PCSK_SKI1_1	767	771	PF00082	0.427
CLV_PCSK_SKI1_1	79	83	PF00082	0.356
CLV_PCSK_SKI1_1	88	92	PF00082	0.359
CLV_PCSK_SKI1_1	931	935	PF00082	0.401
CLV_PCSK_SKI1_1	951	955	PF00082	0.171
CLV_PCSK_SKI1_1	964	968	PF00082	0.272
CLV_Separin_Metazoa	726	730	PF03568	0.612
DEG_APCC_DBOX_1	678	686	PF00400	0.605
DEG_COP1_1	204	212	PF00400	0.408
DEG_SCF_FBW7_1	616	623	PF00400	0.360
DOC_ANK_TNKS_1	492	499	PF00023	0.266
DOC_CDC14_PxL_1	524	532	PF14671	0.319
DOC_CYCLIN_RxL_1	764	771	PF00134	0.623
DOC_MAPK_gen_1	200	209	PF00069	0.381
DOC_MAPK_gen_1	320	330	PF00069	0.263
DOC_MAPK_gen_1	773	779	PF00069	0.691
DOC_MAPK_gen_1	946	956	PF00069	0.495
DOC_MAPK_MEF2A_6	160	168	PF00069	0.390
DOC_MAPK_MEF2A_6	223	232	PF00069	0.368
DOC_MAPK_MEF2A_6	323	332	PF00069	0.263
DOC_MAPK_MEF2A_6	342	349	PF00069	0.463
DOC_MAPK_MEF2A_6	737	744	PF00069	0.470
DOC_MAPK_RevD_3	420	436	PF00069	0.328
DOC_PP1_RVXF_1	641	647	PF00149	0.466
DOC_PP1_RVXF_1	949	956	PF00149	0.483
DOC_PP2B_LxvP_1	336	339	PF13499	0.376
DOC_PP2B_LxvP_1	663	666	PF13499	0.612
DOC_PP4_FxxP_1	176	179	PF00568	0.406
DOC_PP4_FxxP_1	506	509	PF00568	0.317
DOC_USP7_MATH_1	105	109	PF00917	0.638
DOC_USP7_MATH_1	179	183	PF00917	0.414
DOC_USP7_MATH_1	309	313	PF00917	0.442
DOC_USP7_MATH_1	550	554	PF00917	0.257
DOC_USP7_MATH_1	620	624	PF00917	0.378
DOC_USP7_MATH_1	677	681	PF00917	0.596
DOC_USP7_MATH_1	707	711	PF00917	0.681
DOC_USP7_MATH_1	796	800	PF00917	0.674
DOC_USP7_MATH_1	834	838	PF00917	0.682
DOC_USP7_MATH_1	857	861	PF00917	0.676
DOC_USP7_MATH_1	882	886	PF00917	0.428
DOC_USP7_UBL2_3	864	868	PF12436	0.677
DOC_WW_Pin1_4	119	124	PF00397	0.717
DOC_WW_Pin1_4	596	601	PF00397	0.317
DOC_WW_Pin1_4	616	621	PF00397	0.171
DOC_WW_Pin1_4	638	643	PF00397	0.490
DOC_WW_Pin1_4	798	803	PF00397	0.699
DOC_WW_Pin1_4	809	814	PF00397	0.706
LIG_14-3-3_CanoR_1	183	193	PF00244	0.311
LIG_14-3-3_CanoR_1	202	210	PF00244	0.417
LIG_14-3-3_CanoR_1	223	230	PF00244	0.375
LIG_14-3-3_CanoR_1	254	262	PF00244	0.584
LIG_14-3-3_CanoR_1	3	8	PF00244	0.465
LIG_14-3-3_CanoR_1	342	346	PF00244	0.448
LIG_14-3-3_CanoR_1	699	707	PF00244	0.680
LIG_14-3-3_CanoR_1	746	753	PF00244	0.602
LIG_14-3-3_CanoR_1	79	85	PF00244	0.532
LIG_14-3-3_CanoR_1	867	871	PF00244	0.722
LIG_14-3-3_CanoR_1	949	954	PF00244	0.507
LIG_14-3-3_CanoR_1	964	973	PF00244	0.554
LIG_Actin_WH2_2	241	256	PF00022	0.367
LIG_APCC_ABBA_1	975	980	PF00400	0.582
LIG_APCC_ABBAyCdc20_2	402	408	PF00400	0.317
LIG_BRCT_BRCA1_1	181	185	PF00533	0.324
LIG_BRCT_BRCA1_1	287	291	PF00533	0.376
LIG_BRCT_BRCA1_1	838	842	PF00533	0.657
LIG_CaM_IQ_9	83	98	PF13499	0.598
LIG_CSL_BTD_1	176	179	PF09270	0.423
LIG_deltaCOP1_diTrp_1	144	149	PF00928	0.598
LIG_eIF4E_1	606	612	PF01652	0.306
LIG_FHA_1	21	27	PF00498	0.304
LIG_FHA_1	217	223	PF00498	0.367
LIG_FHA_1	227	233	PF00498	0.340
LIG_FHA_1	243	249	PF00498	0.250
LIG_FHA_1	282	288	PF00498	0.369
LIG_FHA_1	302	308	PF00498	0.292
LIG_FHA_1	395	401	PF00498	0.311
LIG_FHA_1	408	414	PF00498	0.219
LIG_FHA_1	416	422	PF00498	0.318
LIG_FHA_1	470	476	PF00498	0.440
LIG_FHA_1	499	505	PF00498	0.352
LIG_FHA_1	557	563	PF00498	0.303
LIG_FHA_1	574	580	PF00498	0.254
LIG_FHA_1	58	64	PF00498	0.334
LIG_FHA_1	588	594	PF00498	0.263
LIG_FHA_1	617	623	PF00498	0.376
LIG_FHA_1	700	706	PF00498	0.709
LIG_FHA_1	81	87	PF00498	0.570
LIG_FHA_1	810	816	PF00498	0.683
LIG_FHA_2	114	120	PF00498	0.703
LIG_FHA_2	206	212	PF00498	0.353
LIG_FHA_2	272	278	PF00498	0.463
LIG_FHA_2	306	312	PF00498	0.455
LIG_FHA_2	50	56	PF00498	0.400
LIG_FHA_2	597	603	PF00498	0.274
LIG_FHA_2	867	873	PF00498	0.678
LIG_FHA_2	875	881	PF00498	0.421
LIG_GBD_Chelix_1	161	169	PF00786	0.356
LIG_HCF-1_HBM_1	298	301	PF13415	0.345
LIG_LIR_Apic_2	175	179	PF02991	0.360
LIG_LIR_Apic_2	503	509	PF02991	0.317
LIG_LIR_Gen_1	382	390	PF02991	0.317
LIG_LIR_Gen_1	407	414	PF02991	0.306
LIG_LIR_Gen_1	417	428	PF02991	0.250
LIG_LIR_Gen_1	449	458	PF02991	0.304
LIG_LIR_Gen_1	461	471	PF02991	0.299
LIG_LIR_Gen_1	561	572	PF02991	0.317
LIG_LIR_Gen_1	65	75	PF02991	0.300
LIG_LIR_LC3C_4	410	414	PF02991	0.328
LIG_LIR_Nem_3	288	294	PF02991	0.396
LIG_LIR_Nem_3	382	386	PF02991	0.317
LIG_LIR_Nem_3	407	412	PF02991	0.306
LIG_LIR_Nem_3	417	423	PF02991	0.250
LIG_LIR_Nem_3	449	453	PF02991	0.341
LIG_LIR_Nem_3	461	467	PF02991	0.348
LIG_LIR_Nem_3	561	567	PF02991	0.309
LIG_LIR_Nem_3	602	606	PF02991	0.362
LIG_LIR_Nem_3	65	70	PF02991	0.273
LIG_NRBOX	332	338	PF00104	0.364
LIG_NRBOX	624	630	PF00104	0.328
LIG_PCNA_yPIPBox_3	342	350	PF02747	0.517
LIG_PDZ_Class_2	979	984	PF00595	0.571
LIG_Pex14_1	416	420	PF04695	0.376
LIG_Pex14_2	291	295	PF04695	0.300
LIG_SH2_CRK	240	244	PF00017	0.329
LIG_SH2_CRK	366	370	PF00017	0.360
LIG_SH2_CRK	4	8	PF00017	0.483
LIG_SH2_CRK	409	413	PF00017	0.306
LIG_SH2_CRK	450	454	PF00017	0.300
LIG_SH2_CRK	580	584	PF00017	0.317
LIG_SH2_CRK	606	610	PF00017	0.279
LIG_SH2_GRB2like	606	609	PF00017	0.287
LIG_SH2_NCK_1	580	584	PF00017	0.317
LIG_SH2_PTP2	522	525	PF00017	0.317
LIG_SH2_PTP2	564	567	PF00017	0.300
LIG_SH2_SRC	564	567	PF00017	0.317
LIG_SH2_SRC	606	609	PF00017	0.274
LIG_SH2_STAP1	240	244	PF00017	0.315
LIG_SH2_STAP1	366	370	PF00017	0.376
LIG_SH2_STAP1	4	8	PF00017	0.483
LIG_SH2_STAP1	409	413	PF00017	0.317
LIG_SH2_STAP1	438	442	PF00017	0.506
LIG_SH2_STAP1	443	447	PF00017	0.506
LIG_SH2_STAP1	606	610	PF00017	0.274
LIG_SH2_STAT3	261	264	PF00017	0.561
LIG_SH2_STAT3	388	391	PF00017	0.317
LIG_SH2_STAT5	17	20	PF00017	0.376
LIG_SH2_STAT5	242	245	PF00017	0.298
LIG_SH2_STAT5	380	383	PF00017	0.300
LIG_SH2_STAT5	388	391	PF00017	0.263
LIG_SH2_STAT5	409	412	PF00017	0.279
LIG_SH2_STAT5	443	446	PF00017	0.483
LIG_SH2_STAT5	466	469	PF00017	0.285
LIG_SH2_STAT5	522	525	PF00017	0.317
LIG_SH2_STAT5	564	567	PF00017	0.266
LIG_SH2_STAT5	743	746	PF00017	0.589
LIG_SH3_3	207	213	PF00018	0.341
LIG_SH3_3	44	50	PF00018	0.440
LIG_SH3_3	522	528	PF00018	0.263
LIG_SH3_3	590	596	PF00018	0.263
LIG_SH3_3	65	71	PF00018	0.376
LIG_SH3_3	670	676	PF00018	0.652
LIG_SH3_3	953	959	PF00018	0.494
LIG_Sin3_3	283	290	PF02671	0.328
LIG_SUMO_SIM_anti_2	20	27	PF11976	0.376
LIG_SUMO_SIM_anti_2	245	252	PF11976	0.324
LIG_SUMO_SIM_anti_2	334	339	PF11976	0.376
LIG_SUMO_SIM_anti_2	410	415	PF11976	0.328
LIG_SUMO_SIM_anti_2	60	65	PF11976	0.319
LIG_SUMO_SIM_anti_2	607	613	PF11976	0.274
LIG_SUMO_SIM_par_1	22	27	PF11976	0.243
LIG_SUMO_SIM_par_1	407	415	PF11976	0.263
LIG_SUMO_SIM_par_1	59	65	PF11976	0.243
LIG_TRAF2_1	116	119	PF00917	0.693
LIG_TRAF2_1	877	880	PF00917	0.500
LIG_TRFH_1	67	71	PF08558	0.360
LIG_TYR_ITIM	364	369	PF00017	0.360
LIG_TYR_ITIM	562	567	PF00017	0.376
LIG_UBA3_1	38	45	PF00899	0.510
LIG_WRC_WIRS_1	173	178	PF05994	0.314
LIG_WRC_WIRS_1	190	195	PF05994	0.330
LIG_WRC_WIRS_1	383	388	PF05994	0.376
LIG_WRC_WIRS_1	63	68	PF05994	0.323
MOD_CDC14_SPxK_1	122	125	PF00782	0.628
MOD_CDC14_SPxK_1	801	804	PF00782	0.618
MOD_CDK_SPK_2	638	643	PF00069	0.328
MOD_CDK_SPxK_1	119	125	PF00069	0.640
MOD_CDK_SPxK_1	798	804	PF00069	0.612
MOD_CK1_1	109	115	PF00069	0.619
MOD_CK1_1	341	347	PF00069	0.294
MOD_CK1_1	382	388	PF00069	0.376
MOD_CK1_1	554	560	PF00069	0.459
MOD_CK1_1	62	68	PF00069	0.315
MOD_CK1_1	638	644	PF00069	0.433
MOD_CK1_1	649	655	PF00069	0.312
MOD_CK1_1	858	864	PF00069	0.763
MOD_CK1_1	889	895	PF00069	0.439
MOD_CK1_1	907	913	PF00069	0.280
MOD_CK2_1	112	118	PF00069	0.645
MOD_CK2_1	205	211	PF00069	0.464
MOD_CK2_1	271	277	PF00069	0.300
MOD_CK2_1	305	311	PF00069	0.565
MOD_CK2_1	49	55	PF00069	0.498
MOD_CK2_1	834	840	PF00069	0.616
MOD_CK2_1	874	880	PF00069	0.355
MOD_CMANNOS	416	419	PF00535	0.376
MOD_Cter_Amidation	509	512	PF01082	0.243
MOD_GlcNHglycan	109	112	PF01048	0.577
MOD_GlcNHglycan	311	314	PF01048	0.494
MOD_GlcNHglycan	460	463	PF01048	0.414
MOD_GlcNHglycan	485	488	PF01048	0.414
MOD_GlcNHglycan	545	550	PF01048	0.365
MOD_GlcNHglycan	637	640	PF01048	0.408
MOD_GlcNHglycan	651	654	PF01048	0.335
MOD_GlcNHglycan	679	682	PF01048	0.563
MOD_GlcNHglycan	719	724	PF01048	0.618
MOD_GlcNHglycan	770	773	PF01048	0.532
MOD_GlcNHglycan	798	801	PF01048	0.629
MOD_GlcNHglycan	843	846	PF01048	0.653
MOD_GlcNHglycan	874	877	PF01048	0.411
MOD_GlcNHglycan	898	901	PF01048	0.457
MOD_GlcNHglycan	908	912	PF01048	0.354
MOD_GlcNHglycan	938	941	PF01048	0.283
MOD_GlcNHglycan	968	971	PF01048	0.475
MOD_GSK3_1	105	112	PF00069	0.591
MOD_GSK3_1	201	208	PF00069	0.525
MOD_GSK3_1	222	229	PF00069	0.447
MOD_GSK3_1	281	288	PF00069	0.376
MOD_GSK3_1	301	308	PF00069	0.326
MOD_GSK3_1	341	348	PF00069	0.309
MOD_GSK3_1	469	476	PF00069	0.392
MOD_GSK3_1	550	557	PF00069	0.372
MOD_GSK3_1	616	623	PF00069	0.378
MOD_GSK3_1	866	873	PF00069	0.684
MOD_GSK3_1	882	889	PF00069	0.354
MOD_GSK3_1	892	899	PF00069	0.353
MOD_N-GLC_1	179	184	PF02516	0.462
MOD_N-GLC_1	205	210	PF02516	0.483
MOD_N-GLC_1	309	314	PF02516	0.507
MOD_N-GLC_1	57	62	PF02516	0.265
MOD_NEK2_1	243	248	PF00069	0.321
MOD_NEK2_1	253	258	PF00069	0.371
MOD_NEK2_1	331	336	PF00069	0.344
MOD_NEK2_1	369	374	PF00069	0.360
MOD_NEK2_1	379	384	PF00069	0.360
MOD_NEK2_1	412	417	PF00069	0.416
MOD_NEK2_1	421	426	PF00069	0.312
MOD_NEK2_1	441	446	PF00069	0.459
MOD_NEK2_1	458	463	PF00069	0.420
MOD_NEK2_1	504	509	PF00069	0.376
MOD_NEK2_1	57	62	PF00069	0.410
MOD_NEK2_1	635	640	PF00069	0.387
MOD_NEK2_1	646	651	PF00069	0.301
MOD_NEK2_1	86	91	PF00069	0.482
MOD_NEK2_2	469	474	PF00069	0.369
MOD_PIKK_1	253	259	PF00454	0.468
MOD_PK_1	3	9	PF00069	0.328
MOD_PKA_1	202	208	PF00069	0.454
MOD_PKA_2	201	207	PF00069	0.569
MOD_PKA_2	222	228	PF00069	0.473
MOD_PKA_2	253	259	PF00069	0.451
MOD_PKA_2	341	347	PF00069	0.300
MOD_PKA_2	745	751	PF00069	0.489
MOD_PKA_2	866	872	PF00069	0.640
MOD_PKB_1	200	208	PF00069	0.496
MOD_Plk_1	205	211	PF00069	0.487
MOD_Plk_1	226	232	PF00069	0.436
MOD_Plk_1	407	413	PF00069	0.300
MOD_Plk_1	528	534	PF00069	0.324
MOD_Plk_1	57	63	PF00069	0.265
MOD_Plk_1	587	593	PF00069	0.481
MOD_Plk_1	719	725	PF00069	0.574
MOD_Plk_2-3	866	872	PF00069	0.576
MOD_Plk_4	172	178	PF00069	0.390
MOD_Plk_4	20	26	PF00069	0.223
MOD_Plk_4	285	291	PF00069	0.366
MOD_Plk_4	3	9	PF00069	0.354
MOD_Plk_4	331	337	PF00069	0.304
MOD_Plk_4	341	347	PF00069	0.292
MOD_Plk_4	407	413	PF00069	0.344
MOD_Plk_4	415	421	PF00069	0.262
MOD_Plk_4	446	452	PF00069	0.332
MOD_Plk_4	469	475	PF00069	0.409
MOD_Plk_4	558	564	PF00069	0.376
MOD_Plk_4	59	65	PF00069	0.316
MOD_Plk_4	620	626	PF00069	0.381
MOD_Plk_4	80	86	PF00069	0.422
MOD_Plk_4	866	872	PF00069	0.596
MOD_Plk_4	892	898	PF00069	0.312
MOD_Plk_4	958	964	PF00069	0.360
MOD_ProDKin_1	119	125	PF00069	0.656
MOD_ProDKin_1	596	602	PF00069	0.376
MOD_ProDKin_1	616	622	PF00069	0.171
MOD_ProDKin_1	638	644	PF00069	0.338
MOD_ProDKin_1	798	804	PF00069	0.632
MOD_ProDKin_1	809	815	PF00069	0.642
MOD_SUMO_for_1	141	144	PF00179	0.484
MOD_SUMO_rev_2	778	784	PF00179	0.590
MOD_SUMO_rev_2	860	870	PF00179	0.598
TRG_DiLeu_BaEn_3	823	829	PF01217	0.527
TRG_DiLeu_BaLyEn_6	925	930	PF01217	0.479
TRG_ENDOCYTIC_2	240	243	PF00928	0.304
TRG_ENDOCYTIC_2	366	369	PF00928	0.300
TRG_ENDOCYTIC_2	383	386	PF00928	0.300
TRG_ENDOCYTIC_2	4	7	PF00928	0.325
TRG_ENDOCYTIC_2	409	412	PF00928	0.376
TRG_ENDOCYTIC_2	438	441	PF00928	0.310
TRG_ENDOCYTIC_2	443	446	PF00928	0.286
TRG_ENDOCYTIC_2	450	453	PF00928	0.306
TRG_ENDOCYTIC_2	522	525	PF00928	0.382
TRG_ENDOCYTIC_2	564	567	PF00928	0.369
TRG_ENDOCYTIC_2	580	583	PF00928	0.416
TRG_ENDOCYTIC_2	606	609	PF00928	0.360
TRG_ENDOCYTIC_2	78	81	PF00928	0.416
TRG_ER_diArg_1	152	155	PF00400	0.406
TRG_ER_diArg_1	183	185	PF00400	0.503
TRG_ER_diArg_1	258	261	PF00400	0.403
TRG_ER_diArg_1	265	267	PF00400	0.350
TRG_ER_diArg_1	433	436	PF00400	0.300
TRG_ER_diArg_1	492	495	PF00400	0.413
TRG_ER_diArg_1	50	53	PF00400	0.522
TRG_NES_CRM1_1	719	733	PF08389	0.506
TRG_Pf-PMV_PEXEL_1	323	327	PF00026	0.376
TRG_Pf-PMV_PEXEL_1	495	499	PF00026	0.394
TRG_Pf-PMV_PEXEL_1	928	932	PF00026	0.379

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X3B5	Leishmania donovani	99%	91%
A0A422N2V3	Trypanosoma rangeli	35%	100%
A4HIA6	Leishmania braziliensis	72%	100%
D0A6T6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9B0T5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q7E3	Leishmania major	86%	100%