LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Zinc finger - C3HC4 type (RING finger) containing protein - putative
Species:
Leishmania infantum
UniProt:
A4I5F4_LEIIN
TriTrypDb:
LINF_300017900
Length:
723

Annotations

Annotations by Jardim et al.

Metal Binding, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005730 nucleolus 5 1
GO:0005737 cytoplasm 2 1
GO:0043226 organelle 2 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4I5F4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5F4

Function

Biological processes
Term Name Level Count
GO:0006414 translational elongation 5 11
GO:0008152 metabolic process 1 11
GO:0009058 biosynthetic process 2 11
GO:0009059 macromolecule biosynthetic process 4 11
GO:0009987 cellular process 1 11
GO:0034645 obsolete cellular macromolecule biosynthetic process 4 11
GO:0043170 macromolecule metabolic process 3 11
GO:0044237 cellular metabolic process 2 11
GO:0044249 cellular biosynthetic process 3 11
GO:0044260 obsolete cellular macromolecule metabolic process 3 11
GO:0071704 organic substance metabolic process 2 11
GO:0072344 rescue of stalled ribosome 6 11
GO:1901576 organic substance biosynthetic process 3 11
GO:0006807 nitrogen compound metabolic process 2 1
GO:0016567 protein ubiquitination 7 1
GO:0019538 protein metabolic process 3 1
GO:0032446 protein modification by small protein conjugation 6 1
GO:0036211 protein modification process 4 1
GO:0043412 macromolecule modification 4 1
GO:0044238 primary metabolic process 2 1
GO:0070647 protein modification by small protein conjugation or removal 5 1
GO:1901564 organonitrogen compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 11
GO:0004842 ubiquitin-protein transferase activity 4 11
GO:0016740 transferase activity 2 11
GO:0019787 ubiquitin-like protein transferase activity 3 11
GO:0061630 ubiquitin protein ligase activity 5 11
GO:0061659 ubiquitin-like protein ligase activity 4 11
GO:0140096 catalytic activity, acting on a protein 2 11
GO:0005488 binding 1 4
GO:0043021 ribonucleoprotein complex binding 3 1
GO:0043022 ribosome binding 4 1
GO:0043167 ion binding 2 4
GO:0043169 cation binding 3 4
GO:0044877 protein-containing complex binding 2 1
GO:0046872 metal ion binding 4 4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 103 105 PF00675 0.575
CLV_NRD_NRD_1 360 362 PF00675 0.649
CLV_NRD_NRD_1 546 548 PF00675 0.570
CLV_NRD_NRD_1 590 592 PF00675 0.690
CLV_NRD_NRD_1 705 707 PF00675 0.645
CLV_NRD_NRD_1 73 75 PF00675 0.410
CLV_PCSK_KEX2_1 103 105 PF00082 0.575
CLV_PCSK_KEX2_1 213 215 PF00082 0.543
CLV_PCSK_KEX2_1 360 362 PF00082 0.647
CLV_PCSK_KEX2_1 705 707 PF00082 0.643
CLV_PCSK_PC1ET2_1 213 215 PF00082 0.543
CLV_PCSK_SKI1_1 104 108 PF00082 0.508
CLV_PCSK_SKI1_1 173 177 PF00082 0.334
CLV_PCSK_SKI1_1 460 464 PF00082 0.431
CLV_PCSK_SKI1_1 592 596 PF00082 0.640
CLV_PCSK_SKI1_1 597 601 PF00082 0.617
CLV_PCSK_SKI1_1 75 79 PF00082 0.355
DEG_APCC_KENBOX_2 351 355 PF00400 0.636
DEG_SPOP_SBC_1 404 408 PF00917 0.681
DEG_SPOP_SBC_1 422 426 PF00917 0.524
DEG_SPOP_SBC_1 634 638 PF00917 0.723
DOC_ANK_TNKS_1 704 711 PF00023 0.538
DOC_CKS1_1 669 674 PF01111 0.603
DOC_MAPK_gen_1 74 82 PF00069 0.364
DOC_PP1_RVXF_1 297 303 PF00149 0.503
DOC_PP4_FxxP_1 497 500 PF00568 0.516
DOC_USP7_MATH_1 134 138 PF00917 0.418
DOC_USP7_MATH_1 310 314 PF00917 0.581
DOC_USP7_MATH_1 319 323 PF00917 0.644
DOC_USP7_MATH_1 325 329 PF00917 0.656
DOC_USP7_MATH_1 404 408 PF00917 0.651
DOC_USP7_MATH_1 414 418 PF00917 0.649
DOC_USP7_MATH_1 423 427 PF00917 0.680
DOC_USP7_MATH_1 567 571 PF00917 0.614
DOC_USP7_MATH_1 577 581 PF00917 0.597
DOC_USP7_MATH_1 626 630 PF00917 0.737
DOC_USP7_MATH_1 635 639 PF00917 0.659
DOC_USP7_MATH_1 642 646 PF00917 0.627
DOC_USP7_MATH_1 661 665 PF00917 0.441
DOC_USP7_MATH_1 673 677 PF00917 0.607
DOC_WW_Pin1_4 115 120 PF00397 0.475
DOC_WW_Pin1_4 22 27 PF00397 0.648
DOC_WW_Pin1_4 300 305 PF00397 0.585
DOC_WW_Pin1_4 461 466 PF00397 0.539
DOC_WW_Pin1_4 578 583 PF00397 0.752
DOC_WW_Pin1_4 584 589 PF00397 0.662
DOC_WW_Pin1_4 668 673 PF00397 0.719
DOC_WW_Pin1_4 678 683 PF00397 0.663
LIG_14-3-3_CanoR_1 103 112 PF00244 0.535
LIG_14-3-3_CanoR_1 200 204 PF00244 0.556
LIG_14-3-3_CanoR_1 240 246 PF00244 0.476
LIG_14-3-3_CanoR_1 419 423 PF00244 0.725
LIG_14-3-3_CanoR_1 61 66 PF00244 0.410
LIG_Actin_WH2_2 98 115 PF00022 0.462
LIG_AP2alpha_2 145 147 PF02296 0.494
LIG_APCC_ABBA_1 24 29 PF00400 0.518
LIG_BIR_II_1 1 5 PF00653 0.713
LIG_BRCT_BRCA1_1 387 391 PF00533 0.432
LIG_BRCT_BRCA1_1 424 428 PF00533 0.681
LIG_BRCT_BRCA1_1 664 668 PF00533 0.564
LIG_eIF4E_1 219 225 PF01652 0.355
LIG_EVH1_2 207 211 PF00568 0.425
LIG_FHA_1 130 136 PF00498 0.448
LIG_FHA_1 232 238 PF00498 0.410
LIG_FHA_1 318 324 PF00498 0.560
LIG_FHA_1 393 399 PF00498 0.570
LIG_FHA_1 511 517 PF00498 0.408
LIG_FHA_1 533 539 PF00498 0.588
LIG_FHA_1 82 88 PF00498 0.407
LIG_LIR_Apic_2 130 134 PF02991 0.332
LIG_LIR_Apic_2 495 500 PF02991 0.513
LIG_LIR_Gen_1 145 153 PF02991 0.436
LIG_LIR_Gen_1 162 170 PF02991 0.341
LIG_LIR_Gen_1 336 343 PF02991 0.431
LIG_LIR_Gen_1 467 474 PF02991 0.548
LIG_LIR_Gen_1 486 497 PF02991 0.305
LIG_LIR_Nem_3 162 168 PF02991 0.448
LIG_LIR_Nem_3 244 248 PF02991 0.378
LIG_LIR_Nem_3 336 340 PF02991 0.415
LIG_LIR_Nem_3 388 394 PF02991 0.421
LIG_LIR_Nem_3 467 471 PF02991 0.536
LIG_LIR_Nem_3 485 491 PF02991 0.355
LIG_LIR_Nem_3 505 510 PF02991 0.320
LIG_LIR_Nem_3 693 699 PF02991 0.594
LIG_LRP6_Inhibitor_1 699 705 PF00058 0.604
LIG_NRP_CendR_1 722 723 PF00754 0.729
LIG_PCNA_PIPBox_1 150 159 PF02747 0.359
LIG_PCNA_yPIPBox_3 519 527 PF02747 0.395
LIG_Pex14_1 139 143 PF04695 0.418
LIG_Pex14_2 243 247 PF04695 0.486
LIG_Pex14_2 337 341 PF04695 0.528
LIG_Pex14_2 503 507 PF04695 0.414
LIG_SH2_CRK 131 135 PF00017 0.362
LIG_SH2_CRK 489 493 PF00017 0.401
LIG_SH2_SRC 143 146 PF00017 0.494
LIG_SH2_STAP1 183 187 PF00017 0.428
LIG_SH2_STAP1 233 237 PF00017 0.483
LIG_SH2_STAP1 27 31 PF00017 0.455
LIG_SH2_STAP1 474 478 PF00017 0.484
LIG_SH2_STAP1 489 493 PF00017 0.531
LIG_SH2_STAT5 131 134 PF00017 0.298
LIG_SH2_STAT5 165 168 PF00017 0.315
LIG_SH2_STAT5 233 236 PF00017 0.497
LIG_SH2_STAT5 385 388 PF00017 0.457
LIG_SH2_STAT5 474 477 PF00017 0.502
LIG_SH2_STAT5 53 56 PF00017 0.327
LIG_SH3_3 370 376 PF00018 0.504
LIG_SH3_3 459 465 PF00018 0.616
LIG_SH3_3 666 672 PF00018 0.686
LIG_SH3_3 676 682 PF00018 0.652
LIG_SH3_3 694 700 PF00018 0.546
LIG_SUMO_SIM_anti_2 283 288 PF11976 0.486
LIG_SUMO_SIM_par_1 507 513 PF11976 0.352
LIG_TRAF2_1 375 378 PF00917 0.512
LIG_TRAF2_1 522 525 PF00917 0.503
LIG_TRAF2_1 541 544 PF00917 0.422
LIG_TRAF2_1 88 91 PF00917 0.527
LIG_TRAF2_2 620 625 PF00917 0.719
LIG_TYR_ITIM 163 168 PF00017 0.315
MOD_CDK_SPxxK_3 584 591 PF00069 0.710
MOD_CK1_1 201 207 PF00069 0.496
MOD_CK1_1 25 31 PF00069 0.592
MOD_CK1_1 311 317 PF00069 0.621
MOD_CK1_1 397 403 PF00069 0.647
MOD_CK1_1 417 423 PF00069 0.692
MOD_CK1_1 464 470 PF00069 0.488
MOD_CK1_1 570 576 PF00069 0.739
MOD_CK1_1 664 670 PF00069 0.629
MOD_CK2_1 85 91 PF00069 0.560
MOD_CK2_1 92 98 PF00069 0.550
MOD_Cter_Amidation 358 361 PF01082 0.636
MOD_GlcNHglycan 14 17 PF01048 0.642
MOD_GlcNHglycan 18 21 PF01048 0.545
MOD_GlcNHglycan 309 313 PF01048 0.631
MOD_GlcNHglycan 387 390 PF01048 0.570
MOD_GlcNHglycan 407 410 PF01048 0.738
MOD_GlcNHglycan 420 423 PF01048 0.470
MOD_GlcNHglycan 425 428 PF01048 0.643
MOD_GlcNHglycan 480 483 PF01048 0.404
MOD_GlcNHglycan 617 620 PF01048 0.734
MOD_GlcNHglycan 625 629 PF01048 0.498
MOD_GlcNHglycan 637 640 PF01048 0.632
MOD_GlcNHglycan 664 667 PF01048 0.619
MOD_GlcNHglycan 675 678 PF01048 0.641
MOD_GlcNHglycan 94 97 PF01048 0.526
MOD_GSK3_1 12 19 PF00069 0.694
MOD_GSK3_1 243 250 PF00069 0.457
MOD_GSK3_1 319 326 PF00069 0.680
MOD_GSK3_1 413 420 PF00069 0.742
MOD_GSK3_1 478 485 PF00069 0.479
MOD_GSK3_1 604 611 PF00069 0.670
MOD_GSK3_1 626 633 PF00069 0.658
MOD_GSK3_1 664 671 PF00069 0.642
MOD_GSK3_1 673 680 PF00069 0.608
MOD_GSK3_1 81 88 PF00069 0.453
MOD_LATS_1 470 476 PF00433 0.385
MOD_N-GLC_1 16 21 PF02516 0.756
MOD_N-GLC_1 417 422 PF02516 0.733
MOD_N-GLC_1 577 582 PF02516 0.614
MOD_NEK2_1 243 248 PF00069 0.398
MOD_NEK2_1 394 399 PF00069 0.585
MOD_NEK2_1 478 483 PF00069 0.461
MOD_NEK2_1 613 618 PF00069 0.731
MOD_NEK2_2 51 56 PF00069 0.410
MOD_NEK2_2 642 647 PF00069 0.740
MOD_OFUCOSY 133 138 PF10250 0.410
MOD_OFUCOSY 50 55 PF10250 0.410
MOD_PIKK_1 532 538 PF00454 0.571
MOD_PIKK_1 75 81 PF00454 0.353
MOD_PKA_2 199 205 PF00069 0.540
MOD_PKA_2 414 420 PF00069 0.737
MOD_PKA_2 66 72 PF00069 0.246
MOD_Plk_1 198 204 PF00069 0.482
MOD_Plk_1 692 698 PF00069 0.662
MOD_Plk_1 75 81 PF00069 0.306
MOD_Plk_4 220 226 PF00069 0.435
MOD_Plk_4 664 670 PF00069 0.552
MOD_ProDKin_1 115 121 PF00069 0.469
MOD_ProDKin_1 22 28 PF00069 0.636
MOD_ProDKin_1 300 306 PF00069 0.587
MOD_ProDKin_1 461 467 PF00069 0.535
MOD_ProDKin_1 578 584 PF00069 0.753
MOD_ProDKin_1 668 674 PF00069 0.719
MOD_ProDKin_1 678 684 PF00069 0.664
MOD_SUMO_rev_2 545 555 PF00179 0.545
TRG_DiLeu_LyEn_5 505 510 PF01217 0.285
TRG_ENDOCYTIC_2 165 168 PF00928 0.315
TRG_ENDOCYTIC_2 468 471 PF00928 0.447
TRG_ENDOCYTIC_2 488 491 PF00928 0.309
TRG_ER_diArg_1 102 104 PF00400 0.482
TRG_ER_diArg_1 704 706 PF00400 0.707
TRG_NES_CRM1_1 149 162 PF08389 0.429

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IA72 Leptomonas seymouri 65% 100%
A0A0S4KKN7 Bodo saltans 39% 100%
A0A1X0P1Y0 Trypanosomatidae 43% 100%
A0A3S7X380 Leishmania donovani 100% 100%
A0A422P542 Trypanosoma rangeli 40% 100%
A4HI75 Leishmania braziliensis 81% 100%
E9B0Q2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q4Q7I1 Leishmania major 94% 100%
V5BYZ6 Trypanosoma cruzi 36% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS