ATP-binding cassette protein subfamily H, member 3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP-binding cassette protein subfamily H - member 3 - putative

Species:

Leishmania infantum

UniProt:

A4I5G4_LEIIN

TriTrypDb:

LINF_300018900

Length:

441

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I5G4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5G4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0005215	transporter activity	1	1
GO:0015399	primary active transmembrane transporter activity	4	1
GO:0022804	active transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1
GO:0042626	ATPase-coupled transmembrane transporter activity	2	1
GO:0140657	ATP-dependent activity	1	1
GO:0003824	catalytic activity	1	1
GO:0016787	hydrolase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	191	195	PF00656	0.714
CLV_C14_Caspase3-7	31	35	PF00656	0.462
CLV_C14_Caspase3-7	94	98	PF00656	0.512
CLV_NRD_NRD_1	27	29	PF00675	0.413
CLV_NRD_NRD_1	53	55	PF00675	0.349
CLV_NRD_NRD_1	82	84	PF00675	0.400
CLV_PCSK_KEX2_1	148	150	PF00082	0.602
CLV_PCSK_KEX2_1	208	210	PF00082	0.563
CLV_PCSK_KEX2_1	273	275	PF00082	0.426
CLV_PCSK_KEX2_1	337	339	PF00082	0.327
CLV_PCSK_KEX2_1	52	54	PF00082	0.361
CLV_PCSK_KEX2_1	82	84	PF00082	0.478
CLV_PCSK_PC1ET2_1	148	150	PF00082	0.602
CLV_PCSK_PC1ET2_1	208	210	PF00082	0.493
CLV_PCSK_PC1ET2_1	273	275	PF00082	0.426
CLV_PCSK_PC1ET2_1	337	339	PF00082	0.291
CLV_PCSK_SKI1_1	222	226	PF00082	0.389
CLV_PCSK_SKI1_1	237	241	PF00082	0.305
CLV_PCSK_SKI1_1	258	262	PF00082	0.320
CLV_PCSK_SKI1_1	303	307	PF00082	0.398
CLV_PCSK_SKI1_1	317	321	PF00082	0.122
CLV_PCSK_SKI1_1	380	384	PF00082	0.374
CLV_PCSK_SKI1_1	83	87	PF00082	0.382
CLV_Separin_Metazoa	87	91	PF03568	0.536
DEG_APCC_DBOX_1	82	90	PF00400	0.480
DEG_Nend_Nbox_1	1	3	PF02207	0.535
DEG_SPOP_SBC_1	171	175	PF00917	0.711
DEG_SPOP_SBC_1	180	184	PF00917	0.586
DOC_CKS1_1	187	192	PF01111	0.740
DOC_MAPK_gen_1	208	214	PF00069	0.430
DOC_MAPK_gen_1	273	281	PF00069	0.426
DOC_MAPK_gen_1	312	322	PF00069	0.339
DOC_MAPK_gen_1	337	345	PF00069	0.320
DOC_MAPK_gen_1	82	88	PF00069	0.374
DOC_MAPK_MEF2A_6	315	324	PF00069	0.346
DOC_MAPK_MEF2A_6	337	345	PF00069	0.312
DOC_MAPK_NFAT4_5	338	346	PF00069	0.320
DOC_PP1_RVXF_1	122	129	PF00149	0.534
DOC_PP1_RVXF_1	224	231	PF00149	0.398
DOC_PP2B_LxvP_1	134	137	PF13499	0.462
DOC_USP7_MATH_1	160	164	PF00917	0.694
DOC_USP7_MATH_1	180	184	PF00917	0.669
DOC_USP7_MATH_1	188	192	PF00917	0.508
DOC_USP7_MATH_1	283	287	PF00917	0.355
DOC_USP7_UBL2_3	129	133	PF12436	0.453
DOC_USP7_UBL2_3	222	226	PF12436	0.393
DOC_WW_Pin1_4	18	23	PF00397	0.459
DOC_WW_Pin1_4	186	191	PF00397	0.720
LIG_14-3-3_CanoR_1	366	370	PF00244	0.417
LIG_14-3-3_CanoR_1	380	385	PF00244	0.271
LIG_14-3-3_CanoR_1	416	423	PF00244	0.491
LIG_14-3-3_CanoR_1	82	86	PF00244	0.397
LIG_Clathr_ClatBox_1	117	121	PF01394	0.510
LIG_CSL_BTD_1	5	8	PF09270	0.499
LIG_DLG_GKlike_1	264	271	PF00625	0.410
LIG_eIF4E_1	364	370	PF01652	0.503
LIG_FHA_1	102	108	PF00498	0.385
LIG_FHA_1	113	119	PF00498	0.388
LIG_FHA_1	133	139	PF00498	0.210
LIG_FHA_1	356	362	PF00498	0.367
LIG_FHA_1	64	70	PF00498	0.482
LIG_FHA_2	357	363	PF00498	0.414
LIG_FHA_2	73	79	PF00498	0.358
LIG_FHA_2	82	88	PF00498	0.388
LIG_GBD_Chelix_1	32	40	PF00786	0.378
LIG_HP1_1	350	354	PF01393	0.339
LIG_LIR_Apic_2	184	190	PF02991	0.538
LIG_LIR_Gen_1	229	238	PF02991	0.390
LIG_LIR_Gen_1	290	300	PF02991	0.377
LIG_LIR_Nem_3	127	131	PF02991	0.399
LIG_LIR_Nem_3	223	228	PF02991	0.413
LIG_LIR_Nem_3	229	233	PF02991	0.343
LIG_LIR_Nem_3	290	295	PF02991	0.390
LIG_LIR_Nem_3	388	394	PF02991	0.361
LIG_NRBOX	341	347	PF00104	0.362
LIG_OCRL_FandH_1	260	272	PF00620	0.402
LIG_PDZ_Class_3	436	441	PF00595	0.456
LIG_PTB_Apo_2	224	231	PF02174	0.390
LIG_REV1ctd_RIR_1	258	268	PF16727	0.362
LIG_SH2_CRK	59	63	PF00017	0.329
LIG_SH2_SRC	374	377	PF00017	0.432
LIG_SH2_STAP1	102	106	PF00017	0.372
LIG_SH2_STAP1	141	145	PF00017	0.500
LIG_SH2_STAP1	276	280	PF00017	0.355
LIG_SH2_STAP1	374	378	PF00017	0.376
LIG_SH2_STAP1	386	390	PF00017	0.298
LIG_SH2_STAT3	141	144	PF00017	0.496
LIG_SH2_STAT5	68	71	PF00017	0.333
LIG_SH3_3	156	162	PF00018	0.717
LIG_SH3_3	16	22	PF00018	0.410
LIG_SH3_3	2	8	PF00018	0.469
LIG_SH3_5	137	141	PF00018	0.523
LIG_SUMO_SIM_anti_2	115	121	PF11976	0.393
LIG_SUMO_SIM_anti_2	267	272	PF11976	0.355
LIG_SUMO_SIM_anti_2	84	90	PF11976	0.418
LIG_SUMO_SIM_par_1	318	323	PF11976	0.390
LIG_SUMO_SIM_par_1	347	356	PF11976	0.305
LIG_TYR_ITIM	219	224	PF00017	0.393
LIG_TYR_ITIM	57	62	PF00017	0.311
LIG_UBA3_1	251	258	PF00899	0.320
LIG_UBA3_1	341	349	PF00899	0.320
MOD_CK1_1	165	171	PF00069	0.673
MOD_CK2_1	308	314	PF00069	0.449
MOD_CK2_1	329	335	PF00069	0.305
MOD_CK2_1	45	51	PF00069	0.402
MOD_CK2_1	81	87	PF00069	0.547
MOD_Cter_Amidation	271	274	PF01082	0.426
MOD_DYRK1A_RPxSP_1	18	22	PF00069	0.560
MOD_GlcNHglycan	168	171	PF01048	0.704
MOD_GlcNHglycan	176	179	PF01048	0.723
MOD_GlcNHglycan	183	186	PF01048	0.687
MOD_GSK3_1	162	169	PF00069	0.635
MOD_GSK3_1	170	177	PF00069	0.648
MOD_GSK3_1	243	250	PF00069	0.350
MOD_GSK3_1	380	387	PF00069	0.371
MOD_N-GLC_1	226	231	PF02516	0.418
MOD_N-GLC_1	243	248	PF02516	0.185
MOD_NEK2_1	308	313	PF00069	0.454
MOD_NEK2_1	38	43	PF00069	0.384
MOD_NEK2_1	404	409	PF00069	0.388
MOD_PIKK_1	162	168	PF00454	0.657
MOD_PK_1	28	34	PF00069	0.483
MOD_PKA_1	28	34	PF00069	0.504
MOD_PKA_2	308	314	PF00069	0.402
MOD_PKA_2	365	371	PF00069	0.393
MOD_PKA_2	38	44	PF00069	0.501
MOD_PKA_2	415	421	PF00069	0.521
MOD_PKA_2	81	87	PF00069	0.401
MOD_Plk_1	226	232	PF00069	0.378
MOD_Plk_1	374	380	PF00069	0.505
MOD_Plk_1	404	410	PF00069	0.538
MOD_Plk_2-3	356	362	PF00069	0.397
MOD_Plk_2-3	45	51	PF00069	0.453
MOD_Plk_2-3	72	78	PF00069	0.371
MOD_Plk_2-3	81	87	PF00069	0.385
MOD_Plk_4	195	201	PF00069	0.643
MOD_Plk_4	247	253	PF00069	0.305
MOD_Plk_4	266	272	PF00069	0.305
MOD_Plk_4	365	371	PF00069	0.358
MOD_Plk_4	380	386	PF00069	0.299
MOD_Plk_4	63	69	PF00069	0.465
MOD_ProDKin_1	18	24	PF00069	0.463
MOD_ProDKin_1	186	192	PF00069	0.721
MOD_SUMO_rev_2	121	131	PF00179	0.471
MOD_SUMO_rev_2	21	31	PF00179	0.557
MOD_SUMO_rev_2	332	339	PF00179	0.275
TRG_ENDOCYTIC_2	221	224	PF00928	0.401
TRG_ENDOCYTIC_2	276	279	PF00928	0.320
TRG_ENDOCYTIC_2	59	62	PF00928	0.334
TRG_ER_diArg_1	52	54	PF00400	0.339
TRG_NES_CRM1_1	314	327	PF08389	0.362

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0H2VFI8	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	25%	79%
A0A0N1I8R4	Leptomonas seymouri	70%	84%
A0A0S4J6G0	Bodo saltans	51%	85%
A0A1X0P1Z8	Trypanosomatidae	56%	86%
A0A3R7K7R6	Trypanosoma rangeli	56%	88%
A0A3S7X391	Leishmania donovani	99%	100%
A4HI85	Leishmania braziliensis	79%	100%
C9ZQV0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	85%
E9B0R2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
P0A9W3	Escherichia coli (strain K12)	25%	79%
P0A9W4	Escherichia coli O157:H7	25%	79%
P0A9W5	Shigella flexneri	25%	79%
P39115	Bacillus subtilis (strain 168)	23%	81%
P45127	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	25%	79%
Q4Q7H1	Leishmania major	93%	100%
Q87G35	Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)	24%	76%
V5BPK8	Trypanosoma cruzi	57%	94%