Putative p22 protein

Quick info Annotations Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

p22 protein precursor - putative

Species:

Leishmania infantum

UniProt:

A4I5C8_LEIIN

TriTrypDb:

LINF_300015300

Length:

204

Annotations

Annotations by Jardim et al.

Membrane associated proteins, p22

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 18
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0005759	mitochondrial matrix	5	20
GO:0031974	membrane-enclosed lumen	2	20
GO:0043233	organelle lumen	3	20
GO:0070013	intracellular organelle lumen	4	20
GO:0110165	cellular anatomical entity	1	20

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I5C8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5C8

PDB structure(s): 1yqf_A , 1yqf_B , 1yqf_C , 1yqf_D , 1yqf_E , 1yqf_F

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	22	26	PF00656	0.407
CLV_C14_Caspase3-7	83	87	PF00656	0.550
CLV_NRD_NRD_1	20	22	PF00675	0.497
CLV_NRD_NRD_1	33	35	PF00675	0.461
CLV_NRD_NRD_1	58	60	PF00675	0.398
CLV_PCSK_KEX2_1	142	144	PF00082	0.241
CLV_PCSK_KEX2_1	169	171	PF00082	0.307
CLV_PCSK_KEX2_1	20	22	PF00082	0.495
CLV_PCSK_KEX2_1	33	35	PF00082	0.458
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.295
CLV_PCSK_PC1ET2_1	169	171	PF00082	0.307
DEG_SPOP_SBC_1	7	11	PF00917	0.425
DOC_CKS1_1	48	53	PF01111	0.547
DOC_PP2B_LxvP_1	16	19	PF13499	0.490
DOC_USP7_MATH_1	19	23	PF00917	0.617
DOC_USP7_MATH_1	8	12	PF00917	0.667
DOC_WW_Pin1_4	47	52	PF00397	0.548
LIG_14-3-3_CanoR_1	20	28	PF00244	0.388
LIG_14-3-3_CanoR_1	6	16	PF00244	0.564
LIG_BIR_II_1	1	5	PF00653	0.435
LIG_CtBP_PxDLS_1	74	80	PF00389	0.456
LIG_deltaCOP1_diTrp_1	193	202	PF00928	0.417
LIG_FHA_1	146	152	PF00498	0.503
LIG_FHA_1	63	69	PF00498	0.425
LIG_FHA_2	133	139	PF00498	0.441
LIG_FHA_2	163	169	PF00498	0.413
LIG_FHA_2	30	36	PF00498	0.411
LIG_FHA_2	81	87	PF00498	0.488
LIG_GBD_Chelix_1	151	159	PF00786	0.307
LIG_LIR_Apic_2	145	150	PF02991	0.423
LIG_LIR_Gen_1	154	164	PF02991	0.507
LIG_LIR_Gen_1	178	187	PF02991	0.507
LIG_LIR_Gen_1	2	12	PF02991	0.462
LIG_LIR_LC3C_4	75	79	PF02991	0.452
LIG_LIR_Nem_3	154	160	PF02991	0.449
LIG_LIR_Nem_3	178	182	PF02991	0.490
LIG_LIR_Nem_3	2	7	PF02991	0.473
LIG_LIR_Nem_3	94	99	PF02991	0.430
LIG_LRP6_Inhibitor_1	118	124	PF00058	0.307
LIG_PTB_Apo_2	119	126	PF02174	0.462
LIG_SH2_CRK	147	151	PF00017	0.448
LIG_SH2_CRK	157	161	PF00017	0.448
LIG_SH2_NCK_1	126	130	PF00017	0.508
LIG_SH2_SRC	126	129	PF00017	0.495
LIG_SH2_STAP1	126	130	PF00017	0.539
LIG_SH2_STAP1	183	187	PF00017	0.444
LIG_SH2_STAP1	192	196	PF00017	0.345
LIG_SH2_STAT3	98	101	PF00017	0.507
LIG_SH2_STAT5	147	150	PF00017	0.507
LIG_SH2_STAT5	166	169	PF00017	0.423
LIG_SH2_STAT5	98	101	PF00017	0.466
LIG_SH3_3	43	49	PF00018	0.448
LIG_SH3_3	55	61	PF00018	0.593
LIG_TRAF2_1	112	115	PF00917	0.507
LIG_TYR_ITIM	155	160	PF00017	0.486
LIG_WRC_WIRS_1	182	187	PF05994	0.507
MOD_CK1_1	11	17	PF00069	0.659
MOD_CK2_1	109	115	PF00069	0.499
MOD_CK2_1	132	138	PF00069	0.448
MOD_CK2_1	162	168	PF00069	0.473
MOD_CK2_1	29	35	PF00069	0.365
MOD_GlcNHglycan	1	4	PF01048	0.597
MOD_GlcNHglycan	10	13	PF01048	0.552
MOD_GlcNHglycan	134	138	PF01048	0.275
MOD_GlcNHglycan	21	24	PF01048	0.430
MOD_GSK3_1	62	69	PF00069	0.402
MOD_GSK3_1	7	14	PF00069	0.564
MOD_GSK3_1	80	87	PF00069	0.527
MOD_GSK3_1	99	106	PF00069	0.425
MOD_NEK2_1	66	71	PF00069	0.362
MOD_PIKK_1	97	103	PF00454	0.413
MOD_PKA_2	19	25	PF00069	0.582
MOD_PKA_2	79	85	PF00069	0.473
MOD_Plk_1	109	115	PF00069	0.522
MOD_Plk_4	162	168	PF00069	0.430
MOD_Plk_4	181	187	PF00069	0.444
MOD_ProDKin_1	47	53	PF00069	0.553
MOD_SUMO_rev_2	168	176	PF00179	0.507
TRG_DiLeu_BaEn_1	114	119	PF01217	0.473
TRG_DiLeu_BaEn_1	73	78	PF01217	0.475
TRG_ENDOCYTIC_2	157	160	PF00928	0.486
TRG_ER_diArg_1	19	21	PF00400	0.513
TRG_Pf-PMV_PEXEL_1	34	38	PF00026	0.479

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P990	Leptomonas seymouri	86%	88%
A0A0N1HS24	Leptomonas seymouri	24%	80%
A0A0S4ITN8	Bodo saltans	39%	90%
A0A1X0NTH7	Trypanosomatidae	25%	78%
A0A1X0P207	Trypanosomatidae	46%	91%
A0A3Q8IBW7	Leishmania donovani	100%	88%
A0A3Q8IFM4	Leishmania donovani	27%	80%
A0A422P4Z7	Trypanosoma rangeli	41%	91%
A4HCI6	Leishmania braziliensis	28%	100%
A4HI52	Leishmania braziliensis	94%	100%
A4I007	Leishmania infantum	27%	100%
C9ZQR0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	90%
C9ZSQ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	78%
E9AVY0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9B0M6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4Q7K6	Leishmania major	98%	100%
Q4QBJ9	Leishmania major	27%	100%
V5BDB3	Trypanosoma cruzi	26%	78%