Guanine nucleotide-binding protein subunit beta-like protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain - G-beta repeat - putative

Species:

Leishmania infantum

UniProt:

A4I5H1_LEIIN

TriTrypDb:

LINF_300019600

Length:

553

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	9
GO:0032991	protein-containing complex	1	9
GO:0043226	organelle	2	9
GO:0043228	non-membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043232	intracellular non-membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	9
GO:1990904	ribonucleoprotein complex	2	9
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4I5H1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5H1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	105	109	PF00656	0.628
CLV_C14_Caspase3-7	184	188	PF00656	0.516
CLV_C14_Caspase3-7	417	421	PF00656	0.402
CLV_NRD_NRD_1	270	272	PF00675	0.347
CLV_PCSK_KEX2_1	270	272	PF00082	0.347
CLV_PCSK_KEX2_1	388	390	PF00082	0.404
CLV_PCSK_KEX2_1	464	466	PF00082	0.468
CLV_PCSK_PC1ET2_1	388	390	PF00082	0.404
CLV_PCSK_PC1ET2_1	464	466	PF00082	0.456
CLV_PCSK_SKI1_1	245	249	PF00082	0.491
CLV_PCSK_SKI1_1	428	432	PF00082	0.408
CLV_PCSK_SKI1_1	529	533	PF00082	0.379
DEG_Kelch_Keap1_1	511	516	PF01344	0.448
DEG_SPOP_SBC_1	319	323	PF00917	0.468
DEG_SPOP_SBC_1	58	62	PF00917	0.537
DOC_PP4_FxxP_1	10	13	PF00568	0.636
DOC_PP4_FxxP_1	532	535	PF00568	0.391
DOC_USP7_MATH_1	185	189	PF00917	0.461
DOC_USP7_MATH_1	200	204	PF00917	0.681
DOC_USP7_MATH_1	220	224	PF00917	0.659
DOC_USP7_MATH_1	319	323	PF00917	0.511
DOC_USP7_MATH_1	49	53	PF00917	0.643
DOC_USP7_MATH_1	533	537	PF00917	0.396
DOC_USP7_MATH_1	58	62	PF00917	0.759
DOC_USP7_MATH_1	94	98	PF00917	0.774
DOC_WW_Pin1_4	146	151	PF00397	0.578
DOC_WW_Pin1_4	206	211	PF00397	0.584
DOC_WW_Pin1_4	221	226	PF00397	0.499
DOC_WW_Pin1_4	445	450	PF00397	0.367
DOC_WW_Pin1_4	531	536	PF00397	0.364
DOC_WW_Pin1_4	89	94	PF00397	0.775
LIG_14-3-3_CanoR_1	138	145	PF00244	0.701
LIG_14-3-3_CanoR_1	166	172	PF00244	0.475
LIG_14-3-3_CanoR_1	265	273	PF00244	0.547
LIG_14-3-3_CanoR_1	422	431	PF00244	0.462
LIG_14-3-3_CanoR_1	50	54	PF00244	0.662
LIG_14-3-3_CanoR_1	57	67	PF00244	0.597
LIG_14-3-3_CanoR_1	91	97	PF00244	0.793
LIG_APCC_ABBA_1	406	411	PF00400	0.450
LIG_BIR_III_4	420	424	PF00653	0.446
LIG_BRCT_BRCA1_1	6	10	PF00533	0.586
LIG_Clathr_ClatBox_1	190	194	PF01394	0.336
LIG_deltaCOP1_diTrp_1	259	266	PF00928	0.453
LIG_FHA_1	132	138	PF00498	0.622
LIG_FHA_1	140	146	PF00498	0.478
LIG_FHA_1	256	262	PF00498	0.472
LIG_FHA_1	29	35	PF00498	0.612
LIG_FHA_1	300	306	PF00498	0.476
LIG_FHA_1	325	331	PF00498	0.490
LIG_FHA_1	358	364	PF00498	0.528
LIG_FHA_1	368	374	PF00498	0.511
LIG_FHA_1	512	518	PF00498	0.528
LIG_FHA_1	62	68	PF00498	0.663
LIG_FHA_2	103	109	PF00498	0.610
LIG_FHA_2	241	247	PF00498	0.384
LIG_FHA_2	415	421	PF00498	0.371
LIG_FHA_2	480	486	PF00498	0.349
LIG_Integrin_isoDGR_2	504	506	PF01839	0.469
LIG_LIR_Apic_2	169	175	PF02991	0.432
LIG_LIR_Apic_2	530	535	PF02991	0.386
LIG_LIR_Apic_2	7	13	PF02991	0.631
LIG_LIR_Gen_1	353	363	PF02991	0.487
LIG_LIR_Nem_3	119	125	PF02991	0.682
LIG_LIR_Nem_3	353	358	PF02991	0.487
LIG_PCNA_PIPBox_1	244	253	PF02747	0.478
LIG_SH2_CRK	122	126	PF00017	0.588
LIG_SH2_STAP1	324	328	PF00017	0.453
LIG_SH2_STAP1	489	493	PF00017	0.513
LIG_SH2_STAP1	519	523	PF00017	0.390
LIG_SH2_STAT5	251	254	PF00017	0.310
LIG_SH3_1	172	178	PF00018	0.522
LIG_SH3_3	172	178	PF00018	0.466
LIG_SH3_3	192	198	PF00018	0.259
LIG_SH3_3	449	455	PF00018	0.413
LIG_SH3_3	77	83	PF00018	0.697
