LeishMANIAdb
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Adenosine kinase

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Adenosine kinase
Gene product:
adenosine kinase - putative
Species:
Leishmania infantum
UniProt:
A4I5C0_LEIIN
TriTrypDb:
LINF_300014400
Length:
345

Annotations

Annotations by Jardim et al.

Purine metabolism, adenosine kinase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 2
Forrest at al. (procyclic) yes yes: 2
Silverman et al. no yes: 0
Pissara et al. yes yes: 12
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 6
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0005654 nucleoplasm 2 1
GO:0005737 cytoplasm 2 1
GO:0005829 cytosol 2 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I5C0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5C0

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 13
GO:0006163 purine nucleotide metabolic process 5 13
GO:0006164 purine nucleotide biosynthetic process 6 13
GO:0006166 purine ribonucleoside salvage 5 13
GO:0006167 AMP biosynthetic process 8 13
GO:0006725 cellular aromatic compound metabolic process 3 13
GO:0006753 nucleoside phosphate metabolic process 4 13
GO:0006793 phosphorus metabolic process 3 13
GO:0006796 phosphate-containing compound metabolic process 4 13
GO:0006807 nitrogen compound metabolic process 2 13
GO:0008152 metabolic process 1 13
GO:0009058 biosynthetic process 2 13
GO:0009116 nucleoside metabolic process 4 13
GO:0009117 nucleotide metabolic process 5 13
GO:0009119 ribonucleoside metabolic process 5 13
GO:0009123 nucleoside monophosphate metabolic process 5 13
GO:0009124 nucleoside monophosphate biosynthetic process 6 13
GO:0009126 purine nucleoside monophosphate metabolic process 6 13
GO:0009127 purine nucleoside monophosphate biosynthetic process 7 13
GO:0009150 purine ribonucleotide metabolic process 6 13
GO:0009152 purine ribonucleotide biosynthetic process 7 13
GO:0009156 ribonucleoside monophosphate biosynthetic process 7 13
GO:0009161 ribonucleoside monophosphate metabolic process 6 13
GO:0009163 nucleoside biosynthetic process 5 13
GO:0009165 nucleotide biosynthetic process 6 13
GO:0009167 purine ribonucleoside monophosphate metabolic process 7 13
GO:0009168 purine ribonucleoside monophosphate biosynthetic process 8 13
GO:0009259 ribonucleotide metabolic process 5 13
GO:0009260 ribonucleotide biosynthetic process 6 13
GO:0009987 cellular process 1 13
GO:0016310 phosphorylation 5 13
GO:0018130 heterocycle biosynthetic process 4 13
GO:0019438 aromatic compound biosynthetic process 4 13
GO:0019637 organophosphate metabolic process 3 13
GO:0019693 ribose phosphate metabolic process 4 13
GO:0032261 purine nucleotide salvage 5 13
GO:0034404 nucleobase-containing small molecule biosynthetic process 4 13
GO:0034641 cellular nitrogen compound metabolic process 3 13
GO:0034654 nucleobase-containing compound biosynthetic process 4 13
GO:0042278 purine nucleoside metabolic process 5 13
GO:0042451 purine nucleoside biosynthetic process 6 13
GO:0042455 ribonucleoside biosynthetic process 6 13
GO:0043094 cellular metabolic compound salvage 3 13
GO:0043101 purine-containing compound salvage 4 13
GO:0043173 nucleotide salvage 4 13
GO:0043174 nucleoside salvage 4 13
GO:0044209 AMP salvage 7 13
GO:0044237 cellular metabolic process 2 13
GO:0044238 primary metabolic process 2 13
GO:0044249 cellular biosynthetic process 3 13
GO:0044271 cellular nitrogen compound biosynthetic process 4 13
GO:0044281 small molecule metabolic process 2 13
GO:0044283 small molecule biosynthetic process 3 13
GO:0046033 AMP metabolic process 7 13
GO:0046128 purine ribonucleoside metabolic process 6 13
GO:0046129 purine ribonucleoside biosynthetic process 7 13
GO:0046390 ribose phosphate biosynthetic process 5 13
GO:0046483 heterocycle metabolic process 3 13
GO:0055086 nucleobase-containing small molecule metabolic process 3 13
GO:0071704 organic substance metabolic process 2 13
GO:0072521 purine-containing compound metabolic process 4 13
GO:0072522 purine-containing compound biosynthetic process 5 13
GO:0090407 organophosphate biosynthetic process 4 13
GO:0106380 purine ribonucleotide salvage 6 13
GO:1901135 carbohydrate derivative metabolic process 3 13
GO:1901137 carbohydrate derivative biosynthetic process 4 13
GO:1901293 nucleoside phosphate biosynthetic process 5 13
GO:1901360 organic cyclic compound metabolic process 3 13
GO:1901362 organic cyclic compound biosynthetic process 4 13
GO:1901564 organonitrogen compound metabolic process 3 13
GO:1901566 organonitrogen compound biosynthetic process 4 13
GO:1901576 organic substance biosynthetic process 3 13
GO:1901657 glycosyl compound metabolic process 4 13
GO:1901659 glycosyl compound biosynthetic process 5 13
GO:0006144 purine nucleobase metabolic process 5 1
GO:0009112 nucleobase metabolic process 4 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 13
GO:0003824 catalytic activity 1 13
GO:0004001 adenosine kinase activity 5 13
GO:0005488 binding 1 13
GO:0005524 ATP binding 5 13
GO:0016301 kinase activity 4 13
GO:0016740 transferase activity 2 13
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 13
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 13
GO:0017076 purine nucleotide binding 4 13
GO:0019205 nucleobase-containing compound kinase activity 5 13
GO:0019206 nucleoside kinase activity 6 13
GO:0030554 adenyl nucleotide binding 5 13
GO:0032553 ribonucleotide binding 3 13
GO:0032555 purine ribonucleotide binding 4 13
GO:0032559 adenyl ribonucleotide binding 5 13
GO:0035639 purine ribonucleoside triphosphate binding 4 13
GO:0036094 small molecule binding 2 13
GO:0043167 ion binding 2 13
GO:0043168 anion binding 3 13
GO:0097159 organic cyclic compound binding 2 13
GO:0097367 carbohydrate derivative binding 2 13
GO:1901265 nucleoside phosphate binding 3 13
GO:1901363 heterocyclic compound binding 2 13

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_SKI1_1 44 48 PF00082 0.254
CLV_PCSK_SKI1_1 96 100 PF00082 0.249
DOC_CDC14_PxL_1 1 9 PF14671 0.462
DOC_CYCLIN_yCln2_LP_2 195 201 PF00134 0.411
DOC_MAPK_gen_1 244 250 PF00069 0.402
DOC_MAPK_gen_1 274 283 PF00069 0.417
DOC_MAPK_MEF2A_6 210 219 PF00069 0.471
DOC_PP1_RVXF_1 256 263 PF00149 0.411
DOC_PP2B_LxvP_1 195 198 PF13499 0.411
DOC_USP7_MATH_1 118 122 PF00917 0.422
DOC_USP7_MATH_1 184 188 PF00917 0.449
DOC_USP7_MATH_1 272 276 PF00917 0.491
DOC_USP7_MATH_1 287 291 PF00917 0.563
DOC_USP7_MATH_1 60 64 PF00917 0.413
DOC_USP7_MATH_1 78 82 PF00917 0.516
LIG_APCC_ABBA_1 107 112 PF00400 0.513
LIG_BIR_II_1 1 5 PF00653 0.360
LIG_BRCT_BRCA1_1 195 199 PF00533 0.402
LIG_FHA_1 167 173 PF00498 0.402
LIG_FHA_1 237 243 PF00498 0.427
LIG_FHA_1 276 282 PF00498 0.476
LIG_FHA_1 65 71 PF00498 0.435
LIG_FHA_2 334 340 PF00498 0.424
LIG_LIR_LC3C_4 257 261 PF02991 0.449
LIG_LIR_Nem_3 80 85 PF02991 0.428
LIG_LIR_Nem_3 91 97 PF02991 0.387
LIG_Pex14_2 204 208 PF04695 0.424
LIG_Pex14_2 301 305 PF04695 0.411
LIG_SH2_CRK 94 98 PF00017 0.402
LIG_SH2_SRC 214 217 PF00017 0.415
LIG_SH2_SRC 58 61 PF00017 0.436
LIG_SH2_STAP1 113 117 PF00017 0.513
LIG_SH2_STAT3 176 179 PF00017 0.513
LIG_SH2_STAT3 29 32 PF00017 0.446
LIG_SH2_STAT5 113 116 PF00017 0.436
LIG_SH2_STAT5 164 167 PF00017 0.402
LIG_SH2_STAT5 176 179 PF00017 0.402
LIG_SH2_STAT5 203 206 PF00017 0.451
LIG_SH2_STAT5 214 217 PF00017 0.364
LIG_SH2_STAT5 58 61 PF00017 0.436
LIG_SH2_STAT5 8 11 PF00017 0.254
LIG_SH2_STAT5 85 88 PF00017 0.427
LIG_SH3_3 14 20 PF00018 0.407
LIG_SH3_3 335 341 PF00018 0.402
LIG_SUMO_SIM_par_1 13 18 PF11976 0.274
LIG_SUMO_SIM_par_1 168 173 PF11976 0.411
LIG_UBA3_1 38 44 PF00899 0.379
MOD_CK1_1 266 272 PF00069 0.486
MOD_CK1_1 275 281 PF00069 0.478
MOD_CK2_1 235 241 PF00069 0.488
MOD_CK2_1 333 339 PF00069 0.424
MOD_GlcNHglycan 1 4 PF01048 0.426
MOD_GlcNHglycan 126 129 PF01048 0.285
MOD_GlcNHglycan 137 140 PF01048 0.213
MOD_GlcNHglycan 143 146 PF01048 0.147
MOD_GlcNHglycan 16 20 PF01048 0.220
MOD_GlcNHglycan 186 189 PF01048 0.239
MOD_GlcNHglycan 195 198 PF01048 0.172
MOD_GlcNHglycan 252 255 PF01048 0.253
MOD_GlcNHglycan 274 277 PF01048 0.277
MOD_GlcNHglycan 34 37 PF01048 0.273
MOD_GlcNHglycan 62 65 PF01048 0.213
MOD_GSK3_1 112 119 PF00069 0.402
MOD_GSK3_1 266 273 PF00069 0.422
MOD_GSK3_1 275 282 PF00069 0.422
MOD_GSK3_1 60 67 PF00069 0.425
MOD_N-GLC_1 135 140 PF02516 0.313
MOD_N-GLC_1 193 198 PF02516 0.202
MOD_N-GLC_1 54 59 PF02516 0.275
MOD_N-GLC_2 333 335 PF02516 0.249
MOD_NEK2_1 111 116 PF00069 0.455
MOD_NEK2_1 15 20 PF00069 0.283
MOD_NEK2_1 193 198 PF00069 0.436
MOD_NEK2_1 204 209 PF00069 0.436
MOD_PIKK_1 260 266 PF00454 0.513
MOD_PK_1 277 283 PF00069 0.417
MOD_PKA_2 184 190 PF00069 0.449
MOD_Plk_1 129 135 PF00069 0.402
MOD_Plk_1 54 60 PF00069 0.501
MOD_Plk_4 266 272 PF00069 0.430
MOD_Plk_4 287 293 PF00069 0.508
MOD_Plk_4 54 60 PF00069 0.501
MOD_Plk_4 78 84 PF00069 0.414
MOD_SUMO_rev_2 222 228 PF00179 0.509
TRG_DiLeu_BaLyEn_6 10 15 PF01217 0.261
TRG_ENDOCYTIC_2 214 217 PF00928 0.402
TRG_ENDOCYTIC_2 94 97 PF00928 0.402
TRG_NES_CRM1_1 161 173 PF08389 0.449
TRG_Pf-PMV_PEXEL_1 96 100 PF00026 0.197

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5A6 Leptomonas seymouri 33% 92%
A0A0N0P8X0 Leptomonas seymouri 73% 100%
A0A0N1PDV7 Leptomonas seymouri 39% 94%
A0A0S4IRE7 Bodo saltans 61% 100%
A0A0S4JPW2 Bodo saltans 38% 97%
A0A1X0P296 Trypanosomatidae 59% 97%
A0A1X0PBE6 Trypanosomatidae 34% 97%
A0A3S5H7M6 Leishmania donovani 100% 100%
A0A3S7X8F0 Leishmania donovani 35% 89%
A0A422P4V2 Trypanosoma rangeli 60% 100%
A1A6H3 Arabidopsis thaliana 25% 91%
A4HB78 Leishmania braziliensis 35% 100%
A4HI44 Leishmania braziliensis 85% 100%
A4IAC6 Leishmania infantum 35% 89%
A4IPB3 Geobacillus thermodenitrificans (strain NG80-2) 26% 100%
C9ZQQ3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 55% 100%
C9ZQQ4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 55% 100%
E9AYU4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
E9B0L7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
E9B0L8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 37% 100%
E9B5E9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 100%
O29891 Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) 23% 100%
O49923 Physcomitrium patens 42% 100%
O60116 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 24% 100%
O93919 Schizophyllum commune 36% 100%
P44331 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) 25% 100%
P44482 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) 24% 100%
P47143 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 36% 100%
P55262 Cricetulus griseus 43% 96%
P55263 Homo sapiens 41% 95%
P55264 Mus musculus 41% 96%
P78825 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 34% 100%
Q4Q2I4 Leishmania major 35% 100%
Q4Q7L4 Leishmania major 34% 100%
Q4Q7L5 Leishmania major 97% 100%
Q54MB5 Dictyostelium discoideum 37% 100%
Q55480 Synechocystis sp. (strain PCC 6803 / Kazusa) 25% 100%
Q5KYR3 Geobacillus kaustophilus (strain HTA426) 24% 100%
Q64640 Rattus norvegicus 41% 96%
Q8R1Q9 Mus musculus 27% 100%
Q9LZG0 Arabidopsis thaliana 42% 100%
Q9SF85 Arabidopsis thaliana 42% 100%
Q9TVW2 Toxoplasma gondii 33% 95%
V5B941 Trypanosoma cruzi 61% 100%
V5BLW1 Trypanosoma cruzi 34% 85%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS