DUF5063 domain-containing protein

Quick info Annotations Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I5A8_LEIIN

TriTrypDb:

LINF_300013100

Length:

124

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005815	microtubule organizing center	2	1
GO:0005930	axoneme	2	1
GO:0036064	ciliary basal body	3	1
GO:0110165	cellular anatomical entity	1	1

Phosphorylation

Amastigote: 118, 122

Expansion

Sequence features

A4I5A8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5A8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	110	112	PF00082	0.427
CLV_PCSK_KEX2_1	70	72	PF00082	0.552
CLV_PCSK_PC1ET2_1	110	112	PF00082	0.427
CLV_PCSK_PC1ET2_1	70	72	PF00082	0.584
CLV_PCSK_SKI1_1	34	38	PF00082	0.545
CLV_PCSK_SKI1_1	50	54	PF00082	0.425
CLV_Separin_Metazoa	93	97	PF03568	0.433
DEG_MDM2_SWIB_1	86	94	PF02201	0.385
DEG_Nend_UBRbox_3	1	3	PF02207	0.624
DOC_PP1_RVXF_1	22	29	PF00149	0.356
DOC_PP1_RVXF_1	32	39	PF00149	0.477
DOC_PP4_FxxP_1	38	41	PF00568	0.503
LIG_LIR_Gen_1	27	37	PF02991	0.374
LIG_LIR_Nem_3	27	32	PF02991	0.376
LIG_PCNA_PIPBox_1	22	31	PF02747	0.551
LIG_PCNA_yPIPBox_3	17	29	PF02747	0.561
LIG_Pex14_2	86	90	PF04695	0.377
LIG_SH2_SRC	112	115	PF00017	0.489
LIG_SH2_STAT3	19	22	PF00017	0.439
LIG_SH2_STAT5	112	115	PF00017	0.417
LIG_SH2_STAT5	19	22	PF00017	0.405
MOD_CK2_1	98	104	PF00069	0.517
MOD_GlcNHglycan	62	65	PF01048	0.615
MOD_GSK3_1	115	122	PF00069	0.577
MOD_GSK3_1	56	63	PF00069	0.549
MOD_N-GLC_1	56	61	PF02516	0.582
MOD_PKA_2	20	26	PF00069	0.393
MOD_PKB_1	96	104	PF00069	0.527
MOD_SUMO_rev_2	73	78	PF00179	0.477
TRG_ENDOCYTIC_2	29	32	PF00928	0.526

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JBX9	Bodo saltans	52%	100%
A0A1X0P2S3	Trypanosomatidae	50%	100%
A0A3R7MCC7	Trypanosoma rangeli	46%	81%
A0A3S7X371	Leishmania donovani	100%	100%
A4HI32	Leishmania braziliensis	61%	100%
C6K3W5	Leptomonas seymouri	64%	100%
C9ZQP2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	96%
E9B0K4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q7M8	Leishmania major	87%	100%