Palmitoyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DHHC palmitoyltransferase - putative

Species:

Leishmania infantum

UniProt:

A4I5E8_LEIIN

TriTrypDb:

LINF_300017300

Length:

682

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8
GO:0005783	endoplasmic reticulum	5	1
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4I5E8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5E8

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	1
GO:0006605	protein targeting	5	1
GO:0006612	protein targeting to membrane	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018198	peptidyl-cysteine modification	6	1
GO:0018230	peptidyl-L-cysteine S-palmitoylation	7	1
GO:0018231	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	7	1
GO:0018345	protein palmitoylation	6	1
GO:0019538	protein metabolic process	3	1
GO:0033036	macromolecule localization	2	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043543	protein acylation	5	1
GO:0044238	primary metabolic process	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0071705	nitrogen compound transport	4	1
GO:0072657	protein localization to membrane	4	1
GO:0090150	establishment of protein localization to membrane	4	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0016409	palmitoyltransferase activity	5	8
GO:0016417	S-acyltransferase activity	5	8
GO:0016740	transferase activity	2	8
GO:0016746	acyltransferase activity	3	8
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	8
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	8
GO:0019707	protein-cysteine S-acyltransferase activity	3	8
GO:0140096	catalytic activity, acting on a protein	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	648	652	PF00656	0.615
CLV_NRD_NRD_1	112	114	PF00675	0.509
CLV_NRD_NRD_1	236	238	PF00675	0.405
CLV_NRD_NRD_1	326	328	PF00675	0.387
CLV_NRD_NRD_1	525	527	PF00675	0.450
CLV_NRD_NRD_1	643	645	PF00675	0.363
CLV_PCSK_KEX2_1	20	22	PF00082	0.515
CLV_PCSK_KEX2_1	236	238	PF00082	0.389
CLV_PCSK_KEX2_1	325	327	PF00082	0.377
CLV_PCSK_KEX2_1	405	407	PF00082	0.485
CLV_PCSK_KEX2_1	525	527	PF00082	0.481
CLV_PCSK_KEX2_1	575	577	PF00082	0.346
CLV_PCSK_KEX2_1	676	678	PF00082	0.428
CLV_PCSK_PC1ET2_1	20	22	PF00082	0.515
CLV_PCSK_PC1ET2_1	405	407	PF00082	0.461
CLV_PCSK_PC1ET2_1	575	577	PF00082	0.346
CLV_PCSK_PC1ET2_1	676	678	PF00082	0.428
CLV_PCSK_SKI1_1	185	189	PF00082	0.435
CLV_PCSK_SKI1_1	329	333	PF00082	0.402
CLV_PCSK_SKI1_1	422	426	PF00082	0.548
CLV_PCSK_SKI1_1	525	529	PF00082	0.453
CLV_PCSK_SKI1_1	562	566	PF00082	0.291
CLV_Separin_Metazoa	668	672	PF03568	0.636
DEG_APCC_DBOX_1	324	332	PF00400	0.629
DEG_APCC_DBOX_1	524	532	PF00400	0.219
DEG_APCC_DBOX_1	53	61	PF00400	0.647
DEG_APCC_KENBOX_2	180	184	PF00400	0.700
DEG_COP1_1	431	440	PF00400	0.628
DOC_CYCLIN_yCln2_LP_2	440	446	PF00134	0.580
DOC_MAPK_FxFP_2	548	551	PF00069	0.364
DOC_MAPK_gen_1	525	536	PF00069	0.320
DOC_MAPK_MEF2A_6	334	342	PF00069	0.622
DOC_MAPK_MEF2A_6	529	538	PF00069	0.267
DOC_PP1_RVXF_1	630	636	PF00149	0.589
DOC_PP2B_LxvP_1	435	438	PF13499	0.623
DOC_PP2B_LxvP_1	637	640	PF13499	0.573
DOC_PP4_FxxP_1	317	320	PF00568	0.556
DOC_PP4_FxxP_1	548	551	PF00568	0.364
DOC_USP7_MATH_1	176	180	PF00917	0.674
DOC_USP7_MATH_1	290	294	PF00917	0.319
DOC_USP7_MATH_1	378	382	PF00917	0.731
DOC_USP7_MATH_1	387	391	PF00917	0.617
DOC_USP7_MATH_1	45	49	PF00917	0.745
DOC_USP7_MATH_1	65	69	PF00917	0.603
DOC_USP7_MATH_1	72	76	PF00917	0.740
DOC_USP7_MATH_1	82	86	PF00917	0.675
DOC_USP7_UBL2_3	181	185	PF12436	0.661
DOC_USP7_UBL2_3	571	575	PF12436	0.469
DOC_WW_Pin1_4	1	6	PF00397	0.671
DOC_WW_Pin1_4	48	53	PF00397	0.784
DOC_WW_Pin1_4	9	14	PF00397	0.692
LIG_14-3-3_CanoR_1	21	28	PF00244	0.743
LIG_14-3-3_CanoR_1	329	338	PF00244	0.556
LIG_14-3-3_CanoR_1	33	42	PF00244	0.683
LIG_14-3-3_CanoR_1	406	410	PF00244	0.666
LIG_14-3-3_CanoR_1	429	437	PF00244	0.619
LIG_14-3-3_CanoR_1	514	518	PF00244	0.286
LIG_14-3-3_CanoR_1	54	60	PF00244	0.797
LIG_14-3-3_CanoR_1	562	570	PF00244	0.486
LIG_BIR_II_1	1	5	PF00653	0.732
LIG_BRCT_BRCA1_1	240	244	PF00533	0.636
LIG_BRCT_BRCA1_1	492	496	PF00533	0.424
LIG_BRCT_BRCA1_1	576	580	PF00533	0.580
LIG_deltaCOP1_diTrp_1	292	302	PF00928	0.312
LIG_eIF4E_1	489	495	PF01652	0.364
LIG_FHA_1	175	181	PF00498	0.705
LIG_FHA_1	418	424	PF00498	0.627
LIG_FHA_1	447	453	PF00498	0.450
LIG_FHA_2	195	201	PF00498	0.543
LIG_FHA_2	563	569	PF00498	0.466
LIG_GBD_Chelix_1	299	307	PF00786	0.332
LIG_Integrin_RGD_1	334	336	PF01839	0.476
LIG_LIR_Apic_2	516	520	PF02991	0.286
LIG_LIR_Gen_1	200	209	PF02991	0.554
LIG_LIR_Gen_1	292	303	PF02991	0.295
LIG_LIR_Gen_1	308	317	PF02991	0.262
LIG_LIR_Gen_1	493	504	PF02991	0.386
LIG_LIR_Nem_3	200	206	PF02991	0.550
LIG_LIR_Nem_3	292	298	PF02991	0.365
LIG_LIR_Nem_3	308	314	PF02991	0.233
LIG_LIR_Nem_3	439	445	PF02991	0.602
LIG_LIR_Nem_3	493	499	PF02991	0.402
LIG_LIR_Nem_3	541	545	PF02991	0.339
LIG_LIR_Nem_3	577	583	PF02991	0.574
LIG_LIR_Nem_3	616	622	PF02991	0.568
LIG_LIR_Nem_3	8	14	PF02991	0.712
LIG_LYPXL_S_1	280	284	PF13949	0.364
LIG_MLH1_MIPbox_1	492	496	PF16413	0.386
LIG_MLH1_MIPbox_1	576	580	PF16413	0.580
LIG_MYND_3	437	441	PF01753	0.594
LIG_PCNA_PIPBox_1	409	418	PF02747	0.585
LIG_Pex14_1	269	273	PF04695	0.364
LIG_Pex14_2	442	446	PF04695	0.582
LIG_Pex14_2	491	495	PF04695	0.386
LIG_SH2_CRK	203	207	PF00017	0.589
LIG_SH2_CRK	275	279	PF00017	0.364
LIG_SH2_CRK	503	507	PF00017	0.364
LIG_SH2_CRK	532	536	PF00017	0.309
LIG_SH2_CRK	592	596	PF00017	0.571
LIG_SH2_GRB2like	592	595	PF00017	0.567
LIG_SH2_NCK_1	11	15	PF00017	0.709
LIG_SH2_NCK_1	203	207	PF00017	0.584
LIG_SH2_SRC	517	520	PF00017	0.344
LIG_SH2_SRC	530	533	PF00017	0.218
LIG_SH2_SRC	592	595	PF00017	0.567
LIG_SH2_STAP1	203	207	PF00017	0.584
LIG_SH2_STAP1	383	387	PF00017	0.679
LIG_SH2_STAP1	503	507	PF00017	0.386
LIG_SH2_STAP1	596	600	PF00017	0.565
LIG_SH2_STAP1	91	95	PF00017	0.704
LIG_SH2_STAT5	383	386	PF00017	0.685
LIG_SH2_STAT5	415	418	PF00017	0.652
LIG_SH2_STAT5	489	492	PF00017	0.364
LIG_SH2_STAT5	517	520	PF00017	0.295
LIG_SH2_STAT5	530	533	PF00017	0.235
LIG_SH2_STAT5	539	542	PF00017	0.366
LIG_SH2_STAT5	579	582	PF00017	0.574
LIG_SH3_3	130	136	PF00018	0.710
LIG_SH3_3	227	233	PF00018	0.593
LIG_SH3_3	260	266	PF00018	0.555
LIG_SH3_3	337	343	PF00018	0.568
LIG_SH3_3	36	42	PF00018	0.751
LIG_SH3_3	57	63	PF00018	0.709
LIG_SUMO_SIM_anti_2	305	311	PF11976	0.378
LIG_SUMO_SIM_anti_2	336	341	PF11976	0.619
LIG_SUMO_SIM_anti_2	55	61	PF11976	0.648
LIG_SxIP_EBH_1	185	199	PF03271	0.635
LIG_TRAF2_1	198	201	PF00917	0.580
LIG_TRAF2_1	605	608	PF00917	0.625
LIG_TRAF2_1	640	643	PF00917	0.543
LIG_TYR_ITIM	501	506	PF00017	0.364
LIG_WRC_WIRS_1	539	544	PF05994	0.364
MOD_CDC14_SPxK_1	51	54	PF00782	0.546
MOD_CDK_SPxK_1	48	54	PF00069	0.565
MOD_CK1_1	23	29	PF00069	0.746
MOD_CK1_1	305	311	PF00069	0.395
MOD_CK1_1	381	387	PF00069	0.609
MOD_CK1_1	48	54	PF00069	0.696
MOD_CK1_1	55	61	PF00069	0.649
MOD_CK2_1	172	178	PF00069	0.702
MOD_CK2_1	194	200	PF00069	0.459
MOD_CK2_1	562	568	PF00069	0.304
MOD_CK2_1	82	88	PF00069	0.744
MOD_GlcNHglycan	144	147	PF01048	0.736
MOD_GlcNHglycan	150	153	PF01048	0.569
MOD_GlcNHglycan	174	177	PF01048	0.746
MOD_GlcNHglycan	292	295	PF01048	0.526
MOD_GlcNHglycan	304	307	PF01048	0.380
MOD_GlcNHglycan	373	376	PF01048	0.716
MOD_GlcNHglycan	380	383	PF01048	0.521
MOD_GlcNHglycan	389	392	PF01048	0.535
MOD_GlcNHglycan	47	50	PF01048	0.694
MOD_GlcNHglycan	88	91	PF01048	0.709
MOD_GSK3_1	140	147	PF00069	0.649
MOD_GSK3_1	170	177	PF00069	0.662
MOD_GSK3_1	20	27	PF00069	0.816
MOD_GSK3_1	228	235	PF00069	0.447
MOD_GSK3_1	29	36	PF00069	0.739
MOD_GSK3_1	404	411	PF00069	0.590
MOD_GSK3_1	48	55	PF00069	0.626
MOD_GSK3_1	82	89	PF00069	0.681
MOD_N-GLC_1	329	334	PF02516	0.550
MOD_N-GLC_1	378	383	PF02516	0.633
MOD_N-GLC_1	45	50	PF02516	0.654
MOD_N-GLC_2	479	481	PF02516	0.452
MOD_NEK2_1	188	193	PF00069	0.509
MOD_NEK2_1	238	243	PF00069	0.512
MOD_NEK2_1	446	451	PF00069	0.343
MOD_NEK2_1	490	495	PF00069	0.364
MOD_NEK2_1	557	562	PF00069	0.318
MOD_NEK2_1	86	91	PF00069	0.646
MOD_NEK2_2	176	181	PF00069	0.516
MOD_PIKK_1	33	39	PF00454	0.603
MOD_PIKK_1	584	590	PF00454	0.452
MOD_PKA_1	20	26	PF00069	0.654
MOD_PKA_1	405	411	PF00069	0.527
MOD_PKA_2	20	26	PF00069	0.707
MOD_PKA_2	29	35	PF00069	0.615
MOD_PKA_2	405	411	PF00069	0.616
MOD_PKA_2	428	434	PF00069	0.595
MOD_PKA_2	513	519	PF00069	0.332
MOD_PKB_1	327	335	PF00069	0.429
MOD_Plk_1	378	384	PF00069	0.599
MOD_Plk_4	305	311	PF00069	0.368
MOD_Plk_4	397	403	PF00069	0.540
MOD_Plk_4	405	411	PF00069	0.587
MOD_Plk_4	490	496	PF00069	0.364
MOD_Plk_4	513	519	PF00069	0.332
MOD_Plk_4	55	61	PF00069	0.588
MOD_ProDKin_1	1	7	PF00069	0.593
MOD_ProDKin_1	48	54	PF00069	0.749
MOD_ProDKin_1	9	15	PF00069	0.621
MOD_SUMO_rev_2	219	227	PF00179	0.530
MOD_SUMO_rev_2	629	633	PF00179	0.413
MOD_SUMO_rev_2	642	647	PF00179	0.416
TRG_DiLeu_BaLyEn_6	595	600	PF01217	0.397
TRG_ENDOCYTIC_2	11	14	PF00928	0.645
TRG_ENDOCYTIC_2	203	206	PF00928	0.460
TRG_ENDOCYTIC_2	275	278	PF00928	0.364
TRG_ENDOCYTIC_2	281	284	PF00928	0.364
TRG_ENDOCYTIC_2	487	490	PF00928	0.312
TRG_ENDOCYTIC_2	503	506	PF00928	0.304
TRG_ENDOCYTIC_2	539	542	PF00928	0.318
TRG_ENDOCYTIC_2	592	595	PF00928	0.442
TRG_ENDOCYTIC_2	596	599	PF00928	0.413
TRG_ENDOCYTIC_2	619	622	PF00928	0.428
TRG_ER_diArg_1	236	238	PF00400	0.499
TRG_ER_diArg_1	324	327	PF00400	0.455
TRG_ER_diArg_1	524	526	PF00400	0.281

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P984	Leptomonas seymouri	65%	96%
A0A1X0P316	Trypanosomatidae	34%	100%
A0A3Q8IHU7	Leishmania donovani	100%	100%
A4HI71	Leishmania braziliensis	72%	100%
E9B0P6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q7I6	Leishmania major	93%	100%