Putative surface protein amastin

Quick info Annotations Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

surface protein amastin - putative

Species:

Leishmania infantum

UniProt:

A4I5B8_LEIIN

TriTrypDb:

LINF_300014200

Length:

198

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Part of the greater amastin family, a cell adhesion protein critical for intracellular parasitism. Localization: Cell surface (experimental)

Annotations by Jardim et al.

Plasma membrane, surface amastin

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 2
Forrest at al. (procyclic)	yes	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 18

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 6, no: 80
NetGPI	no	yes: 0, no: 86

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	75
GO:0110165	cellular anatomical entity	1	75

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I5B8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5B8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	115	119	PF00082	0.227
CLV_PCSK_SKI1_1	81	85	PF00082	0.513
DOC_CYCLIN_RxL_1	78	88	PF00134	0.170
DOC_MAPK_gen_1	113	121	PF00069	0.506
DOC_MAPK_gen_1	7	14	PF00069	0.452
DOC_MAPK_MEF2A_6	113	121	PF00069	0.491
DOC_MAPK_MEF2A_6	7	16	PF00069	0.496
DOC_USP7_MATH_1	163	167	PF00917	0.178
LIG_BRCT_BRCA1_1	86	90	PF00533	0.235
LIG_FHA_1	147	153	PF00498	0.314
LIG_FHA_1	185	191	PF00498	0.313
LIG_GBD_Chelix_1	96	104	PF00786	0.390
LIG_LIR_Gen_1	125	136	PF02991	0.340
LIG_LIR_Nem_3	125	131	PF02991	0.328
LIG_LIR_Nem_3	87	93	PF02991	0.234
LIG_NRBOX	116	122	PF00104	0.178
LIG_Pex14_1	140	144	PF04695	0.295
LIG_SH2_STAT5	108	111	PF00017	0.277
LIG_SH2_STAT5	144	147	PF00017	0.258
LIG_SH2_STAT5	91	94	PF00017	0.325
LIG_SUMO_SIM_par_1	119	125	PF11976	0.248
LIG_TRFH_1	128	132	PF08558	0.325
LIG_WRC_WIRS_1	96	101	PF05994	0.354
MOD_CK1_1	49	55	PF00069	0.318
MOD_CK1_1	98	104	PF00069	0.327
MOD_GlcNHglycan	104	107	PF01048	0.351
MOD_GlcNHglycan	155	158	PF01048	0.546
MOD_GlcNHglycan	174	177	PF01048	0.436
MOD_GlcNHglycan	28	31	PF01048	0.335
MOD_GlcNHglycan	42	45	PF01048	0.471
MOD_GSK3_1	12	19	PF00069	0.332
MOD_GSK3_1	168	175	PF00069	0.173
MOD_GSK3_1	26	33	PF00069	0.293
MOD_GSK3_1	42	49	PF00069	0.251
MOD_GSK3_1	98	105	PF00069	0.290
MOD_N-GLC_1	152	157	PF02516	0.469
MOD_N-GLC_1	40	45	PF02516	0.399
MOD_N-GLC_2	143	145	PF02516	0.465
MOD_N-GLC_2	61	63	PF02516	0.502
MOD_NEK2_1	16	21	PF00069	0.347
MOD_NEK2_1	168	173	PF00069	0.256
MOD_NEK2_1	25	30	PF00069	0.326
MOD_NEK2_2	146	151	PF00069	0.311
MOD_PIKK_1	184	190	PF00454	0.442
MOD_PIKK_1	30	36	PF00454	0.380
MOD_PK_1	71	77	PF00069	0.173
MOD_PKA_2	168	174	PF00069	0.333
MOD_PKA_2	70	76	PF00069	0.376
MOD_Plk_4	12	18	PF00069	0.291
MOD_Plk_4	163	169	PF00069	0.181
MOD_Plk_4	52	58	PF00069	0.285
MOD_Plk_4	95	101	PF00069	0.316
TRG_ER_diArg_1	35	38	PF00400	0.248
TRG_ER_diArg_1	6	9	PF00400	0.654

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2C4	Leptomonas seymouri	28%	100%
A0A0N0P547	Leptomonas seymouri	23%	100%
A0A0N0P6P9	Leptomonas seymouri	21%	86%
A0A0N0P993	Leptomonas seymouri	28%	88%
A0A0N1PAD5	Leptomonas seymouri	25%	79%
A0A0N1PDH0	Leptomonas seymouri	26%	98%
A0A0S4J784	Bodo saltans	22%	89%
A0A1X0NQ58	Trypanosomatidae	28%	100%
A0A1X0NUH1	Trypanosomatidae	24%	87%
A0A1X0NX02	Trypanosomatidae	26%	100%
A0A1X0P2R3	Trypanosomatidae	27%	94%
A0A1X0P988	Trypanosomatidae	26%	100%
A0A381MTN2	Leishmania infantum	25%	100%
A0A3Q8ID16	Leishmania donovani	21%	100%
A0A3Q8IEC2	Leishmania donovani	22%	100%
A0A3Q8IEI1	Leishmania donovani	28%	100%
A0A3Q8IFB9	Leishmania donovani	22%	98%
A0A3Q8IFI8	Leishmania donovani	99%	100%
A0A3Q8IL03	Leishmania donovani	21%	100%
A0A3Q8IUR5	Leishmania donovani	25%	100%
A0A3S5H666	Leishmania donovani	25%	100%
A0A3S5H7D2	Leishmania donovani	25%	100%
A0A3S7WQA8	Leishmania donovani	25%	100%
A0A3S7X357	Leishmania donovani	28%	89%
A0A3S7X381	Leishmania donovani	99%	100%
A0A3S7X7E5	Leishmania donovani	27%	79%
A0A3S7X7U4	Leishmania donovani	23%	76%
A0A3S7X7Y0	Leishmania donovani	23%	100%
A4H5G0	Leishmania braziliensis	24%	100%
A4H5G9	Leishmania braziliensis	23%	100%
A4H5H2	Leishmania braziliensis	24%	100%
A4H6C8	Leishmania braziliensis	23%	100%
A4H7D7	Leishmania braziliensis	22%	100%
A4HAM2	Leishmania braziliensis	24%	100%
A4HAM4	Leishmania braziliensis	24%	100%
A4HAR1	Leishmania braziliensis	24%	100%
A4HAZ8	Leishmania braziliensis	25%	100%
A4HB47	Leishmania braziliensis	24%	100%
A4HBJ1	Leishmania braziliensis	24%	100%
A4HDI2	Leishmania braziliensis	23%	100%
A4HDI3	Leishmania braziliensis	25%	82%
A4HDL3	Leishmania braziliensis	25%	100%
A4HI41	Leishmania braziliensis	77%	100%
A4HI43	Leishmania braziliensis	25%	100%
A4HTM3	Leishmania infantum	23%	97%
A4HTM4	Leishmania infantum	23%	92%
A4HTM5	Leishmania infantum	21%	100%
A4I0W4	Leishmania infantum	25%	88%
A4I0W5	Leishmania infantum	21%	100%
A4I5B9	Leishmania infantum	28%	89%
A4I9Q4	Leishmania infantum	23%	100%
A4I9R5	Leishmania infantum	22%	98%
A4I9X0	Leishmania infantum	22%	94%
A4IA59	Leishmania infantum	25%	76%
A4IAL7	Leishmania infantum	24%	100%
C6K3X5	Leptomonas seymouri	59%	99%
C6K3X9	Leptomonas seymouri	25%	100%
E8NHF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	100%
E8NHH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E8NHI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E8NHL7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E8NHS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AME9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	91%
E9AMF9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	21%	98%
E9AWW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	97%
E9B0L4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9B0L5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9B0L6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9B4R7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9B4R8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	21%	100%
E9B4R9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	98%
Q4Q317	Leishmania major	24%	100%
Q4Q397	Leishmania major	23%	76%
Q4Q3A8	Leishmania major	24%	99%
Q4Q7L6	Leishmania major	28%	100%
Q4Q7L7	Leishmania major	94%	98%
Q4Q7L8	Leishmania major	94%	98%
Q4QAK4	Leishmania major	22%	100%
Q4QAK5	Leishmania major	24%	100%
Q4QAK6	Leishmania major	26%	88%
Q4QI84	Leishmania major	26%	89%
Q4QI85	Leishmania major	27%	97%
Q4QI86	Leishmania major	27%	89%
Q4QI87	Leishmania major	27%	98%
Q4QI88	Leishmania major	23%	98%