LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
AAA domain containing protein - putative
Species:
Leishmania infantum
UniProt:
A4I5F3_LEIIN
TriTrypDb:
LINF_300017800
Length:
930

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 3
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I5F3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5F3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 433 437 PF00656 0.464
CLV_C14_Caspase3-7 451 455 PF00656 0.433
CLV_C14_Caspase3-7 548 552 PF00656 0.549
CLV_C14_Caspase3-7 560 564 PF00656 0.545
CLV_NRD_NRD_1 127 129 PF00675 0.841
CLV_NRD_NRD_1 168 170 PF00675 0.778
CLV_NRD_NRD_1 199 201 PF00675 0.859
CLV_NRD_NRD_1 513 515 PF00675 0.543
CLV_NRD_NRD_1 820 822 PF00675 0.740
CLV_NRD_NRD_1 866 868 PF00675 0.781
CLV_NRD_NRD_1 92 94 PF00675 0.856
CLV_PCSK_KEX2_1 125 127 PF00082 0.784
CLV_PCSK_KEX2_1 167 169 PF00082 0.789
CLV_PCSK_KEX2_1 199 201 PF00082 0.859
CLV_PCSK_KEX2_1 513 515 PF00082 0.493
CLV_PCSK_KEX2_1 546 548 PF00082 0.514
CLV_PCSK_KEX2_1 820 822 PF00082 0.740
CLV_PCSK_KEX2_1 92 94 PF00082 0.856
CLV_PCSK_PC1ET2_1 125 127 PF00082 0.784
CLV_PCSK_PC1ET2_1 546 548 PF00082 0.514
CLV_PCSK_PC7_1 542 548 PF00082 0.506
CLV_PCSK_SKI1_1 153 157 PF00082 0.756
CLV_PCSK_SKI1_1 735 739 PF00082 0.565
CLV_PCSK_SKI1_1 839 843 PF00082 0.798
CLV_Separin_Metazoa 409 413 PF03568 0.409
DEG_APCC_DBOX_1 734 742 PF00400 0.563
DEG_APCC_DBOX_1 819 827 PF00400 0.727
DEG_ODPH_VHL_1 651 664 PF01847 0.505
DEG_SCF_FBW7_1 755 761 PF00400 0.842
DEG_SPOP_SBC_1 40 44 PF00917 0.752
DOC_ANK_TNKS_1 546 553 PF00023 0.537
DOC_CKS1_1 104 109 PF01111 0.789
DOC_CKS1_1 755 760 PF01111 0.740
DOC_CKS1_1 872 877 PF01111 0.723
DOC_CYCLIN_yCln2_LP_2 444 450 PF00134 0.433
DOC_MAPK_DCC_7 820 828 PF00069 0.701
DOC_MAPK_gen_1 301 309 PF00069 0.601
DOC_MAPK_gen_1 513 521 PF00069 0.552
DOC_MAPK_gen_1 765 773 PF00069 0.641
DOC_MAPK_gen_1 820 828 PF00069 0.701
DOC_MAPK_MEF2A_6 513 521 PF00069 0.446
DOC_MAPK_MEF2A_6 693 700 PF00069 0.558
DOC_PP2B_LxvP_1 357 360 PF13499 0.534
DOC_PP2B_LxvP_1 692 695 PF13499 0.680
DOC_PP2B_LxvP_1 771 774 PF13499 0.634
DOC_PP2B_LxvP_1 815 818 PF13499 0.733
DOC_USP7_MATH_1 140 144 PF00917 0.738
DOC_USP7_MATH_1 18 22 PF00917 0.743
DOC_USP7_MATH_1 242 246 PF00917 0.691
DOC_USP7_MATH_1 29 33 PF00917 0.623
DOC_USP7_MATH_1 290 294 PF00917 0.559
DOC_USP7_MATH_1 315 319 PF00917 0.433
DOC_USP7_MATH_1 380 384 PF00917 0.534
DOC_USP7_MATH_1 456 460 PF00917 0.433
DOC_USP7_MATH_1 520 524 PF00917 0.622
DOC_USP7_MATH_1 550 554 PF00917 0.564
DOC_USP7_MATH_1 594 598 PF00917 0.798
DOC_USP7_MATH_1 679 683 PF00917 0.812
DOC_USP7_MATH_1 705 709 PF00917 0.548
DOC_USP7_MATH_1 79 83 PF00917 0.722
DOC_USP7_MATH_1 803 807 PF00917 0.743
DOC_USP7_MATH_1 837 841 PF00917 0.756
DOC_USP7_UBL2_3 125 129 PF12436 0.834
DOC_WW_Pin1_4 103 108 PF00397 0.723
DOC_WW_Pin1_4 191 196 PF00397 0.749
DOC_WW_Pin1_4 224 229 PF00397 0.741
DOC_WW_Pin1_4 275 280 PF00397 0.615
DOC_WW_Pin1_4 597 602 PF00397 0.837
DOC_WW_Pin1_4 754 759 PF00397 0.739
DOC_WW_Pin1_4 853 858 PF00397 0.797
DOC_WW_Pin1_4 871 876 PF00397 0.673
DOC_WW_Pin1_4 920 925 PF00397 0.737
LIG_14-3-3_CanoR_1 200 206 PF00244 0.767
LIG_14-3-3_CanoR_1 399 407 PF00244 0.433
LIG_14-3-3_CanoR_1 457 463 PF00244 0.391
LIG_14-3-3_CanoR_1 588 592 PF00244 0.713
LIG_14-3-3_CanoR_1 611 617 PF00244 0.563
LIG_14-3-3_CanoR_1 634 640 PF00244 0.501
LIG_14-3-3_CanoR_1 659 665 PF00244 0.490
LIG_APCC_ABBA_1 694 699 PF00400 0.549
LIG_APCC_ABBA_1 94 99 PF00400 0.726
LIG_BIR_III_4 154 158 PF00653 0.739
LIG_BIR_III_4 253 257 PF00653 0.651
LIG_BRCT_BRCA1_1 263 267 PF00533 0.722
LIG_BRCT_BRCA1_1 478 482 PF00533 0.433
LIG_BRCT_BRCA1_1 725 729 PF00533 0.525
LIG_EVH1_1 94 98 PF00568 0.723
LIG_FHA_1 11 17 PF00498 0.720
LIG_FHA_1 132 138 PF00498 0.769
LIG_FHA_1 187 193 PF00498 0.751
LIG_FHA_1 342 348 PF00498 0.433
LIG_FHA_1 385 391 PF00498 0.381
LIG_FHA_1 415 421 PF00498 0.409
LIG_FHA_1 506 512 PF00498 0.625
LIG_FHA_1 528 534 PF00498 0.532
LIG_FHA_1 634 640 PF00498 0.454
LIG_FHA_1 646 652 PF00498 0.462
LIG_FHA_1 659 665 PF00498 0.462
LIG_FHA_1 709 715 PF00498 0.516
LIG_FHA_1 718 724 PF00498 0.532
LIG_FHA_1 745 751 PF00498 0.705
LIG_FHA_1 759 765 PF00498 0.750
LIG_FHA_1 768 774 PF00498 0.695
LIG_FHA_1 846 852 PF00498 0.828
LIG_FHA_1 885 891 PF00498 0.637
LIG_FHA_1 99 105 PF00498 0.828
LIG_FHA_2 144 150 PF00498 0.731
LIG_FHA_2 431 437 PF00498 0.534
LIG_FHA_2 478 484 PF00498 0.433
LIG_FHA_2 625 631 PF00498 0.630
LIG_FHA_2 778 784 PF00498 0.624
LIG_IRF3_LxIS_1 828 834 PF10401 0.736
LIG_LIR_Gen_1 404 414 PF02991 0.414
LIG_LIR_Gen_1 423 432 PF02991 0.433
LIG_LIR_Nem_3 264 270 PF02991 0.770
LIG_LIR_Nem_3 373 379 PF02991 0.399
LIG_LIR_Nem_3 404 410 PF02991 0.414
LIG_LIR_Nem_3 423 428 PF02991 0.433
LIG_LIR_Nem_3 439 444 PF02991 0.374
LIG_LIR_Nem_3 508 512 PF02991 0.458
LIG_LIR_Nem_3 614 620 PF02991 0.661
LIG_LIR_Nem_3 726 732 PF02991 0.547
LIG_LIR_Nem_3 91 97 PF02991 0.641
LIG_Pex14_2 729 733 PF04695 0.569
LIG_REV1ctd_RIR_1 555 563 PF16727 0.530
LIG_SH2_CRK 270 274 PF00017 0.626
LIG_SH2_CRK 425 429 PF00017 0.433
LIG_SH2_CRK 617 621 PF00017 0.543
LIG_SH2_CRK 724 728 PF00017 0.479
LIG_SH2_STAP1 377 381 PF00017 0.433
LIG_SH2_STAP1 425 429 PF00017 0.378
LIG_SH2_STAP1 724 728 PF00017 0.479
LIG_SH2_STAT5 467 470 PF00017 0.433
LIG_SH2_STAT5 510 513 PF00017 0.509
LIG_SH2_STAT5 526 529 PF00017 0.514
LIG_SH2_STAT5 724 727 PF00017 0.532
LIG_SH3_1 92 98 PF00018 0.724
LIG_SH3_3 130 136 PF00018 0.749
LIG_SH3_3 189 195 PF00018 0.749
LIG_SH3_3 227 233 PF00018 0.730
LIG_SH3_3 252 258 PF00018 0.815
LIG_SH3_3 465 471 PF00018 0.534
LIG_SH3_3 501 507 PF00018 0.625
LIG_SH3_3 514 520 PF00018 0.555
LIG_SH3_3 53 59 PF00018 0.732
LIG_SH3_3 588 594 PF00018 0.741
LIG_SH3_3 752 758 PF00018 0.723
LIG_SH3_3 810 816 PF00018 0.734
LIG_SH3_3 869 875 PF00018 0.721
LIG_SH3_3 910 916 PF00018 0.644
LIG_SH3_3 92 98 PF00018 0.646
LIG_SUMO_SIM_anti_2 186 192 PF11976 0.542
LIG_SUMO_SIM_anti_2 416 423 PF11976 0.409
LIG_SUMO_SIM_par_1 158 164 PF11976 0.621
LIG_SUMO_SIM_par_1 186 194 PF11976 0.726
LIG_SUMO_SIM_par_1 343 348 PF11976 0.433
LIG_SUMO_SIM_par_1 386 392 PF11976 0.433
LIG_SUMO_SIM_par_1 660 666 PF11976 0.532
LIG_TRAF2_1 31 34 PF00917 0.819
LIG_TRAF2_1 672 675 PF00917 0.760
LIG_TRAF2_1 881 884 PF00917 0.742
LIG_TYR_ITSM 266 273 PF00017 0.670
LIG_UBA3_1 320 327 PF00899 0.433
LIG_WW_2 813 816 PF00397 0.816
LIG_WW_3 573 577 PF00397 0.765
MOD_CDK_SPK_2 754 759 PF00069 0.739
MOD_CDK_SPxxK_3 758 765 PF00069 0.767
MOD_CK1_1 131 137 PF00069 0.746
MOD_CK1_1 143 149 PF00069 0.748
MOD_CK1_1 201 207 PF00069 0.835
MOD_CK1_1 21 27 PF00069 0.774
MOD_CK1_1 223 229 PF00069 0.753
MOD_CK1_1 265 271 PF00069 0.685
MOD_CK1_1 536 542 PF00069 0.639
MOD_CK1_1 579 585 PF00069 0.744
MOD_CK1_1 586 592 PF00069 0.795
MOD_CK1_1 597 603 PF00069 0.730
MOD_CK1_1 708 714 PF00069 0.525
MOD_CK1_1 753 759 PF00069 0.734
MOD_CK1_1 840 846 PF00069 0.722
MOD_CK1_1 876 882 PF00069 0.743
MOD_CK2_1 143 149 PF00069 0.731
MOD_CK2_1 191 197 PF00069 0.830
MOD_CK2_1 28 34 PF00069 0.715
MOD_CK2_1 477 483 PF00069 0.433
MOD_CK2_1 610 616 PF00069 0.511
MOD_CK2_1 624 630 PF00069 0.645
MOD_CK2_1 713 719 PF00069 0.523
MOD_CK2_1 840 846 PF00069 0.705
MOD_Cter_Amidation 197 200 PF01082 0.837
MOD_DYRK1A_RPxSP_1 275 279 PF00069 0.608
MOD_GlcNHglycan 130 133 PF01048 0.656
MOD_GlcNHglycan 20 23 PF01048 0.768
MOD_GlcNHglycan 200 203 PF01048 0.769
MOD_GlcNHglycan 222 225 PF01048 0.841
MOD_GlcNHglycan 275 278 PF01048 0.561
MOD_GlcNHglycan 321 324 PF01048 0.433
MOD_GlcNHglycan 522 525 PF01048 0.573
MOD_GlcNHglycan 582 585 PF01048 0.818
MOD_GlcNHglycan 607 610 PF01048 0.630
MOD_GlcNHglycan 782 786 PF01048 0.777
MOD_GlcNHglycan 833 836 PF01048 0.724
MOD_GlcNHglycan 839 842 PF01048 0.744
MOD_GlcNHglycan 99 104 PF01048 0.784
MOD_GSK3_1 200 207 PF00069 0.766
MOD_GSK3_1 220 227 PF00069 0.591
MOD_GSK3_1 238 245 PF00069 0.685
MOD_GSK3_1 261 268 PF00069 0.748
MOD_GSK3_1 315 322 PF00069 0.433
MOD_GSK3_1 341 348 PF00069 0.421
MOD_GSK3_1 380 387 PF00069 0.383
MOD_GSK3_1 388 395 PF00069 0.390
MOD_GSK3_1 520 527 PF00069 0.525
MOD_GSK3_1 563 570 PF00069 0.678
MOD_GSK3_1 57 64 PF00069 0.747
MOD_GSK3_1 575 582 PF00069 0.682
MOD_GSK3_1 583 590 PF00069 0.826
MOD_GSK3_1 595 602 PF00069 0.508
MOD_GSK3_1 663 670 PF00069 0.547
MOD_GSK3_1 705 712 PF00069 0.540
MOD_GSK3_1 713 720 PF00069 0.537
MOD_GSK3_1 749 756 PF00069 0.723
MOD_GSK3_1 763 770 PF00069 0.649
MOD_GSK3_1 777 784 PF00069 0.630
MOD_GSK3_1 884 891 PF00069 0.622
MOD_GSK3_1 916 923 PF00069 0.750
MOD_GSK3_1 99 106 PF00069 0.848
MOD_N-GLC_1 477 482 PF02516 0.433
MOD_NEK2_1 220 225 PF00069 0.754
MOD_NEK2_1 262 267 PF00069 0.804
MOD_NEK2_1 345 350 PF00069 0.408
MOD_NEK2_1 365 370 PF00069 0.204
MOD_NEK2_1 476 481 PF00069 0.378
MOD_NEK2_1 533 538 PF00069 0.551
MOD_NEK2_1 557 562 PF00069 0.531
MOD_NEK2_1 587 592 PF00069 0.715
MOD_NEK2_1 633 638 PF00069 0.529
MOD_NEK2_1 709 714 PF00069 0.516
MOD_NEK2_1 71 76 PF00069 0.773
MOD_NEK2_1 723 728 PF00069 0.545
MOD_NEK2_1 751 756 PF00069 0.830
MOD_NEK2_1 831 836 PF00069 0.752
MOD_NEK2_1 860 865 PF00069 0.719
MOD_NEK2_2 140 145 PF00069 0.651
MOD_NEK2_2 242 247 PF00069 0.611
MOD_NEK2_2 4 9 PF00069 0.805
MOD_NEK2_2 79 84 PF00069 0.639
MOD_NEK2_2 803 808 PF00069 0.744
MOD_NMyristoyl 1 7 PF02799 0.688
MOD_PIKK_1 365 371 PF00454 0.433
MOD_PIKK_1 491 497 PF00454 0.538
MOD_PIKK_1 533 539 PF00454 0.551
MOD_PIKK_1 599 605 PF00454 0.689
MOD_PIKK_1 71 77 PF00454 0.715
MOD_PKA_1 128 134 PF00069 0.724
MOD_PKA_2 198 204 PF00069 0.763
MOD_PKA_2 392 398 PF00069 0.433
MOD_PKA_2 456 462 PF00069 0.391
MOD_PKA_2 575 581 PF00069 0.778
MOD_PKA_2 587 593 PF00069 0.652
MOD_PKA_2 610 616 PF00069 0.568
MOD_PKA_2 623 629 PF00069 0.546
MOD_PKA_2 633 639 PF00069 0.419
MOD_PKA_2 658 664 PF00069 0.528
MOD_PKA_2 69 75 PF00069 0.776
MOD_PKB_1 126 134 PF00069 0.720
MOD_Plk_1 186 192 PF00069 0.703
MOD_Plk_1 355 361 PF00069 0.459
MOD_Plk_1 477 483 PF00069 0.386
MOD_Plk_1 645 651 PF00069 0.449
MOD_Plk_1 803 809 PF00069 0.750
MOD_Plk_1 861 867 PF00069 0.813
MOD_Plk_1 99 105 PF00069 0.809
MOD_Plk_2-3 392 398 PF00069 0.433
MOD_Plk_4 140 146 PF00069 0.772
MOD_Plk_4 186 192 PF00069 0.707
MOD_Plk_4 316 322 PF00069 0.433
MOD_Plk_4 341 347 PF00069 0.433
MOD_Plk_4 384 390 PF00069 0.433
MOD_Plk_4 505 511 PF00069 0.545
MOD_Plk_4 528 534 PF00069 0.511
MOD_Plk_4 564 570 PF00069 0.617
MOD_Plk_4 646 652 PF00069 0.502
MOD_Plk_4 709 715 PF00069 0.468
MOD_Plk_4 803 809 PF00069 0.744
MOD_Plk_4 909 915 PF00069 0.761
MOD_ProDKin_1 103 109 PF00069 0.721
MOD_ProDKin_1 191 197 PF00069 0.748
MOD_ProDKin_1 224 230 PF00069 0.739
MOD_ProDKin_1 275 281 PF00069 0.621
MOD_ProDKin_1 597 603 PF00069 0.830
MOD_ProDKin_1 754 760 PF00069 0.739
MOD_ProDKin_1 853 859 PF00069 0.796
MOD_ProDKin_1 871 877 PF00069 0.674
MOD_ProDKin_1 920 926 PF00069 0.735
MOD_SUMO_for_1 545 548 PF00179 0.495
MOD_SUMO_for_1 672 675 PF00179 0.678
MOD_SUMO_rev_2 477 486 PF00179 0.433
TRG_DiLeu_BaEn_1 186 191 PF01217 0.687
TRG_DiLeu_BaEn_1 341 346 PF01217 0.433
TRG_DiLeu_BaEn_2 803 809 PF01217 0.764
TRG_DiLeu_BaEn_4 439 445 PF01217 0.433
TRG_DiLeu_BaEn_4 99 105 PF01217 0.727
TRG_DiLeu_BaLyEn_6 258 263 PF01217 0.740
TRG_DiLeu_BaLyEn_6 471 476 PF01217 0.433
TRG_DiLeu_BaLyEn_6 539 544 PF01217 0.515
TRG_ENDOCYTIC_2 270 273 PF00928 0.631
TRG_ENDOCYTIC_2 286 289 PF00928 0.638
TRG_ENDOCYTIC_2 425 428 PF00928 0.433
TRG_ENDOCYTIC_2 450 453 PF00928 0.433
TRG_ENDOCYTIC_2 509 512 PF00928 0.600
TRG_ENDOCYTIC_2 617 620 PF00928 0.544
TRG_ENDOCYTIC_2 724 727 PF00928 0.483
TRG_ER_diArg_1 166 169 PF00400 0.780
TRG_ER_diArg_1 512 514 PF00400 0.536
TRG_ER_diArg_1 67 70 PF00400 0.789
TRG_ER_diArg_1 92 94 PF00400 0.856
TRG_NES_CRM1_1 361 374 PF08389 0.534
TRG_NLS_MonoExtC_3 124 129 PF00514 0.789

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I3L1 Leptomonas seymouri 54% 100%
A0A3Q8IRW3 Leishmania donovani 99% 100%
A4HI74 Leishmania braziliensis 72% 100%
E9B0Q1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS