LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Domain of unknown function (DUF4139) - putative
Species:
Leishmania infantum
UniProt:
A4I5C4_LEIIN
TriTrypDb:
LINF_300014900
Length:
579

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) yes yes: 6
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 12
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 18
NetGPI no yes: 0, no: 18
Cellular components
Term Name Level Count
GO:0005741 mitochondrial outer membrane 5 1
GO:0016020 membrane 2 1
GO:0019867 outer membrane 3 1
GO:0031090 organelle membrane 3 1
GO:0031966 mitochondrial membrane 4 1
GO:0031968 organelle outer membrane 4 1
GO:0098588 bounding membrane of organelle 4 1
GO:0110165 cellular anatomical entity 1 2
GO:0005739 mitochondrion 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Phosphorylation

Amastigote: 325

Expansion

Sequence features

A4I5C4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5C4

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 2
GO:0016829 lyase activity 2 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 166 168 PF00675 0.444
CLV_NRD_NRD_1 319 321 PF00675 0.389
CLV_NRD_NRD_1 462 464 PF00675 0.317
CLV_PCSK_KEX2_1 166 168 PF00082 0.501
CLV_PCSK_KEX2_1 318 320 PF00082 0.460
CLV_PCSK_KEX2_1 462 464 PF00082 0.341
CLV_PCSK_KEX2_1 98 100 PF00082 0.558
CLV_PCSK_PC1ET2_1 98 100 PF00082 0.438
CLV_PCSK_PC7_1 458 464 PF00082 0.337
CLV_PCSK_SKI1_1 166 170 PF00082 0.509
CLV_PCSK_SKI1_1 209 213 PF00082 0.567
DEG_APCC_DBOX_1 177 185 PF00400 0.564
DEG_APCC_KENBOX_2 333 337 PF00400 0.275
DEG_SCF_FBW7_2 340 346 PF00400 0.222
DEG_SPOP_SBC_1 471 475 PF00917 0.297
DOC_CKS1_1 340 345 PF01111 0.222
DOC_CKS1_1 571 576 PF01111 0.492
DOC_CYCLIN_yClb1_LxF_4 387 392 PF00134 0.461
DOC_MAPK_gen_1 383 392 PF00069 0.384
DOC_MAPK_gen_1 555 565 PF00069 0.469
DOC_MAPK_MEF2A_6 397 404 PF00069 0.451
DOC_PP1_RVXF_1 387 393 PF00149 0.461
DOC_PP4_FxxP_1 24 27 PF00568 0.500
DOC_PP4_FxxP_1 328 331 PF00568 0.523
DOC_PP4_FxxP_1 337 340 PF00568 0.218
DOC_PP4_FxxP_1 490 493 PF00568 0.243
DOC_USP7_MATH_1 158 162 PF00917 0.480
DOC_USP7_MATH_1 418 422 PF00917 0.376
DOC_USP7_MATH_1 491 495 PF00917 0.484
DOC_USP7_UBL2_3 555 559 PF12436 0.235
DOC_USP7_UBL2_3 94 98 PF12436 0.516
DOC_WW_Pin1_4 239 244 PF00397 0.357
DOC_WW_Pin1_4 280 285 PF00397 0.316
DOC_WW_Pin1_4 286 291 PF00397 0.320
DOC_WW_Pin1_4 339 344 PF00397 0.362
DOC_WW_Pin1_4 436 441 PF00397 0.464
DOC_WW_Pin1_4 570 575 PF00397 0.565
DOC_WW_Pin1_4 73 78 PF00397 0.459
LIG_14-3-3_CanoR_1 166 174 PF00244 0.505
LIG_14-3-3_CanoR_1 19 25 PF00244 0.392
LIG_14-3-3_CanoR_1 276 284 PF00244 0.371
LIG_14-3-3_CanoR_1 3 7 PF00244 0.554
LIG_APCC_ABBA_1 13 18 PF00400 0.421
LIG_BIR_II_1 1 5 PF00653 0.501
LIG_BRCT_BRCA1_1 324 328 PF00533 0.275
LIG_BRCT_BRCA1_1 420 424 PF00533 0.420
LIG_deltaCOP1_diTrp_1 44 51 PF00928 0.572
LIG_deltaCOP1_diTrp_1 546 551 PF00928 0.419
LIG_FHA_1 213 219 PF00498 0.478
LIG_FHA_1 340 346 PF00498 0.465
LIG_FHA_1 451 457 PF00498 0.376
LIG_FHA_1 497 503 PF00498 0.392
LIG_FHA_1 51 57 PF00498 0.468
LIG_FHA_1 542 548 PF00498 0.468
LIG_FHA_2 266 272 PF00498 0.322
LIG_FHA_2 410 416 PF00498 0.438
LIG_FHA_2 537 543 PF00498 0.431
LIG_Integrin_RGD_1 133 135 PF01839 0.524
LIG_LIR_Apic_2 23 27 PF02991 0.517
LIG_LIR_Apic_2 298 303 PF02991 0.275
LIG_LIR_Apic_2 325 331 PF02991 0.275
LIG_LIR_Apic_2 335 340 PF02991 0.432
LIG_LIR_Apic_2 360 365 PF02991 0.461
LIG_LIR_Apic_2 488 493 PF02991 0.243
LIG_LIR_Gen_1 269 279 PF02991 0.312
LIG_LIR_Gen_1 412 420 PF02991 0.405
LIG_LIR_Gen_1 48 58 PF02991 0.430
LIG_LIR_LC3C_4 213 218 PF02991 0.527
LIG_LIR_Nem_3 269 275 PF02991 0.312
LIG_LIR_Nem_3 412 417 PF02991 0.407
LIG_LIR_Nem_3 44 49 PF02991 0.439
LIG_LIR_Nem_3 50 54 PF02991 0.438
LIG_MLH1_MIPbox_1 324 328 PF16413 0.222
LIG_MYND_1 291 295 PF01753 0.461
LIG_Pex14_1 241 245 PF04695 0.360
LIG_Pex14_2 561 565 PF04695 0.331
LIG_REV1ctd_RIR_1 160 171 PF16727 0.561
LIG_RPA_C_Plants 167 178 PF08784 0.410
LIG_SH2_CRK 362 366 PF00017 0.461
LIG_SH2_NCK_1 362 366 PF00017 0.461
LIG_SH2_SRC 251 254 PF00017 0.463
LIG_SH2_SRC 362 365 PF00017 0.461
LIG_SH2_STAP1 245 249 PF00017 0.372
LIG_SH2_STAP1 260 264 PF00017 0.339
LIG_SH2_STAP1 414 418 PF00017 0.297
LIG_SH2_STAP1 483 487 PF00017 0.370
LIG_SH2_STAT5 485 488 PF00017 0.409
LIG_SH3_3 26 32 PF00018 0.509
LIG_SH3_3 289 295 PF00018 0.424
LIG_SH3_3 300 306 PF00018 0.379
LIG_SH3_3 337 343 PF00018 0.473
LIG_SH3_3 390 396 PF00018 0.439
LIG_SH3_3 568 574 PF00018 0.527
LIG_SUMO_SIM_anti_2 253 261 PF11976 0.336
LIG_SUMO_SIM_anti_2 513 519 PF11976 0.331
LIG_SUMO_SIM_par_1 228 233 PF11976 0.491
LIG_SUMO_SIM_par_1 35 41 PF11976 0.510
LIG_SUMO_SIM_par_1 498 504 PF11976 0.361
LIG_TRAF2_1 106 109 PF00917 0.557
LIG_TRAF2_1 113 116 PF00917 0.572
LIG_TRAF2_1 440 443 PF00917 0.415
LIG_TYR_ITSM 410 417 PF00017 0.339
LIG_WRC_WIRS_1 159 164 PF05994 0.564
MOD_CDC14_SPxK_1 76 79 PF00782 0.464
MOD_CDK_SPxK_1 73 79 PF00069 0.462
MOD_CK1_1 2 8 PF00069 0.505
MOD_CK1_1 280 286 PF00069 0.328
MOD_CK1_1 357 363 PF00069 0.341
MOD_CK1_1 447 453 PF00069 0.357
MOD_CK1_1 466 472 PF00069 0.180
MOD_CK1_1 474 480 PF00069 0.381
MOD_CK2_1 207 213 PF00069 0.435
MOD_CK2_1 251 257 PF00069 0.495
MOD_CK2_1 409 415 PF00069 0.450
MOD_CK2_1 436 442 PF00069 0.385
MOD_CK2_1 536 542 PF00069 0.444
MOD_CMANNOS 294 297 PF00535 0.461
MOD_GlcNHglycan 129 132 PF01048 0.558
MOD_GlcNHglycan 141 144 PF01048 0.530
MOD_GlcNHglycan 201 204 PF01048 0.664
MOD_GlcNHglycan 209 212 PF01048 0.554
MOD_GlcNHglycan 223 226 PF01048 0.516
MOD_GlcNHglycan 236 239 PF01048 0.501
MOD_GlcNHglycan 24 27 PF01048 0.547
MOD_GlcNHglycan 260 263 PF01048 0.339
MOD_GlcNHglycan 32 35 PF01048 0.586
MOD_GlcNHglycan 404 407 PF01048 0.427
MOD_GSK3_1 158 165 PF00069 0.563
MOD_GSK3_1 230 237 PF00069 0.401
MOD_GSK3_1 322 329 PF00069 0.489
MOD_GSK3_1 353 360 PF00069 0.337
MOD_GSK3_1 450 457 PF00069 0.418
MOD_GSK3_1 463 470 PF00069 0.395
MOD_N-GLC_1 357 362 PF02516 0.471
MOD_N-GLC_1 409 414 PF02516 0.361
MOD_N-GLC_1 430 435 PF02516 0.408
MOD_N-GLC_1 73 78 PF02516 0.459
MOD_N-GLC_2 529 531 PF02516 0.436
MOD_NEK2_1 114 119 PF00069 0.409
MOD_NEK2_1 127 132 PF00069 0.548
MOD_NEK2_1 162 167 PF00069 0.519
MOD_NEK2_1 212 217 PF00069 0.454
MOD_NEK2_1 22 27 PF00069 0.461
MOD_NEK2_1 277 282 PF00069 0.370
MOD_NEK2_1 404 409 PF00069 0.431
MOD_NEK2_1 444 449 PF00069 0.342
MOD_NEK2_1 472 477 PF00069 0.368
MOD_NEK2_2 158 163 PF00069 0.440
MOD_NEK2_2 322 327 PF00069 0.222
MOD_NEK2_2 366 371 PF00069 0.326
MOD_PIKK_1 430 436 PF00454 0.436
MOD_PIKK_1 474 480 PF00454 0.392
MOD_PKA_1 166 172 PF00069 0.359
MOD_PKA_2 166 172 PF00069 0.556
MOD_PKA_2 193 199 PF00069 0.485
MOD_PKA_2 2 8 PF00069 0.587
MOD_PKA_2 277 283 PF00069 0.376
MOD_PKA_2 295 301 PF00069 0.210
MOD_PKA_2 78 84 PF00069 0.586
MOD_PKB_1 276 284 PF00069 0.461
MOD_Plk_1 212 218 PF00069 0.421
MOD_Plk_1 230 236 PF00069 0.243
MOD_Plk_1 357 363 PF00069 0.444
MOD_Plk_1 430 436 PF00069 0.383
MOD_Plk_1 444 450 PF00069 0.405
MOD_Plk_1 466 472 PF00069 0.432
MOD_Plk_2-3 536 542 PF00069 0.286
MOD_Plk_4 11 17 PF00069 0.425
MOD_Plk_4 158 164 PF00069 0.505
MOD_Plk_4 212 218 PF00069 0.449
MOD_Plk_4 322 328 PF00069 0.439
MOD_Plk_4 357 363 PF00069 0.483
MOD_Plk_4 425 431 PF00069 0.328
MOD_Plk_4 467 473 PF00069 0.485
MOD_Plk_4 496 502 PF00069 0.355
MOD_ProDKin_1 239 245 PF00069 0.357
MOD_ProDKin_1 280 286 PF00069 0.316
MOD_ProDKin_1 339 345 PF00069 0.362
MOD_ProDKin_1 436 442 PF00069 0.464
MOD_ProDKin_1 570 576 PF00069 0.573
MOD_ProDKin_1 73 79 PF00069 0.462
MOD_SUMO_for_1 533 536 PF00179 0.286
MOD_SUMO_for_1 554 557 PF00179 0.243
MOD_SUMO_for_1 8 11 PF00179 0.425
MOD_SUMO_rev_2 552 561 PF00179 0.317
TRG_ENDOCYTIC_2 414 417 PF00928 0.385
TRG_ER_diArg_1 275 278 PF00400 0.434
TRG_ER_diArg_1 318 320 PF00400 0.463
TRG_ER_diArg_1 389 392 PF00400 0.339
TRG_ER_diArg_1 461 463 PF00400 0.348
TRG_Pf-PMV_PEXEL_1 172 176 PF00026 0.485

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I3W3 Leptomonas seymouri 23% 92%
A0A0N1IA86 Leptomonas seymouri 60% 100%
A0A0S4JNB4 Bodo saltans 30% 100%
A0A0S4KK03 Bodo saltans 25% 95%
A0A1X0P222 Trypanosomatidae 30% 94%
A0A3Q8IFG9 Leishmania donovani 24% 90%
A0A3Q8IHT6 Leishmania donovani 100% 100%
A0A422P4V3 Trypanosoma rangeli 30% 100%
A4HHL0 Leishmania braziliensis 26% 100%
A4HI48 Leishmania braziliensis 81% 100%
A4I4S0 Leishmania infantum 25% 100%
C9ZQQ7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
E9AE72 Leishmania major 26% 90%
E9ALL3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
E9B0M2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
Q4Q7L0 Leishmania major 94% 100%
V5DQS5 Trypanosoma cruzi 35% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS