G domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

50S ribosome-binding GTPase - putative

Species:

Leishmania infantum

UniProt:

A4I5B7_LEIIN

TriTrypDb:

LINF_300014000

Length:

918

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I5B7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5B7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0003824	catalytic activity	1	2
GO:0005488	binding	1	6
GO:0005525	GTP binding	5	5
GO:0016787	hydrolase activity	2	2
GO:0017076	purine nucleotide binding	4	5
GO:0019001	guanyl nucleotide binding	5	5
GO:0032553	ribonucleotide binding	3	5
GO:0032555	purine ribonucleotide binding	4	5
GO:0032561	guanyl ribonucleotide binding	5	5
GO:0035639	purine ribonucleoside triphosphate binding	4	5
GO:0036094	small molecule binding	2	6
GO:0043167	ion binding	2	5
GO:0043168	anion binding	3	5
GO:0097159	organic cyclic compound binding	2	6
GO:0097367	carbohydrate derivative binding	2	5
GO:1901265	nucleoside phosphate binding	3	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	556	560	PF00656	0.615
CLV_NRD_NRD_1	136	138	PF00675	0.612
CLV_NRD_NRD_1	194	196	PF00675	0.694
CLV_NRD_NRD_1	233	235	PF00675	0.615
CLV_NRD_NRD_1	379	381	PF00675	0.562
CLV_NRD_NRD_1	464	466	PF00675	0.402
CLV_NRD_NRD_1	511	513	PF00675	0.585
CLV_NRD_NRD_1	550	552	PF00675	0.525
CLV_NRD_NRD_1	671	673	PF00675	0.426
CLV_NRD_NRD_1	675	677	PF00675	0.430
CLV_NRD_NRD_1	782	784	PF00675	0.458
CLV_NRD_NRD_1	832	834	PF00675	0.601
CLV_NRD_NRD_1	840	842	PF00675	0.599
CLV_PCSK_FUR_1	779	783	PF00082	0.521
CLV_PCSK_FUR_1	830	834	PF00082	0.540
CLV_PCSK_FUR_1	837	841	PF00082	0.530
CLV_PCSK_KEX2_1	135	137	PF00082	0.621
CLV_PCSK_KEX2_1	379	381	PF00082	0.575
CLV_PCSK_KEX2_1	464	466	PF00082	0.402
CLV_PCSK_KEX2_1	490	492	PF00082	0.470
CLV_PCSK_KEX2_1	511	513	PF00082	0.585
CLV_PCSK_KEX2_1	671	673	PF00082	0.426
CLV_PCSK_KEX2_1	781	783	PF00082	0.486
CLV_PCSK_KEX2_1	832	834	PF00082	0.606
CLV_PCSK_KEX2_1	839	841	PF00082	0.594
CLV_PCSK_PC1ET2_1	135	137	PF00082	0.739
CLV_PCSK_PC1ET2_1	490	492	PF00082	0.470
CLV_PCSK_PC1ET2_1	839	841	PF00082	0.680
CLV_PCSK_SKI1_1	234	238	PF00082	0.621
CLV_PCSK_SKI1_1	361	365	PF00082	0.539
CLV_PCSK_SKI1_1	393	397	PF00082	0.542
CLV_PCSK_SKI1_1	594	598	PF00082	0.559
CLV_PCSK_SKI1_1	662	666	PF00082	0.509
CLV_PCSK_SKI1_1	7	11	PF00082	0.729
CLV_PCSK_SKI1_1	708	712	PF00082	0.408
CLV_PCSK_SKI1_1	80	84	PF00082	0.776
CLV_PCSK_SKI1_1	840	844	PF00082	0.659
CLV_Separin_Metazoa	822	826	PF03568	0.435
DEG_APCC_DBOX_1	661	669	PF00400	0.582
DEG_APCC_DBOX_1	707	715	PF00400	0.420
DOC_CKS1_1	570	575	PF01111	0.460
DOC_CKS1_1	650	655	PF01111	0.442
DOC_CYCLIN_RxL_1	106	117	PF00134	0.601
DOC_CYCLIN_RxL_1	658	666	PF00134	0.504
DOC_CYCLIN_RxL_1	704	716	PF00134	0.487
DOC_MAPK_gen_1	204	211	PF00069	0.565
DOC_MAPK_gen_1	393	403	PF00069	0.423
DOC_MAPK_gen_1	464	472	PF00069	0.393
DOC_MAPK_gen_1	590	598	PF00069	0.589
DOC_MAPK_gen_1	781	790	PF00069	0.411
DOC_MAPK_MEF2A_6	396	405	PF00069	0.402
DOC_MAPK_MEF2A_6	464	472	PF00069	0.406
DOC_PP1_RVXF_1	233	240	PF00149	0.622
DOC_PP1_RVXF_1	706	713	PF00149	0.531
DOC_PP2B_LxvP_1	540	543	PF13499	0.514
DOC_PP2B_LxvP_1	68	71	PF13499	0.513
DOC_PP2B_LxvP_1	685	688	PF13499	0.561
DOC_PP2B_LxvP_1	742	745	PF13499	0.400
DOC_PP4_FxxP_1	271	274	PF00568	0.468
DOC_PP4_FxxP_1	33	36	PF00568	0.695
DOC_PP4_FxxP_1	474	477	PF00568	0.411
DOC_PP4_FxxP_1	678	681	PF00568	0.509
DOC_SPAK_OSR1_1	218	222	PF12202	0.639
DOC_USP7_MATH_1	189	193	PF00917	0.693
DOC_USP7_MATH_1	61	65	PF00917	0.729
DOC_USP7_MATH_1	82	86	PF00917	0.717
DOC_USP7_MATH_1	874	878	PF00917	0.726
DOC_USP7_MATH_1	882	886	PF00917	0.764
DOC_USP7_MATH_1	91	95	PF00917	0.696
DOC_USP7_UBL2_3	231	235	PF12436	0.685
DOC_USP7_UBL2_3	590	594	PF12436	0.557
DOC_WW_Pin1_4	356	361	PF00397	0.587
DOC_WW_Pin1_4	569	574	PF00397	0.461
DOC_WW_Pin1_4	649	654	PF00397	0.443
DOC_WW_Pin1_4	84	89	PF00397	0.727
DOC_WW_Pin1_4	97	102	PF00397	0.625
LIG_14-3-3_CanoR_1	380	386	PF00244	0.529
LIG_14-3-3_CanoR_1	440	445	PF00244	0.463
LIG_14-3-3_CanoR_1	612	616	PF00244	0.529
LIG_14-3-3_CanoR_1	626	636	PF00244	0.660
LIG_14-3-3_CanoR_1	662	668	PF00244	0.504
LIG_14-3-3_CanoR_1	671	675	PF00244	0.364
LIG_14-3-3_CanoR_1	763	773	PF00244	0.447
LIG_14-3-3_CanoR_1	809	814	PF00244	0.402
LIG_14-3-3_CanoR_1	840	847	PF00244	0.624
LIG_14-3-3_CanoR_1	864	869	PF00244	0.659
LIG_14-3-3_CanoR_1	896	905	PF00244	0.652
LIG_BIR_III_4	294	298	PF00653	0.511
LIG_BIR_III_4	559	563	PF00653	0.630
LIG_BRCT_BRCA1_1	729	733	PF00533	0.411
LIG_BRCT_BRCA1_1	770	774	PF00533	0.439
LIG_BRCT_BRCA1_1	901	905	PF00533	0.614
LIG_Clathr_ClatBox_1	166	170	PF01394	0.641
LIG_Clathr_ClatBox_1	751	755	PF01394	0.638
LIG_deltaCOP1_diTrp_1	341	346	PF00928	0.531
LIG_eIF4E_1	417	423	PF01652	0.436
LIG_eIF4E_1	650	656	PF01652	0.565
LIG_FHA_1	259	265	PF00498	0.514
LIG_FHA_1	387	393	PF00498	0.476
LIG_FHA_1	45	51	PF00498	0.723
LIG_FHA_1	494	500	PF00498	0.495
LIG_FHA_1	517	523	PF00498	0.454
LIG_FHA_1	603	609	PF00498	0.632
LIG_FHA_1	650	656	PF00498	0.449
LIG_FHA_1	689	695	PF00498	0.407
LIG_FHA_2	346	352	PF00498	0.458
LIG_FHA_2	554	560	PF00498	0.585
LIG_FXI_DFP_1	408	412	PF00024	0.398
LIG_LIR_Apic_2	269	274	PF02991	0.497
LIG_LIR_Apic_2	414	420	PF02991	0.419
LIG_LIR_Apic_2	647	653	PF02991	0.535
LIG_LIR_Gen_1	341	347	PF02991	0.517
LIG_LIR_Gen_1	350	360	PF02991	0.460
LIG_LIR_Gen_1	747	754	PF02991	0.639
LIG_LIR_Gen_1	902	912	PF02991	0.565
LIG_LIR_Nem_3	293	299	PF02991	0.437
LIG_LIR_Nem_3	341	346	PF02991	0.531
LIG_LIR_Nem_3	350	355	PF02991	0.444
LIG_LIR_Nem_3	519	524	PF02991	0.397
LIG_LIR_Nem_3	747	751	PF02991	0.619
LIG_LIR_Nem_3	771	777	PF02991	0.449
LIG_LIR_Nem_3	902	908	PF02991	0.586
LIG_MYND_1	653	657	PF01753	0.442
LIG_NRBOX	663	669	PF00104	0.500
LIG_PCNA_PIPBox_1	325	334	PF02747	0.470
LIG_PCNA_yPIPBox_3	478	491	PF02747	0.551
LIG_PCNA_yPIPBox_3	661	672	PF02747	0.466
LIG_PTB_Apo_2	438	445	PF02174	0.447
LIG_SH2_CRK	207	211	PF00017	0.568
LIG_SH2_CRK	417	421	PF00017	0.448
LIG_SH2_CRK	571	575	PF00017	0.463
LIG_SH2_CRK	650	654	PF00017	0.566
LIG_SH2_NCK_1	417	421	PF00017	0.448
LIG_SH2_NCK_1	571	575	PF00017	0.463
LIG_SH2_NCK_1	650	654	PF00017	0.566
LIG_SH2_PTP2	298	301	PF00017	0.575
LIG_SH2_STAP1	321	325	PF00017	0.446
LIG_SH2_STAP1	748	752	PF00017	0.626
LIG_SH2_STAT3	307	310	PF00017	0.570
LIG_SH2_STAT3	541	544	PF00017	0.647
LIG_SH2_STAT3	715	718	PF00017	0.407
LIG_SH2_STAT5	298	301	PF00017	0.428
LIG_SH2_STAT5	307	310	PF00017	0.450
LIG_SH2_STAT5	462	465	PF00017	0.420
LIG_SH2_STAT5	520	523	PF00017	0.395
LIG_SH2_STAT5	541	544	PF00017	0.537
LIG_SH2_STAT5	555	558	PF00017	0.465
LIG_SH2_STAT5	571	574	PF00017	0.460
LIG_SH2_STAT5	648	651	PF00017	0.482
LIG_SH2_STAT5	715	718	PF00017	0.392
LIG_SH2_STAT5	772	775	PF00017	0.430
LIG_SH2_STAT5	789	792	PF00017	0.380
LIG_SH3_3	270	276	PF00018	0.581
LIG_SH3_3	510	516	PF00018	0.564
LIG_SH3_3	539	545	PF00018	0.511
LIG_SH3_3	700	706	PF00018	0.507
LIG_SH3_3	797	803	PF00018	0.455
LIG_SH3_3	817	823	PF00018	0.231
LIG_SH3_3	866	872	PF00018	0.725
LIG_SH3_3	889	895	PF00018	0.701
LIG_SUMO_SIM_anti_2	64	69	PF11976	0.522
LIG_SUMO_SIM_anti_2	663	669	PF11976	0.468
LIG_SUMO_SIM_par_1	163	170	PF11976	0.592
LIG_SUMO_SIM_par_1	401	407	PF11976	0.355
LIG_TRAF2_1	348	351	PF00917	0.468
LIG_TRAF2_1	622	625	PF00917	0.621
LIG_TRFH_1	684	688	PF08558	0.415
LIG_WW_3	705	709	PF00397	0.534
MOD_CDK_SPK_2	356	361	PF00069	0.587
MOD_CK1_1	663	669	PF00069	0.450
MOD_CK1_1	858	864	PF00069	0.640
MOD_CK1_1	86	92	PF00069	0.771
MOD_CK1_1	885	891	PF00069	0.732
MOD_CK1_1	899	905	PF00069	0.535
MOD_CK2_1	345	351	PF00069	0.470
MOD_CK2_1	497	503	PF00069	0.479
MOD_CK2_1	874	880	PF00069	0.726
MOD_Cter_Amidation	377	380	PF01082	0.561
MOD_GlcNHglycan	191	194	PF01048	0.621
MOD_GlcNHglycan	3	6	PF01048	0.657
MOD_GlcNHglycan	383	386	PF01048	0.512
MOD_GlcNHglycan	487	490	PF01048	0.392
MOD_GlcNHglycan	499	502	PF01048	0.388
MOD_GlcNHglycan	866	869	PF01048	0.718
MOD_GlcNHglycan	876	879	PF01048	0.741
MOD_GlcNHglycan	89	92	PF01048	0.713
MOD_GlcNHglycan	898	901	PF01048	0.658
MOD_GSK3_1	117	124	PF00069	0.578
MOD_GSK3_1	174	181	PF00069	0.670
MOD_GSK3_1	421	428	PF00069	0.571
MOD_GSK3_1	445	452	PF00069	0.465
MOD_GSK3_1	493	500	PF00069	0.500
MOD_GSK3_1	590	597	PF00069	0.554
MOD_GSK3_1	611	618	PF00069	0.696
MOD_GSK3_1	627	634	PF00069	0.685
MOD_GSK3_1	764	771	PF00069	0.468
MOD_GSK3_1	794	801	PF00069	0.493
MOD_GSK3_1	82	89	PF00069	0.760
MOD_GSK3_1	97	104	PF00069	0.647
MOD_LATS_1	588	594	PF00433	0.573
MOD_LATS_1	894	900	PF00433	0.758
MOD_N-GLC_1	199	204	PF02516	0.676
MOD_N-GLC_1	258	263	PF02516	0.543
MOD_N-GLC_1	289	294	PF02516	0.601
MOD_N-GLC_1	425	430	PF02516	0.476
MOD_N-GLC_1	440	445	PF02516	0.440
MOD_N-GLC_2	30	32	PF02516	0.632
MOD_NEK2_1	107	112	PF00069	0.670
MOD_NEK2_1	425	430	PF00069	0.549
MOD_NEK2_1	596	601	PF00069	0.545
MOD_NEK2_1	670	675	PF00069	0.407
MOD_NEK2_1	713	718	PF00069	0.388
MOD_NEK2_1	766	771	PF00069	0.443
MOD_NEK2_1	793	798	PF00069	0.510
MOD_NEK2_2	688	693	PF00069	0.366
MOD_NEK2_2	882	887	PF00069	0.745
MOD_PIKK_1	174	180	PF00454	0.752
MOD_PIKK_1	345	351	PF00454	0.459
MOD_PIKK_1	642	648	PF00454	0.581
MOD_PIKK_1	714	720	PF00454	0.409
MOD_PK_1	449	455	PF00069	0.645
MOD_PKA_1	135	141	PF00069	0.738
MOD_PKA_1	590	596	PF00069	0.570
MOD_PKA_1	840	846	PF00069	0.622
MOD_PKA_2	135	141	PF00069	0.610
MOD_PKA_2	189	195	PF00069	0.631
MOD_PKA_2	611	617	PF00069	0.542
MOD_PKA_2	627	633	PF00069	0.624
MOD_PKA_2	670	676	PF00069	0.413
MOD_PKA_2	764	770	PF00069	0.450
MOD_PKA_2	840	846	PF00069	0.622
MOD_PKA_2	855	861	PF00069	0.599
MOD_Plk_1	258	264	PF00069	0.547
MOD_Plk_1	425	431	PF00069	0.469
MOD_Plk_1	440	446	PF00069	0.446
MOD_Plk_1	449	455	PF00069	0.514
MOD_Plk_1	882	888	PF00069	0.757
MOD_Plk_2-3	849	855	PF00069	0.723
MOD_Plk_4	142	148	PF00069	0.568
MOD_Plk_4	259	265	PF00069	0.586
MOD_Plk_4	411	417	PF00069	0.390
MOD_Plk_4	425	431	PF00069	0.397
MOD_Plk_4	458	464	PF00069	0.489
MOD_Plk_4	516	522	PF00069	0.420
MOD_Plk_4	528	534	PF00069	0.402
MOD_Plk_4	644	650	PF00069	0.573
MOD_Plk_4	663	669	PF00069	0.293
MOD_Plk_4	688	694	PF00069	0.378
MOD_Plk_4	858	864	PF00069	0.640
MOD_ProDKin_1	356	362	PF00069	0.585
MOD_ProDKin_1	569	575	PF00069	0.465
MOD_ProDKin_1	649	655	PF00069	0.441
MOD_ProDKin_1	84	90	PF00069	0.729
MOD_ProDKin_1	97	103	PF00069	0.617
MOD_SUMO_for_1	622	625	PF00179	0.738
MOD_SUMO_rev_2	230	237	PF00179	0.620
MOD_SUMO_rev_2	252	262	PF00179	0.632
MOD_SUMO_rev_2	583	593	PF00179	0.600
TRG_DiLeu_BaEn_3	341	347	PF01217	0.517
TRG_DiLeu_BaEn_4	164	170	PF01217	0.681
TRG_DiLeu_BaLyEn_6	33	38	PF01217	0.699
TRG_DiLeu_BaLyEn_6	861	866	PF01217	0.676
TRG_ENDOCYTIC_2	207	210	PF00928	0.575
TRG_ENDOCYTIC_2	748	751	PF00928	0.622
TRG_ER_diArg_1	136	139	PF00400	0.640
TRG_ER_diArg_1	439	442	PF00400	0.419
TRG_ER_diArg_1	463	465	PF00400	0.400
TRG_ER_diArg_1	510	512	PF00400	0.582
TRG_ER_diArg_1	584	587	PF00400	0.706
TRG_ER_diArg_1	626	629	PF00400	0.550
TRG_ER_diArg_1	670	672	PF00400	0.433
TRG_ER_diArg_1	763	766	PF00400	0.506
TRG_ER_diArg_1	779	782	PF00400	0.491
TRG_ER_diArg_1	808	811	PF00400	0.401
TRG_ER_diArg_1	829	832	PF00400	0.550
TRG_ER_diArg_1	840	842	PF00400	0.616
TRG_NES_CRM1_1	199	215	PF08389	0.620
TRG_NLS_MonoExtC_3	134	139	PF00514	0.727
TRG_NLS_MonoExtN_4	836	843	PF00514	0.665
TRG_Pf-PMV_PEXEL_1	393	397	PF00026	0.457

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JAV8	Bodo saltans	56%	100%
A0A1X0P214	Trypanosomatidae	64%	95%
A0A3Q8IFP9	Leishmania donovani	100%	100%
A0A3R7N4Q1	Trypanosoma rangeli	66%	99%
A4HI40	Leishmania braziliensis	89%	100%
C6K3X4	Leptomonas seymouri	72%	90%
C9ZQP9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	100%
E9B0L3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q7L9	Leishmania major	96%	100%
V5BU91	Trypanosoma cruzi	62%	100%