Homologous to the obscure animal PLAC8 protein. These proteins likely immerse into the cell membrane, but without crossing it. Might be involved in heavy metal extrusion.. Might carry exosomal signals on its N-terminus.
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 3 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | no | yes: 12 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 25 |
| NetGPI | no | yes: 0, no: 25 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0016020 | membrane | 2 | 16 |
| GO:0110165 | cellular anatomical entity | 1 | 16 |
Related structures:
AlphaFold database: A4I5H0
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_NRD_NRD_1 | 110 | 112 | PF00675 | 0.354 |
| CLV_PCSK_KEX2_1 | 109 | 111 | PF00082 | 0.354 |
| CLV_PCSK_PC7_1 | 105 | 111 | PF00082 | 0.350 |
| DEG_APCC_DBOX_1 | 14 | 22 | PF00400 | 0.359 |
| DEG_COP1_1 | 87 | 97 | PF00400 | 0.230 |
| DOC_CYCLIN_yCln2_LP_2 | 78 | 84 | PF00134 | 0.350 |
| DOC_MAPK_MEF2A_6 | 75 | 84 | PF00069 | 0.296 |
| DOC_PP2B_LxvP_1 | 78 | 81 | PF13499 | 0.350 |
| DOC_USP7_MATH_1 | 147 | 151 | PF00917 | 0.567 |
| LIG_BRCT_BRCA1_1 | 64 | 68 | PF00533 | 0.350 |
| LIG_FHA_1 | 26 | 32 | PF00498 | 0.463 |
| LIG_FHA_2 | 44 | 50 | PF00498 | 0.350 |
| LIG_LIR_Gen_1 | 55 | 64 | PF02991 | 0.299 |
| LIG_LIR_Gen_1 | 65 | 76 | PF02991 | 0.224 |
| LIG_LIR_Gen_1 | 7 | 16 | PF02991 | 0.402 |
| LIG_LIR_Nem_3 | 55 | 61 | PF02991 | 0.260 |
| LIG_LIR_Nem_3 | 65 | 71 | PF02991 | 0.236 |
| LIG_LIR_Nem_3 | 7 | 12 | PF02991 | 0.422 |
| LIG_PDZ_Class_2 | 160 | 165 | PF00595 | 0.695 |
| LIG_SH2_CRK | 9 | 13 | PF00017 | 0.509 |
| LIG_SH2_NCK_1 | 9 | 13 | PF00017 | 0.457 |
| LIG_SH2_STAP1 | 41 | 45 | PF00017 | 0.374 |
| LIG_SH2_STAT5 | 102 | 105 | PF00017 | 0.512 |
| LIG_SH3_3 | 153 | 159 | PF00018 | 0.601 |
| LIG_SH3_3 | 32 | 38 | PF00018 | 0.367 |
| LIG_SUMO_SIM_anti_2 | 16 | 22 | PF11976 | 0.376 |
| MOD_CK1_1 | 26 | 32 | PF00069 | 0.522 |
| MOD_CK1_1 | 4 | 10 | PF00069 | 0.518 |
| MOD_CK2_1 | 2 | 8 | PF00069 | 0.405 |
| MOD_CK2_1 | 43 | 49 | PF00069 | 0.316 |
| MOD_GlcNHglycan | 91 | 94 | PF01048 | 0.385 |
| MOD_GSK3_1 | 39 | 46 | PF00069 | 0.290 |
| MOD_GSK3_1 | 89 | 96 | PF00069 | 0.332 |
| MOD_N-GLC_1 | 2 | 7 | PF02516 | 0.593 |
| MOD_N-GLC_2 | 51 | 53 | PF02516 | 0.577 |
| MOD_NEK2_1 | 1 | 6 | PF00069 | 0.536 |
| MOD_NEK2_1 | 138 | 143 | PF00069 | 0.567 |
| MOD_NEK2_1 | 43 | 48 | PF00069 | 0.322 |
| MOD_NEK2_1 | 84 | 89 | PF00069 | 0.405 |
| MOD_OFUCOSY | 47 | 53 | PF10250 | 0.538 |
| MOD_PIKK_1 | 158 | 164 | PF00454 | 0.534 |
| MOD_PIKK_1 | 26 | 32 | PF00454 | 0.449 |
| MOD_Plk_1 | 138 | 144 | PF00069 | 0.551 |
| MOD_Plk_1 | 26 | 32 | PF00069 | 0.465 |
| MOD_Plk_1 | 7 | 13 | PF00069 | 0.403 |
| MOD_Plk_4 | 122 | 128 | PF00069 | 0.508 |
| MOD_Plk_4 | 7 | 13 | PF00069 | 0.546 |
| MOD_Plk_4 | 93 | 99 | PF00069 | 0.356 |
| TRG_ENDOCYTIC_2 | 9 | 12 | PF00928 | 0.475 |
| TRG_ER_diArg_1 | 108 | 111 | PF00400 | 0.519 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N1I1Y6 | Leptomonas seymouri | 40% | 75% |
| A0A0N1IBY3 | Leptomonas seymouri | 62% | 100% |
| A0A0N1PGF6 | Leptomonas seymouri | 43% | 100% |
| A0A0S4IV30 | Bodo saltans | 29% | 67% |
| A0A0S4JGP6 | Bodo saltans | 33% | 100% |
| A0A0S4JJU8 | Bodo saltans | 32% | 77% |
| A0A0S4JMM9 | Bodo saltans | 28% | 68% |
| A0A1X0NEC8 | Trypanosomatidae | 38% | 77% |
| A0A3Q8IER4 | Leishmania donovani | 99% | 100% |
| A0A3S7X3B7 | Leishmania donovani | 42% | 94% |
| A0A422NIG0 | Trypanosoma rangeli | 33% | 91% |
| A4HI90 | Leishmania braziliensis | 78% | 100% |
| A4HI92 | Leishmania braziliensis | 40% | 100% |
| A4HI93 | Leishmania braziliensis | 43% | 81% |
| E9AHJ8 | Leishmania infantum | 42% | 94% |
| E9AHJ9 | Leishmania infantum | 41% | 95% |
| E9AHK0 | Leishmania infantum | 43% | 80% |
| E9B0R8 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 90% | 100% |
| E9B0S0 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 41% | 100% |
| E9B0S1 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 45% | 100% |
| Q4Q7G1 | Leishmania major | 41% | 100% |
| Q4Q7G2 | Leishmania major | 42% | 100% |
| Q4Q7G3 | Leishmania major | 46% | 100% |
| Q4Q7G5 | Leishmania major | 92% | 100% |