LeishMANIAdb
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Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Guanine nucleotide-binding protein subunit beta-like protein
Gene product:
Histone-binding protein RBBP4 or subunit C of CAF1 complex/WD domain - G-beta repeat - putative
Species:
Leishmania infantum
UniProt:
A4I5C6_LEIIN
TriTrypDb:
LINF_300015100
Length:
648

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 7
GO:0005840 ribosome 5 7
GO:0032991 protein-containing complex 1 7
GO:0043226 organelle 2 7
GO:0043227 membrane-bounded organelle 3 7
GO:0043228 non-membrane-bounded organelle 3 7
GO:0043229 intracellular organelle 3 7
GO:0043231 intracellular membrane-bounded organelle 4 7
GO:0043232 intracellular non-membrane-bounded organelle 4 7
GO:0110165 cellular anatomical entity 1 7
GO:1990904 ribonucleoprotein complex 2 7

Expansion

Sequence features

A4I5C6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5C6

Function

Biological processes
Term Name Level Count
GO:0006325 chromatin organization 4 1
GO:0006338 chromatin remodeling 5 1
GO:0006355 regulation of DNA-templated transcription 6 1
GO:0009889 regulation of biosynthetic process 4 1
GO:0009987 cellular process 1 1
GO:0010468 regulation of gene expression 5 1
GO:0010556 regulation of macromolecule biosynthetic process 5 1
GO:0016043 cellular component organization 3 1
GO:0019219 regulation of nucleobase-containing compound metabolic process 5 1
GO:0019222 regulation of metabolic process 3 1
GO:0031323 regulation of cellular metabolic process 4 1
GO:0031326 regulation of cellular biosynthetic process 5 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0051171 regulation of nitrogen compound metabolic process 4 1
GO:0051252 regulation of RNA metabolic process 5 1
GO:0060255 regulation of macromolecule metabolic process 4 1
GO:0065007 biological regulation 1 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:0080090 regulation of primary metabolic process 4 1
GO:1903506 regulation of nucleic acid-templated transcription 7 1
GO:2001141 regulation of RNA biosynthetic process 6 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 1
GO:0005515 protein binding 2 1
GO:0042393 histone binding 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 126 130 PF00656 0.741
CLV_C14_Caspase3-7 144 148 PF00656 0.505
CLV_C14_Caspase3-7 152 156 PF00656 0.726
CLV_C14_Caspase3-7 385 389 PF00656 0.485
CLV_C14_Caspase3-7 477 481 PF00656 0.524
CLV_C14_Caspase3-7 7 11 PF00656 0.700
CLV_NRD_NRD_1 132 134 PF00675 0.743
CLV_NRD_NRD_1 135 137 PF00675 0.720
CLV_NRD_NRD_1 178 180 PF00675 0.738
CLV_NRD_NRD_1 395 397 PF00675 0.602
CLV_NRD_NRD_1 50 52 PF00675 0.605
CLV_NRD_NRD_1 533 535 PF00675 0.449
CLV_NRD_NRD_1 77 79 PF00675 0.762
CLV_PCSK_FUR_1 133 137 PF00082 0.794
CLV_PCSK_FUR_1 48 52 PF00082 0.597
CLV_PCSK_KEX2_1 132 134 PF00082 0.741
CLV_PCSK_KEX2_1 135 137 PF00082 0.722
CLV_PCSK_KEX2_1 178 180 PF00082 0.738
CLV_PCSK_KEX2_1 325 327 PF00082 0.639
CLV_PCSK_KEX2_1 395 397 PF00082 0.509
CLV_PCSK_KEX2_1 50 52 PF00082 0.605
CLV_PCSK_KEX2_1 533 535 PF00082 0.437
CLV_PCSK_PC1ET2_1 325 327 PF00082 0.639
CLV_PCSK_SKI1_1 27 31 PF00082 0.791
CLV_PCSK_SKI1_1 570 574 PF00082 0.450
CLV_PCSK_SKI1_1 634 638 PF00082 0.388
DEG_APCC_DBOX_1 569 577 PF00400 0.523
DEG_APCC_DBOX_1 633 641 PF00400 0.378
DEG_MDM2_SWIB_1 399 406 PF02201 0.447
DEG_SPOP_SBC_1 492 496 PF00917 0.493
DOC_CYCLIN_RxL_1 212 222 PF00134 0.646
DOC_CYCLIN_yClb5_NLxxxL_5 368 377 PF00134 0.437
DOC_MAPK_MEF2A_6 283 291 PF00069 0.517
DOC_PP1_RVXF_1 568 575 PF00149 0.417
DOC_PP2B_LxvP_1 590 593 PF13499 0.584
DOC_PP4_FxxP_1 17 20 PF00568 0.715
DOC_PP4_FxxP_1 254 257 PF00568 0.524
DOC_USP7_MATH_1 106 110 PF00917 0.655
DOC_USP7_MATH_1 12 16 PF00917 0.727
DOC_USP7_MATH_1 29 33 PF00917 0.668
DOC_USP7_MATH_1 475 479 PF00917 0.524
DOC_USP7_MATH_1 492 496 PF00917 0.515
DOC_USP7_MATH_1 500 504 PF00917 0.447
DOC_USP7_MATH_1 523 527 PF00917 0.462
DOC_USP7_MATH_1 593 597 PF00917 0.491
DOC_USP7_MATH_2 186 192 PF00917 0.690
DOC_WW_Pin1_4 110 115 PF00397 0.809
DOC_WW_Pin1_4 18 23 PF00397 0.704
DOC_WW_Pin1_4 552 557 PF00397 0.429
LIG_14-3-3_CanoR_1 39 49 PF00244 0.767
LIG_14-3-3_CanoR_1 489 497 PF00244 0.513
LIG_14-3-3_CanoR_1 533 539 PF00244 0.433
LIG_14-3-3_CanoR_1 605 611 PF00244 0.441
LIG_BIR_III_4 140 144 PF00653 0.739
LIG_deltaCOP1_diTrp_1 240 248 PF00928 0.524
LIG_FHA_1 234 240 PF00498 0.496
LIG_FHA_1 241 247 PF00498 0.469
LIG_FHA_1 279 285 PF00498 0.492
LIG_FHA_1 35 41 PF00498 0.725
LIG_FHA_1 354 360 PF00498 0.419
LIG_FHA_1 428 434 PF00498 0.654
LIG_FHA_1 446 452 PF00498 0.205
LIG_FHA_1 558 564 PF00498 0.497
LIG_FHA_1 57 63 PF00498 0.715
LIG_FHA_1 578 584 PF00498 0.270
LIG_FHA_1 625 631 PF00498 0.549
LIG_FHA_2 111 117 PF00498 0.763
LIG_FHA_2 142 148 PF00498 0.793
LIG_FHA_2 291 297 PF00498 0.623
LIG_FHA_2 376 382 PF00498 0.546
LIG_FHA_2 383 389 PF00498 0.359
LIG_FHA_2 442 448 PF00498 0.606
LIG_FHA_2 75 81 PF00498 0.760
LIG_LIR_Apic_2 15 20 PF02991 0.679
LIG_LIR_Apic_2 251 257 PF02991 0.524
LIG_LIR_Gen_1 262 272 PF02991 0.524
LIG_LIR_Gen_1 402 411 PF02991 0.427
LIG_LIR_Gen_1 594 603 PF02991 0.452
LIG_LIR_Nem_3 240 244 PF02991 0.524
LIG_LIR_Nem_3 262 268 PF02991 0.498
LIG_LIR_Nem_3 296 302 PF02991 0.569
LIG_LIR_Nem_3 402 406 PF02991 0.428
LIG_LIR_Nem_3 416 422 PF02991 0.379
LIG_LIR_Nem_3 594 600 PF02991 0.552
LIG_LIR_Nem_3 642 646 PF02991 0.577
LIG_Pex14_2 399 403 PF04695 0.435
LIG_SH2_CRK 371 375 PF00017 0.450
LIG_SH2_CRK 633 637 PF00017 0.494
LIG_SH2_GRB2like 419 422 PF00017 0.425
LIG_SH2_NCK_1 371 375 PF00017 0.406
LIG_SH2_STAP1 261 265 PF00017 0.524
LIG_SH2_STAT3 261 264 PF00017 0.524
LIG_SH2_STAT5 233 236 PF00017 0.586
LIG_SH2_STAT5 261 264 PF00017 0.524
LIG_SH2_STAT5 265 268 PF00017 0.524
LIG_SH2_STAT5 419 422 PF00017 0.438
LIG_SH3_2 22 27 PF14604 0.745
LIG_SH3_3 19 25 PF00018 0.783
LIG_SH3_3 236 242 PF00018 0.502
LIG_SH3_3 284 290 PF00018 0.524
LIG_SH3_3 59 65 PF00018 0.751
LIG_SH3_3 629 635 PF00018 0.423
LIG_SH3_5 257 261 PF00018 0.524
LIG_SUMO_SIM_par_1 242 247 PF11976 0.597
LIG_SUMO_SIM_par_1 355 363 PF11976 0.425
LIG_SUMO_SIM_par_1 429 435 PF11976 0.599
LIG_SUMO_SIM_par_1 559 564 PF11976 0.458
LIG_SxIP_EBH_1 489 503 PF03271 0.492
LIG_TRAF2_1 123 126 PF00917 0.727
LIG_TYR_ITIM 263 268 PF00017 0.524
LIG_TYR_ITIM 420 425 PF00017 0.422
MOD_CDC14_SPxK_1 21 24 PF00782 0.698
MOD_CDK_SPxK_1 18 24 PF00069 0.696
MOD_CK1_1 171 177 PF00069 0.798
MOD_CK1_1 184 190 PF00069 0.546
MOD_CK1_1 222 228 PF00069 0.316
MOD_CK1_1 4 10 PF00069 0.657
MOD_CK1_1 402 408 PF00069 0.434
MOD_CK1_1 491 497 PF00069 0.510
MOD_CK1_1 503 509 PF00069 0.422
MOD_CK1_1 56 62 PF00069 0.791
MOD_CK1_1 610 616 PF00069 0.533
MOD_CK1_1 623 629 PF00069 0.390
MOD_CK1_1 95 101 PF00069 0.724
MOD_CK2_1 375 381 PF00069 0.539
MOD_CK2_1 441 447 PF00069 0.607
MOD_CK2_1 611 617 PF00069 0.580
MOD_CK2_1 74 80 PF00069 0.695
MOD_Cter_Amidation 323 326 PF01082 0.640
MOD_GlcNHglycan 108 111 PF01048 0.749
MOD_GlcNHglycan 144 147 PF01048 0.802
MOD_GlcNHglycan 175 178 PF01048 0.716
MOD_GlcNHglycan 183 186 PF01048 0.572
MOD_GlcNHglycan 275 278 PF01048 0.397
MOD_GlcNHglycan 31 34 PF01048 0.750
MOD_GlcNHglycan 343 346 PF01048 0.340
MOD_GlcNHglycan 364 367 PF01048 0.381
MOD_GlcNHglycan 412 415 PF01048 0.410
MOD_GlcNHglycan 435 439 PF01048 0.636
MOD_GlcNHglycan 490 493 PF01048 0.537
MOD_GlcNHglycan 498 501 PF01048 0.498
MOD_GlcNHglycan 502 505 PF01048 0.495
MOD_GlcNHglycan 622 625 PF01048 0.531
MOD_GSK3_1 106 113 PF00069 0.709
MOD_GSK3_1 124 131 PF00069 0.676
MOD_GSK3_1 164 171 PF00069 0.654
MOD_GSK3_1 184 191 PF00069 0.649
MOD_GSK3_1 34 41 PF00069 0.739
MOD_GSK3_1 423 430 PF00069 0.474
MOD_GSK3_1 441 448 PF00069 0.592
MOD_GSK3_1 488 495 PF00069 0.519
MOD_GSK3_1 496 503 PF00069 0.490
MOD_GSK3_1 52 59 PF00069 0.655
MOD_GSK3_1 557 564 PF00069 0.427
MOD_GSK3_1 607 614 PF00069 0.509
MOD_GSK3_1 620 627 PF00069 0.355
MOD_GSK3_1 92 99 PF00069 0.728
MOD_N-GLC_1 4 9 PF02516 0.697
MOD_N-GLC_1 611 616 PF02516 0.506
MOD_N-GLC_2 160 162 PF02516 0.604
MOD_NEK2_1 399 404 PF00069 0.433
MOD_NEK2_1 410 415 PF00069 0.415
MOD_NEK2_1 473 478 PF00069 0.524
MOD_NEK2_1 557 562 PF00069 0.503
MOD_NEK2_2 12 17 PF00069 0.606
MOD_NEK2_2 278 283 PF00069 0.444
MOD_PIKK_1 267 273 PF00454 0.524
MOD_PIKK_1 375 381 PF00454 0.541
MOD_PIKK_1 40 46 PF00454 0.648
MOD_PIKK_1 445 451 PF00454 0.512
MOD_PIKK_1 466 472 PF00454 0.524
MOD_PKA_2 23 29 PF00069 0.754
MOD_PKA_2 38 44 PF00069 0.645
MOD_PKA_2 427 433 PF00069 0.544
MOD_PKA_2 488 494 PF00069 0.500
MOD_PKA_2 532 538 PF00069 0.456
MOD_PKA_2 604 610 PF00069 0.443
MOD_PKB_1 200 208 PF00069 0.755
MOD_Plk_1 12 18 PF00069 0.713
MOD_Plk_1 259 265 PF00069 0.524
MOD_Plk_1 336 342 PF00069 0.433
MOD_Plk_1 4 10 PF00069 0.665
MOD_Plk_1 434 440 PF00069 0.632
MOD_Plk_1 593 599 PF00069 0.387
MOD_Plk_1 607 613 PF00069 0.406
MOD_Plk_4 12 18 PF00069 0.604
MOD_Plk_4 557 563 PF00069 0.403
MOD_Plk_4 593 599 PF00069 0.387
MOD_ProDKin_1 110 116 PF00069 0.806
MOD_ProDKin_1 18 24 PF00069 0.707
MOD_ProDKin_1 552 558 PF00069 0.430
MOD_SUMO_rev_2 222 230 PF00179 0.491
MOD_SUMO_rev_2 53 62 PF00179 0.735
TRG_DiLeu_BaLyEn_6 544 549 PF01217 0.344
TRG_DiLeu_BaLyEn_6 632 637 PF01217 0.368
TRG_ENDOCYTIC_2 265 268 PF00928 0.524
TRG_ENDOCYTIC_2 371 374 PF00928 0.443
TRG_ENDOCYTIC_2 422 425 PF00928 0.427
TRG_ENDOCYTIC_2 633 636 PF00928 0.435
TRG_ER_diArg_1 132 135 PF00400 0.728
TRG_ER_diArg_1 48 51 PF00400 0.602
TRG_ER_diArg_1 532 534 PF00400 0.438
TRG_Pf-PMV_PEXEL_1 215 220 PF00026 0.500
TRG_Pf-PMV_PEXEL_1 228 232 PF00026 0.324

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P8W9 Leptomonas seymouri 59% 97%
A0A3S7X390 Leishmania donovani 100% 100%
A0A3S7X6T4 Leishmania donovani 23% 100%
A4HI50 Leishmania braziliensis 76% 100%
A4HLQ3 Leishmania braziliensis 23% 100%
A4I953 Leishmania infantum 23% 100%
E9B0M4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
E9B428 Leishmania mexicana (strain MHOM/GT/2001/U1103) 23% 100%
O22607 Arabidopsis thaliana 22% 100%
P0CS36 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) 31% 100%
P0CS37 Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) 31% 100%
Q4Q3Z6 Leishmania major 22% 100%
Q4Q7K8 Leishmania major 92% 100%
Q6C7Q4 Yarrowia lipolytica (strain CLIB 122 / E 150) 26% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS