LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I5D5_LEIIN
TriTrypDb:
LINF_300016000
Length:
250

Annotations

Annotations by Jardim et al.

Tricarboxylic acid cycle, Succinate dehydrogenase subunit 7 (SDH7)Complex II Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 5, no: 5
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005749 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) 4 1
GO:0032991 protein-containing complex 1 1
GO:0045257 succinate dehydrogenase complex (ubiquinone) 5 1
GO:0045281 succinate dehydrogenase complex 4 1
GO:0045283 fumarate reductase complex 3 1
GO:0098796 membrane protein complex 2 1
GO:0098798 mitochondrial protein-containing complex 2 1
GO:0098800 inner mitochondrial membrane protein complex 3 1
GO:0098803 respiratory chain complex 3 1
GO:1902494 catalytic complex 2 1
GO:1990204 oxidoreductase complex 3 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I5D5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5D5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 203 207 PF00656 0.488
CLV_NRD_NRD_1 154 156 PF00675 0.440
CLV_NRD_NRD_1 2 4 PF00675 0.548
CLV_NRD_NRD_1 247 249 PF00675 0.558
CLV_PCSK_KEX2_1 2 4 PF00082 0.548
CLV_PCSK_KEX2_1 242 244 PF00082 0.461
CLV_PCSK_KEX2_1 247 249 PF00082 0.485
CLV_PCSK_KEX2_1 56 58 PF00082 0.426
CLV_PCSK_PC1ET2_1 242 244 PF00082 0.461
CLV_PCSK_PC1ET2_1 56 58 PF00082 0.426
CLV_PCSK_PC7_1 243 249 PF00082 0.537
CLV_PCSK_SKI1_1 137 141 PF00082 0.434
CLV_PCSK_SKI1_1 161 165 PF00082 0.411
CLV_PCSK_SKI1_1 243 247 PF00082 0.535
CLV_PCSK_SKI1_1 56 60 PF00082 0.413
CLV_PCSK_SKI1_1 88 92 PF00082 0.419
DEG_APCC_DBOX_1 87 95 PF00400 0.465
DEG_MDM2_SWIB_1 110 118 PF02201 0.393
DEG_Nend_UBRbox_1 1 4 PF02207 0.551
DEG_SPOP_SBC_1 26 30 PF00917 0.655
DOC_CYCLIN_RxL_1 82 95 PF00134 0.436
DOC_MAPK_gen_1 217 226 PF00069 0.460
DOC_MAPK_HePTP_8 216 228 PF00069 0.517
DOC_MAPK_MEF2A_6 217 226 PF00069 0.471
DOC_PP1_RVXF_1 159 166 PF00149 0.490
DOC_USP7_MATH_1 204 208 PF00917 0.435
DOC_USP7_MATH_1 227 231 PF00917 0.501
DOC_USP7_MATH_1 25 29 PF00917 0.584
DOC_USP7_UBL2_3 146 150 PF12436 0.419
LIG_14-3-3_CanoR_1 117 122 PF00244 0.406
LIG_14-3-3_CanoR_1 34 44 PF00244 0.553
LIG_14-3-3_CanoR_1 57 64 PF00244 0.453
LIG_BRCT_BRCA1_1 65 69 PF00533 0.450
LIG_CtBP_PxDLS_1 213 217 PF00389 0.507
LIG_deltaCOP1_diTrp_1 46 54 PF00928 0.429
LIG_DLG_GKlike_1 117 124 PF00625 0.473
LIG_eIF4E_1 159 165 PF01652 0.459
LIG_FHA_1 244 250 PF00498 0.591
LIG_LIR_Apic_2 68 73 PF02991 0.488
LIG_LIR_Gen_1 171 182 PF02991 0.375
LIG_LIR_Nem_3 108 113 PF02991 0.395
LIG_LIR_Nem_3 122 128 PF02991 0.362
LIG_LIR_Nem_3 132 138 PF02991 0.396
LIG_LIR_Nem_3 171 177 PF02991 0.375
LIG_LIR_Nem_3 38 43 PF02991 0.465
LIG_LIR_Nem_3 62 67 PF02991 0.406
LIG_LIR_Nem_3 68 72 PF02991 0.431
LIG_MYND_3 221 225 PF01753 0.513
LIG_Pex14_1 106 110 PF04695 0.381
LIG_Pex14_2 110 114 PF04695 0.376
LIG_PTB_Apo_2 159 166 PF02174 0.498
LIG_SH2_CRK 125 129 PF00017 0.404
LIG_SH2_CRK 136 140 PF00017 0.410
LIG_SH2_CRK 174 178 PF00017 0.376
LIG_SH2_NCK_1 174 178 PF00017 0.404
LIG_SH2_STAP1 174 178 PF00017 0.371
LIG_SH2_STAT3 182 185 PF00017 0.442
LIG_SH2_STAT5 129 132 PF00017 0.423
LIG_SH2_STAT5 138 141 PF00017 0.411
LIG_SH2_STAT5 159 162 PF00017 0.371
LIG_SH2_STAT5 174 177 PF00017 0.378
LIG_SH2_STAT5 183 186 PF00017 0.397
LIG_SH2_STAT5 197 200 PF00017 0.298
LIG_SH2_STAT5 37 40 PF00017 0.521
LIG_SH2_STAT5 89 92 PF00017 0.344
LIG_SUMO_SIM_anti_2 225 230 PF11976 0.469
LIG_TYR_ITAM 122 139 PF00017 0.449
LIG_UBA3_1 153 161 PF00899 0.505
LIG_WRC_WIRS_1 205 210 PF05994 0.386
LIG_WRC_WIRS_1 64 69 PF05994 0.429
MOD_CK1_1 14 20 PF00069 0.704
MOD_CK2_1 102 108 PF00069 0.354
MOD_CK2_1 57 63 PF00069 0.444
MOD_CK2_1 89 95 PF00069 0.373
MOD_Cter_Amidation 208 211 PF01082 0.527
MOD_Cter_Amidation 240 243 PF01082 0.555
MOD_GlcNHglycan 13 16 PF01048 0.636
MOD_GlcNHglycan 8 11 PF01048 0.643
MOD_GSK3_1 14 21 PF00069 0.675
MOD_GSK3_1 35 42 PF00069 0.482
MOD_GSK3_1 59 66 PF00069 0.412
MOD_N-GLC_1 141 146 PF02516 0.404
MOD_N-GLC_1 50 55 PF02516 0.481
MOD_NEK2_1 102 107 PF00069 0.384
MOD_NEK2_1 124 129 PF00069 0.387
MOD_NEK2_1 35 40 PF00069 0.597
MOD_NEK2_2 227 232 PF00069 0.507
MOD_PIKK_1 57 63 PF00454 0.496
MOD_PKA_1 56 62 PF00069 0.418
MOD_PKA_2 56 62 PF00069 0.399
MOD_PKB_1 115 123 PF00069 0.469
MOD_Plk_1 50 56 PF00069 0.498
MOD_Plk_2-3 63 69 PF00069 0.545
MOD_Plk_4 109 115 PF00069 0.409
MOD_Plk_4 124 130 PF00069 0.349
MOD_Plk_4 50 56 PF00069 0.487
TRG_DiLeu_BaLyEn_6 97 102 PF01217 0.394
TRG_ENDOCYTIC_2 125 128 PF00928 0.395
TRG_ENDOCYTIC_2 136 139 PF00928 0.375
TRG_ENDOCYTIC_2 174 177 PF00928 0.378
TRG_ENDOCYTIC_2 64 67 PF00928 0.399
TRG_ER_diArg_1 1 3 PF00400 0.556
TRG_ER_diArg_1 247 249 PF00400 0.558

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PEB7 Leptomonas seymouri 80% 100%
A0A0S4J0Y6 Bodo saltans 47% 100%
A0A1X0P208 Trypanosomatidae 56% 100%
A0A3R7MXF5 Trypanosoma rangeli 59% 100%
A0A3S7X3E5 Leishmania donovani 99% 100%
A4HI59 Leishmania braziliensis 85% 100%
C9ZQR7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 56% 100%
E9B0N3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
Q4Q7J9 Leishmania major 98% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS