Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I5D3_LEIIN

TriTrypDb:

LINF_300015800

Length:

538

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I5D3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5D3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	204	208	PF00656	0.618
CLV_C14_Caspase3-7	308	312	PF00656	0.663
CLV_C14_Caspase3-7	49	53	PF00656	0.716
CLV_NRD_NRD_1	138	140	PF00675	0.608
CLV_NRD_NRD_1	243	245	PF00675	0.685
CLV_NRD_NRD_1	246	248	PF00675	0.693
CLV_NRD_NRD_1	371	373	PF00675	0.801
CLV_NRD_NRD_1	389	391	PF00675	0.598
CLV_NRD_NRD_1	438	440	PF00675	0.528
CLV_NRD_NRD_1	54	56	PF00675	0.624
CLV_PCSK_FUR_1	21	25	PF00082	0.647
CLV_PCSK_FUR_1	244	248	PF00082	0.709
CLV_PCSK_FUR_1	39	43	PF00082	0.628
CLV_PCSK_KEX2_1	138	140	PF00082	0.608
CLV_PCSK_KEX2_1	209	211	PF00082	0.594
CLV_PCSK_KEX2_1	23	25	PF00082	0.644
CLV_PCSK_KEX2_1	243	245	PF00082	0.689
CLV_PCSK_KEX2_1	246	248	PF00082	0.688
CLV_PCSK_KEX2_1	41	43	PF00082	0.633
CLV_PCSK_KEX2_1	438	440	PF00082	0.503
CLV_PCSK_KEX2_1	54	56	PF00082	0.624
CLV_PCSK_PC1ET2_1	209	211	PF00082	0.594
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.644
CLV_PCSK_PC1ET2_1	41	43	PF00082	0.642
CLV_PCSK_PC7_1	19	25	PF00082	0.648
CLV_PCSK_SKI1_1	15	19	PF00082	0.587
CLV_PCSK_SKI1_1	159	163	PF00082	0.527
CLV_PCSK_SKI1_1	173	177	PF00082	0.592
CLV_PCSK_SKI1_1	390	394	PF00082	0.577
CLV_Separin_Metazoa	340	344	PF03568	0.536
CLV_Separin_Metazoa	415	419	PF03568	0.610
DEG_APCC_DBOX_1	172	180	PF00400	0.552
DEG_APCC_DBOX_1	409	417	PF00400	0.502
DEG_APCC_DBOX_1	437	445	PF00400	0.552
DEG_Nend_Nbox_1	1	3	PF02207	0.603
DEG_SPOP_SBC_1	261	265	PF00917	0.634
DEG_SPOP_SBC_1	275	279	PF00917	0.589
DOC_CYCLIN_RxL_1	473	484	PF00134	0.543
DOC_CYCLIN_yCln2_LP_2	321	327	PF00134	0.670
DOC_MAPK_DCC_7	438	446	PF00069	0.528
DOC_MAPK_gen_1	334	341	PF00069	0.501
DOC_MAPK_gen_1	390	399	PF00069	0.684
DOC_MAPK_gen_1	438	446	PF00069	0.481
DOC_MAPK_MEF2A_6	438	447	PF00069	0.475
DOC_PP2B_LxvP_1	321	324	PF13499	0.567
DOC_PP2B_LxvP_1	76	79	PF13499	0.516
DOC_USP7_MATH_1	261	265	PF00917	0.673
DOC_USP7_MATH_1	276	280	PF00917	0.576
DOC_USP7_MATH_1	293	297	PF00917	0.772
DOC_USP7_MATH_1	330	334	PF00917	0.724
DOC_USP7_MATH_1	409	413	PF00917	0.522
DOC_USP7_MATH_1	491	495	PF00917	0.522
DOC_WW_Pin1_4	257	262	PF00397	0.798
DOC_WW_Pin1_4	263	268	PF00397	0.545
LIG_14-3-3_CanoR_1	11	18	PF00244	0.655
LIG_14-3-3_CanoR_1	257	261	PF00244	0.709
LIG_14-3-3_CanoR_1	3	8	PF00244	0.660
LIG_14-3-3_CanoR_1	407	417	PF00244	0.599
LIG_14-3-3_CanoR_1	42	50	PF00244	0.629
LIG_14-3-3_CanoR_1	438	442	PF00244	0.557
LIG_14-3-3_CanoR_1	460	469	PF00244	0.617
LIG_14-3-3_CanoR_1	476	481	PF00244	0.391
LIG_Actin_WH2_2	112	130	PF00022	0.647
LIG_BIR_III_2	432	436	PF00653	0.681
LIG_BIR_III_4	328	332	PF00653	0.669
LIG_BRCT_BRCA1_1	13	17	PF00533	0.677
LIG_BRCT_BRCA1_1	276	280	PF00533	0.708
LIG_BRCT_BRCA1_1	483	487	PF00533	0.498
LIG_Clathr_ClatBox_1	444	448	PF01394	0.472
LIG_CSL_BTD_1	504	507	PF09270	0.518
LIG_deltaCOP1_diTrp_1	503	511	PF00928	0.518
LIG_eIF4E_1	225	231	PF01652	0.533
LIG_EVH1_2	267	271	PF00568	0.797
LIG_FHA_1	122	128	PF00498	0.605
LIG_FHA_1	279	285	PF00498	0.693
LIG_FHA_1	376	382	PF00498	0.787
LIG_FHA_1	387	393	PF00498	0.668
LIG_FHA_1	45	51	PF00498	0.768
LIG_FHA_2	202	208	PF00498	0.746
LIG_FHA_2	3	9	PF00498	0.705
LIG_FHA_2	306	312	PF00498	0.730
LIG_GBD_Chelix_1	125	133	PF00786	0.410
LIG_GBD_Chelix_1	157	165	PF00786	0.572
LIG_IBAR_NPY_1	104	106	PF08397	0.601
LIG_LIR_Gen_1	152	161	PF02991	0.532
LIG_LIR_Gen_1	364	371	PF02991	0.599
LIG_LIR_Gen_1	448	456	PF02991	0.626
LIG_LIR_Nem_3	152	157	PF02991	0.557
LIG_LIR_Nem_3	364	369	PF02991	0.596
LIG_LIR_Nem_3	448	452	PF02991	0.560
LIG_LIR_Nem_3	484	490	PF02991	0.463
LIG_SH2_CRK	40	44	PF00017	0.627
LIG_SH2_CRK	449	453	PF00017	0.588
LIG_SH2_NCK_1	449	453	PF00017	0.588
LIG_SH2_STAP1	449	453	PF00017	0.471
LIG_SH2_STAT5	421	424	PF00017	0.533
LIG_SH2_STAT5	514	517	PF00017	0.658
LIG_SH3_3	128	134	PF00018	0.440
LIG_SH3_3	145	151	PF00018	0.561
LIG_SH3_3	356	362	PF00018	0.476
LIG_SUMO_SIM_par_1	442	448	PF11976	0.478
LIG_TRAF2_1	88	91	PF00917	0.534
LIG_TYR_ITIM	447	452	PF00017	0.553
LIG_WRC_WIRS_1	4	9	PF05994	0.524
MOD_CK1_1	201	207	PF00069	0.562
MOD_CK1_1	259	265	PF00069	0.733
MOD_CK1_1	274	280	PF00069	0.697
MOD_CK1_1	316	322	PF00069	0.651
MOD_CK1_1	364	370	PF00069	0.661
MOD_CK1_1	376	382	PF00069	0.587
MOD_CK1_1	44	50	PF00069	0.747
MOD_CK1_1	463	469	PF00069	0.625
MOD_CK1_1	85	91	PF00069	0.546
MOD_CK2_1	343	349	PF00069	0.553
MOD_CK2_1	409	415	PF00069	0.586
MOD_CK2_1	85	91	PF00069	0.546
MOD_Cter_Amidation	207	210	PF01082	0.618
MOD_Cter_Amidation	52	55	PF01082	0.626
MOD_DYRK1A_RPxSP_1	257	261	PF00069	0.714
MOD_GlcNHglycan	170	173	PF01048	0.604
MOD_GlcNHglycan	316	319	PF01048	0.728
MOD_GlcNHglycan	321	324	PF01048	0.695
MOD_GlcNHglycan	344	348	PF01048	0.532
MOD_GlcNHglycan	483	486	PF01048	0.550
MOD_GSK3_1	182	189	PF00069	0.469
MOD_GSK3_1	194	201	PF00069	0.585
MOD_GSK3_1	235	242	PF00069	0.637
MOD_GSK3_1	256	263	PF00069	0.696
MOD_GSK3_1	271	278	PF00069	0.684
MOD_GSK3_1	280	287	PF00069	0.617
MOD_GSK3_1	289	296	PF00069	0.538
MOD_GSK3_1	313	320	PF00069	0.654
MOD_GSK3_1	41	48	PF00069	0.687
MOD_GSK3_1	460	467	PF00069	0.659
MOD_N-GLC_1	100	105	PF02516	0.612
MOD_N-GLC_1	121	126	PF02516	0.561
MOD_NEK2_1	121	126	PF00069	0.561
MOD_NEK2_1	168	173	PF00069	0.578
MOD_NEK2_1	186	191	PF00069	0.466
MOD_NEK2_1	2	7	PF00069	0.633
MOD_NEK2_1	230	235	PF00069	0.645
MOD_NEK2_1	256	261	PF00069	0.643
MOD_NEK2_1	280	285	PF00069	0.717
MOD_NEK2_1	408	413	PF00069	0.584
MOD_NEK2_1	490	495	PF00069	0.532
MOD_PIKK_1	293	299	PF00454	0.763
MOD_PK_1	42	48	PF00069	0.761
MOD_PKA_1	41	47	PF00069	0.624
MOD_PKA_2	10	16	PF00069	0.589
MOD_PKA_2	2	8	PF00069	0.714
MOD_PKA_2	256	262	PF00069	0.708
MOD_PKA_2	30	36	PF00069	0.573
MOD_PKA_2	409	415	PF00069	0.508
MOD_PKA_2	41	47	PF00069	0.624
MOD_PKA_2	437	443	PF00069	0.551
MOD_PKB_1	458	466	PF00069	0.705
MOD_Plk_1	121	127	PF00069	0.551
MOD_Plk_1	186	192	PF00069	0.576
MOD_Plk_1	376	382	PF00069	0.762
MOD_Plk_1	447	453	PF00069	0.570
MOD_Plk_1	491	497	PF00069	0.516
MOD_Plk_4	115	121	PF00069	0.559
MOD_Plk_4	153	159	PF00069	0.507
MOD_Plk_4	280	286	PF00069	0.664
MOD_Plk_4	305	311	PF00069	0.646
MOD_Plk_4	469	475	PF00069	0.546
MOD_Plk_4	491	497	PF00069	0.516
MOD_ProDKin_1	257	263	PF00069	0.797
MOD_SUMO_rev_2	111	119	PF00179	0.624
MOD_SUMO_rev_2	155	164	PF00179	0.530
MOD_SUMO_rev_2	201	211	PF00179	0.661
TRG_DiLeu_BaLyEn_6	348	353	PF01217	0.561
TRG_ENDOCYTIC_2	40	43	PF00928	0.638
TRG_ENDOCYTIC_2	449	452	PF00928	0.531
TRG_ER_diArg_1	138	140	PF00400	0.598
TRG_ER_diArg_1	18	21	PF00400	0.617
TRG_ER_diArg_1	231	234	PF00400	0.657
TRG_ER_diArg_1	243	246	PF00400	0.736
TRG_Pf-PMV_PEXEL_1	391	395	PF00026	0.561
TRG_Pf-PMV_PEXEL_1	476	481	PF00026	0.463
TRG_Pf-PMV_PEXEL_1	488	492	PF00026	0.403

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PGI0	Leptomonas seymouri	48%	93%
A0A1X0P334	Trypanosomatidae	38%	100%
A0A3Q8IFQ7	Leishmania donovani	99%	100%
A4HI57	Leishmania braziliensis	74%	100%
C9ZQR5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9B0N1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q7K1	Leishmania major	91%	100%