LeishMANIAdb
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Small nuclear ribonucleoprotein E

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Small nuclear ribonucleoprotein E
Gene product:
small nuclear ribonucleoprotein polypeptide e - putative
Species:
Leishmania infantum
UniProt:
A4I5F2_LEIIN
TriTrypDb:
LINF_300017700
Length:
86

Annotations

Annotations by Jardim et al.

Nucleic acid binding, small nuclear ribonucleo polypeptide e

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 25
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0005681 spliceosomal complex 3 9
GO:0005682 U5 snRNP 5 9
GO:0005685 U1 snRNP 5 9
GO:0005686 U2 snRNP 5 9
GO:0005687 U4 snRNP 5 9
GO:0005737 cytoplasm 2 9
GO:0030532 small nuclear ribonucleoprotein complex 3 9
GO:0032991 protein-containing complex 1 9
GO:0046540 U4/U6 x U5 tri-snRNP complex 6 9
GO:0097525 spliceosomal snRNP complex 4 9
GO:0097526 spliceosomal tri-snRNP complex 5 9
GO:0110165 cellular anatomical entity 1 9
GO:0120114 Sm-like protein family complex 2 9
GO:0140513 nuclear protein-containing complex 2 9
GO:1990904 ribonucleoprotein complex 2 9
GO:0071011 precatalytic spliceosome 4 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I5F2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5F2

Function

Biological processes
Term Name Level Count
GO:0000387 spliceosomal snRNP assembly 7 9
GO:0009987 cellular process 1 9
GO:0016043 cellular component organization 3 9
GO:0022607 cellular component assembly 4 9
GO:0022618 ribonucleoprotein complex assembly 6 9
GO:0043933 protein-containing complex organization 4 9
GO:0065003 protein-containing complex assembly 5 9
GO:0071826 ribonucleoprotein complex subunit organization 5 9
GO:0071840 cellular component organization or biogenesis 2 9
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 9
GO:0003723 RNA binding 4 9
GO:0005488 binding 1 9
GO:0097159 organic cyclic compound binding 2 9
GO:1901363 heterocyclic compound binding 2 9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_SKI1_1 70 74 PF00082 0.242
DOC_CYCLIN_RxL_1 64 76 PF00134 0.447
DOC_MAPK_gen_1 64 73 PF00069 0.498
LIG_14-3-3_CanoR_1 61 67 PF00244 0.488
LIG_BIR_II_1 1 5 PF00653 0.600
LIG_FHA_1 10 16 PF00498 0.423
LIG_LIR_Gen_1 45 52 PF02991 0.442
LIG_LIR_Nem_3 45 50 PF02991 0.453
LIG_PDZ_Class_2 81 86 PF00595 0.514
LIG_SH2_STAP1 44 48 PF00017 0.442
LIG_SH3_3 27 33 PF00018 0.483
LIG_SH3_3 77 83 PF00018 0.466
MOD_CK1_1 2 8 PF00069 0.612
MOD_GlcNHglycan 1 4 PF01048 0.630
MOD_N-GLC_1 62 67 PF02516 0.213
MOD_Plk_1 62 68 PF00069 0.413
TRG_ENDOCYTIC_2 44 47 PF00928 0.426

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PE83 Leptomonas seymouri 86% 100%
A0A0S4KHT0 Bodo saltans 41% 99%
A0A3Q8IEV2 Leishmania donovani 99% 100%
A1XQR9 Sus scrofa 35% 93%
A4FUI2 Bos taurus 35% 93%
A4HI73 Leishmania braziliensis 88% 100%
A8XDT0 Caenorhabditis briggsae 39% 96%
C9ZQT9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 66% 100%
E9B0Q0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 98% 100%
P62303 Gallus gallus 35% 93%
P62304 Homo sapiens 35% 93%
P62305 Mus musculus 35% 93%
Q12330 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 34% 91%
Q4Q7I2 Leishmania major 98% 100%
Q7ZUG0 Danio rerio 35% 93%
Q9USZ3 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 39% 100%
Q9VLV5 Drosophila melanogaster 38% 91%
Q9XTU6 Caenorhabditis elegans 39% 96%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS