LeishMANIAdb
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Putative rac serine-threonine kinase

Quick info Annotations Function or PPIs Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative rac serine-threonine kinase
Gene product:
rac serine-threonine kinase - putative
Species:
Leishmania infantum
UniProt:
A4I5B1_LEIIN
TriTrypDb:
LINF_300013400
Length:
510

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Annotations by Jardim et al.

Protein kinase, rac serine-threonine kinase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 25
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Could not find GO cellular_component term for this entry.

Phosphorylation

Amastigote: 423, 427

Expansion

Sequence features

A4I5B1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5B1

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 9
GO:0006793 phosphorus metabolic process 3 9
GO:0006796 phosphate-containing compound metabolic process 4 9
GO:0006807 nitrogen compound metabolic process 2 9
GO:0008152 metabolic process 1 9
GO:0009987 cellular process 1 9
GO:0016310 phosphorylation 5 9
GO:0019538 protein metabolic process 3 9
GO:0036211 protein modification process 4 9
GO:0043170 macromolecule metabolic process 3 9
GO:0043412 macromolecule modification 4 9
GO:0044237 cellular metabolic process 2 9
GO:0044238 primary metabolic process 2 9
GO:0071704 organic substance metabolic process 2 9
GO:1901564 organonitrogen compound metabolic process 3 9
GO:0007165 signal transduction 2 1
GO:0018105 peptidyl-serine phosphorylation 6 1
GO:0018193 peptidyl-amino acid modification 5 1
GO:0018209 peptidyl-serine modification 6 1
GO:0035556 intracellular signal transduction 3 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0065007 biological regulation 1 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 9
GO:0003824 catalytic activity 1 9
GO:0004672 protein kinase activity 3 9
GO:0004674 protein serine/threonine kinase activity 4 9
GO:0005488 binding 1 9
GO:0005524 ATP binding 5 9
GO:0016301 kinase activity 4 9
GO:0016740 transferase activity 2 9
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 9
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 9
GO:0017076 purine nucleotide binding 4 9
GO:0030554 adenyl nucleotide binding 5 9
GO:0032553 ribonucleotide binding 3 9
GO:0032555 purine ribonucleotide binding 4 9
GO:0032559 adenyl ribonucleotide binding 5 9
GO:0035639 purine ribonucleoside triphosphate binding 4 9
GO:0036094 small molecule binding 2 9
GO:0043167 ion binding 2 9
GO:0043168 anion binding 3 9
GO:0097159 organic cyclic compound binding 2 9
GO:0097367 carbohydrate derivative binding 2 9
GO:0140096 catalytic activity, acting on a protein 2 9
GO:1901265 nucleoside phosphate binding 3 9
GO:1901363 heterocyclic compound binding 2 9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 345 347 PF00675 0.344
CLV_NRD_NRD_1 369 371 PF00675 0.414
CLV_NRD_NRD_1 437 439 PF00675 0.617
CLV_NRD_NRD_1 495 497 PF00675 0.708
CLV_NRD_NRD_1 79 81 PF00675 0.447
CLV_PCSK_FUR_1 435 439 PF00082 0.620
CLV_PCSK_KEX2_1 345 347 PF00082 0.327
CLV_PCSK_KEX2_1 437 439 PF00082 0.617
CLV_PCSK_SKI1_1 109 113 PF00082 0.503
CLV_PCSK_SKI1_1 154 158 PF00082 0.292
CLV_PCSK_SKI1_1 227 231 PF00082 0.313
CLV_PCSK_SKI1_1 313 317 PF00082 0.416
CLV_PCSK_SKI1_1 336 340 PF00082 0.297
CLV_PCSK_SKI1_1 370 374 PF00082 0.487
CLV_PCSK_SKI1_1 388 392 PF00082 0.444
CLV_PCSK_SKI1_1 48 52 PF00082 0.368
CLV_PCSK_SKI1_1 497 501 PF00082 0.659
DEG_APCC_DBOX_1 153 161 PF00400 0.326
DOC_CKS1_1 375 380 PF01111 0.527
DOC_CYCLIN_RxL_1 40 51 PF00134 0.386
DOC_CYCLIN_yClb1_LxF_4 297 303 PF00134 0.386
DOC_CYCLIN_yCln2_LP_2 372 378 PF00134 0.487
DOC_MAPK_gen_1 227 236 PF00069 0.386
DOC_MAPK_gen_1 354 364 PF00069 0.550
DOC_PP1_RVXF_1 279 286 PF00149 0.292
DOC_PP2B_LxvP_1 372 375 PF13499 0.486
DOC_PP2B_PxIxI_1 322 328 PF00149 0.319
DOC_PP4_FxxP_1 505 508 PF00568 0.636
DOC_USP7_UBL2_3 126 130 PF12436 0.305
DOC_USP7_UBL2_3 503 507 PF12436 0.637
DOC_WW_Pin1_4 374 379 PF00397 0.506
DOC_WW_Pin1_4 397 402 PF00397 0.625
DOC_WW_Pin1_4 420 425 PF00397 0.667
DOC_WW_Pin1_4 449 454 PF00397 0.680
DOC_WW_Pin1_4 462 467 PF00397 0.552
DOC_WW_Pin1_4 6 11 PF00397 0.319
LIG_14-3-3_CanoR_1 345 351 PF00244 0.410
LIG_14-3-3_CanoR_1 437 442 PF00244 0.491
LIG_14-3-3_CanoR_1 460 466 PF00244 0.670
LIG_14-3-3_CanoR_1 80 88 PF00244 0.429
LIG_Actin_WH2_2 38 55 PF00022 0.386
LIG_APCC_ABBAyCdc20_2 222 228 PF00400 0.386
LIG_BIR_II_1 1 5 PF00653 0.335
LIG_DLG_GKlike_1 437 445 PF00625 0.502
LIG_EH1_1 178 186 PF00400 0.386
LIG_eIF4E_1 179 185 PF01652 0.386
LIG_eIF4E_1 268 274 PF01652 0.386
LIG_FHA_1 14 20 PF00498 0.368
LIG_FHA_1 314 320 PF00498 0.397
LIG_FHA_1 329 335 PF00498 0.386
LIG_FHA_1 389 395 PF00498 0.571
LIG_FHA_1 58 64 PF00498 0.386
LIG_FHA_2 100 106 PF00498 0.468
LIG_FHA_2 190 196 PF00498 0.386
LIG_FHA_2 29 35 PF00498 0.368
LIG_FHA_2 427 433 PF00498 0.755
LIG_FHA_2 49 55 PF00498 0.163
LIG_LIR_Apic_2 265 271 PF02991 0.292
LIG_LIR_Apic_2 504 508 PF02991 0.636
LIG_LIR_Gen_1 15 26 PF02991 0.386
LIG_LIR_Gen_1 189 199 PF02991 0.386
LIG_LIR_Gen_1 2 10 PF02991 0.386
LIG_LIR_Gen_1 294 303 PF02991 0.402
LIG_LIR_Nem_3 116 120 PF02991 0.335
LIG_LIR_Nem_3 15 21 PF02991 0.346
LIG_LIR_Nem_3 189 194 PF02991 0.312
LIG_LIR_Nem_3 2 7 PF02991 0.331
LIG_LIR_Nem_3 284 288 PF02991 0.331
LIG_LIR_Nem_3 294 300 PF02991 0.331
LIG_LIR_Nem_3 363 367 PF02991 0.362
LIG_Pex14_1 14 18 PF04695 0.386
LIG_Pex14_2 106 110 PF04695 0.386
LIG_Pex14_2 386 390 PF04695 0.448
LIG_PTB_Apo_2 358 365 PF02174 0.438
LIG_SH2_CRK 117 121 PF00017 0.386
LIG_SH2_PTP2 18 21 PF00017 0.368
LIG_SH2_SRC 18 21 PF00017 0.368
LIG_SH2_SRC 218 221 PF00017 0.326
LIG_SH2_STAP1 208 212 PF00017 0.326
LIG_SH2_STAP1 413 417 PF00017 0.467
LIG_SH2_STAT3 170 173 PF00017 0.292
LIG_SH2_STAT3 193 196 PF00017 0.368
LIG_SH2_STAT5 18 21 PF00017 0.233
LIG_SH2_STAT5 193 196 PF00017 0.403
LIG_SH2_STAT5 218 221 PF00017 0.351
LIG_SH2_STAT5 262 265 PF00017 0.310
LIG_SH2_STAT5 268 271 PF00017 0.272
LIG_SH2_STAT5 4 7 PF00017 0.318
LIG_SH2_STAT5 411 414 PF00017 0.517
LIG_SH2_STAT5 72 75 PF00017 0.328
LIG_SH3_3 251 257 PF00018 0.368
LIG_SH3_3 316 322 PF00018 0.396
LIG_SH3_3 372 378 PF00018 0.415
LIG_SH3_3 4 10 PF00018 0.319
LIG_SH3_3 52 58 PF00018 0.398
LIG_TRAF2_1 171 174 PF00917 0.386
LIG_TRAF2_1 418 421 PF00917 0.611
LIG_TYR_ITIM 224 229 PF00017 0.292
LIG_TYR_ITSM 14 21 PF00017 0.386
LIG_UBA3_1 334 341 PF00899 0.386
MOD_CDK_SPxxK_3 6 13 PF00069 0.319
MOD_CK1_1 462 468 PF00069 0.820
MOD_CK1_1 93 99 PF00069 0.593
MOD_CK2_1 168 174 PF00069 0.390
MOD_CK2_1 189 195 PF00069 0.310
MOD_CK2_1 415 421 PF00069 0.626
MOD_CK2_1 426 432 PF00069 0.765
MOD_CK2_1 48 54 PF00069 0.331
MOD_CK2_1 93 99 PF00069 0.710
MOD_GlcNHglycan 1 4 PF01048 0.328
MOD_GlcNHglycan 136 140 PF01048 0.335
MOD_GlcNHglycan 36 40 PF01048 0.368
MOD_GlcNHglycan 95 98 PF01048 0.583
MOD_GSK3_1 258 265 PF00069 0.302
MOD_GSK3_1 420 427 PF00069 0.693
MOD_GSK3_1 437 444 PF00069 0.562
MOD_GSK3_1 445 452 PF00069 0.705
MOD_GSK3_1 458 465 PF00069 0.801
MOD_GSK3_1 497 504 PF00069 0.794
MOD_GSK3_1 53 60 PF00069 0.413
MOD_GSK3_1 91 98 PF00069 0.607
MOD_N-GLC_1 397 402 PF02516 0.742
MOD_N-GLC_1 445 450 PF02516 0.735
MOD_N-GLC_1 458 463 PF02516 0.786
MOD_N-GLC_1 501 506 PF02516 0.719
MOD_N-GLC_1 91 96 PF02516 0.554
MOD_NEK2_1 168 173 PF00069 0.304
MOD_NEK2_1 441 446 PF00069 0.685
MOD_NEK2_2 84 89 PF00069 0.368
MOD_PIKK_1 399 405 PF00454 0.638
MOD_PKA_1 125 131 PF00069 0.326
MOD_PKA_1 437 443 PF00069 0.664
MOD_PKA_1 497 503 PF00069 0.708
MOD_PKA_2 437 443 PF00069 0.634
MOD_PKA_2 459 465 PF00069 0.697
MOD_PKA_2 79 85 PF00069 0.368
MOD_PKB_1 435 443 PF00069 0.628
MOD_Plk_1 501 507 PF00069 0.683
MOD_Plk_1 68 74 PF00069 0.368
MOD_Plk_2-3 189 195 PF00069 0.340
MOD_Plk_2-3 99 105 PF00069 0.485
MOD_Plk_4 68 74 PF00069 0.354
MOD_ProDKin_1 374 380 PF00069 0.518
MOD_ProDKin_1 397 403 PF00069 0.631
MOD_ProDKin_1 420 426 PF00069 0.671
MOD_ProDKin_1 449 455 PF00069 0.680
MOD_ProDKin_1 462 468 PF00069 0.553
MOD_ProDKin_1 6 12 PF00069 0.319
MOD_SUMO_for_1 229 232 PF00179 0.292
MOD_SUMO_rev_2 105 111 PF00179 0.365
MOD_SUMO_rev_2 140 150 PF00179 0.386
MOD_SUMO_rev_2 20 26 PF00179 0.372
MOD_SUMO_rev_2 329 334 PF00179 0.368
MOD_SUMO_rev_2 44 50 PF00179 0.461
MOD_SUMO_rev_2 76 82 PF00179 0.368
TRG_DiLeu_BaEn_1 330 335 PF01217 0.386
TRG_ENDOCYTIC_2 117 120 PF00928 0.386
TRG_ENDOCYTIC_2 179 182 PF00928 0.295
TRG_ENDOCYTIC_2 18 21 PF00928 0.239
TRG_ENDOCYTIC_2 226 229 PF00928 0.292
TRG_ENDOCYTIC_2 4 7 PF00928 0.324
TRG_ER_diArg_1 345 347 PF00400 0.334
TRG_ER_diArg_1 434 437 PF00400 0.749
TRG_NLS_Bipartite_1 480 500 PF00514 0.647
TRG_Pf-PMV_PEXEL_1 154 158 PF00026 0.326
TRG_Pf-PMV_PEXEL_1 227 232 PF00026 0.292
TRG_Pf-PMV_PEXEL_1 313 317 PF00026 0.386
TRG_Pf-PMV_PEXEL_1 415 419 PF00026 0.501

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P4J7 Leptomonas seymouri 29% 100%
A0A0S4IWM4 Bodo saltans 25% 69%
A0A0S4J842 Bodo saltans 26% 95%
A0A0S4JER5 Bodo saltans 44% 100%
A0A0S4JI67 Bodo saltans 30% 100%
A0A0S4JM47 Bodo saltans 24% 94%
A0A1X0P3J5 Trypanosomatidae 40% 100%
A0A3Q8IC87 Leishmania donovani 28% 100%
A0A3Q8IIG1 Leishmania donovani 27% 100%
A0A3Q8INQ4 Leishmania donovani 33% 100%
A0A3Q8IRT6 Leishmania donovani 100% 100%
A0A3S5H5U5 Leishmania donovani 28% 100%
A0A3S7WTN9 Leishmania donovani 31% 100%
A0A3S7WWE7 Leishmania donovani 25% 100%
A0A3S7X7Y2 Leishmania donovani 25% 100%
A0A3S7X9R4 Leishmania donovani 41% 100%
A0A3S7X9S2 Leishmania donovani 39% 100%
A0A422NZ62 Trypanosoma rangeli 35% 74%
A0A422P4V9 Trypanosoma rangeli 41% 100%
A4H4S9 Leishmania braziliensis 28% 100%
A4H8C4 Leishmania braziliensis 30% 100%
A4HAS1 Leishmania braziliensis 26% 100%
A4HBL4 Leishmania braziliensis 26% 100%
A4HCD7 Leishmania braziliensis 30% 100%
A4HCE6 Leishmania braziliensis 28% 100%
A4HED7 Leishmania braziliensis 34% 100%
A4HFF3 Leishmania braziliensis 26% 100%
A4HI35 Leishmania braziliensis 93% 100%
A4HLR0 Leishmania braziliensis 28% 100%
A4HN71 Leishmania braziliensis 41% 100%
A4HNT2 Leishmania braziliensis 22% 100%
A4HWP5 Leishmania infantum 31% 100%
A4HZA2 Leishmania infantum 25% 100%
A4HZV1 Leishmania infantum 28% 98%
A4I1T4 Leishmania infantum 33% 100%
A4I435 Leishmania infantum 27% 100%
A4I9Y5 Leishmania infantum 25% 100%
A4IBT4 Leishmania infantum 41% 100%
A4IBT9 Leishmania infantum 41% 100%
C6K3W8 Leptomonas seymouri 73% 97%
C9ZQP5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 100%
C9ZTP2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 100%
E8NHS0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
E9AFM1 Leishmania major 39% 100%
E9AG71 Leishmania infantum 28% 100%
E9AKZ7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9AQF3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9AUY2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 100%
E9AVR5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 98%
E9AVS7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9AXW8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
E9B0C2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9B0K7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
E9B436 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
E9B4Z4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 100%
E9B6S4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 40% 100%
E9B6S9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 40% 100%
O13310 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 30% 100%
P05126 Bos taurus 33% 76%
P05771 Homo sapiens 33% 76%
P05772 Oryctolagus cuniculus 33% 76%
P18961 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 38% 75%
P23443 Homo sapiens 42% 97%
P28867 Mus musculus 33% 76%
P31748 AKT8 murine leukemia virus 36% 100%
P31749 Homo sapiens 35% 100%
P31750 Mus musculus 36% 100%
P38070 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 34% 97%
P47196 Rattus norvegicus 36% 100%
P53894 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 30% 67%
P54644 Dictyostelium discoideum 37% 100%
P67998 Oryctolagus cuniculus 42% 97%
P67999 Rattus norvegicus 42% 97%
P68403 Rattus norvegicus 33% 76%
P68404 Mus musculus 33% 76%
Q09831 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 35% 90%
Q09898 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 28% 84%
Q15835 Homo sapiens 31% 91%
Q4Q204 Leishmania major 24% 100%
Q4Q2Z2 Leishmania major 24% 100%
Q4Q7M5 Leishmania major 98% 100%
Q4Q7W2 Leishmania major 27% 100%
Q4Q9K2 Leishmania major 35% 100%
Q4QBQ2 Leishmania major 28% 100%
Q4QBR6 Leishmania major 29% 99%
Q4QCK0 Leishmania major 25% 100%
Q4QF23 Leishmania major 33% 100%
Q4QFK4 Leishmania major 25% 100%
Q4QIV8 Leishmania major 28% 100%
Q54IH8 Dictyostelium discoideum 28% 94%
Q5AP53 Candida albicans (strain SC5314 / ATCC MYA-2876) 30% 70%
Q5R7A7 Pongo abelii 37% 100%
Q63531 Rattus norvegicus 40% 69%
Q6BLJ9 Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) 31% 71%
Q6CFS5 Yarrowia lipolytica (strain CLIB 122 / E 150) 30% 87%
Q6TGC6 Pneumocystis carinii 31% 100%
Q6TJY3 Bos taurus 42% 97%
Q7LZQ8 Xenopus laevis 33% 76%
Q8BSK8 Mus musculus 42% 97%
Q8R4V0 Rattus norvegicus 37% 100%
Q96BR1 Homo sapiens 37% 100%
Q98TY9 Xenopus laevis 34% 100%
Q9ERE3 Mus musculus 37% 100%
Q9GNR4 Leishmania major 41% 100%
Q9UBS0 Homo sapiens 40% 100%
Q9UK32 Homo sapiens 24% 68%
Q9Z1M4 Mus musculus 40% 100%
V5BCH2 Trypanosoma cruzi 34% 100%
V5DQT5 Trypanosoma cruzi 41% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS