LeishMANIAdb
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Putative N-acyl-L-amino acid amidohydrolase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative N-acyl-L-amino acid amidohydrolase
Gene product:
amidohydrolase - putative
Species:
Leishmania infantum
UniProt:
A4I5G9_LEIIN
TriTrypDb:
LINF_300019400
Length:
441

Annotations

Annotations by Jardim et al.

Amino acid metabolism, N-acyl-L-amino acid amidohydrolase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 2
Forrest at al. (procyclic) yes yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I5G9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5G9

Function

Could not find GO biological_process term for this entry.
Molecular functions
TermNameLevelCount
GO:0003824 catalytic activity 1 6
GO:0004046 aminoacylase activity 5 5
GO:0016787 hydrolase activity 2 6
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 3 5
GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 4 5
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_NRD_NRD_1 271 273 PF00675 0.374
CLV_NRD_NRD_1 64 66 PF00675 0.336
CLV_PCSK_KEX2_1 64 66 PF00082 0.336
CLV_PCSK_SKI1_1 178 182 PF00082 0.324
CLV_PCSK_SKI1_1 205 209 PF00082 0.324
DEG_Nend_UBRbox_3 1 3 PF02207 0.530
DOC_CDC14_PxL_1 67 75 PF14671 0.327
DOC_CYCLIN_yCln2_LP_2 252 258 PF00134 0.386
DOC_MAPK_DCC_7 9 18 PF00069 0.527
DOC_MAPK_gen_1 9 18 PF00069 0.527
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N0P2N6 Leptomonas seymouri 39% 100%
A0A0N0P327 Leptomonas seymouri 24% 100%
A0A1X0NW20 Trypanosomatidae 45% 100%
A0A1X0NW36 Trypanosomatidae 47% 100%
A0A1X0NWQ6 Trypanosomatidae 44% 100%
A0A3Q8IBS0 Leishmania donovani 44% 100%
A0A3Q8IIH2 Leishmania donovani 39% 100%
A0A3Q8IJC1 Leishmania donovani 100% 100%
A0A3S7WW66 Leishmania donovani 43% 100%
A0A3S7WW80 Leishmania donovani 42% 81%
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Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS