Prefoldin subunit

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Prefoldin subunit

Gene product:

Prefoldin subunit - putative

Species:

Leishmania infantum

UniProt:

A4I5B6_LEIIN

TriTrypDb:

LINF_300013900

Length:

146

Annotations

Annotations by Jardim et al.

Chaperone/Protein Folding, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016272	prefoldin complex	2	11
GO:0032991	protein-containing complex	1	11
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I5B6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5B6

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	11
GO:0009987	cellular process	1	11

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0051082	unfolded protein binding	3	11
GO:0044183	protein folding chaperone	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	122	124	PF00675	0.471
CLV_NRD_NRD_1	51	53	PF00675	0.258
CLV_PCSK_KEX2_1	122	124	PF00082	0.490
CLV_PCSK_KEX2_1	47	49	PF00082	0.344
CLV_PCSK_KEX2_1	51	53	PF00082	0.267
CLV_PCSK_PC1ET2_1	47	49	PF00082	0.344
CLV_PCSK_SKI1_1	129	133	PF00082	0.563
CLV_PCSK_SKI1_1	42	46	PF00082	0.344
DEG_APCC_DBOX_1	128	136	PF00400	0.564
DOC_MAPK_gen_1	107	115	PF00069	0.512
DOC_MAPK_gen_1	47	57	PF00069	0.517
DOC_USP7_MATH_1	137	141	PF00917	0.577
LIG_14-3-3_CanoR_1	109	115	PF00244	0.505
LIG_14-3-3_CanoR_1	28	33	PF00244	0.565
LIG_14-3-3_CanoR_1	42	47	PF00244	0.500
LIG_14-3-3_CanoR_1	52	58	PF00244	0.479
LIG_14-3-3_CterR_2	141	146	PF00244	0.630
LIG_Actin_WH2_2	32	49	PF00022	0.544
LIG_BIR_II_1	1	5	PF00653	0.559
LIG_FHA_1	108	114	PF00498	0.499
LIG_FHA_1	39	45	PF00498	0.487
LIG_FHA_2	19	25	PF00498	0.543
LIG_FHA_2	54	60	PF00498	0.496
LIG_SH2_CRK	70	74	PF00017	0.516
LIG_TRAF2_1	124	127	PF00917	0.530
LIG_TYR_ITIM	68	73	PF00017	0.516
MOD_CK1_1	2	8	PF00069	0.576
MOD_CK2_1	18	24	PF00069	0.547
MOD_CK2_1	53	59	PF00069	0.456
MOD_GSK3_1	1	8	PF00069	0.625
MOD_GSK3_1	28	35	PF00069	0.542
MOD_GSK3_1	38	45	PF00069	0.514
MOD_N-GLC_1	2	7	PF02516	0.585
MOD_NEK2_1	1	6	PF00069	0.639
MOD_NEK2_1	32	37	PF00069	0.478
MOD_PIKK_1	139	145	PF00454	0.577
MOD_PKA_2	101	107	PF00069	0.486
MOD_PKA_2	108	114	PF00069	0.490
MOD_PKA_2	32	38	PF00069	0.477
MOD_Plk_1	18	24	PF00069	0.505
MOD_Plk_1	2	8	PF00069	0.657
MOD_SUMO_for_1	115	118	PF00179	0.512
TRG_ENDOCYTIC_2	70	73	PF00928	0.464
TRG_ER_diArg_1	121	123	PF00400	0.524

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JDG9	Bodo saltans	46%	100%
A0A1X0P260	Trypanosomatidae	51%	100%
A0A3S7X344	Leishmania donovani	99%	100%
A0A422P4U7	Trypanosoma rangeli	49%	100%
A4HI39	Leishmania braziliensis	90%	100%
C6K3X3	Leptomonas seymouri	86%	100%
C9ZQP8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9B0L2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4Q7M0	Leishmania major	96%	100%