Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MA3 domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4I5E6_LEIIN

TriTrypDb:

LINF_300017100

Length:

860

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I5E6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5E6

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	1
GO:0022613	ribonucleoprotein complex biogenesis	4	1
GO:0042274	ribosomal small subunit biogenesis	5	1
GO:0044085	cellular component biogenesis	3	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003723	RNA binding	4	10
GO:0005488	binding	1	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	328	332	PF00656	0.539
CLV_C14_Caspase3-7	815	819	PF00656	0.784
CLV_MEL_PAP_1	263	269	PF00089	0.343
CLV_NRD_NRD_1	185	187	PF00675	0.336
CLV_NRD_NRD_1	382	384	PF00675	0.413
CLV_NRD_NRD_1	412	414	PF00675	0.462
CLV_NRD_NRD_1	416	418	PF00675	0.473
CLV_NRD_NRD_1	448	450	PF00675	0.455
CLV_NRD_NRD_1	49	51	PF00675	0.474
CLV_NRD_NRD_1	54	56	PF00675	0.384
CLV_NRD_NRD_1	616	618	PF00675	0.292
CLV_NRD_NRD_1	737	739	PF00675	0.373
CLV_NRD_NRD_1	806	808	PF00675	0.486
CLV_NRD_NRD_1	95	97	PF00675	0.436
CLV_PCSK_KEX2_1	114	116	PF00082	0.546
CLV_PCSK_KEX2_1	185	187	PF00082	0.352
CLV_PCSK_KEX2_1	382	384	PF00082	0.415
CLV_PCSK_KEX2_1	416	418	PF00082	0.424
CLV_PCSK_KEX2_1	448	450	PF00082	0.365
CLV_PCSK_KEX2_1	452	454	PF00082	0.335
CLV_PCSK_KEX2_1	53	55	PF00082	0.389
CLV_PCSK_KEX2_1	547	549	PF00082	0.467
CLV_PCSK_KEX2_1	571	573	PF00082	0.301
CLV_PCSK_KEX2_1	616	618	PF00082	0.271
CLV_PCSK_KEX2_1	737	739	PF00082	0.373
CLV_PCSK_KEX2_1	755	757	PF00082	0.428
CLV_PCSK_KEX2_1	806	808	PF00082	0.511
CLV_PCSK_KEX2_1	846	848	PF00082	0.263
CLV_PCSK_KEX2_1	97	99	PF00082	0.413
CLV_PCSK_PC1ET2_1	114	116	PF00082	0.567
CLV_PCSK_PC1ET2_1	452	454	PF00082	0.346
CLV_PCSK_PC1ET2_1	547	549	PF00082	0.467
CLV_PCSK_PC1ET2_1	571	573	PF00082	0.301
CLV_PCSK_PC1ET2_1	755	757	PF00082	0.395
CLV_PCSK_PC1ET2_1	846	848	PF00082	0.276
CLV_PCSK_PC1ET2_1	97	99	PF00082	0.421
CLV_PCSK_PC7_1	448	454	PF00082	0.436
CLV_PCSK_PC7_1	50	56	PF00082	0.386
CLV_PCSK_SKI1_1	103	107	PF00082	0.500
CLV_PCSK_SKI1_1	309	313	PF00082	0.486
CLV_PCSK_SKI1_1	365	369	PF00082	0.307
CLV_PCSK_SKI1_1	389	393	PF00082	0.433
CLV_PCSK_SKI1_1	417	421	PF00082	0.416
CLV_PCSK_SKI1_1	449	453	PF00082	0.346
CLV_PCSK_SKI1_1	520	524	PF00082	0.410
CLV_PCSK_SKI1_1	572	576	PF00082	0.299
CLV_PCSK_SKI1_1	699	703	PF00082	0.261
CLV_PCSK_SKI1_1	704	708	PF00082	0.267
CLV_PCSK_SKI1_1	737	741	PF00082	0.334
CLV_PCSK_SKI1_1	825	829	PF00082	0.479
CLV_PCSK_SKI1_1	853	857	PF00082	0.308
DEG_APCC_DBOX_1	698	706	PF00400	0.449
DEG_APCC_KENBOX_2	513	517	PF00400	0.689
DEG_Nend_UBRbox_1	1	4	PF02207	0.673
DEG_SCF_FBW7_1	207	213	PF00400	0.536
DEG_SPOP_SBC_1	165	169	PF00917	0.717
DEG_SPOP_SBC_1	235	239	PF00917	0.613
DEG_SPOP_SBC_1	332	336	PF00917	0.476
DOC_CKS1_1	207	212	PF01111	0.536
DOC_CYCLIN_RxL_1	306	316	PF00134	0.449
DOC_CYCLIN_RxL_1	448	458	PF00134	0.624
DOC_CYCLIN_RxL_1	633	646	PF00134	0.525
DOC_CYCLIN_RxL_1	680	690	PF00134	0.483
DOC_CYCLIN_RxL_1	734	741	PF00134	0.595
DOC_MAPK_DCC_7	477	485	PF00069	0.632
DOC_MAPK_gen_1	448	456	PF00069	0.570
DOC_MAPK_gen_1	58	66	PF00069	0.663
DOC_MAPK_MEF2A_6	477	485	PF00069	0.632
DOC_MAPK_MEF2A_6	699	707	PF00069	0.463
DOC_PP1_RVXF_1	264	270	PF00149	0.556
DOC_PP1_RVXF_1	636	643	PF00149	0.525
DOC_PP2B_LxvP_1	707	710	PF13499	0.451
DOC_USP7_MATH_1	104	108	PF00917	0.703
DOC_USP7_MATH_1	165	169	PF00917	0.766
DOC_USP7_MATH_1	210	214	PF00917	0.561
DOC_USP7_MATH_1	31	35	PF00917	0.749
DOC_USP7_MATH_1	327	331	PF00917	0.515
DOC_USP7_MATH_1	332	336	PF00917	0.473
DOC_USP7_MATH_1	381	385	PF00917	0.544
DOC_USP7_MATH_1	510	514	PF00917	0.734
DOC_USP7_MATH_1	83	87	PF00917	0.657
DOC_WW_Pin1_4	171	176	PF00397	0.692
DOC_WW_Pin1_4	206	211	PF00397	0.581
DOC_WW_Pin1_4	29	34	PF00397	0.647
DOC_WW_Pin1_4	334	339	PF00397	0.499
DOC_WW_Pin1_4	367	372	PF00397	0.619
DOC_WW_Pin1_4	468	473	PF00397	0.594
DOC_WW_Pin1_4	820	825	PF00397	0.687
LIG_14-3-3_CanoR_1	2	8	PF00244	0.700
LIG_14-3-3_CanoR_1	214	218	PF00244	0.479
LIG_14-3-3_CanoR_1	266	272	PF00244	0.561
LIG_14-3-3_CanoR_1	382	391	PF00244	0.558
LIG_14-3-3_CanoR_1	416	426	PF00244	0.618
LIG_14-3-3_CanoR_1	448	452	PF00244	0.553
LIG_14-3-3_CanoR_1	453	461	PF00244	0.493
LIG_14-3-3_CanoR_1	565	574	PF00244	0.527
LIG_14-3-3_CanoR_1	576	585	PF00244	0.491
LIG_14-3-3_CanoR_1	65	72	PF00244	0.674
LIG_14-3-3_CanoR_1	713	719	PF00244	0.571
LIG_14-3-3_CanoR_1	811	817	PF00244	0.718
LIG_Actin_WH2_2	352	370	PF00022	0.339
LIG_Actin_WH2_2	841	858	PF00022	0.490
LIG_APCC_ABBA_1	590	595	PF00400	0.482
LIG_BIR_III_2	39	43	PF00653	0.614
LIG_BRCT_BRCA1_1	744	748	PF00533	0.537
LIG_CaM_IQ_9	89	105	PF13499	0.620
LIG_EH1_1	620	628	PF00400	0.513
LIG_eIF4E_1	621	627	PF01652	0.525
LIG_FAT_LD_1	426	434	PF03623	0.549
LIG_FHA_1	165	171	PF00498	0.664
LIG_FHA_1	198	204	PF00498	0.551
LIG_FHA_1	207	213	PF00498	0.501
LIG_FHA_1	237	243	PF00498	0.545
LIG_FHA_1	284	290	PF00498	0.549
LIG_FHA_1	314	320	PF00498	0.394
LIG_FHA_1	455	461	PF00498	0.505
LIG_FHA_1	654	660	PF00498	0.454
LIG_FHA_1	691	697	PF00498	0.528
LIG_FHA_1	731	737	PF00498	0.503
LIG_FHA_2	326	332	PF00498	0.511
LIG_FHA_2	370	376	PF00498	0.560
LIG_FHA_2	426	432	PF00498	0.556
LIG_FHA_2	468	474	PF00498	0.585
LIG_FHA_2	578	584	PF00498	0.575
LIG_FHA_2	65	71	PF00498	0.548
LIG_FHA_2	813	819	PF00498	0.620
LIG_IBAR_NPY_1	619	621	PF08397	0.435
LIG_Integrin_isoDGR_2	516	518	PF01839	0.433
LIG_LIR_Gen_1	394	404	PF02991	0.508
LIG_LIR_Gen_1	465	472	PF02991	0.517
LIG_LIR_Gen_1	586	596	PF02991	0.497
LIG_LIR_Gen_1	599	609	PF02991	0.435
LIG_LIR_Gen_1	741	749	PF02991	0.561
LIG_LIR_Gen_1	760	767	PF02991	0.453
LIG_LIR_Nem_3	241	247	PF02991	0.476
LIG_LIR_Nem_3	394	400	PF02991	0.510
LIG_LIR_Nem_3	465	469	PF02991	0.556
LIG_LIR_Nem_3	573	578	PF02991	0.497
LIG_LIR_Nem_3	586	591	PF02991	0.454
LIG_LIR_Nem_3	595	601	PF02991	0.483
LIG_LIR_Nem_3	615	621	PF02991	0.327
LIG_LIR_Nem_3	646	651	PF02991	0.434
LIG_LIR_Nem_3	741	746	PF02991	0.595
LIG_LIR_Nem_3	760	765	PF02991	0.429
LIG_MLH1_MIPbox_1	744	748	PF16413	0.537
LIG_NRBOX	307	313	PF00104	0.445
LIG_NRBOX	735	741	PF00104	0.567
LIG_OCRL_FandH_1	6	18	PF00620	0.710
LIG_PCNA_yPIPBox_3	649	662	PF02747	0.459
LIG_Pex14_1	757	761	PF04695	0.498
LIG_PTB_Apo_2	616	623	PF02174	0.435
LIG_PTB_Phospho_1	616	622	PF10480	0.435
LIG_SH2_CRK	852	856	PF00017	0.544
LIG_SH2_GRB2like	661	664	PF00017	0.451
LIG_SH2_NCK_1	762	766	PF00017	0.489
LIG_SH2_PTP2	622	625	PF00017	0.513
LIG_SH2_SRC	479	482	PF00017	0.642
LIG_SH2_STAP1	762	766	PF00017	0.489
LIG_SH2_STAT3	621	624	PF00017	0.435
LIG_SH2_STAT5	294	297	PF00017	0.299
LIG_SH2_STAT5	321	324	PF00017	0.324
LIG_SH2_STAT5	479	482	PF00017	0.608
LIG_SH2_STAT5	598	601	PF00017	0.574
LIG_SH2_STAT5	622	625	PF00017	0.451
LIG_SH2_STAT5	661	664	PF00017	0.451
LIG_SH2_STAT5	747	750	PF00017	0.483
LIG_SH3_2	472	477	PF14604	0.505
LIG_SH3_3	466	472	PF00018	0.575
LIG_SH3_3	521	527	PF00018	0.633
LIG_SH3_3	818	824	PF00018	0.597
LIG_Sin3_3	397	404	PF02671	0.576
LIG_SUMO_SIM_anti_2	213	219	PF11976	0.586
LIG_SUMO_SIM_anti_2	286	291	PF11976	0.522
LIG_SUMO_SIM_par_1	195	200	PF11976	0.540
LIG_TRAF2_1	277	280	PF00917	0.576
LIG_TRAF2_1	377	380	PF00917	0.605
LIG_TRAF2_1	438	441	PF00917	0.651
LIG_TRAF2_1	612	615	PF00917	0.471
LIG_TRAF2_1	799	802	PF00917	0.677
LIG_TYR_ITIM	850	855	PF00017	0.537
LIG_WW_3	474	478	PF00397	0.562
MOD_CDC14_SPxK_1	471	474	PF00782	0.496
MOD_CDK_SPK_2	820	825	PF00069	0.593
