DNAj-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

DNAj-like protein

Gene product:

DNAj-like protein

Species:

Leishmania infantum

UniProt:

A4I5D4_LEIIN

TriTrypDb:

LINF_300015900

Length:

312

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I5D4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5D4

PDB structure(s): 7am2_BS

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	1
GO:0009987	cellular process	1	1
GO:0061077	chaperone-mediated protein folding	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0044183	protein folding chaperone	1	1
GO:0051082	unfolded protein binding	3	1
GO:0051087	protein-folding chaperone binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	255	259	PF00656	0.633
CLV_C14_Caspase3-7	275	279	PF00656	0.603
CLV_MEL_PAP_1	2	8	PF00089	0.545
CLV_NRD_NRD_1	120	122	PF00675	0.514
CLV_NRD_NRD_1	133	135	PF00675	0.561
CLV_NRD_NRD_1	19	21	PF00675	0.454
CLV_NRD_NRD_1	31	33	PF00675	0.693
CLV_NRD_NRD_1	4	6	PF00675	0.539
CLV_NRD_NRD_1	63	65	PF00675	0.753
CLV_NRD_NRD_1	85	87	PF00675	0.590
CLV_PCSK_FUR_1	118	122	PF00082	0.521
CLV_PCSK_KEX2_1	118	120	PF00082	0.507
CLV_PCSK_KEX2_1	133	135	PF00082	0.547
CLV_PCSK_KEX2_1	18	20	PF00082	0.382
CLV_PCSK_KEX2_1	31	33	PF00082	0.693
CLV_PCSK_KEX2_1	4	6	PF00082	0.512
CLV_PCSK_KEX2_1	63	65	PF00082	0.750
CLV_PCSK_KEX2_1	85	87	PF00082	0.603
DEG_Nend_Nbox_1	1	3	PF02207	0.405
DEG_SPOP_SBC_1	149	153	PF00917	0.804
DEG_SPOP_SBC_1	71	75	PF00917	0.762
DOC_CKS1_1	231	236	PF01111	0.491
DOC_PP1_SILK_1	192	197	PF00149	0.649
DOC_PP4_FxxP_1	79	82	PF00568	0.547
DOC_USP7_MATH_1	149	153	PF00917	0.735
DOC_USP7_MATH_1	54	58	PF00917	0.740
DOC_WW_Pin1_4	151	156	PF00397	0.726
DOC_WW_Pin1_4	230	235	PF00397	0.487
DOC_WW_Pin1_4	253	258	PF00397	0.590
DOC_WW_Pin1_4	277	282	PF00397	0.663
DOC_WW_Pin1_4	46	51	PF00397	0.768
LIG_14-3-3_CanoR_1	284	289	PF00244	0.575
LIG_14-3-3_CanoR_1	4	13	PF00244	0.425
LIG_AP2alpha_1	100	104	PF02296	0.514
LIG_BRCT_BRCA1_1	75	79	PF00533	0.659
LIG_CaM_IQ_9	113	129	PF13499	0.575
LIG_DLG_GKlike_1	284	292	PF00625	0.572
LIG_FHA_1	290	296	PF00498	0.569
LIG_FHA_2	106	112	PF00498	0.532
LIG_FHA_2	175	181	PF00498	0.559
LIG_FHA_2	231	237	PF00498	0.471
LIG_FHA_2	273	279	PF00498	0.644
LIG_Integrin_RGD_1	93	95	PF01839	0.460
LIG_LIR_Apic_2	307	311	PF02991	0.443
LIG_LIR_Apic_2	76	82	PF02991	0.548
LIG_LIR_Gen_1	7	17	PF02991	0.432
LIG_LIR_Nem_3	214	219	PF02991	0.452
LIG_LIR_Nem_3	7	13	PF02991	0.435
LIG_Pex14_2	100	104	PF04695	0.422
LIG_SH2_CRK	308	312	PF00017	0.452
LIG_SH2_CRK	87	91	PF00017	0.642
LIG_SH2_SRC	265	268	PF00017	0.659
LIG_SH2_SRC	276	279	PF00017	0.562
LIG_SH2_SRC	294	297	PF00017	0.570
LIG_SH2_STAP1	244	248	PF00017	0.421
LIG_SH2_STAT5	294	297	PF00017	0.587
LIG_SH3_3	198	204	PF00018	0.603
LIG_SH3_3	206	212	PF00018	0.490
LIG_SH3_3	215	221	PF00018	0.352
LIG_SH3_3	223	229	PF00018	0.414
LIG_SH3_3	231	237	PF00018	0.455
LIG_WRPW_2	219	222	PF00400	0.435
MOD_CDK_SPxxK_3	253	260	PF00069	0.608
MOD_CDK_SPxxK_3	277	284	PF00069	0.586
MOD_CK1_1	145	151	PF00069	0.778
MOD_CK1_1	252	258	PF00069	0.640
MOD_CK1_1	57	63	PF00069	0.796
MOD_CK1_1	69	75	PF00069	0.685
MOD_CK2_1	105	111	PF00069	0.589
MOD_CK2_1	174	180	PF00069	0.592
MOD_CK2_1	230	236	PF00069	0.460
MOD_Cter_Amidation	61	64	PF01082	0.553
MOD_GlcNHglycan	284	287	PF01048	0.500
MOD_GlcNHglycan	36	39	PF01048	0.745
MOD_GlcNHglycan	57	60	PF01048	0.802
MOD_GSK3_1	137	144	PF00069	0.709
MOD_GSK3_1	145	152	PF00069	0.770
MOD_GSK3_1	242	249	PF00069	0.600
MOD_GSK3_1	252	259	PF00069	0.580
MOD_GSK3_1	280	287	PF00069	0.527
MOD_GSK3_1	42	49	PF00069	0.733
MOD_GSK3_1	65	72	PF00069	0.724
MOD_N-GLC_1	145	150	PF02516	0.745
MOD_PIKK_1	242	248	PF00454	0.645
MOD_PKA_1	4	10	PF00069	0.562
MOD_PKA_1	64	70	PF00069	0.722
MOD_PKA_2	4	10	PF00069	0.562
MOD_PKA_2	54	60	PF00069	0.727
MOD_Plk_1	246	252	PF00069	0.633
MOD_Plk_2-3	105	111	PF00069	0.540
MOD_ProDKin_1	151	157	PF00069	0.725
MOD_ProDKin_1	230	236	PF00069	0.490
MOD_ProDKin_1	253	259	PF00069	0.587
MOD_ProDKin_1	277	283	PF00069	0.661
MOD_ProDKin_1	46	52	PF00069	0.771
MOD_SUMO_rev_2	102	109	PF00179	0.474
TRG_ENDOCYTIC_2	10	13	PF00928	0.426
TRG_ENDOCYTIC_2	216	219	PF00928	0.459
TRG_ER_diArg_1	118	121	PF00400	0.516
TRG_ER_diArg_1	17	20	PF00400	0.606
TRG_ER_diArg_1	3	5	PF00400	0.566
TRG_ER_diArg_1	85	87	PF00400	0.604
TRG_Pf-PMV_PEXEL_1	107	111	PF00026	0.572

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8S6	Leptomonas seymouri	59%	76%
A0A0S4JEE6	Bodo saltans	30%	98%
A0A1X0P2B2	Trypanosomatidae	36%	85%
A0A3Q8IFJ9	Leishmania donovani	99%	74%
A0A3R7P4U9	Trypanosoma rangeli	38%	92%
A4HI58	Leishmania braziliensis	79%	99%
C9ZQR6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	81%
E9B0N2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q7K0	Leishmania major	87%	100%
V5BPN3	Trypanosoma cruzi	34%	93%