Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I5I9_LEIIN

TriTrypDb:

LINF_300021100

Length:

532

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I5I9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5I9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	123	125	PF00675	0.506
CLV_NRD_NRD_1	304	306	PF00675	0.658
CLV_NRD_NRD_1	307	309	PF00675	0.516
CLV_NRD_NRD_1	375	377	PF00675	0.587
CLV_NRD_NRD_1	402	404	PF00675	0.584
CLV_PCSK_FUR_1	121	125	PF00082	0.348
CLV_PCSK_FUR_1	305	309	PF00082	0.343
CLV_PCSK_FUR_1	373	377	PF00082	0.636
CLV_PCSK_KEX2_1	123	125	PF00082	0.506
CLV_PCSK_KEX2_1	304	306	PF00082	0.566
CLV_PCSK_KEX2_1	307	309	PF00082	0.526
CLV_PCSK_KEX2_1	361	363	PF00082	0.569
CLV_PCSK_KEX2_1	375	377	PF00082	0.497
CLV_PCSK_KEX2_1	379	381	PF00082	0.457
CLV_PCSK_PC1ET2_1	361	363	PF00082	0.576
CLV_PCSK_PC1ET2_1	379	381	PF00082	0.378
CLV_PCSK_PC7_1	375	381	PF00082	0.608
CLV_PCSK_SKI1_1	380	384	PF00082	0.630
CLV_PCSK_SKI1_1	93	97	PF00082	0.465
CLV_Separin_Metazoa	38	42	PF03568	0.504
DEG_APCC_DBOX_1	92	100	PF00400	0.432
DEG_SPOP_SBC_1	100	104	PF00917	0.477
DEG_SPOP_SBC_1	274	278	PF00917	0.553
DOC_CDC14_PxL_1	84	92	PF14671	0.478
DOC_CKS1_1	325	330	PF01111	0.555
DOC_CKS1_1	481	486	PF01111	0.659
DOC_CYCLIN_yCln2_LP_2	347	353	PF00134	0.532
DOC_MAPK_gen_1	121	128	PF00069	0.447
DOC_MAPK_MEF2A_6	83	91	PF00069	0.473
DOC_MAPK_MEF2A_6	93	101	PF00069	0.401
DOC_PP1_RVXF_1	111	117	PF00149	0.424
DOC_PP2B_LxvP_1	347	350	PF13499	0.519
DOC_PP2B_LxvP_1	97	100	PF13499	0.459
DOC_USP7_MATH_1	100	104	PF00917	0.499
DOC_USP7_MATH_1	409	413	PF00917	0.780
DOC_USP7_MATH_1	469	473	PF00917	0.624
DOC_USP7_MATH_1	53	57	PF00917	0.751
DOC_USP7_MATH_1	59	63	PF00917	0.773
DOC_USP7_UBL2_3	280	284	PF12436	0.735
DOC_WW_Pin1_4	324	329	PF00397	0.619
DOC_WW_Pin1_4	389	394	PF00397	0.654
DOC_WW_Pin1_4	480	485	PF00397	0.608
LIG_14-3-3_CanoR_1	165	174	PF00244	0.528
LIG_14-3-3_CanoR_1	378	383	PF00244	0.683
LIG_14-3-3_CanoR_1	434	442	PF00244	0.720
LIG_14-3-3_CanoR_1	502	508	PF00244	0.659
LIG_BIR_II_1	1	5	PF00653	0.638
LIG_BRCT_BRCA1_1	329	333	PF00533	0.602
LIG_CSL_BTD_1	490	493	PF09270	0.535
LIG_deltaCOP1_diTrp_1	109	116	PF00928	0.479
LIG_eIF4E_1	84	90	PF01652	0.473
LIG_FHA_1	127	133	PF00498	0.451
LIG_FHA_1	26	32	PF00498	0.532
LIG_FHA_1	34	40	PF00498	0.452
LIG_FHA_1	70	76	PF00498	0.493
LIG_FHA_2	216	222	PF00498	0.765
LIG_FHA_2	49	55	PF00498	0.780
LIG_FHA_2	502	508	PF00498	0.631
LIG_FHA_2	512	518	PF00498	0.544
LIG_FHA_2	65	71	PF00498	0.504
LIG_LIR_Gen_1	109	116	PF02991	0.539
LIG_LIR_Gen_1	365	374	PF02991	0.557
LIG_LIR_Gen_1	474	485	PF02991	0.657
LIG_LIR_Gen_1	81	91	PF02991	0.533
LIG_LIR_Nem_3	109	114	PF02991	0.539
LIG_LIR_Nem_3	188	193	PF02991	0.610
LIG_LIR_Nem_3	28	32	PF02991	0.496
LIG_LIR_Nem_3	365	371	PF02991	0.552
LIG_LIR_Nem_3	474	480	PF02991	0.674
LIG_LIR_Nem_3	81	87	PF02991	0.533
LIG_LYPXL_yS_3	29	32	PF13949	0.535
LIG_MYND_1	206	210	PF01753	0.662
LIG_NRBOX	312	318	PF00104	0.536
LIG_PTB_Apo_2	238	245	PF02174	0.390
LIG_PTB_Phospho_1	238	244	PF10480	0.396
LIG_Rb_pABgroove_1	350	358	PF01858	0.484
LIG_SH2_CRK	84	88	PF00017	0.483
LIG_SH2_GRB2like	166	169	PF00017	0.566
LIG_SH2_SRC	351	354	PF00017	0.528
LIG_SH2_STAT3	11	14	PF00017	0.529
LIG_SH2_STAT5	18	21	PF00017	0.400
LIG_SH2_STAT5	351	354	PF00017	0.510
LIG_SH2_STAT5	358	361	PF00017	0.509
LIG_SH3_3	24	30	PF00018	0.555
LIG_SH3_3	322	328	PF00018	0.554
LIG_SH3_3	483	489	PF00018	0.620
LIG_SUMO_SIM_anti_2	4	10	PF11976	0.561
LIG_SUMO_SIM_par_1	124	131	PF11976	0.398
LIG_TRAF2_1	443	446	PF00917	0.720
LIG_TRAF2_1	514	517	PF00917	0.593
LIG_TYR_ITIM	82	87	PF00017	0.469
LIG_UBA3_1	294	301	PF00899	0.455
LIG_UBA3_1	355	361	PF00899	0.475
MOD_CK1_1	103	109	PF00069	0.457
MOD_CK1_1	149	155	PF00069	0.445
MOD_CK1_1	196	202	PF00069	0.631
MOD_CK1_1	381	387	PF00069	0.717
MOD_CK1_1	391	397	PF00069	0.669
MOD_CK1_1	430	436	PF00069	0.706
MOD_CK1_1	453	459	PF00069	0.686
MOD_CK1_1	460	466	PF00069	0.629
MOD_CK1_1	498	504	PF00069	0.437
MOD_CK1_1	60	66	PF00069	0.727
MOD_CK2_1	103	109	PF00069	0.498
MOD_CK2_1	215	221	PF00069	0.746
MOD_CK2_1	31	37	PF00069	0.520
MOD_CK2_1	440	446	PF00069	0.800
MOD_CK2_1	511	517	PF00069	0.526
MOD_GlcNHglycan	1	4	PF01048	0.635
MOD_GlcNHglycan	133	136	PF01048	0.506
MOD_GlcNHglycan	141	144	PF01048	0.542
MOD_GlcNHglycan	230	233	PF01048	0.706
MOD_GlcNHglycan	329	332	PF01048	0.666
MOD_GlcNHglycan	406	409	PF01048	0.797
MOD_GlcNHglycan	411	414	PF01048	0.712
MOD_GlcNHglycan	437	440	PF01048	0.755
MOD_GlcNHglycan	463	466	PF01048	0.705
MOD_GlcNHglycan	54	58	PF01048	0.748
MOD_GlcNHglycan	59	62	PF01048	0.734
MOD_GlcNHglycan	67	70	PF01048	0.533
MOD_GSK3_1	160	167	PF00069	0.565
MOD_GSK3_1	193	200	PF00069	0.553
MOD_GSK3_1	323	330	PF00069	0.588
MOD_GSK3_1	378	385	PF00069	0.607
MOD_GSK3_1	428	435	PF00069	0.703
MOD_GSK3_1	450	457	PF00069	0.666
MOD_GSK3_1	459	466	PF00069	0.610
MOD_GSK3_1	469	476	PF00069	0.509
MOD_GSK3_1	53	60	PF00069	0.688
MOD_GSK3_1	65	72	PF00069	0.570
MOD_GSK3_1	99	106	PF00069	0.497
MOD_N-GLC_1	200	205	PF02516	0.622
MOD_N-GLC_1	428	433	PF02516	0.658
MOD_N-GLC_1	521	526	PF02516	0.536
MOD_NEK2_1	101	106	PF00069	0.486
MOD_NEK2_1	128	133	PF00069	0.440
MOD_NEK2_1	228	233	PF00069	0.684
MOD_NEK2_1	275	280	PF00069	0.652
MOD_NEK2_1	382	387	PF00069	0.719
MOD_NEK2_1	427	432	PF00069	0.575
MOD_NEK2_1	455	460	PF00069	0.647
MOD_NEK2_1	495	500	PF00069	0.439
MOD_PIKK_1	166	172	PF00454	0.349
MOD_PIKK_1	384	390	PF00454	0.591
MOD_PKA_1	378	384	PF00069	0.638
MOD_PKA_2	164	170	PF00069	0.617
MOD_PKA_2	244	250	PF00069	0.359
MOD_PKA_2	398	404	PF00069	0.812
MOD_PKA_2	433	439	PF00069	0.684
MOD_PKA_2	501	507	PF00069	0.596
MOD_PKA_2	518	524	PF00069	0.369
MOD_PKB_1	288	296	PF00069	0.666
MOD_PKB_1	376	384	PF00069	0.675
MOD_Plk_1	109	115	PF00069	0.532
MOD_Plk_1	200	206	PF00069	0.704
MOD_Plk_1	450	456	PF00069	0.790
MOD_Plk_1	473	479	PF00069	0.718
MOD_Plk_1	69	75	PF00069	0.422
MOD_Plk_4	14	20	PF00069	0.363
MOD_Plk_4	244	250	PF00069	0.537
MOD_Plk_4	290	296	PF00069	0.630
MOD_Plk_4	473	479	PF00069	0.752
MOD_Plk_4	495	501	PF00069	0.458
MOD_Plk_4	521	527	PF00069	0.555
MOD_ProDKin_1	324	330	PF00069	0.633
MOD_ProDKin_1	389	395	PF00069	0.655
MOD_ProDKin_1	480	486	PF00069	0.599
TRG_DiLeu_BaEn_1	38	43	PF01217	0.556
TRG_DiLeu_BaEn_4	109	115	PF01217	0.532
TRG_DiLeu_BaLyEn_6	490	495	PF01217	0.529
TRG_DiLeu_BaLyEn_6	85	90	PF01217	0.487
TRG_DiLeu_LyEn_5	38	43	PF01217	0.556
TRG_ENDOCYTIC_2	257	260	PF00928	0.401
TRG_ENDOCYTIC_2	29	32	PF00928	0.535
TRG_ENDOCYTIC_2	84	87	PF00928	0.479
TRG_ER_diArg_1	120	123	PF00400	0.506
TRG_ER_diArg_1	303	305	PF00400	0.660
TRG_ER_diArg_1	306	308	PF00400	0.590
TRG_ER_diArg_1	375	378	PF00400	0.608
TRG_NES_CRM1_1	175	189	PF08389	0.533
TRG_NLS_Bipartite_1	361	382	PF00514	0.622
TRG_NLS_MonoExtN_4	375	382	PF00514	0.664
TRG_Pf-PMV_PEXEL_1	41	45	PF00026	0.591

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P973	Leptomonas seymouri	45%	100%
A0A3Q8IFL5	Leishmania donovani	98%	100%
A0A3R7NW81	Trypanosoma rangeli	25%	100%
A4HIA5	Leishmania braziliensis	74%	100%
E9B0T4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q7E4	Leishmania major	90%	100%
V5BZ01	Trypanosoma cruzi	25%	100%