Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I5C7_LEIIN

TriTrypDb:

LINF_300015200

Length:

451

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I5C7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5C7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	197	199	PF00675	0.683
CLV_NRD_NRD_1	65	67	PF00675	0.688
CLV_PCSK_KEX2_1	197	199	PF00082	0.652
CLV_PCSK_KEX2_1	43	45	PF00082	0.764
CLV_PCSK_PC1ET2_1	43	45	PF00082	0.752
CLV_PCSK_SKI1_1	396	400	PF00082	0.647
CLV_PCSK_SKI1_1	446	450	PF00082	0.611
CLV_PCSK_SKI1_1	67	71	PF00082	0.600
DEG_Nend_UBRbox_3	1	3	PF02207	0.567
DOC_CDC14_PxL_1	266	274	PF14671	0.648
DOC_CKS1_1	75	80	PF01111	0.706
DOC_CYCLIN_yClb1_LxF_4	399	405	PF00134	0.561
DOC_CYCLIN_yCln2_LP_2	149	155	PF00134	0.643
DOC_CYCLIN_yCln2_LP_2	349	355	PF00134	0.635
DOC_PP2B_LxvP_1	115	118	PF13499	0.595
DOC_PP2B_LxvP_1	149	152	PF13499	0.664
DOC_PP2B_LxvP_1	79	82	PF13499	0.634
DOC_PP4_FxxP_1	404	407	PF00568	0.568
DOC_PP4_FxxP_1	410	413	PF00568	0.536
DOC_USP7_MATH_1	105	109	PF00917	0.543
DOC_USP7_MATH_1	169	173	PF00917	0.633
DOC_USP7_MATH_1	306	310	PF00917	0.649
DOC_USP7_MATH_1	39	43	PF00917	0.619
DOC_USP7_MATH_1	94	98	PF00917	0.631
DOC_WW_Pin1_4	101	106	PF00397	0.568
DOC_WW_Pin1_4	151	156	PF00397	0.647
DOC_WW_Pin1_4	239	244	PF00397	0.678
DOC_WW_Pin1_4	273	278	PF00397	0.665
DOC_WW_Pin1_4	326	331	PF00397	0.708
DOC_WW_Pin1_4	359	364	PF00397	0.656
DOC_WW_Pin1_4	375	380	PF00397	0.628
DOC_WW_Pin1_4	4	9	PF00397	0.656
DOC_WW_Pin1_4	49	54	PF00397	0.685
DOC_WW_Pin1_4	74	79	PF00397	0.698
DOC_WW_Pin1_4	90	95	PF00397	0.580
LIG_14-3-3_CanoR_1	159	166	PF00244	0.708
LIG_14-3-3_CanoR_1	184	191	PF00244	0.606
LIG_14-3-3_CanoR_1	197	201	PF00244	0.594
LIG_14-3-3_CanoR_1	299	304	PF00244	0.657
LIG_14-3-3_CanoR_1	361	367	PF00244	0.743
LIG_14-3-3_CanoR_1	73	78	PF00244	0.591
LIG_Clathr_ClatBox_1	402	406	PF01394	0.564
LIG_CtBP_PxDLS_1	379	383	PF00389	0.442
LIG_CtBP_PxDLS_1	46	50	PF00389	0.696
LIG_FHA_1	11	17	PF00498	0.608
LIG_FHA_1	177	183	PF00498	0.669
LIG_FHA_1	290	296	PF00498	0.713
LIG_FHA_1	310	316	PF00498	0.490
LIG_FHA_1	397	403	PF00498	0.567
LIG_FHA_1	74	80	PF00498	0.643
LIG_FHA_2	102	108	PF00498	0.668
LIG_FHA_2	259	265	PF00498	0.659
LIG_FHA_2	424	430	PF00498	0.567
LIG_FHA_2	60	66	PF00498	0.634
LIG_HCF-1_HBM_1	420	423	PF13415	0.585
LIG_LIR_Apic_2	72	78	PF02991	0.688
LIG_LIR_Gen_1	255	265	PF02991	0.635
LIG_LIR_Nem_3	255	260	PF02991	0.727
LIG_LIR_Nem_3	261	266	PF02991	0.556
LIG_PDZ_Class_1	446	451	PF00595	0.604
LIG_Pex14_2	394	398	PF04695	0.557
LIG_Rb_LxCxE_1	172	194	PF01857	0.583
LIG_SH2_CRK	75	79	PF00017	0.629
LIG_SH2_STAT5	75	78	PF00017	0.673
LIG_SH3_1	274	280	PF00018	0.670
LIG_SH3_3	149	155	PF00018	0.667
LIG_SH3_3	240	246	PF00018	0.695
LIG_SH3_3	265	271	PF00018	0.633
LIG_SH3_3	27	33	PF00018	0.654
LIG_SH3_3	274	280	PF00018	0.578
LIG_SH3_3	349	355	PF00018	0.683
LIG_SH3_3	402	408	PF00018	0.567
LIG_SH3_3	5	11	PF00018	0.657
LIG_SUMO_SIM_anti_2	131	137	PF11976	0.585
LIG_SUMO_SIM_par_1	412	417	PF11976	0.593
LIG_TRAF2_1	141	144	PF00917	0.616
LIG_TRAF2_1	435	438	PF00917	0.601
LIG_WW_3	56	60	PF00397	0.657
MOD_CDK_SPK_2	273	278	PF00069	0.665
MOD_CDK_SPxK_1	74	80	PF00069	0.702
MOD_CK1_1	212	218	PF00069	0.598
MOD_CK1_1	252	258	PF00069	0.655
MOD_CK1_1	281	287	PF00069	0.649
MOD_CK1_1	289	295	PF00069	0.594
MOD_CK1_1	297	303	PF00069	0.518
MOD_CK1_1	309	315	PF00069	0.527
MOD_CK1_1	317	323	PF00069	0.557
MOD_CK1_1	329	335	PF00069	0.573
MOD_CK1_1	357	363	PF00069	0.669
MOD_CK1_1	390	396	PF00069	0.513
MOD_CK1_1	52	58	PF00069	0.655
MOD_CK2_1	138	144	PF00069	0.633
MOD_CK2_1	151	157	PF00069	0.538
MOD_CK2_1	184	190	PF00069	0.656
MOD_CK2_1	317	323	PF00069	0.701
MOD_CK2_1	432	438	PF00069	0.651
MOD_CK2_1	59	65	PF00069	0.644
MOD_GlcNHglycan	123	126	PF01048	0.686
MOD_GlcNHglycan	160	163	PF01048	0.710
MOD_GlcNHglycan	18	21	PF01048	0.727
MOD_GlcNHglycan	211	214	PF01048	0.705
MOD_GlcNHglycan	30	33	PF01048	0.606
MOD_GlcNHglycan	387	392	PF01048	0.514
MOD_GSK3_1	101	108	PF00069	0.606
MOD_GSK3_1	130	137	PF00069	0.681
MOD_GSK3_1	196	203	PF00069	0.679
MOD_GSK3_1	208	215	PF00069	0.615
MOD_GSK3_1	233	240	PF00069	0.625
MOD_GSK3_1	249	256	PF00069	0.686
MOD_GSK3_1	294	301	PF00069	0.653
MOD_GSK3_1	325	332	PF00069	0.698
MOD_GSK3_1	353	360	PF00069	0.649
MOD_GSK3_1	361	368	PF00069	0.466
MOD_GSK3_1	69	76	PF00069	0.547
MOD_GSK3_1	90	97	PF00069	0.695
MOD_N-GLC_1	105	110	PF02516	0.671
MOD_N-GLC_1	309	314	PF02516	0.616
MOD_NEK2_1	16	21	PF00069	0.698
MOD_NEK2_1	272	277	PF00069	0.661
MOD_NEK2_1	28	33	PF00069	0.618
MOD_NEK2_1	325	330	PF00069	0.803
MOD_NEK2_1	69	74	PF00069	0.624
MOD_NEK2_1	98	103	PF00069	0.689
MOD_PIKK_1	202	208	PF00454	0.728
MOD_PIKK_1	281	287	PF00454	0.727
MOD_PIKK_1	52	58	PF00454	0.694
MOD_PK_1	299	305	PF00069	0.586
MOD_PKA_2	158	164	PF00069	0.707
MOD_PKA_2	196	202	PF00069	0.617
MOD_PKA_2	298	304	PF00069	0.645
MOD_PKB_1	71	79	PF00069	0.558
MOD_Plk_1	105	111	PF00069	0.762
MOD_Plk_1	249	255	PF00069	0.681
MOD_Plk_2-3	432	438	PF00069	0.585
MOD_Plk_4	130	136	PF00069	0.602
MOD_Plk_4	18	24	PF00069	0.598
MOD_Plk_4	278	284	PF00069	0.686
MOD_Plk_4	423	429	PF00069	0.688
MOD_ProDKin_1	101	107	PF00069	0.567
MOD_ProDKin_1	151	157	PF00069	0.647
MOD_ProDKin_1	239	245	PF00069	0.674
MOD_ProDKin_1	273	279	PF00069	0.666
MOD_ProDKin_1	326	332	PF00069	0.708
MOD_ProDKin_1	359	365	PF00069	0.656
MOD_ProDKin_1	375	381	PF00069	0.627
MOD_ProDKin_1	4	10	PF00069	0.656
MOD_ProDKin_1	49	55	PF00069	0.686
MOD_ProDKin_1	74	80	PF00069	0.702
MOD_ProDKin_1	90	96	PF00069	0.580
MOD_SUMO_for_1	191	194	PF00179	0.594
MOD_SUMO_rev_2	437	445	PF00179	0.568
MOD_SUMO_rev_2	61	69	PF00179	0.780
TRG_DiLeu_BaLyEn_6	110	115	PF01217	0.655
TRG_DiLeu_BaLyEn_6	268	273	PF01217	0.652
TRG_ER_diArg_1	70	73	PF00400	0.639
TRG_Pf-PMV_PEXEL_1	43	47	PF00026	0.723

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IRU8	Leishmania donovani	99%	77%
A4HI51	Leishmania braziliensis	64%	100%
E9B0M5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q7K7	Leishmania major	84%	100%