MOD_CDK_SPxK_1	468	474	PF00069	0.482
MOD_CK1_1	213	219	PF00069	0.546
MOD_CK1_1	330	336	PF00069	0.521
MOD_CK1_1	337	343	PF00069	0.252
MOD_CK1_1	462	468	PF00069	0.553
MOD_CK1_1	487	493	PF00069	0.668
MOD_CK1_1	5	11	PF00069	0.780
MOD_CK1_1	525	531	PF00069	0.679
MOD_CK1_1	712	718	PF00069	0.559
MOD_CK1_1	833	839	PF00069	0.631
MOD_CK2_1	104	110	PF00069	0.675
MOD_CK2_1	367	373	PF00069	0.620
MOD_CK2_1	374	380	PF00069	0.615
MOD_CK2_1	425	431	PF00069	0.540
MOD_CK2_1	467	473	PF00069	0.594
MOD_CK2_1	487	493	PF00069	0.610
MOD_CK2_1	64	70	PF00069	0.548
MOD_Cter_Amidation	112	115	PF01082	0.540
MOD_GlcNHglycan	339	342	PF01048	0.381
MOD_GlcNHglycan	384	387	PF01048	0.374
MOD_GlcNHglycan	461	464	PF01048	0.438
MOD_GlcNHglycan	486	489	PF01048	0.516
MOD_GlcNHglycan	496	500	PF01048	0.561
MOD_GlcNHglycan	506	509	PF01048	0.497
MOD_GlcNHglycan	561	564	PF01048	0.402
MOD_GlcNHglycan	630	633	PF01048	0.235
MOD_GlcNHglycan	724	727	PF01048	0.442
MOD_GlcNHglycan	773	776	PF01048	0.465
MOD_GlcNHglycan	787	790	PF01048	0.375
MOD_GlcNHglycan	794	799	PF01048	0.425
MOD_GlcNHglycan	818	821	PF01048	0.473
MOD_GlcNHglycan	832	835	PF01048	0.463
MOD_GSK3_1	119	126	PF00069	0.599
MOD_GSK3_1	197	204	PF00069	0.491
MOD_GSK3_1	206	213	PF00069	0.515
MOD_GSK3_1	234	241	PF00069	0.544
MOD_GSK3_1	303	310	PF00069	0.324
MOD_GSK3_1	327	334	PF00069	0.538
MOD_GSK3_1	443	450	PF00069	0.623
MOD_GSK3_1	455	462	PF00069	0.485
MOD_GSK3_1	483	490	PF00069	0.641
MOD_GSK3_1	495	502	PF00069	0.682
MOD_GSK3_1	506	513	PF00069	0.680
MOD_GSK3_1	738	745	PF00069	0.578
MOD_GSK3_1	812	819	PF00069	0.736
MOD_GSK3_1	826	833	PF00069	0.696
MOD_N-GLC_1	389	394	PF02516	0.427
MOD_N-GLC_1	677	682	PF02516	0.337
MOD_N-GLC_1	690	695	PF02516	0.228
MOD_N-GLC_1	751	756	PF02516	0.381
MOD_N-GLC_2	135	137	PF02516	0.537
MOD_NEK2_1	236	241	PF00069	0.563
MOD_NEK2_1	3	8	PF00069	0.795
MOD_NEK2_1	303	308	PF00069	0.292
MOD_NEK2_1	374	379	PF00069	0.600
MOD_NEK2_1	454	459	PF00069	0.522
MOD_NEK2_1	484	489	PF00069	0.570
MOD_NEK2_1	64	69	PF00069	0.605
MOD_NEK2_1	687	692	PF00069	0.512
MOD_NEK2_1	771	776	PF00069	0.651
MOD_NEK2_1	785	790	PF00069	0.726
MOD_NEK2_1	816	821	PF00069	0.643
MOD_NEK2_1	828	833	PF00069	0.648
MOD_PIKK_1	443	449	PF00454	0.664
MOD_PIKK_1	64	70	PF00454	0.637
MOD_PIKK_1	712	718	PF00454	0.571
MOD_PK_1	647	653	PF00069	0.536
MOD_PKA_1	382	388	PF00069	0.601
MOD_PKA_2	130	136	PF00069	0.720
MOD_PKA_2	213	219	PF00069	0.534
MOD_PKA_2	265	271	PF00069	0.555
MOD_PKA_2	381	387	PF00069	0.571
MOD_PKA_2	447	453	PF00069	0.628
MOD_PKA_2	64	70	PF00069	0.675
MOD_PKA_2	712	718	PF00069	0.571
MOD_PKA_2	785	791	PF00069	0.759
MOD_PKA_2	83	89	PF00069	0.569
MOD_Plk_1	138	144	PF00069	0.596
MOD_Plk_1	374	380	PF00069	0.647
MOD_Plk_1	677	683	PF00069	0.539
MOD_Plk_1	690	696	PF00069	0.425
MOD_Plk_1	731	737	PF00069	0.535
MOD_Plk_2-3	369	375	PF00069	0.598
MOD_Plk_2-3	532	538	PF00069	0.673
MOD_Plk_4	147	153	PF00069	0.641
MOD_Plk_4	213	219	PF00069	0.500
MOD_Plk_4	283	289	PF00069	0.542
MOD_Plk_4	303	309	PF00069	0.178
MOD_Plk_4	425	431	PF00069	0.503
MOD_Plk_4	432	438	PF00069	0.493
MOD_Plk_4	677	683	PF00069	0.578
MOD_Plk_4	731	737	PF00069	0.592
MOD_Plk_4	742	748	PF00069	0.578
MOD_Plk_4	812	818	PF00069	0.729
MOD_ProDKin_1	171	177	PF00069	0.685
MOD_ProDKin_1	206	212	PF00069	0.577
MOD_ProDKin_1	29	35	PF00069	0.649
MOD_ProDKin_1	334	340	PF00069	0.490
MOD_ProDKin_1	367	373	PF00069	0.620
MOD_ProDKin_1	468	474	PF00069	0.592
MOD_ProDKin_1	820	826	PF00069	0.683
MOD_SUMO_for_1	546	549	PF00179	0.591
MOD_SUMO_rev_2	45	52	PF00179	0.679
MOD_SUMO_rev_2	57	64	PF00179	0.541
TRG_DiLeu_BaLyEn_6	314	319	PF01217	0.373
TRG_DiLeu_BaLyEn_6	701	706	PF01217	0.460
TRG_DiLeu_BaLyEn_6	735	740	PF01217	0.569
TRG_ENDOCYTIC_2	598	601	PF00928	0.574
TRG_ENDOCYTIC_2	622	625	PF00928	0.435
TRG_ENDOCYTIC_2	661	664	PF00928	0.451
TRG_ENDOCYTIC_2	762	765	PF00928	0.511
TRG_ENDOCYTIC_2	852	855	PF00928	0.537
TRG_ER_diArg_1	184	186	PF00400	0.537
TRG_ER_diArg_1	53	55	PF00400	0.589
TRG_ER_diArg_1	616	618	PF00400	0.395
TRG_ER_diArg_1	736	738	PF00400	0.572
TRG_ER_diArg_1	805	807	PF00400	0.691
TRG_NLS_MonoExtC_3	412	417	PF00514	0.700
TRG_NLS_MonoExtC_3	95	100	PF00514	0.669
TRG_NLS_MonoExtN_4	411	417	PF00514	0.694
TRG_NLS_MonoExtN_4	94	101	PF00514	0.664
TRG_Pf-PMV_PEXEL_1	309	314	PF00026	0.564
TRG_Pf-PMV_PEXEL_1	365	369	PF00026	0.307
TRG_Pf-PMV_PEXEL_1	417	421	PF00026	0.448
TRG_Pf-PMV_PEXEL_1	683	688	PF00026	0.286
TRG_Pf-PMV_PEXEL_1	704	708	PF00026	0.250
TRG_Pf-PMV_PEXEL_1	756	760	PF00026	0.443

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8W4	Leptomonas seymouri	62%	99%
A0A1X0P271	Trypanosomatidae	42%	100%
A0A3S7X3B0	Leishmania donovani	99%	100%
A0A422P4Z6	Trypanosoma rangeli	40%	100%
A4HI69	Leishmania braziliensis	78%	100%
C9ZQT3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9B0P4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q7I8	Leishmania major	92%	100%
Q5C9Z4	Homo sapiens	23%	100%
V5BPM5	Trypanosoma cruzi	39%	100%