Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I5B3_LEIIN

TriTrypDb:

LINF_300013600

Length:

249

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A4I5B3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5B3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	154	158	PF00656	0.688
CLV_C14_Caspase3-7	177	181	PF00656	0.686
CLV_NRD_NRD_1	135	137	PF00675	0.546
CLV_PCSK_KEX2_1	135	137	PF00082	0.546
DEG_Nend_UBRbox_3	1	3	PF02207	0.506
DOC_CKS1_1	182	187	PF01111	0.661
DOC_CYCLIN_yCln2_LP_2	232	238	PF00134	0.746
DOC_PP2B_LxvP_1	222	225	PF13499	0.807
DOC_PP2B_LxvP_1	232	235	PF13499	0.725
DOC_USP7_MATH_1	225	229	PF00917	0.750
DOC_USP7_MATH_1	40	44	PF00917	0.672
DOC_USP7_MATH_1	71	75	PF00917	0.501
DOC_USP7_MATH_1	9	13	PF00917	0.452
DOC_WW_Pin1_4	181	186	PF00397	0.792
LIG_14-3-3_CanoR_1	105	109	PF00244	0.688
LIG_14-3-3_CanoR_1	136	146	PF00244	0.800
LIG_14-3-3_CanoR_1	211	218	PF00244	0.676
LIG_APCC_ABBA_1	99	104	PF00400	0.492
LIG_BRCT_BRCA1_1	56	60	PF00533	0.452
LIG_FHA_1	224	230	PF00498	0.823
LIG_FHA_1	243	249	PF00498	0.597
LIG_FHA_2	138	144	PF00498	0.747
LIG_LIR_Apic_2	216	221	PF02991	0.768
LIG_LIR_Gen_1	174	183	PF02991	0.687
LIG_LIR_Nem_3	107	112	PF02991	0.687
LIG_LIR_Nem_3	13	19	PF02991	0.452
LIG_LIR_Nem_3	174	179	PF02991	0.710
LIG_LIR_Nem_3	187	192	PF02991	0.703
LIG_LIR_Nem_3	48	54	PF02991	0.505
LIG_NRBOX	24	30	PF00104	0.355
LIG_PDZ_Class_2	244	249	PF00595	0.766
LIG_Pex14_1	96	100	PF04695	0.452
LIG_Pex14_2	47	51	PF04695	0.510
LIG_SH2_CRK	16	20	PF00017	0.452
LIG_SH2_CRK	218	222	PF00017	0.770
LIG_SH2_NCK_1	139	143	PF00017	0.748
LIG_SH2_STAT3	236	239	PF00017	0.747
LIG_SH2_STAT5	100	103	PF00017	0.636
LIG_SH2_STAT5	108	111	PF00017	0.697
LIG_SH2_STAT5	137	140	PF00017	0.745
LIG_SH2_STAT5	192	195	PF00017	0.751
LIG_SH2_STAT5	236	239	PF00017	0.747
LIG_SH3_3	179	185	PF00018	0.660
LIG_SUMO_SIM_par_1	220	226	PF11976	0.808
LIG_UBA3_1	25	34	PF00899	0.602
MOD_CK1_1	213	219	PF00069	0.766
MOD_CK1_1	242	248	PF00069	0.764
MOD_CK2_1	171	177	PF00069	0.691
MOD_GlcNHglycan	114	117	PF01048	0.471
MOD_GlcNHglycan	12	15	PF01048	0.463
MOD_GlcNHglycan	131	134	PF01048	0.480
MOD_GlcNHglycan	157	160	PF01048	0.497
MOD_GlcNHglycan	171	174	PF01048	0.461
MOD_GlcNHglycan	213	216	PF01048	0.545
MOD_GSK3_1	151	158	PF00069	0.716
MOD_GSK3_1	165	172	PF00069	0.662
MOD_GSK3_1	50	57	PF00069	0.504
MOD_NEK2_1	167	172	PF00069	0.725
MOD_NEK2_1	50	55	PF00069	0.513
MOD_PIKK_1	184	190	PF00454	0.766
MOD_PK_1	151	157	PF00069	0.688
MOD_PKA_2	104	110	PF00069	0.683
MOD_PKA_2	210	216	PF00069	0.670
MOD_Plk_1	239	245	PF00069	0.770
MOD_Plk_4	104	110	PF00069	0.698
MOD_Plk_4	213	219	PF00069	0.767
MOD_Plk_4	54	60	PF00069	0.495
MOD_ProDKin_1	181	187	PF00069	0.794
TRG_DiLeu_BaEn_1	75	80	PF01217	0.380
TRG_ENDOCYTIC_2	16	19	PF00928	0.452
TRG_ER_diArg_1	135	137	PF00400	0.746

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X345	Leishmania donovani	100%	100%
E9B0K9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q7M3	Leishmania major	89%	100%