Transmembrane protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I5B2_LEIIN

TriTrypDb:

LINF_300013500

Length:

198

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 5, no: 4
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4I5B2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5B2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	136	138	PF00675	0.752
CLV_NRD_NRD_1	182	184	PF00675	0.504
CLV_PCSK_KEX2_1	193	195	PF00082	0.533
CLV_PCSK_PC1ET2_1	193	195	PF00082	0.512
DEG_Nend_UBRbox_1	1	4	PF02207	0.639
DEG_SPOP_SBC_1	112	116	PF00917	0.355
DEG_SPOP_SBC_1	26	30	PF00917	0.538
DOC_PP1_RVXF_1	73	80	PF00149	0.457
DOC_PP2B_LxvP_1	172	175	PF13499	0.678
DOC_PP2B_LxvP_1	177	180	PF13499	0.688
DOC_USP7_MATH_1	104	108	PF00917	0.409
DOC_USP7_MATH_1	144	148	PF00917	0.474
DOC_USP7_MATH_1	26	30	PF00917	0.628
DOC_USP7_MATH_1	73	77	PF00917	0.429
DOC_WW_Pin1_4	117	122	PF00397	0.485
DOC_WW_Pin1_4	138	143	PF00397	0.593
DOC_WW_Pin1_4	27	32	PF00397	0.461
LIG_14-3-3_CanoR_1	194	198	PF00244	0.622
LIG_14-3-3_CanoR_1	75	80	PF00244	0.448
LIG_Actin_WH2_2	95	112	PF00022	0.470
LIG_BRCT_BRCA1_1	75	79	PF00533	0.388
LIG_Clathr_ClatBox_1	99	103	PF01394	0.431
LIG_FHA_1	11	17	PF00498	0.565
LIG_FHA_1	117	123	PF00498	0.439
LIG_FHA_1	32	38	PF00498	0.506
LIG_FHA_1	60	66	PF00498	0.405
LIG_FHA_1	72	78	PF00498	0.403
LIG_FHA_1	90	96	PF00498	0.363
LIG_IRF3_LxIS_1	121	127	PF10401	0.471
LIG_LIR_Gen_1	76	87	PF02991	0.455
LIG_LIR_Nem_3	76	82	PF02991	0.349
LIG_MAD2	167	175	PF02301	0.706
LIG_PCNA_yPIPBox_3	46	58	PF02747	0.441
LIG_SH2_CRK	22	26	PF00017	0.403
LIG_SH2_PTP2	52	55	PF00017	0.371
LIG_SH2_STAT5	22	25	PF00017	0.514
LIG_SH2_STAT5	52	55	PF00017	0.371
LIG_SH3_3	90	96	PF00018	0.413
LIG_Sin3_3	149	156	PF02671	0.408
LIG_SUMO_SIM_par_1	167	173	PF11976	0.740
LIG_SUMO_SIM_par_1	90	97	PF11976	0.452
LIG_TYR_ITIM	20	25	PF00017	0.522
LIG_TYR_ITIM	50	55	PF00017	0.286
LIG_WRC_WIRS_1	186	191	PF05994	0.724
MOD_CK1_1	111	117	PF00069	0.462
MOD_CK1_1	127	133	PF00069	0.294
MOD_CK1_1	147	153	PF00069	0.432
MOD_CK1_1	188	194	PF00069	0.717
MOD_CK1_1	5	11	PF00069	0.456
MOD_CK1_1	85	91	PF00069	0.447
MOD_CK2_1	127	133	PF00069	0.495
MOD_GlcNHglycan	110	113	PF01048	0.632
MOD_GlcNHglycan	146	149	PF01048	0.402
MOD_GlcNHglycan	67	70	PF01048	0.617
MOD_GlcNHglycan	84	87	PF01048	0.608
MOD_GSK3_1	104	111	PF00069	0.397
MOD_GSK3_1	112	119	PF00069	0.445
MOD_GSK3_1	140	147	PF00069	0.528
MOD_GSK3_1	185	192	PF00069	0.723
MOD_GSK3_1	2	9	PF00069	0.574
MOD_GSK3_1	27	34	PF00069	0.482
MOD_GSK3_1	71	78	PF00069	0.363
MOD_GSK3_1	81	88	PF00069	0.344
MOD_NEK2_1	102	107	PF00069	0.436
MOD_NEK2_1	124	129	PF00069	0.361
MOD_NEK2_1	189	194	PF00069	0.716
MOD_NEK2_1	25	30	PF00069	0.595
MOD_NEK2_1	71	76	PF00069	0.361
MOD_PK_1	167	173	PF00069	0.702
MOD_Plk_1	89	95	PF00069	0.426
MOD_Plk_4	10	16	PF00069	0.570
MOD_Plk_4	104	110	PF00069	0.413
MOD_Plk_4	167	173	PF00069	0.650
MOD_ProDKin_1	117	123	PF00069	0.483
MOD_ProDKin_1	138	144	PF00069	0.593
MOD_ProDKin_1	27	33	PF00069	0.459
TRG_ENDOCYTIC_2	22	25	PF00928	0.523
TRG_ENDOCYTIC_2	52	55	PF00928	0.351
TRG_NES_CRM1_1	35	48	PF08389	0.412

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM14	Leptomonas seymouri	46%	100%
A0A1X0P359	Trypanosomatidae	33%	100%
A0A3S7X383	Leishmania donovani	99%	100%
A0A422P4T9	Trypanosoma rangeli	33%	100%
A4HI36	Leishmania braziliensis	79%	100%
C9ZQP6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9B0K8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q7M4	Leishmania major	92%	100%