Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I5B0_LEIIN

TriTrypDb:

LINF_300013300

Length:

425

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I5B0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5B0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	117	121	PF00656	0.547
CLV_C14_Caspase3-7	128	132	PF00656	0.500
CLV_C14_Caspase3-7	151	155	PF00656	0.601
CLV_NRD_NRD_1	194	196	PF00675	0.629
CLV_NRD_NRD_1	214	216	PF00675	0.526
CLV_NRD_NRD_1	247	249	PF00675	0.521
CLV_NRD_NRD_1	333	335	PF00675	0.592
CLV_NRD_NRD_1	350	352	PF00675	0.509
CLV_NRD_NRD_1	358	360	PF00675	0.451
CLV_NRD_NRD_1	58	60	PF00675	0.622
CLV_PCSK_FUR_1	245	249	PF00082	0.519
CLV_PCSK_KEX2_1	247	249	PF00082	0.521
CLV_PCSK_KEX2_1	333	335	PF00082	0.573
CLV_PCSK_KEX2_1	349	351	PF00082	0.506
CLV_PCSK_KEX2_1	358	360	PF00082	0.440
CLV_PCSK_KEX2_1	419	421	PF00082	0.514
CLV_PCSK_KEX2_1	42	44	PF00082	0.577
CLV_PCSK_KEX2_1	423	425	PF00082	0.526
CLV_PCSK_PC1ET2_1	419	421	PF00082	0.514
CLV_PCSK_PC1ET2_1	42	44	PF00082	0.577
CLV_PCSK_PC1ET2_1	423	425	PF00082	0.526
CLV_PCSK_PC7_1	243	249	PF00082	0.521
CLV_PCSK_PC7_1	329	335	PF00082	0.550
CLV_PCSK_SKI1_1	162	166	PF00082	0.564
CLV_PCSK_SKI1_1	216	220	PF00082	0.745
CLV_PCSK_SKI1_1	371	375	PF00082	0.630
CLV_PCSK_SKI1_1	416	420	PF00082	0.417
CLV_PCSK_SKI1_1	42	46	PF00082	0.614
CLV_Separin_Metazoa	159	163	PF03568	0.568
DEG_APCC_DBOX_1	350	358	PF00400	0.496
DEG_SCF_FBW7_2	150	156	PF00400	0.603
DOC_CKS1_1	150	155	PF01111	0.604
DOC_MAPK_gen_1	349	357	PF00069	0.507
DOC_MAPK_gen_1	358	365	PF00069	0.381
DOC_MAPK_RevD_3	29	43	PF00069	0.526
DOC_PP2B_LxvP_1	138	141	PF13499	0.561
DOC_USP7_MATH_1	141	145	PF00917	0.605
DOC_USP7_MATH_1	17	21	PF00917	0.601
DOC_USP7_MATH_2	310	316	PF00917	0.582
DOC_USP7_UBL2_3	419	423	PF12436	0.521
DOC_WW_Pin1_4	149	154	PF00397	0.614
DOC_WW_Pin1_4	202	207	PF00397	0.665
DOC_WW_Pin1_4	316	321	PF00397	0.624
LIG_14-3-3_CanoR_1	135	141	PF00244	0.588
LIG_14-3-3_CanoR_1	204	212	PF00244	0.649
LIG_14-3-3_CanoR_1	224	234	PF00244	0.512
LIG_14-3-3_CanoR_1	247	256	PF00244	0.579
LIG_14-3-3_CanoR_1	409	417	PF00244	0.434
LIG_14-3-3_CanoR_1	43	47	PF00244	0.713
LIG_APCC_ABBA_1	61	66	PF00400	0.630
LIG_BIR_II_1	1	5	PF00653	0.541
LIG_BRCT_BRCA1_1	222	226	PF00533	0.651
LIG_BRCT_BRCA1_1	314	318	PF00533	0.591
LIG_FHA_1	155	161	PF00498	0.532
LIG_FHA_1	236	242	PF00498	0.618
LIG_FHA_1	249	255	PF00498	0.505
LIG_FHA_1	279	285	PF00498	0.729
LIG_FHA_1	30	36	PF00498	0.539
LIG_FHA_1	330	336	PF00498	0.558
LIG_FHA_1	394	400	PF00498	0.481
LIG_FHA_2	198	204	PF00498	0.754
LIG_FHA_2	311	317	PF00498	0.674
LIG_FHA_2	341	347	PF00498	0.529
LIG_FHA_2	46	52	PF00498	0.634
LIG_LIR_Gen_1	125	134	PF02991	0.576
LIG_LIR_Gen_1	379	388	PF02991	0.459
LIG_LIR_Nem_3	125	130	PF02991	0.561
LIG_LIR_Nem_3	182	188	PF02991	0.540
LIG_LIR_Nem_3	2	7	PF02991	0.598
LIG_LIR_Nem_3	379	383	PF02991	0.451
LIG_Pex14_3	160	165	PF04695	0.565
LIG_RPA_C_Fungi	354	366	PF08784	0.430
LIG_SH2_STAP1	188	192	PF00017	0.539
LIG_SH2_STAP1	99	103	PF00017	0.528
LIG_SH2_STAT5	111	114	PF00017	0.687
LIG_SH2_STAT5	201	204	PF00017	0.715
LIG_SH2_STAT5	360	363	PF00017	0.499
LIG_SH3_3	147	153	PF00018	0.623
LIG_SH3_3	228	234	PF00018	0.644
LIG_SH3_3	314	320	PF00018	0.537
LIG_SUMO_SIM_anti_2	156	163	PF11976	0.568
LIG_SUMO_SIM_anti_2	352	358	PF11976	0.495
LIG_TRAF2_1	48	51	PF00917	0.628
LIG_WRC_WIRS_1	4	9	PF05994	0.552
MOD_CK1_1	139	145	PF00069	0.569
MOD_CK1_1	205	211	PF00069	0.639
MOD_CK1_1	225	231	PF00069	0.490
MOD_CK1_1	235	241	PF00069	0.619
MOD_CK1_1	285	291	PF00069	0.611
MOD_CK1_1	90	96	PF00069	0.597
MOD_CK2_1	122	128	PF00069	0.551
MOD_CK2_1	254	260	PF00069	0.695
MOD_CK2_1	286	292	PF00069	0.586
MOD_CK2_1	3	9	PF00069	0.549
MOD_CK2_1	310	316	PF00069	0.676
MOD_CK2_1	340	346	PF00069	0.538
MOD_CK2_1	45	51	PF00069	0.626
MOD_Cter_Amidation	245	248	PF01082	0.521
MOD_Cter_Amidation	421	424	PF01082	0.533
MOD_Cter_Amidation	57	60	PF01082	0.645
MOD_GlcNHglycan	1	4	PF01048	0.545
MOD_GlcNHglycan	11	14	PF01048	0.559
MOD_GlcNHglycan	141	144	PF01048	0.549
MOD_GlcNHglycan	19	22	PF01048	0.572
MOD_GlcNHglycan	302	305	PF01048	0.550
MOD_GlcNHglycan	320	323	PF01048	0.540
MOD_GSK3_1	222	229	PF00069	0.601
MOD_GSK3_1	261	268	PF00069	0.636
MOD_GSK3_1	278	285	PF00069	0.603
MOD_GSK3_1	300	307	PF00069	0.564
MOD_GSK3_1	312	319	PF00069	0.695
MOD_GSK3_1	336	343	PF00069	0.477
MOD_GSK3_1	388	395	PF00069	0.486
MOD_GSK3_1	86	93	PF00069	0.589
MOD_N-GLC_1	335	340	PF02516	0.491
MOD_N-GLC_1	388	393	PF02516	0.484
MOD_NEK2_1	226	231	PF00069	0.714
MOD_NEK2_1	261	266	PF00069	0.631
MOD_NEK2_1	29	34	PF00069	0.585
MOD_NEK2_1	337	342	PF00069	0.565
MOD_NEK2_1	88	93	PF00069	0.590
MOD_NEK2_2	3	8	PF00069	0.547
MOD_PIKK_1	29	35	PF00454	0.580
MOD_PIKK_1	310	316	PF00454	0.595
MOD_PIKK_1	394	400	PF00454	0.418
MOD_PIKK_1	88	94	PF00454	0.624
MOD_PKA_1	247	253	PF00069	0.519
MOD_PKA_1	42	48	PF00069	0.625
MOD_PKA_2	174	180	PF00069	0.619
MOD_PKA_2	190	196	PF00069	0.577
MOD_PKA_2	226	232	PF00069	0.709
MOD_PKA_2	247	253	PF00069	0.574
MOD_PKA_2	42	48	PF00069	0.625
MOD_PKB_1	245	253	PF00069	0.597
MOD_Plk_1	279	285	PF00069	0.728
MOD_Plk_1	388	394	PF00069	0.489
MOD_Plk_1	401	407	PF00069	0.407
MOD_Plk_2-3	154	160	PF00069	0.574
MOD_Plk_2-3	197	203	PF00069	0.546
MOD_Plk_4	279	285	PF00069	0.623
MOD_ProDKin_1	149	155	PF00069	0.610
MOD_ProDKin_1	202	208	PF00069	0.663
MOD_ProDKin_1	316	322	PF00069	0.617
MOD_SUMO_for_1	399	402	PF00179	0.491
TRG_DiLeu_BaEn_1	156	161	PF01217	0.568
TRG_DiLeu_BaEn_1	352	357	PF01217	0.497
TRG_DiLeu_BaEn_4	352	358	PF01217	0.495
TRG_ENDOCYTIC_2	360	363	PF00928	0.448
TRG_ENDOCYTIC_2	380	383	PF00928	0.336
TRG_ER_diArg_1	244	247	PF00400	0.591
TRG_ER_diArg_1	333	335	PF00400	0.573
TRG_ER_diArg_1	348	351	PF00400	0.512
TRG_ER_diArg_1	357	359	PF00400	0.448
TRG_NES_CRM1_1	25	40	PF08389	0.590
TRG_Pf-PMV_PEXEL_1	371	375	PF00026	0.528

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X346	Leishmania donovani	100%	100%
C6K3W7	Leptomonas seymouri	30%	100%
E9B0K6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q7M6	Leishmania major	88%	100%