Putative DREV methyltransferase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DREV methyltransferase - putative

Species:

Leishmania infantum

UniProt:

A4I5E1_LEIIN

TriTrypDb:

LINF_300016600

Length:

307

Annotations

Annotations by Jardim et al.

Transferases, DREV methyltransferase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I5E1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5E1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008168	methyltransferase activity	4	12
GO:0008170	N-methyltransferase activity	5	12
GO:0008276	protein methyltransferase activity	3	12
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12
GO:0106370	protein-L-histidine N-pros-methyltransferase activity	4	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	201	205	PF00656	0.252
CLV_NRD_NRD_1	154	156	PF00675	0.297
CLV_NRD_NRD_1	177	179	PF00675	0.252
CLV_NRD_NRD_1	297	299	PF00675	0.355
CLV_NRD_NRD_1	95	97	PF00675	0.401
CLV_PCSK_FUR_1	151	155	PF00082	0.380
CLV_PCSK_FUR_1	229	233	PF00082	0.266
CLV_PCSK_KEX2_1	153	155	PF00082	0.325
CLV_PCSK_KEX2_1	177	179	PF00082	0.252
CLV_PCSK_KEX2_1	231	233	PF00082	0.286
CLV_PCSK_KEX2_1	299	301	PF00082	0.501
CLV_PCSK_KEX2_1	95	97	PF00082	0.383
CLV_PCSK_PC1ET2_1	231	233	PF00082	0.394
CLV_PCSK_PC1ET2_1	299	301	PF00082	0.414
CLV_PCSK_PC7_1	149	155	PF00082	0.380
CLV_PCSK_PC7_1	173	179	PF00082	0.180
CLV_PCSK_SKI1_1	18	22	PF00082	0.475
CLV_PCSK_SKI1_1	61	65	PF00082	0.331
CLV_PCSK_SKI1_1	95	99	PF00082	0.300
CLV_Separin_Metazoa	268	272	PF03568	0.363
DEG_APCC_DBOX_1	94	102	PF00400	0.132
DEG_Nend_UBRbox_3	1	3	PF02207	0.607
DOC_CYCLIN_yCln2_LP_2	105	111	PF00134	0.204
DOC_CYCLIN_yCln2_LP_2	97	103	PF00134	0.132
DOC_MAPK_JIP1_4	207	213	PF00069	0.363
DOC_MAPK_MEF2A_6	207	216	PF00069	0.276
DOC_MAPK_MEF2A_6	256	265	PF00069	0.380
DOC_PP2B_LxvP_1	101	104	PF13499	0.382
DOC_USP7_MATH_1	25	29	PF00917	0.267
DOC_WW_Pin1_4	104	109	PF00397	0.420
LIG_14-3-3_CanoR_1	246	251	PF00244	0.297
LIG_14-3-3_CanoR_1	26	30	PF00244	0.374
LIG_14-3-3_CanoR_1	55	60	PF00244	0.434
LIG_14-3-3_CanoR_1	74	81	PF00244	0.271
LIG_AP2alpha_2	164	166	PF02296	0.291
LIG_APCC_ABBA_1	159	164	PF00400	0.291
LIG_DLG_GKlike_1	246	254	PF00625	0.297
LIG_FHA_1	127	133	PF00498	0.286
LIG_FHA_1	25	31	PF00498	0.330
LIG_FHA_1	46	52	PF00498	0.291
LIG_FHA_1	89	95	PF00498	0.376
LIG_GBD_Chelix_1	64	72	PF00786	0.265
LIG_Integrin_RGD_1	300	302	PF01839	0.457
LIG_IRF3_LxIS_1	8	13	PF10401	0.381
LIG_LIR_Gen_1	112	123	PF02991	0.331
LIG_LIR_Gen_1	286	295	PF02991	0.339
LIG_LIR_Gen_1	66	72	PF02991	0.366
LIG_LIR_Nem_3	112	118	PF02991	0.297
LIG_LIR_Nem_3	176	182	PF02991	0.282
LIG_LIR_Nem_3	286	290	PF02991	0.339
LIG_LIR_Nem_3	66	70	PF02991	0.366
LIG_PCNA_yPIPBox_3	53	63	PF02747	0.383
LIG_PDZ_Class_1	302	307	PF00595	0.427
LIG_Pex14_2	67	71	PF04695	0.363
LIG_RPA_C_Fungi	50	62	PF08784	0.363
LIG_SH2_CRK	287	291	PF00017	0.284
LIG_SH2_STAT5	11	14	PF00017	0.424
LIG_SH2_STAT5	140	143	PF00017	0.396
LIG_SH2_STAT5	179	182	PF00017	0.380
LIG_SH2_STAT5	277	280	PF00017	0.252
LIG_SH3_3	105	111	PF00018	0.271
LIG_SH3_3	213	219	PF00018	0.237
LIG_SH3_3	258	264	PF00018	0.277
LIG_TYR_ITIM	285	290	PF00017	0.331
LIG_UBA3_1	198	207	PF00899	0.331
MOD_CK1_1	73	79	PF00069	0.251
MOD_CK2_1	25	31	PF00069	0.271
MOD_GlcNHglycan	12	15	PF01048	0.398
MOD_GlcNHglycan	143	147	PF01048	0.326
MOD_GSK3_1	246	253	PF00069	0.264
MOD_GSK3_1	51	58	PF00069	0.286
MOD_GSK3_1	66	73	PF00069	0.348
MOD_N-GLC_1	55	60	PF02516	0.323
MOD_NEK2_1	10	15	PF00069	0.420
MOD_NEK2_1	144	149	PF00069	0.416
MOD_NEK2_1	202	207	PF00069	0.284
MOD_NEK2_1	250	255	PF00069	0.297
MOD_NEK2_1	51	56	PF00069	0.375
MOD_NEK2_1	72	77	PF00069	0.279
MOD_PK_1	55	61	PF00069	0.204
MOD_PKA_1	231	237	PF00069	0.308
MOD_PKA_2	202	208	PF00069	0.252
MOD_PKA_2	231	237	PF00069	0.308
MOD_PKA_2	25	31	PF00069	0.414
MOD_PKA_2	270	276	PF00069	0.380
MOD_PKA_2	73	79	PF00069	0.271
MOD_PKB_1	53	61	PF00069	0.313
MOD_Plk_1	250	256	PF00069	0.277
MOD_Plk_1	45	51	PF00069	0.369
MOD_Plk_1	55	61	PF00069	0.244
MOD_Plk_4	114	120	PF00069	0.237
MOD_Plk_4	194	200	PF00069	0.333
MOD_Plk_4	25	31	PF00069	0.394
MOD_Plk_4	55	61	PF00069	0.261
MOD_Plk_4	66	72	PF00069	0.404
MOD_ProDKin_1	104	110	PF00069	0.420
TRG_DiLeu_BaEn_2	45	51	PF01217	0.380
TRG_DiLeu_BaLyEn_6	170	175	PF01217	0.180
TRG_DiLeu_BaLyEn_6	93	98	PF01217	0.359
TRG_ENDOCYTIC_2	157	160	PF00928	0.237
TRG_ENDOCYTIC_2	179	182	PF00928	0.239
TRG_ENDOCYTIC_2	287	290	PF00928	0.284
TRG_ER_diArg_1	150	153	PF00400	0.306
TRG_ER_diArg_1	16	19	PF00400	0.410
TRG_ER_diArg_1	177	179	PF00400	0.298
TRG_ER_diArg_1	297	300	PF00400	0.395
TRG_ER_diArg_1	52	55	PF00400	0.265
TRG_ER_diArg_1	94	96	PF00400	0.380

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IBZ8	Leptomonas seymouri	73%	100%
A0A0S4J0V6	Bodo saltans	48%	100%
A0A1X0P223	Trypanosomatidae	53%	92%
A0A3Q8IJA6	Leishmania donovani	99%	100%
A0A3S5ISQ6	Trypanosoma rangeli	52%	99%
A4HI64	Leishmania braziliensis	83%	100%
C9ZQS1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	96%
E9B0N9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q0VCJ8	Bos taurus	39%	97%
Q4Q7J3	Leishmania major	95%	100%
Q5ZMH6	Gallus gallus	37%	96%
Q9EPL4	Mus musculus	41%	97%
Q9H1A3	Homo sapiens	40%	97%
V5DQR7	Trypanosoma cruzi	54%	98%