Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I5G5_LEIIN

TriTrypDb:

LINF_300019000

Length:

318

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I5G5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5G5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	78	82	PF00656	0.737
CLV_NRD_NRD_1	169	171	PF00675	0.649
CLV_NRD_NRD_1	44	46	PF00675	0.572
CLV_PCSK_KEX2_1	104	106	PF00082	0.495
CLV_PCSK_KEX2_1	168	170	PF00082	0.615
CLV_PCSK_KEX2_1	44	46	PF00082	0.572
CLV_PCSK_PC1ET2_1	104	106	PF00082	0.656
CLV_PCSK_PC1ET2_1	168	170	PF00082	0.633
CLV_PCSK_PC7_1	164	170	PF00082	0.640
CLV_PCSK_SKI1_1	152	156	PF00082	0.479
DEG_APCC_DBOX_1	151	159	PF00400	0.576
DEG_SPOP_SBC_1	67	71	PF00917	0.576
DOC_CYCLIN_yCln2_LP_2	28	34	PF00134	0.488
DOC_PP4_FxxP_1	227	230	PF00568	0.697
DOC_USP7_MATH_1	19	23	PF00917	0.510
DOC_USP7_MATH_1	231	235	PF00917	0.693
DOC_USP7_MATH_1	67	71	PF00917	0.673
DOC_WW_Pin1_4	178	183	PF00397	0.686
DOC_WW_Pin1_4	282	287	PF00397	0.652
LIG_14-3-3_CanoR_1	226	230	PF00244	0.709
LIG_FHA_1	128	134	PF00498	0.711
LIG_FHA_2	104	110	PF00498	0.634
LIG_LIR_Apic_2	225	230	PF02991	0.698
LIG_LIR_Gen_1	35	46	PF02991	0.585
LIG_LIR_Nem_3	35	41	PF02991	0.616
LIG_NRP_CendR_1	315	318	PF00754	0.713
LIG_SH2_STAP1	38	42	PF00017	0.620
LIG_SH2_STAT5	27	30	PF00017	0.488
LIG_SH3_3	216	222	PF00018	0.562
LIG_SH3_3	237	243	PF00018	0.747
LIG_SH3_3	290	296	PF00018	0.745
LIG_TRAF2_1	106	109	PF00917	0.581
LIG_TRAF2_1	199	202	PF00917	0.670
LIG_TRAF2_1	203	206	PF00917	0.627
MOD_CK1_1	134	140	PF00069	0.634
MOD_CK1_1	245	251	PF00069	0.761
MOD_CK1_1	253	259	PF00069	0.726
MOD_CK1_1	269	275	PF00069	0.657
MOD_CK2_1	208	214	PF00069	0.771
MOD_CK2_1	34	40	PF00069	0.576
MOD_CK2_1	97	103	PF00069	0.539
MOD_Cter_Amidation	312	315	PF01082	0.604
MOD_GlcNHglycan	244	247	PF01048	0.732
MOD_GlcNHglycan	252	255	PF01048	0.684
MOD_GlcNHglycan	257	260	PF01048	0.653
MOD_GlcNHglycan	268	271	PF01048	0.652
MOD_GlcNHglycan	273	277	PF01048	0.631
MOD_GlcNHglycan	289	292	PF01048	0.642
MOD_GlcNHglycan	308	311	PF01048	0.498
MOD_GlcNHglycan	54	57	PF01048	0.540
MOD_GlcNHglycan	99	102	PF01048	0.553
MOD_GSK3_1	127	134	PF00069	0.652
MOD_GSK3_1	245	252	PF00069	0.695
MOD_GSK3_1	48	55	PF00069	0.547
MOD_N-GLC_1	32	37	PF02516	0.624
MOD_NEK2_1	306	311	PF00069	0.661
MOD_NEK2_1	32	37	PF00069	0.613
MOD_NEK2_1	66	71	PF00069	0.710
MOD_PIKK_1	103	109	PF00454	0.590
MOD_PKA_2	116	122	PF00069	0.688
MOD_PKA_2	225	231	PF00069	0.729
MOD_PKA_2	306	312	PF00069	0.700
MOD_PKA_2	97	103	PF00069	0.675
MOD_Plk_1	222	228	PF00069	0.782
MOD_Plk_2-3	210	216	PF00069	0.700
MOD_ProDKin_1	178	184	PF00069	0.687
MOD_ProDKin_1	282	288	PF00069	0.653
MOD_SUMO_for_1	175	178	PF00179	0.746
TRG_DiLeu_BaEn_1	109	114	PF01217	0.549
TRG_ENDOCYTIC_2	38	41	PF00928	0.617
TRG_ER_diArg_1	44	47	PF00400	0.651
TRG_ER_diLys_1	314	318	PF00400	0.699
TRG_NLS_MonoCore_2	167	172	PF00514	0.686
TRG_NLS_MonoExtC_3	167	173	PF00514	0.684
TRG_NLS_MonoExtC_3	313	318	PF00514	0.771
TRG_NLS_MonoExtN_4	166	172	PF00514	0.660
TRG_Pf-PMV_PEXEL_1	170	174	PF00026	0.645

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P252	Trypanosomatidae	29%	100%
A0A3S7X3H3	Leishmania donovani	99%	100%
A0A422N7B9	Trypanosoma rangeli	30%	100%
A4HI86	Leishmania braziliensis	70%	100%
C9ZQV1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9B0R3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q7H0	Leishmania major	89%	100%
V5BYY3	Trypanosoma cruzi	31%	79%