Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase - putativeGeneDB:LmjF.30.1000

Species:

Leishmania infantum

UniProt:

A4I5D1_LEIIN

TriTrypDb:

LINF_300015600

Length:

611

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I5D1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5D1

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016310	phosphorylation	5	12
GO:0019538	protein metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:0007165	signal transduction	2	1
GO:0018105	peptidyl-serine phosphorylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018209	peptidyl-serine modification	6	1
GO:0035556	intracellular signal transduction	3	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004672	protein kinase activity	3	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016301	kinase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0004674	protein serine/threonine kinase activity	4	2
GO:0106310	protein serine kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	156	160	PF00656	0.561
CLV_C14_Caspase3-7	269	273	PF00656	0.688
CLV_C14_Caspase3-7	380	384	PF00656	0.411
CLV_NRD_NRD_1	292	294	PF00675	0.550
CLV_NRD_NRD_1	303	305	PF00675	0.267
CLV_NRD_NRD_1	393	395	PF00675	0.443
CLV_NRD_NRD_1	429	431	PF00675	0.439
CLV_NRD_NRD_1	452	454	PF00675	0.601
CLV_PCSK_FUR_1	290	294	PF00082	0.568
CLV_PCSK_FUR_1	301	305	PF00082	0.239
CLV_PCSK_FUR_1	450	454	PF00082	0.501
CLV_PCSK_KEX2_1	174	176	PF00082	0.343
CLV_PCSK_KEX2_1	290	292	PF00082	0.552
CLV_PCSK_KEX2_1	303	305	PF00082	0.349
CLV_PCSK_KEX2_1	393	395	PF00082	0.440
CLV_PCSK_KEX2_1	412	414	PF00082	0.199
CLV_PCSK_KEX2_1	429	431	PF00082	0.445
CLV_PCSK_KEX2_1	452	454	PF00082	0.601
CLV_PCSK_PC1ET2_1	174	176	PF00082	0.289
CLV_PCSK_PC1ET2_1	412	414	PF00082	0.424
CLV_PCSK_SKI1_1	174	178	PF00082	0.270
CLV_PCSK_SKI1_1	216	220	PF00082	0.244
CLV_PCSK_SKI1_1	292	296	PF00082	0.547
CLV_PCSK_SKI1_1	430	434	PF00082	0.344
DEG_COP1_1	153	161	PF00400	0.412
DEG_Nend_UBRbox_3	1	3	PF02207	0.599
DEG_SPOP_SBC_1	180	184	PF00917	0.513
DEG_SPOP_SBC_1	285	289	PF00917	0.498
DOC_CKS1_1	564	569	PF01111	0.736
DOC_CYCLIN_RxL_1	184	193	PF00134	0.513
DOC_MAPK_gen_1	216	225	PF00069	0.457
DOC_MAPK_gen_1	228	236	PF00069	0.444
DOC_MAPK_gen_1	290	296	PF00069	0.552
DOC_MAPK_JIP1_4	20	26	PF00069	0.512
DOC_MAPK_MEF2A_6	369	378	PF00069	0.377
DOC_PP1_RVXF_1	185	192	PF00149	0.486
DOC_PP4_FxxP_1	511	514	PF00568	0.519
DOC_USP7_MATH_1	12	16	PF00917	0.582
DOC_USP7_MATH_1	136	140	PF00917	0.484
DOC_USP7_MATH_1	164	168	PF00917	0.566
DOC_USP7_MATH_1	180	184	PF00917	0.421
DOC_USP7_MATH_1	268	272	PF00917	0.712
DOC_USP7_MATH_1	285	289	PF00917	0.690
DOC_USP7_MATH_1	31	35	PF00917	0.373
DOC_USP7_MATH_1	487	491	PF00917	0.672
DOC_USP7_MATH_1	498	502	PF00917	0.347
DOC_USP7_MATH_1	546	550	PF00917	0.732
DOC_USP7_MATH_1	552	556	PF00917	0.678
DOC_USP7_MATH_1	568	572	PF00917	0.716
DOC_USP7_UBL2_3	58	62	PF12436	0.444
DOC_WW_Pin1_4	142	147	PF00397	0.502
DOC_WW_Pin1_4	314	319	PF00397	0.313
DOC_WW_Pin1_4	350	355	PF00397	0.430
DOC_WW_Pin1_4	5	10	PF00397	0.613
DOC_WW_Pin1_4	563	568	PF00397	0.670
LIG_14-3-3_CanoR_1	291	297	PF00244	0.516
LIG_14-3-3_CanoR_1	304	310	PF00244	0.343
LIG_14-3-3_CanoR_1	522	530	PF00244	0.556
LIG_APCC_ABBA_1	414	419	PF00400	0.489
LIG_APCC_ABBA_1	508	513	PF00400	0.393
LIG_APCC_ABBAyCdc20_2	413	419	PF00400	0.320
LIG_BIR_III_2	526	530	PF00653	0.512
LIG_BIR_III_4	381	385	PF00653	0.320
LIG_BIR_III_4	479	483	PF00653	0.554
LIG_Clathr_ClatBox_1	233	237	PF01394	0.444
LIG_deltaCOP1_diTrp_1	323	333	PF00928	0.343
LIG_EH_1	527	531	PF12763	0.477
LIG_FHA_1	152	158	PF00498	0.412
LIG_FHA_1	196	202	PF00498	0.446
LIG_FHA_1	236	242	PF00498	0.514
LIG_FHA_1	564	570	PF00498	0.723
LIG_FHA_2	351	357	PF00498	0.374
LIG_FHA_2	533	539	PF00498	0.605
LIG_FXI_DFP_1	233	237	PF00024	0.244
LIG_LIR_Apic_2	312	318	PF02991	0.283
LIG_LIR_Gen_1	190	199	PF02991	0.471
LIG_LIR_Gen_1	353	362	PF02991	0.321
LIG_LIR_Gen_1	392	402	PF02991	0.258
LIG_LIR_Gen_1	504	514	PF02991	0.405
LIG_LIR_Nem_3	101	107	PF02991	0.508
LIG_LIR_Nem_3	190	194	PF02991	0.471
LIG_LIR_Nem_3	353	358	PF02991	0.481
LIG_LIR_Nem_3	371	376	PF02991	0.247
LIG_LIR_Nem_3	392	398	PF02991	0.258
LIG_LIR_Nem_3	504	509	PF02991	0.378
LIG_LIR_Nem_3	513	519	PF02991	0.355
LIG_LIR_Nem_3	601	607	PF02991	0.535
LIG_PCNA_yPIPBox_3	62	75	PF02747	0.544
LIG_Pex14_2	105	109	PF04695	0.508
LIG_Pex14_2	530	534	PF04695	0.652
LIG_SH2_CRK	506	510	PF00017	0.389
LIG_SH2_NCK_1	340	344	PF00017	0.343
LIG_SH2_PTP2	315	318	PF00017	0.299
LIG_SH2_STAP1	340	344	PF00017	0.355
LIG_SH2_STAP1	516	520	PF00017	0.421
LIG_SH2_STAT3	121	124	PF00017	0.508
LIG_SH2_STAT5	104	107	PF00017	0.384
LIG_SH2_STAT5	121	124	PF00017	0.440
LIG_SH2_STAT5	315	318	PF00017	0.299
LIG_SH2_STAT5	366	369	PF00017	0.407
LIG_SH2_STAT5	519	522	PF00017	0.435
LIG_SH2_STAT5	595	598	PF00017	0.621
LIG_SH2_STAT5	603	606	PF00017	0.661
LIG_SH2_STAT5	89	92	PF00017	0.494
LIG_SH3_3	242	248	PF00018	0.565
LIG_SH3_3	251	257	PF00018	0.555
LIG_SH3_3	48	54	PF00018	0.491
LIG_SH3_3	561	567	PF00018	0.719
LIG_SH3_3	6	12	PF00018	0.611
LIG_SUMO_SIM_par_1	201	206	PF11976	0.532
LIG_SxIP_EBH_1	174	185	PF03271	0.508
LIG_TYR_ITIM	338	343	PF00017	0.318
LIG_WRC_WIRS_1	446	451	PF05994	0.503
MOD_CK1_1	139	145	PF00069	0.562
MOD_CK1_1	167	173	PF00069	0.532
MOD_CK1_1	286	292	PF00069	0.680
MOD_CK1_1	3	9	PF00069	0.591
MOD_CK1_1	327	333	PF00069	0.283
MOD_CK1_1	350	356	PF00069	0.424
MOD_CK1_1	459	465	PF00069	0.682
MOD_CK1_1	481	487	PF00069	0.695
MOD_CK1_1	501	507	PF00069	0.400
MOD_CK2_1	350	356	PF00069	0.424
MOD_CK2_1	362	368	PF00069	0.436
MOD_CK2_1	568	574	PF00069	0.694
MOD_CK2_1	96	102	PF00069	0.428
MOD_GlcNHglycan	165	169	PF01048	0.347
MOD_GlcNHglycan	33	36	PF01048	0.272
MOD_GlcNHglycan	349	352	PF01048	0.368
MOD_GlcNHglycan	462	465	PF01048	0.630
MOD_GlcNHglycan	479	483	PF01048	0.667
MOD_GlcNHglycan	484	487	PF01048	0.532
MOD_GlcNHglycan	497	501	PF01048	0.468
MOD_GlcNHglycan	554	557	PF01048	0.694
MOD_GlcNHglycan	558	561	PF01048	0.614
MOD_GSK3_1	166	173	PF00069	0.495
MOD_GSK3_1	305	312	PF00069	0.474
MOD_GSK3_1	31	38	PF00069	0.461
MOD_GSK3_1	455	462	PF00069	0.592
MOD_GSK3_1	463	470	PF00069	0.621
MOD_GSK3_1	474	481	PF00069	0.740
MOD_GSK3_1	532	539	PF00069	0.642
MOD_GSK3_1	552	559	PF00069	0.749
MOD_NEK2_1	294	299	PF00069	0.518
MOD_NEK2_1	309	314	PF00069	0.317
MOD_NEK2_1	423	428	PF00069	0.433
MOD_NEK2_1	456	461	PF00069	0.601
MOD_NEK2_1	593	598	PF00069	0.607
MOD_NEK2_1	93	98	PF00069	0.444
MOD_PIKK_1	294	300	PF00454	0.679
MOD_PIKK_1	35	41	PF00454	0.505
MOD_PIKK_1	532	538	PF00454	0.605
MOD_PK_1	70	76	PF00069	0.544
MOD_PKA_1	174	180	PF00069	0.545
MOD_PKA_1	292	298	PF00069	0.531
MOD_PKA_1	303	309	PF00069	0.231
MOD_PKA_2	174	180	PF00069	0.545
MOD_PKA_2	292	298	PF00069	0.522
MOD_PKA_2	303	309	PF00069	0.361
MOD_PKA_2	521	527	PF00069	0.538
MOD_PKB_1	290	298	PF00069	0.700
MOD_PKB_1	301	309	PF00069	0.364
MOD_Plk_1	423	429	PF00069	0.406
MOD_Plk_2-3	574	580	PF00069	0.685
MOD_Plk_4	362	368	PF00069	0.333
MOD_Plk_4	487	493	PF00069	0.422
MOD_Plk_4	574	580	PF00069	0.734
MOD_Plk_4	70	76	PF00069	0.544
MOD_ProDKin_1	142	148	PF00069	0.502
MOD_ProDKin_1	314	320	PF00069	0.313
MOD_ProDKin_1	350	356	PF00069	0.430
MOD_ProDKin_1	5	11	PF00069	0.611
MOD_ProDKin_1	563	569	PF00069	0.668
MOD_SUMO_for_1	218	221	PF00179	0.444
MOD_SUMO_rev_2	317	327	PF00179	0.424
TRG_DiLeu_BaLyEn_6	48	53	PF01217	0.470
TRG_ENDOCYTIC_2	104	107	PF00928	0.444
TRG_ENDOCYTIC_2	340	343	PF00928	0.299
TRG_ENDOCYTIC_2	506	509	PF00928	0.398
TRG_ER_diArg_1	290	293	PF00400	0.622
TRG_ER_diArg_1	301	304	PF00400	0.468
TRG_ER_diArg_1	393	395	PF00400	0.427
TRG_ER_diArg_1	428	430	PF00400	0.539
TRG_ER_diArg_1	449	452	PF00400	0.523
TRG_NES_CRM1_1	193	206	PF08389	0.532
TRG_Pf-PMV_PEXEL_1	216	221	PF00026	0.244

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMI5	Leptomonas seymouri	56%	99%
A0A0S4IZ51	Bodo saltans	39%	100%
A0A1X0P290	Trypanosomatidae	45%	100%
A0A3S7X363	Leishmania donovani	100%	100%
A0A422P4X7	Trypanosoma rangeli	39%	100%
A4HI55	Leishmania braziliensis	79%	100%
C9ZQR3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9B0M9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q7K3	Leishmania major	94%	100%
V5BU83	Trypanosoma cruzi	41%	100%