Succinate dehydrogenase assembly factor 2, mitochondrial

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Flavinator of succinate dehydrogenase - putative

Species:

Leishmania infantum

UniProt:

A4I5D8_LEIIN

TriTrypDb:

LINF_300016300

Length:

233

Annotations

Annotations by Jardim et al.

Tricarboxylic acid cycle, Succinate dehydrogenase assembly factor 2,(SDH1)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005759	mitochondrial matrix	5	7
GO:0031974	membrane-enclosed lumen	2	7
GO:0043233	organelle lumen	3	7
GO:0070013	intracellular organelle lumen	4	7
GO:0110165	cellular anatomical entity	1	7
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A4I5D8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5D8

Function

Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	7
GO:0006121	mitochondrial electron transport, succinate to ubiquinone	7	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009060	aerobic respiration	6	7
GO:0009987	cellular process	1	7
GO:0015980	energy derivation by oxidation of organic compounds	4	7
GO:0018293	protein-FAD linkage	5	7
GO:0019538	protein metabolic process	3	7
GO:0019646	aerobic electron transport chain	6	7
GO:0022900	electron transport chain	4	7
GO:0022904	respiratory electron transport chain	5	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0045333	cellular respiration	5	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:0006099	tricarboxylic acid cycle	3	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0033108	mitochondrial respiratory chain complex assembly	6	1
GO:0034552	respiratory chain complex II assembly	6	1
GO:0034553	mitochondrial respiratory chain complex II assembly	7	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	129	133	PF00656	0.587
CLV_C14_Caspase3-7	174	178	PF00656	0.617
CLV_C14_Caspase3-7	42	46	PF00656	0.566
CLV_NRD_NRD_1	147	149	PF00675	0.335
CLV_NRD_NRD_1	219	221	PF00675	0.398
CLV_PCSK_KEX2_1	145	147	PF00082	0.495
CLV_PCSK_KEX2_1	219	221	PF00082	0.393
CLV_PCSK_KEX2_1	84	86	PF00082	0.486
CLV_PCSK_PC1ET2_1	145	147	PF00082	0.517
CLV_PCSK_PC1ET2_1	84	86	PF00082	0.486
CLV_PCSK_SKI1_1	220	224	PF00082	0.408
CLV_PCSK_SKI1_1	4	8	PF00082	0.748
CLV_PCSK_SKI1_1	73	77	PF00082	0.554
DEG_APCC_DBOX_1	169	177	PF00400	0.504
DOC_MAPK_gen_1	154	163	PF00069	0.546
DOC_MAPK_MEF2A_6	156	165	PF00069	0.546
DOC_USP7_MATH_1	106	110	PF00917	0.595
DOC_USP7_MATH_1	138	142	PF00917	0.572
DOC_USP7_MATH_1	51	55	PF00917	0.534
DOC_WW_Pin1_4	73	78	PF00397	0.587
DOC_WW_Pin1_4	89	94	PF00397	0.646
LIG_14-3-3_CanoR_1	34	40	PF00244	0.775
LIG_BIR_III_4	45	49	PF00653	0.585
LIG_BRCT_BRCA1_1	192	196	PF00533	0.546
LIG_BRCT_BRCA1_1	65	69	PF00533	0.573
LIG_EH_1	49	53	PF12763	0.613
LIG_FHA_1	225	231	PF00498	0.557
LIG_FHA_1	51	57	PF00498	0.702
LIG_FHA_1	78	84	PF00498	0.546
LIG_FHA_2	127	133	PF00498	0.626
LIG_FHA_2	57	63	PF00498	0.542
LIG_FHA_2	74	80	PF00498	0.537
LIG_LIR_Gen_1	182	191	PF02991	0.518
LIG_LIR_Gen_1	66	77	PF02991	0.570
LIG_LIR_Nem_3	162	168	PF02991	0.522
LIG_LIR_Nem_3	182	187	PF02991	0.518
LIG_LIR_Nem_3	193	199	PF02991	0.511
LIG_LIR_Nem_3	66	72	PF02991	0.647
LIG_PCNA_PIPBox_1	161	170	PF02747	0.546
LIG_Pex14_2	65	69	PF04695	0.573
LIG_SH2_CRK	184	188	PF00017	0.546
LIG_SH2_STAP1	184	188	PF00017	0.546
LIG_SH3_3	132	138	PF00018	0.586
LIG_SH3_3	200	206	PF00018	0.617
LIG_SH3_3	94	100	PF00018	0.657
LIG_SUMO_SIM_par_1	17	22	PF11976	0.613
MOD_CDK_SPK_2	73	78	PF00069	0.587
MOD_CDK_SPK_2	93	98	PF00069	0.456
MOD_CK1_1	24	30	PF00069	0.729
MOD_CK1_1	37	43	PF00069	0.667
MOD_CK2_1	106	112	PF00069	0.610
MOD_CK2_1	56	62	PF00069	0.534
MOD_CK2_1	73	79	PF00069	0.554
MOD_GlcNHglycan	26	29	PF01048	0.670
MOD_GlcNHglycan	53	56	PF01048	0.596
MOD_GSK3_1	102	109	PF00069	0.555
MOD_GSK3_1	122	129	PF00069	0.427
MOD_GSK3_1	172	179	PF00069	0.571
MOD_GSK3_1	22	29	PF00069	0.643
MOD_GSK3_1	34	41	PF00069	0.638
MOD_GSK3_1	63	70	PF00069	0.627
MOD_GSK3_1	73	80	PF00069	0.534
MOD_GSK3_1	85	92	PF00069	0.552
MOD_NEK2_1	130	135	PF00069	0.625
MOD_NEK2_1	176	181	PF00069	0.571
MOD_NEK2_1	19	24	PF00069	0.658
MOD_NEK2_1	5	10	PF00069	0.648
MOD_PIKK_1	29	35	PF00454	0.626
MOD_PIKK_1	63	69	PF00454	0.525
MOD_PKA_2	130	136	PF00069	0.593
MOD_Plk_1	138	144	PF00069	0.511
MOD_Plk_1	176	182	PF00069	0.555
MOD_Plk_1	67	73	PF00069	0.478
MOD_Plk_4	176	182	PF00069	0.555
MOD_ProDKin_1	73	79	PF00069	0.582
MOD_ProDKin_1	89	95	PF00069	0.646
MOD_SUMO_for_1	222	225	PF00179	0.503
TRG_DiLeu_BaEn_1	183	188	PF01217	0.546
TRG_DiLeu_BaEn_1	225	230	PF01217	0.517
TRG_DiLeu_BaEn_2	216	222	PF01217	0.546
TRG_DiLeu_BaLyEn_6	145	150	PF01217	0.407
TRG_ENDOCYTIC_2	155	158	PF00928	0.546
TRG_ENDOCYTIC_2	184	187	PF00928	0.535
TRG_ER_diArg_1	146	148	PF00400	0.396
TRG_ER_diArg_1	218	220	PF00400	0.617
TRG_NES_CRM1_1	190	204	PF08389	0.546
TRG_NLS_MonoCore_2	144	149	PF00514	0.508
TRG_Pf-PMV_PEXEL_1	147	152	PF00026	0.346
TRG_Pf-PMV_PEXEL_1	220	224	PF00026	0.470
TRG_Pf-PMV_PEXEL_1	58	62	PF00026	0.540

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P987	Leptomonas seymouri	67%	100%
A0A3S7X377	Leishmania donovani	100%	100%
A4HI62	Leishmania braziliensis	74%	97%
E9B0N6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q7J6	Leishmania major	89%	100%