LIG_SH3_4	428	435	PF00018	0.421
LIG_SUMO_SIM_par_1	453	459	PF11976	0.408
LIG_UBA3_1	517	522	PF00899	0.356
LIG_WRC_WIRS_1	440	445	PF05994	0.478
MOD_CDK_SPxxK_3	146	153	PF00069	0.582
MOD_CDK_SPxxK_3	206	213	PF00069	0.571
MOD_CK1_1	124	130	PF00069	0.806
MOD_CK1_1	141	147	PF00069	0.499
MOD_CK1_1	167	173	PF00069	0.498
MOD_CK1_1	221	227	PF00069	0.552
MOD_CK1_1	59	65	PF00069	0.801
MOD_CK1_1	92	98	PF00069	0.724
MOD_CK2_1	167	173	PF00069	0.537
MOD_CK2_1	240	246	PF00069	0.361
MOD_CK2_1	303	309	PF00069	0.467
MOD_CK2_1	353	359	PF00069	0.456
MOD_DYRK1A_RPxSP_1	445	449	PF00069	0.375
MOD_GlcNHglycan	145	148	PF01048	0.558
MOD_GlcNHglycan	202	205	PF01048	0.717
MOD_GlcNHglycan	220	223	PF01048	0.599
MOD_GlcNHglycan	230	233	PF01048	0.213
MOD_GlcNHglycan	273	276	PF01048	0.256
MOD_GlcNHglycan	345	348	PF01048	0.389
MOD_GlcNHglycan	363	366	PF01048	0.158
MOD_GlcNHglycan	425	428	PF01048	0.589
MOD_GlcNHglycan	452	455	PF01048	0.425
MOD_GlcNHglycan	499	502	PF01048	0.369
MOD_GlcNHglycan	6	9	PF01048	0.626
MOD_GlcNHglycan	96	99	PF01048	0.591
MOD_GSK3_1	139	146	PF00069	0.598
MOD_GSK3_1	161	168	PF00069	0.486
MOD_GSK3_1	179	186	PF00069	0.332
MOD_GSK3_1	251	258	PF00069	0.345
MOD_GSK3_1	26	33	PF00069	0.627
MOD_GSK3_1	299	306	PF00069	0.453
MOD_GSK3_1	320	327	PF00069	0.497
MOD_GSK3_1	353	360	PF00069	0.561
MOD_GSK3_1	57	64	PF00069	0.745
MOD_GSK3_1	81	88	PF00069	0.745
MOD_N-GLC_2	311	313	PF02516	0.288
MOD_NEK2_1	121	126	PF00069	0.627
MOD_NEK2_1	165	170	PF00069	0.498
MOD_NEK2_1	299	304	PF00069	0.464
MOD_NEK2_1	318	323	PF00069	0.478
MOD_NEK2_1	383	388	PF00069	0.478
MOD_NEK2_1	456	461	PF00069	0.479
MOD_NEK2_1	497	502	PF00069	0.274
MOD_NEK2_1	56	61	PF00069	0.676
MOD_NEK2_1	85	90	PF00069	0.786
MOD_NEK2_2	133	138	PF00069	0.504
MOD_NEK2_2	324	329	PF00069	0.453
MOD_PIKK_1	303	309	PF00454	0.453
MOD_PIKK_1	350	356	PF00454	0.521
MOD_PK_1	30	36	PF00069	0.656
MOD_PKA_2	165	171	PF00069	0.488
MOD_PKA_2	35	41	PF00069	0.756
MOD_PKA_2	4	10	PF00069	0.767
MOD_PKA_2	49	55	PF00069	0.801
MOD_PKA_2	56	62	PF00069	0.820
MOD_PKB_1	55	63	PF00069	0.546
MOD_PKB_1	76	84	PF00069	0.560
MOD_Plk_1	324	330	PF00069	0.453
MOD_Plk_2-3	240	246	PF00069	0.394
MOD_Plk_4	167	173	PF00069	0.516
MOD_Plk_4	246	252	PF00069	0.466
MOD_Plk_4	414	420	PF00069	0.392
MOD_Plk_4	439	445	PF00069	0.482
MOD_Plk_4	533	539	PF00069	0.416
MOD_Plk_4	81	87	PF00069	0.765
MOD_ProDKin_1	146	152	PF00069	0.577
MOD_ProDKin_1	206	212	PF00069	0.584
MOD_ProDKin_1	221	227	PF00069	0.487
MOD_ProDKin_1	445	451	PF00069	0.363
MOD_ProDKin_1	531	537	PF00069	0.362
MOD_ProDKin_1	89	95	PF00069	0.775
MOD_SUMO_rev_2	240	250	PF00179	0.351
MOD_SUMO_rev_2	274	281	PF00179	0.453
MOD_SUMO_rev_2	516	523	PF00179	0.355
TRG_DiLeu_BaEn_1	513	518	PF01217	0.407
TRG_DiLeu_BaLyEn_6	452	457	PF01217	0.390
TRG_DiLeu_BaLyEn_6	503	508	PF01217	0.431
TRG_ENDOCYTIC_2	122	125	PF00928	0.583
TRG_ER_diArg_1	270	272	PF00400	0.547
TRG_Pf-PMV_PEXEL_1	265	269	PF00026	0.347
TRG_Pf-PMV_PEXEL_1	506	511	PF00026	0.303

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMQ0	Leptomonas seymouri	68%	100%
A0A1X0P1V8	Trypanosomatidae	56%	100%
A0A3Q8IHW0	Leishmania donovani	99%	100%
A0A3R7MF36	Trypanosoma rangeli	51%	100%
A4H666	Leishmania braziliensis	24%	100%
A4HI91	Leishmania braziliensis	80%	100%
C9ZQV5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AN88	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9B0R9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q7G4	Leishmania major	94%	100%
V5BYY0	Trypanosoma cruzi	52%	100%